MX2021006969A - Ligante peptidico. - Google Patents

Ligante peptidico.

Info

Publication number
MX2021006969A
MX2021006969A MX2021006969A MX2021006969A MX2021006969A MX 2021006969 A MX2021006969 A MX 2021006969A MX 2021006969 A MX2021006969 A MX 2021006969A MX 2021006969 A MX2021006969 A MX 2021006969A MX 2021006969 A MX2021006969 A MX 2021006969A
Authority
MX
Mexico
Prior art keywords
sulfonamide
conjugate
formula
peptide binder
active pharmaceutical
Prior art date
Application number
MX2021006969A
Other languages
English (en)
Inventor
Nils Rackelmann
Michael Podeschwa
Stefan Guessregen
Perez Maria Mendez
Martin Will
Thomas Boehme
Garea Ana Villar
Laurent Bialy
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX2021006969A publication Critical patent/MX2021006969A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a una sulfonamida de fórmula (A); un conjugado que comprende una sulfonamida de fórmula (I) y un principio activo farmacéutico; un proceso para preparar un conjugado que comprende una sulfonamida de fórmula (I) y un principio activo farmacéutico; una composición farmacéutica que comprende el conjugado que comprende una sulfonamida de fórmula (I) y un principio activo farmacéutico; y el uso del conjugado como medicamento.
MX2021006969A 2018-12-11 2019-12-10 Ligante peptidico. MX2021006969A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP18306658 2018-12-11
EP18306657 2018-12-11
EP18306659 2018-12-11
PCT/EP2019/084433 WO2020120479A1 (en) 2018-12-11 2019-12-10 Peptide binder

Publications (1)

Publication Number Publication Date
MX2021006969A true MX2021006969A (es) 2021-07-15

Family

ID=68806785

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2021006969A MX2021006969A (es) 2018-12-11 2019-12-10 Ligante peptidico.
MX2021006972A MX2021006972A (es) 2018-12-11 2019-12-10 Conjugados de insulina.
MX2021006970A MX2021006970A (es) 2018-12-11 2019-12-10 Analogos de insulina que tienen una afinidad de union disminuida al receptor de insulina.

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2021006972A MX2021006972A (es) 2018-12-11 2019-12-10 Conjugados de insulina.
MX2021006970A MX2021006970A (es) 2018-12-11 2019-12-10 Analogos de insulina que tienen una afinidad de union disminuida al receptor de insulina.

Country Status (15)

Country Link
US (2) US11098102B2 (es)
EP (3) EP3894391A1 (es)
JP (3) JP2022513776A (es)
KR (3) KR20210102347A (es)
CN (3) CN113396157A (es)
AU (3) AU2019398658A1 (es)
BR (3) BR112021011099A2 (es)
CA (3) CA3122636A1 (es)
CO (1) CO2021007453A2 (es)
IL (3) IL283801A (es)
MX (3) MX2021006969A (es)
PH (1) PH12021551339A1 (es)
SG (3) SG11202106166TA (es)
TW (3) TW202039437A (es)
WO (3) WO2020120463A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112876388B (zh) * 2021-01-14 2023-03-31 山东大学 一种gpr120激动剂及其制备方法与应用
CN116162147B (zh) * 2021-11-24 2023-10-03 成都奥达生物科技有限公司 一种长效胰岛素类似物
CN114230451A (zh) * 2021-12-29 2022-03-25 上海药坦药物研究开发有限公司 卤代酸类化合物的制备方法
WO2023144277A1 (en) * 2022-01-26 2023-08-03 Sanofi Insulin conjugates
WO2023247640A1 (en) 2022-06-23 2023-12-28 Sanofi Single chain insulins and fc conjugates thereof
CN115947822B (zh) * 2022-07-04 2023-08-18 北京惠之衡生物科技有限公司 一种长效酰化胰岛素衍生物及其药物组合物和应用
WO2024051787A1 (zh) * 2022-09-09 2024-03-14 北京惠之衡生物科技有限公司 一种长效酰化胰岛素衍生物及其应用

