MX2018014681A - Biorreactor de un solo uso. - Google Patents
Biorreactor de un solo uso.Info
- Publication number
- MX2018014681A MX2018014681A MX2018014681A MX2018014681A MX2018014681A MX 2018014681 A MX2018014681 A MX 2018014681A MX 2018014681 A MX2018014681 A MX 2018014681A MX 2018014681 A MX2018014681 A MX 2018014681A MX 2018014681 A MX2018014681 A MX 2018014681A
- Authority
- MX
- Mexico
- Prior art keywords
- use bioreactor
- bioreactor
- port
- cells
- sparger
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/14—Bags
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/20—Mixing gases with liquids
- B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
- B01F23/231—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids by bubbling
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/051—Stirrers characterised by their elements, materials or mechanical properties
- B01F27/053—Stirrers characterised by their elements, materials or mechanical properties characterised by their materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/11—Stirrers characterised by the configuration of the stirrers
- B01F27/113—Propeller-shaped stirrers for producing an axial flow, e.g. shaped like a ship or aircraft propeller
- B01F27/1134—Propeller-shaped stirrers for producing an axial flow, e.g. shaped like a ship or aircraft propeller the impeller being of hydrofoil type
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/11—Stirrers characterised by the configuration of the stirrers
- B01F27/19—Stirrers with two or more mixing elements mounted in sequence on the same axis
- B01F27/191—Stirrers with two or more mixing elements mounted in sequence on the same axis with similar elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/86—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis co-operating with deflectors or baffles fixed to the receptacle
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/50—Mixing receptacles
- B01F35/513—Flexible receptacles, e.g. bags supported by rigid containers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/26—Constructional details, e.g. recesses, hinges flexible
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/02—Stirrer or mobile mixing elements
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/18—Flow directing inserts
- C12M27/20—Baffles; Ribs; Ribbons; Auger vanes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0418—Geometrical information
- B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0436—Operational information
- B01F2215/0459—Numerical values of dimensionless numbers, i.e. Re, Pr, Nu, transfer coefficients
Abstract
Se provee un biorreactor de un solo uso. El biorreactor de un solo uso puede incluir un contenedor de bioproceso, una carcasa, al menos un agitador, al menos un aspersor, al menos un puerto de entrada del filtro de gas para los aspersores y espacio libre cubierto, al menos un puerto de relleno, al menos un puerto de recolección, al menos un puerto de muestra y al menos una sonda. En los ejemplos, al menos un controlador puede monitorear y controlar uno o más parámetros asociados al biorreactor de un solo uso. También se provee un método para cultivar