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2164520C2 (ru) 1993-09-17 2001-03-27 Ново Нордиск А/С Производное инсулина, растворимая пролонгированная фармацевтическая композиция, способ пролонгирования гипогликемического действия при лечении диабета
KR19980703039A (ko) 1995-03-17 1998-09-05 켈스버그 라아스 인슐린 유도체
US6451970B1 (en) 1996-02-21 2002-09-17 Novo Nordisk A/S Peptide derivatives
WO1999021578A1 (en) 1997-10-24 1999-05-06 Eli Lilly And Company Insoluble insulin compositions
KR20070029247A (ko) 2004-07-08 2007-03-13 노보 노르디스크 에이/에스 폴리펩티드 연장 태그
ES2490243T3 (es) 2005-02-02 2014-09-03 Novo Nordisk A/S Derivados de insulina
EP1846446B1 (en) 2005-02-02 2013-06-26 Novo Nordisk A/S Insulin derivatives
JP5366546B2 (ja) 2005-08-16 2013-12-11 ノボ・ノルデイスク・エー／エス 成熟インスリンポリペプチドの作製方法
DE602007009496D1 (de) 2006-02-27 2010-11-11 Novo Nordisk As Insulinderivate
WO2007104736A2 (en) 2006-03-13 2007-09-20 Novo Nordisk A/S Acylated single chain insulin
JP5269766B2 (ja) 2006-05-09 2013-08-21 ノボ・ノルデイスク・エー／エス インスリン誘導体
MX2008014061A (es) 2006-05-09 2008-11-14 Novo Nordisk As Derivado de insulina.
CN101573133B (zh) 2006-07-31 2014-08-27 诺沃-诺迪斯克有限公司 Peg化延长的胰岛素
WO2008034881A1 (en) 2006-09-22 2008-03-27 Novo Nordisk A/S Protease resistant insulin analogues
WO2008049711A1 (en) 2006-10-27 2008-05-02 Novo Nordisk A/S Peptide extended insulins
GB0621973D0 (en) 2006-11-03 2006-12-13 Philogen Spa Binding molecules and uses thereof
WO2009010428A1 (en) 2007-07-16 2009-01-22 Novo Nordisk A/S Protease stabilized, pegylated insulin analogues
US9150633B2 (en) 2007-08-15 2015-10-06 Novo Nordisk A/S Insulin analogues with an acyl and alkylene glycol moiety
JP5721432B2 (ja) 2007-08-15 2015-05-20 ノボ・ノルデイスク・エー／エス アミノ酸含有アルキレングリコール反復単位を含むアシル部を有するインスリン
DK2217265T3 (en) 2007-11-20 2017-07-03 Ambrx Inc Modified insulin polypeptides and their use
EP2254905B1 (en) * 2008-03-14 2016-12-14 Novo Nordisk A/S Protease-stabilized insulin analogues
WO2009115469A1 (en) 2008-03-18 2009-09-24 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
WO2009121884A1 (en) 2008-04-01 2009-10-08 Novo Nordisk A/S Insulin albumin conjugates
PL219335B1 (pl) 2008-07-04 2015-04-30 Inst Biotechnologii I Antybiotyków Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna
US9603904B2 (en) 2008-10-30 2017-03-28 Novo Nordisk A/S Treating diabetes melitus using insulin injections with less than daily injection frequency
JP2012511506A (ja) 2008-12-09 2012-05-24 ノヴォ・ノルディスク・アー／エス 新規インスリンアナログ
CA2744558A1 (en) 2008-12-19 2010-07-15 Indiana University Research And Technology Corporation Amide-based insulin prodrugs
AU2009335712B2 (en) 2008-12-19 2015-09-17 Indiana University Research And Technology Corporation Insulin analogs
WO2010130638A1 (en) * 2009-05-14 2010-11-18 Evotec Ag Sulfonamide compounds, pharmaceutical compositions and uses thereof
SG184988A1 (en) 2010-04-27 2012-11-29 Zealand Pharma As Peptide conjugates of glp-1 receptor agonists and gastrin and their use
KR20130092972A (ko) 2010-05-10 2013-08-21 노보 노르디스크 에이/에스 인슐린-아연 복합체의 제조 방법
CN103119057B (zh) 2010-06-24 2016-06-15 印第安纳大学研究及科技有限公司 基于酰胺的胰岛素前药
JP2013540771A (ja) 2010-10-15 2013-11-07 ノヴォ ノルディスク アー／エス 新規ｎ末端修飾インスリン誘導体
CN103596584B (zh) 2011-06-15 2016-12-14 诺沃—诺迪斯克有限公司 多取代的胰岛素