y propagar células de mamífero. El método puede incluir el cultivo en condiciones adecuadas y en un medio de cultivo adecuado en un primer biorreactor de un solo uso, transferir el medio que contiene las células obtenidas mediante la propagación de la al menos una célula de mamífero a un segundo biorreactor de un solo uso, transferir el medio que contiene las células obtenidas mediante propagación de la al menos una célula de mamífero a un tercer biorreactor de un solo uso, y cultivar las células en el tercer biorreactor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662345381P | 2016-06-03 | 2016-06-03 | |
PCT/EP2017/063631 WO2017207822A1 (en) | 2016-06-03 | 2017-06-05 | Single use bioreactor |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018014681A true MX2018014681A (es) | 2019-06-06 |
Family
ID=59014634
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018014681A MX2018014681A (es) | 2016-06-03 | 2017-06-05 | Biorreactor de un solo uso. |
Country Status (13)
Country | Link |
---|---|
US (3) | US10801003B2 (es) |
EP (1) | EP3464547A1 (es) |
JP (1) | JP6942736B2 (es) |
KR (1) | KR102398310B1 (es) |
CN (1) | CN109477052A (es) |
AU (1) | AU2017272892A1 (es) |
BR (1) | BR112018074889A2 (es) |
CA (1) | CA3026170A1 (es) |
EA (1) | EA201892695A1 (es) |
IL (1) | IL263361A (es) |
MX (1) | MX2018014681A (es) |
SG (1) | SG11201810780XA (es) |
WO (1) | WO2017207822A1 (es) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015148704A1 (en) | 2014-03-25 | 2015-10-01 | Terumo Bct, Inc. | Passive replacement of media |
WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
WO2017205667A1 (en) | 2016-05-25 | 2017-11-30 | Terumo Bct, Inc. | Cell expansion |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
CN106076135B (zh) * | 2016-08-01 | 2019-04-16 | 江苏揽山环境科技股份有限公司 | 微气泡发生装置 |
US11327064B2 (en) * | 2017-03-03 | 2022-05-10 | J.M. Canty, Inc. | Foam/liquid monitoring system |
US11629332B2 (en) | 2017-03-31 | 2023-04-18 | Terumo Bct, Inc. | Cell expansion |
US11124754B2 (en) * | 2017-05-30 | 2021-09-21 | Nextern, Inc. | Pressure-controlled apparatus for optimal cellular growth |
EP3848459A1 (en) | 2017-06-30 | 2021-07-14 | Inscripta, Inc. | Automated cell processing methods, modules, instruments and systems |
US10738327B2 (en) | 2017-08-28 | 2020-08-11 | Inscripta, Inc. | Electroporation cuvettes for automation |
CN111372650A (zh) | 2017-09-30 | 2020-07-03 | 因思科瑞普特公司 | 流通式电穿孔仪器 |
BR112020006566B1 (pt) | 2017-10-03 | 2023-03-21 | Abec, Inc | Sistema de reação descartável |
US20200323958A1 (en) * | 2017-11-13 | 2020-10-15 | Amgen Inc. | Methods for producing protein products |
CN108624499A (zh) * | 2017-12-18 | 2018-10-09 | 佛山安普泽生物医药股份有限公司 | 一种哺乳动物细胞大规模生产培养方法 |
DK3502229T3 (da) * | 2017-12-22 | 2022-08-08 | Evologic Tech Gmbh | Inokuleringsbeholder og bioreaktor til hårrodskulturer |
US11288576B2 (en) | 2018-01-05 | 2022-03-29 | Illumina, Inc. | Predicting quality of sequencing results using deep neural networks |
EP3621739B1 (en) * | 2018-01-05 | 2023-07-05 | Illumina Inc. | Predicting reagent chiller instability and flow cell heater failure in sequencing systems |
US11293003B2 (en) * | 2018-01-17 | 2022-04-05 | Life Technologies Corporation | Configurable fluid mixing system housing and support hardware |
WO2019190874A1 (en) * | 2018-03-29 | 2019-10-03 | Inscripta, Inc. | Automated control of cell growth rates for induction and transformation |
JP7232259B2 (ja) * | 2018-04-10 | 2023-03-02 | イー・エム・デイー・ミリポア・コーポレイシヨン | チャネルを有する折り畳み式バッフルを含む一回使用の容器 |
WO2019200004A1 (en) | 2018-04-13 | 2019-10-17 | Inscripta, Inc. | Automated cell processing instruments comprising reagent cartridges |
SG11202010393PA (en) * | 2018-04-23 | 2020-11-27 | Univercells Tech S A | Bioreactor with freeze-thaw capabilities to enhance product recovery and related methods |
US10858761B2 (en) | 2018-04-24 | 2020-12-08 | Inscripta, Inc. | Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells |
US11447730B2 (en) * | 2018-05-30 | 2022-09-20 | Global Life Sciences Solutions Usa Llc | Bioreactor system and method of bioprocessing |
WO2019231949A1 (en) * | 2018-05-30 | 2019-12-05 | Life Technologies Corporation | Control system and method for a fluid mixing apparatus |
WO2019236645A1 (en) | 2018-06-05 | 2019-12-12 | Vbc Holdings Llc | Automated and dynamically adjustable gas mixer for bioreactor system |
AU2019292919A1 (en) | 2018-06-30 | 2021-03-11 | Inscripta, Inc. | Instruments, modules, and methods for improved detection of edited sequences in live cells |
US10752874B2 (en) | 2018-08-14 | 2020-08-25 | Inscripta, Inc. | Instruments, modules, and methods for improved detection of edited sequences in live cells |
US11142740B2 (en) | 2018-08-14 | 2021-10-12 | Inscripta, Inc. | Detection of nuclease edited sequences in automated modules and instruments |
US10532324B1 (en) | 2018-08-14 | 2020-01-14 | Inscripta, Inc. | Instruments, modules, and methods for improved detection of edited sequences in live cells |
NL2021470B1 (en) * | 2018-08-15 | 2020-02-24 | Applikon Biotechnology B V | Lid configuration for a bioreactor |
US11965154B2 (en) | 2018-08-30 | 2024-04-23 | Inscripta, Inc. | Detection of nuclease edited sequences in automated modules and instruments |
GB2576913A (en) * | 2018-09-06 | 2020-03-11 | Trans Ocean Bulk Logistics Ltd | Flexible tank with a mixing member |
CN109517738A (zh) * | 2018-12-14 | 2019-03-26 | 杭州奕安济世生物药业有限公司 | 一种调控生物反应器中二氧化碳含量的方法 |
WO2020141326A1 (en) * | 2019-01-04 | 2020-07-09 | Oribiotech Ltd | Cell processing container, cell processing system and methods of use thereof |
JP7136723B2 (ja) * | 2019-03-06 | 2022-09-13 | 株式会社エビデント | 細胞培養装置 |
SG11202105998PA (en) * | 2019-03-28 | 2021-07-29 | Emd Millipore Corp | Use of vision systems in biomanufacturing processes |
JP2022526607A (ja) * | 2019-04-05 | 2022-05-25 | コーネル ユニヴァーシティー | 人工的代謝を有する動的材料を生成するためのシステムおよび方法 |
CN109971614B (zh) * | 2019-04-16 | 2020-08-25 | 北京航空航天大学 | 一种用于生物发酵罐的节能方法 |
US11739289B2 (en) | 2019-04-22 | 2023-08-29 | Lonza Ltd | Continuous blade impeller |
CN113924355B (zh) * | 2019-05-28 | 2024-04-02 | 上海药明生物技术有限公司 | 用于监测和自动控制灌流细胞培养的拉曼光谱集成灌流细胞培养系统 |
CN113840905A (zh) * | 2019-05-29 | 2021-12-24 | 思拓凡瑞典有限公司 | 用于生物反应器中的探头角度调整的系统和方法 |
US10907125B2 (en) | 2019-06-20 | 2021-02-02 | Inscripta, Inc. | Flow through electroporation modules and instrumentation |