WO2013086785A1 (zh) 2011-12-15 2013-06-20 Qin Shulin 具有降血糖作用的化合物、组合物及其用途
AU2012350586B2 (en) 2011-12-15 2017-02-02 Jiangsu Hengrui Medicine Co., Ltd. Human insulin analogue and acylated derivative thereof
CN104364262A (zh) 2011-12-21 2015-02-18 诺沃—诺迪斯克有限公司 N末端修饰的胰岛素衍生物
US20150111820A1 (en) 2012-07-09 2015-04-23 Novo Nordisk A/S Novel use of insulin derivatives
WO2014071405A2 (en) 2012-11-05 2014-05-08 Case Western Reserve University Long-acting single-chain insulin analogues
ES2868351T3 (es) 2013-02-26 2021-10-21 Hanmi Pharm Ind Co Ltd Conjugados de análogos de insulina y usos de los mismos
AU2014241743B2 (en) * 2013-03-14 2018-07-05 Indiana University Research And Technology Corporation Insulin-incretin conjugates
CN105188736A (zh) 2013-03-20 2015-12-23 诺和诺德股份有限公司 胰岛素给药方案
WO2014177623A1 (en) 2013-04-30 2014-11-06 Novo Nordisk A/S Novel administration regime
CN105308067B (zh) 2013-06-07 2020-07-24 诺和诺德股份有限公司 制备成熟胰岛素多肽的方法
JP6347451B2 (ja) * 2013-08-02 2018-06-27 国立大学法人富山大学 （ベンゼンスルホニルアミノ）ベンズアミド誘導体およびそれらを有効成分とするｓｈｉｐ２阻害剤
JP2017505141A (ja) 2014-01-20 2017-02-16 ハンミ ファーマシューティカル カンパニー リミテッド 長時間作用型インスリンおよびその使用
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
AR100639A1 (es) 2014-05-29 2016-10-19 Hanmi Pharm Ind Co Ltd Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada
KR20160001391A (ko) 2014-06-27 2016-01-06 한미약품 주식회사 신규한 지속형 인슐린 아날로그 결합체 및 이의 용도
WO2016001185A1 (en) 2014-07-02 2016-01-07 Novo Nordisk A/S Dosage regimen for the treatment of diabetes
KR20160007295A (ko) 2014-07-11 2016-01-20 한미약품 주식회사 인슐린 아날로그
US20180000742A1 (en) 2015-01-29 2018-01-04 Novo Nordisk A/S Pharmaceutical Composition for Oral Insulin Administration Comprising a Tablet Core and a Polyvinyl Alcohol Coating
WO2016172269A2 (en) 2015-04-20 2016-10-27 University Of Utah Research Foundation Insulin analogs having shortened b chain peptides and associated methods
MX2018002221A (es) 2015-08-25 2018-03-23 Novo Nordisk As Dispositivo medico de inyeccion con camara limpiadora.
JP2018531899A (ja) 2015-08-25 2018-11-01 ノヴォ ノルディスク アー／エス 新規インスリン誘導体及びその医学的使用
US20190010206A1 (en) 2015-08-25 2019-01-10 Novo Nordisk A/S Novel Insulin Derivatives and the Medical Uses Hereof
PL239062B1 (pl) 2016-01-22 2021-11-02 Inst Biotechnologii I Antybiotykow Sposób wytwarzania insuliny i jej pochodnych
WO2018024186A1 (zh) 2016-08-02 2018-02-08 江苏恒瑞医药股份有限公司 一种人胰岛素或其类似物的酰化衍生物
AU2017332408B2 (en) 2016-09-23 2022-02-10 Hanmi Pharm. Co., Ltd. Insulin analogs with reduced affinity to insulin receptor and use thereof
JP7286160B2 (ja) 2016-11-21 2023-06-05 ケース ウェスタン リザーブ ユニバーシティ 安定性が増強された速効性インスリン類似体
AU2017378102B2 (en) 2016-12-16 2022-10-13 Novo Nordisk A/S Insulin containing pharmaceutical compositions
CA3052410A1 (en) 2017-02-03 2018-08-09 Hanmi Pharm. Co., Ltd. Conjugate of bioactive material having enhanced sustainability and use thereof
KR102629006B1 (ko) 2017-03-23 2024-01-25 한미약품 주식회사 인슐린 수용체와의 결합력이 감소된 인슐린 아날로그의 결합체 및 이의 용도
JOP20190273A1 (ar) 2017-05-26 2019-11-24 Lilly Co Eli مركب إنسولين معالج بأسيل
KR20190036956A (ko) 2017-09-28 2019-04-05 한미약품 주식회사 지속형 단쇄 인슐린 아날로그 및 이의 결합체
EP3740212A4 (en) 2017-12-18 2021-10-27 Merck Sharp & Dohme Corp. CONJUGATE-BASED SYSTEMS FOR CONTROLLED INSULIN DELIVERY