EP3986909A4 (en) | 2019-06-21 | 2023-08-02 | Inscripta, Inc. | GENOME-WIDE RATIONAL DESIGNED MUTATIONS LEADING TO INCREASED LYSINE PRODUCTION IN E. COLI |
US10927385B2 (en) | 2019-06-25 | 2021-02-23 | Inscripta, Inc. | Increased nucleic-acid guided cell editing in yeast |
US20210002598A1 (en) * | 2019-07-02 | 2021-01-07 | Pbs Biotech, Inc. | Methods of mixing and dispensing cells |
CN110354712B (zh) * | 2019-08-15 | 2021-08-24 | 山东中谷饲料有限公司 | 一种维生素预混合给料搅拌系统 |
CN110564586A (zh) * | 2019-09-18 | 2019-12-13 | 南昌绿锦茶疗食品有限公司 | 管道负压式光生物反应器 |
CN110652903A (zh) * | 2019-09-24 | 2020-01-07 | 广东东荣金属制品有限公司 | 一种超高速旋转多刀头气液切割混合氧合器 |
US20210178347A1 (en) * | 2019-09-27 | 2021-06-17 | BWXT Isotope Technology Group, Inc. | Chemistry vessel agitator |
US20210138219A1 (en) * | 2019-11-08 | 2021-05-13 | Global Life Sciences Solutions Usa Llc | Sparger device for a bioprocessing system and method of manufacturing a sparger device |
CN114651218B (zh) * | 2019-11-15 | 2023-09-15 | 赛多利斯司特蒂姆数据分析公司 | 基于拉曼光谱学预测生物过程中的参数的方法和装置组件以及控制生物过程的方法和装置组件 |
EP3822717B1 (en) * | 2019-11-15 | 2022-09-07 | Sartorius Stedim Data Analytics AB | Method and device assembly for predicting a parameter in a bioprocess based on raman spectroscopy and method and device assembly for controlling a bioprocess |
US11535421B2 (en) * | 2019-12-30 | 2022-12-27 | Global Life Sciences Solutions Usa Llc | System and method for packaging a bioprocessing bag and associated components, and packaging for a bioprocessing bag |
US10689669B1 (en) | 2020-01-11 | 2020-06-23 | Inscripta, Inc. | Automated multi-module cell processing methods, instruments, and systems |
WO2021154706A1 (en) | 2020-01-27 | 2021-08-05 | Inscripta, Inc. | Electroporation modules and instrumentation |
AU2021224177A1 (en) * | 2020-02-18 | 2022-10-13 | Orgenesis Inc. | Cell-culture bioreactor |
KR102383013B1 (ko) * | 2020-03-23 | 2022-04-05 | 프레스티지바이오로직스 주식회사 | 항체 의약품 제조 공정을 위한 제균 필터 시스템 및 그 작동 방법 |
KR102383015B1 (ko) * | 2020-03-23 | 2022-04-05 | 프레스티지바이오로직스 주식회사 | 항체 의약품 제조 공정을 위한 하이브리드 무균 연결 시스템 및 무균 연결 방법 |
US20210332388A1 (en) | 2020-04-24 | 2021-10-28 | Inscripta, Inc. | Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells |
US11787841B2 (en) | 2020-05-19 | 2023-10-17 | Inscripta, Inc. | Rationally-designed mutations to the thrA gene for enhanced lysine production in E. coli |
CN111744396B (zh) * | 2020-06-24 | 2022-07-29 | 安徽蓝田农业集团有限公司 | 一种实现对龟鳖饲料调配的混合器 |
CN115867636A (zh) * | 2020-07-06 | 2023-03-28 | 默克专利股份公司 | 用于细胞培养基制备和进行细胞培养的装置和方法 |
CN111821931A (zh) * | 2020-07-14 | 2020-10-27 | 韩智源 | 一种聚合反应釜 |
US20220040648A1 (en) * | 2020-08-06 | 2022-02-10 | Signature Science, Llc | Mixing Chamber Apparatus For High-Volume Sampling |
US20230357684A1 (en) * | 2020-09-18 | 2023-11-09 | University Of Virginia Patent Foundation | 3d-printed modular microchip with an integrated impeller pump to model inter-organ communication |
US11959101B2 (en) | 2020-11-27 | 2024-04-16 | Industrial Technology Research Institute | Cell activation reactor and cell activation method |
CN112892891B (zh) * | 2021-03-03 | 2022-12-06 | 武汉伯瑞恒医药科技有限公司 | 一种抗白血病活性分子及中间体提取用离心装置 |
WO2022214558A1 (en) * | 2021-04-07 | 2022-10-13 | Norgren LLC | Bioprocessing systems |
US11827870B2 (en) * | 2021-05-20 | 2023-11-28 | Generen Labs, Inc. | Device for producing metabolites |
WO2023215564A2 (en) * | 2022-05-06 | 2023-11-09 | Abec, Inc. | Bioreactor systems |
CN114880943B (zh) * | 2022-05-24 | 2023-02-03 | 安及义实业(上海)有限公司 | 一种基于数据库的生物反应器设计方法及系统 |
WO2023244534A1 (en) * | 2022-06-13 | 2023-12-21 | Ultrafab, Inc. | System, apparatus and method for coding cap and tube assemblies for different bottle sizes |
WO2024035904A1 (en) * | 2022-08-12 | 2024-02-15 | Amgen Inc. | Therapeutic product mixing methods |
WO2024039509A1 (en) * | 2022-08-13 | 2024-02-22 | Global Life Sciences Solutions Usa Llc | Flexible baffle for use in a bioreactor or mixer and method of installing the baffle |
EP4324905A1 (de) * | 2022-08-19 | 2024-02-21 | Sartorius Stedim Biotech GmbH | Bioreaktorsystem mit begasungsanlage |
DE102022126030A1 (de) * | 2022-10-07 | 2024-04-18 | Skeleton Technologies GmbH | Wirbelbettreaktorsystem und Verfahren zum Betrieb desselben |
CN116855370A (zh) * | 2023-07-19 | 2023-10-10 | 安及义实业(上海)有限公司 | 生物反应器或发酵罐的自动补料装置及方法 |
Family Cites Families (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5336176Y2 (es) * | 1973-07-26 | 1978-09-04 | ||
JPS5035529A (es) | 1973-08-02 | 1975-04-04 | ||
JPS6028275B2 (ja) * | 1980-06-26 | 1985-07-03 | 積水化学工業株式会社 | 組織培養用成形物 |
JPS62500351A (ja) | 1984-08-28 | 1987-02-19 | マサチュ−セッツ・インステチュ−ト・オブ・テクノロジ− | 微粒子担体からの足場依存性細胞の分離 |
JPS61160698A (ja) | 1985-01-07 | 1986-07-21 | Hitachi Ltd | スラスト軸受保護装置 |
JPH048799Y2 (es) * | 1985-03-28 | 1992-03-05 | ||
IT1258959B (it) | 1992-06-09 | 1996-03-11 | Impianto a moduli mobili per lo sviluppo e la produzione di prodotti biotecnologici su scala pilota | |
JPH0870847A (ja) * | 1994-09-02 | 1996-03-19 | Sumitomo Bakelite Co Ltd | 細胞浮遊培養用容器 |
MXPA06008724A (es) | 2004-02-03 | 2007-02-16 | Xcellerex Llc | Sistema y metodo para elaboracion. |
EP1566447A1 (en) | 2004-02-20 | 2005-08-24 | Aventis Pharma Deutschland GmbH | Glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase C regulation |
BRPI0510291A (pt) * | 2004-04-27 | 2007-10-30 | Baxter Int | sistema de reator com tanque agitado |
GB0410118D0 (en) * | 2004-05-06 | 2004-06-09 | Glaxo Group Ltd | Novel bioreactor |
DK1773976T4 (da) | 2004-06-04 | 2020-02-10 | Global Life Sciences Solutions Usa Llc | Engangsbioreaktorsystemer og -fremgangsmåder |
US7745209B2 (en) | 2005-07-26 | 2010-06-29 | Corning Incorporated | Multilayered cell culture apparatus |
US20090305626A1 (en) | 2005-12-05 | 2009-12-10 | Hope Ernest G | Prevalidated, modular good manufacturing practice-compliant facility |
DE102006021984B4 (de) | 2006-05-10 | 2013-05-08 | Sartorius Stedim Biotech Gmbh | Bioreaktor |
US10632433B2 (en) * | 2006-05-13 | 2020-04-28 | Pall Life Sciences Belgium Bvba | Disposable bioreactor |
US20080118974A1 (en) | 2006-11-20 | 2008-05-22 | Gregory Roger Martin | Large scale cell culture vessel |
US7897379B2 (en) | 2007-02-26 | 2011-03-01 | Corning Incorporated | Device and method for reducing bubble formation in cell culture |
RU2009141965A (ru) | 2007-04-16 | 2011-05-27 | Момента Фармасьютикалз, Инк. (Us) | Определенные продукты гликопротеина и способы их производства |
WO2009116002A1 (fr) * | 2008-03-19 | 2009-09-24 | Sartorius Stedim Biotech Gmbh | Recipient-melangeur |