Also Published As

Publication number Publication date
MX2021006972A (es) 2021-08-16
KR20210102346A (ko) 2021-08-19
CN113395982A (zh) 2021-09-14
SG11202106168VA (en) 2021-07-29
EP3893934A1 (en) 2021-10-20
JP2022513776A (ja) 2022-02-09
CA3122632A1 (en) 2020-06-18
CO2021007453A2 (es) 2021-06-21
JP2022513775A (ja) 2022-02-09
KR20210102345A (ko) 2021-08-19
TW202039438A (zh) 2020-11-01
AU2019398579A1 (en) 2021-07-29
EP3894391A1 (en) 2021-10-20
CA3122636A1 (en) 2020-06-18
AU2019398658A1 (en) 2021-07-29
KR20210102347A (ko) 2021-08-19
IL283803A (en) 2021-07-29
TW202039437A (zh) 2020-11-01
AU2019398402A1 (en) 2021-07-29
BR112021011156A2 (pt) 2021-10-26
CN113423691A (zh) 2021-09-21
EP3894435A1 (en) 2021-10-20
IL283801A (en) 2021-07-29
US20220048968A1 (en) 2022-02-17
WO2020120477A1 (en) 2020-06-18
US20200181223A1 (en) 2020-06-11
TW202039539A (zh) 2020-11-01
CA3122637A1 (en) 2020-06-18
MX2021006970A (es) 2021-07-15
SG11202106166TA (en) 2021-07-29
IL283800A (en) 2021-07-29
WO2020120463A1 (en) 2020-06-18
BR112021011099A2 (pt) 2021-10-26
US11098102B2 (en) 2021-08-24
JP2022511567A (ja) 2022-01-31
WO2020120479A1 (en) 2020-06-18
CN113396157A (zh) 2021-09-14
PH12021551339A1 (en) 2021-11-29
BR112021011050A2 (pt) 2021-08-31
SG11202106167XA (en) 2021-07-29

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