EP2279039A2 (de) | 2008-04-17 | 2011-02-02 | Sartorius Stedim Biotech GmbH | Flexibler beutel mit einer mischvorrichtung |
US8177082B2 (en) | 2008-04-18 | 2012-05-15 | Corning Incorporated | Flexible membrane valve for cell culture vessel |
US8178345B2 (en) | 2008-05-30 | 2012-05-15 | Corning Incorporated | Multilayer cell culture vessels |
US8216828B2 (en) | 2008-05-30 | 2012-07-10 | Corning Incorporated | Assembly of cell culture vessels |
EP2216395A1 (en) | 2009-02-09 | 2010-08-11 | Lonza Biologics plc. | Bioreactor for the cultivation of mammalian cells |
EP2401353B1 (en) | 2009-02-25 | 2015-04-29 | Corning Incorporated | Cell culture system with manifold |
US8771635B2 (en) | 2010-04-26 | 2014-07-08 | Toyota Motor Engineering & Manufacturing North America, Inc. | Hydrogen release from complex metal hydrides by solvation in ionic liquids |
JP5570913B2 (ja) * | 2010-08-27 | 2014-08-13 | 株式会社日立製作所 | 生体細胞の培養容器及び培養装置 |
US10371394B2 (en) | 2010-09-20 | 2019-08-06 | Biologics Modular Llc | Mobile, modular cleanroom facility |
JP5776162B2 (ja) | 2010-10-13 | 2015-09-09 | 東洋製罐グループホールディングス株式会社 | 接着細胞用培養容器、及び接着細胞用培養容器の製造方法 |
WO2012122413A1 (en) | 2011-03-08 | 2012-09-13 | University Of Maryland Baltimore County | Microscale bioprocessing system and method for protein manufacturing |
US9434924B2 (en) * | 2011-04-21 | 2016-09-06 | Nipro Corporation | Cell culture method and cell culture kit |
EP2771452B1 (en) * | 2011-10-25 | 2021-06-23 | Life Technologies Corporation | Fluid mixing systems with adjustable mixing element |
US10385307B2 (en) | 2011-12-21 | 2019-08-20 | Lonza Walkersville, Inc. | Scalable process for therapeutic cell concentration and residual clearance |
SG11201403911WA (en) * | 2012-01-13 | 2014-08-28 | Ge Healthcare Bio Sciences | Temperature controlled support surfaces for single use flexible wall systems |
EP3628396A3 (en) * | 2012-04-06 | 2020-07-01 | Life Technologies Corporation | Fluid mixing system with flexible drive line and foldable impeller |
JP6307501B2 (ja) * | 2012-06-26 | 2018-04-04 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | 混合容器、混合ユニット |
CN105102111B (zh) * | 2012-11-29 | 2018-11-02 | Emd密理博公司 | 用于存储和运送的2d低液面混合袋 |
JP2014121302A (ja) * | 2012-12-21 | 2014-07-03 | Dainippon Printing Co Ltd | 培養袋 |
WO2015030639A1 (en) * | 2013-08-27 | 2015-03-05 | Ge Healthcare Bio-Sciences Ab | Bioreactor with addition tube |
US9880067B2 (en) * | 2013-12-03 | 2018-01-30 | Pall Corporation | Mechanical agitator with seal housing assembly |
CN105828924A (zh) * | 2013-12-17 | 2016-08-03 | 拜耳作物科学有限合伙公司 | 具有可伸展叶轮的混合系统、方法和装置 |
DE102014117658B4 (de) * | 2014-12-02 | 2023-02-16 | Sartorius Stedim Biotech Gmbh | Mischvorrichtung mit Strömungsbrecher |
WO2017066630A1 (en) | 2015-10-16 | 2017-04-20 | Lonza Ltd. | System and method for regulating cell culture based production of biologics |
AU2016347484A1 (en) | 2015-10-26 | 2018-05-10 | Lonza Limited | A manufacturing facility for the production of biopharmaceuticals |
US20180010082A1 (en) | 2016-06-03 | 2018-01-11 | Lonza Ltd | Bioreactor With Higher Agitation Rates |
-
2017
- 2017-06-05 BR BR112018074889A patent/BR112018074889A2/pt not_active Application Discontinuation
- 2017-06-05 SG SG11201810780XA patent/SG11201810780XA/en unknown
- 2017-06-05 JP JP2018563013A patent/JP6942736B2/ja active Active
- 2017-06-05 MX MX2018014681A patent/MX2018014681A/es unknown
- 2017-06-05 CN CN201780041444.1A patent/CN109477052A/zh active Pending
- 2017-06-05 CA CA3026170A patent/CA3026170A1/en not_active Abandoned
- 2017-06-05 US US15/613,954 patent/US10801003B2/en active Active
- 2017-06-05 EP EP17728184.7A patent/EP3464547A1/en active Pending
- 2017-06-05 WO PCT/EP2017/063631 patent/WO2017207822A1/en unknown
- 2017-06-05 KR KR1020197000094A patent/KR102398310B1/ko active IP Right Grant
- 2017-06-05 AU AU2017272892A patent/AU2017272892A1/en not_active Abandoned
- 2017-06-05 EA EA201892695A patent/EA201892695A1/ru unknown
-
2018
- 2018-11-29 IL IL263361A patent/IL263361A/en unknown
-
2020
- 2020-09-14 US US17/019,516 patent/US11371002B2/en active Active
-
2022
- 2022-06-27 US US17/850,452 patent/US20230045226A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA3026170A1 (en) | 2017-12-07 |
SG11201810780XA (en) | 2018-12-28 |
BR112018074889A2 (pt) | 2019-03-06 |
CN109477052A (zh) | 2019-03-15 |
KR20190018670A (ko) | 2019-02-25 |
US20210002597A1 (en) | 2021-01-07 |
US11371002B2 (en) | 2022-06-28 |
US20170349874A1 (en) | 2017-12-07 |
EA201892695A1 (ru) | 2019-05-31 |
JP6942736B2 (ja) | 2021-09-29 |
US20230045226A1 (en) | 2023-02-09 |
AU2017272892A1 (en) | 2019-01-24 |
WO2017207822A1 (en) | 2017-12-07 |
KR102398310B1 (ko) | 2022-05-16 |
JP2019520065A (ja) | 2019-07-18 |
US10801003B2 (en) | 2020-10-13 |
IL263361A (en) | 2018-12-31 |
EP3464547A1 (en) | 2019-04-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2018014681A (es) | Biorreactor de un solo uso. | |
MX2020002851A (es) | Biorreactor de perfusion y metodos de uso relacionados. | |
MX2019003638A (es) | Metodos de cultivo de perfusion y aplicaciones de los mismos. | |
MY152011A (en) | Photobioreactor | |
EP2169048A3 (en) | System and method for cultivating cells | |
MX2020009648A (es) | Muestreador de lecho fijo y metodos relacionados. | |
MX356956B (es) | Alimentación continua controlada sin retroalimentación pre-programada de cultivos celulares. | |
NZ704003A (en) | Bioreactor cartridge and system | |
KR101459022B1 (ko) | 광생물 배양용 반연속식 배양 시스템 및 그 배양 방법 | |
CN104450519A (zh) | 一种精密控制培养液溶解氧浓度的细胞培养系统 | |
CN204474690U (zh) | 精密控制培养液溶解氧浓度的细胞培养系统 | |
CN103305419A (zh) | 一种间充质干细胞提取灌流培养系统 | |
PH12018502223A1 (en) | Method for producing activated stem cells | |
PH12016501509A1 (en) | Air accordion bioreactor | |
TW201129698A (en) | New cell culture method | |
CN104726339B (zh) | 一种微藻的固定化养殖方法 | |
CN204151250U (zh) | 一种带有蒸汽灭菌装置的补料罐 | |
Greuel et al. | Online measurement of oxygen enables continuous noninvasive evaluation of human‐induced pluripotent stem cell (hiPSC) culture in a perfused 3D hollow‐fiber bioreactor | |
BR112012033050A2 (pt) | método e sistema para cultivo de microalgas em um reator de fluxo de tampão expandido | |
CN103525750B (zh) | 培养基及其应用 | |
WO2013007574A9 (en) | Scale up of cell cultures | |
CN206736275U (zh) | 一种植物细胞培养装置 | |
CN202849416U (zh) | 一种细胞生物反应器 | |
CN208632555U (zh) | 一种菌株培养实验观察柜 | |
CN205443307U (zh) | 胎盘干细胞提取灌流系统 |