MX356956B - Alimentación continua controlada sin retroalimentación pre-programada de cultivos celulares. - Google Patents

Alimentación continua controlada sin retroalimentación pre-programada de cultivos celulares.

Info

Publication number
MX356956B
MX356956B MX2014003134A MX2014003134A MX356956B MX 356956 B MX356956 B MX 356956B MX 2014003134 A MX2014003134 A MX 2014003134A MX 2014003134 A MX2014003134 A MX 2014003134A MX 356956 B MX356956 B MX 356956B
Authority
MX
Mexico
Prior art keywords
continuous feeding
cell cultures
feedback controlled
programmed non
controlled continuous
Prior art date
Application number
MX2014003134A
Other languages
English (en)
Other versions
MX2014003134A (es
Inventor
Lin Henry
Bezaire Jeremy
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2014003134A publication Critical patent/MX2014003134A/es
Publication of MX356956B publication Critical patent/MX356956B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/38—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of metabolites or enzymes in the cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a un método de alimentación continua sin retro-alimentación pre-programada basado en un balance de masa del sustrato en el bioreactor para su uso en el crecimiento de cultivo celular y mantenimiento. El método descrito no se basa en instrumento, sonda u operador de retroalimentación. El método proporciona una alternativa eficiente y efectiva para alimentación de bolo.
MX2014003134A 2011-09-16 2012-09-14 Alimentación continua controlada sin retroalimentación pre-programada de cultivos celulares. MX356956B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161535809P 2011-09-16 2011-09-16
PCT/US2012/055552 WO2013040444A1 (en) 2011-09-16 2012-09-14 Pre-programmed non-feedback controlled continuous feeding of cell cultures

Publications (2)

Publication Number Publication Date
MX2014003134A MX2014003134A (es) 2014-04-25
MX356956B true MX356956B (es) 2018-06-21

Family

ID=46964067

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014003134A MX356956B (es) 2011-09-16 2012-09-14 Alimentación continua controlada sin retroalimentación pre-programada de cultivos celulares.

Country Status (16)

Country Link
US (1) US9803166B2 (es)
EP (1) EP2756069B1 (es)
JP (4) JP2014526265A (es)
KR (1) KR101710766B1 (es)
CN (1) CN103946366B (es)
AU (1) AU2012308335A1 (es)
BR (1) BR112014008303A2 (es)
CA (1) CA2846905A1 (es)
EA (1) EA201490502A1 (es)
ES (1) ES2862576T3 (es)
IL (1) IL231032A0 (es)
MX (1) MX356956B (es)
SG (1) SG11201400656SA (es)
TW (1) TWI583788B (es)
WO (1) WO2013040444A1 (es)
ZA (1) ZA201401655B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1172361A4 (en) 1999-04-19 2002-05-08 Shionogi & Co SULFONAMIDE DERIVATIVES HAVING OXADIAZOLE CORES
JP6695814B2 (ja) 2014-06-04 2020-05-20 アムジエン・インコーポレーテツド 哺乳類細胞培養物を回収するための方法
WO2016085787A1 (en) 2014-11-25 2016-06-02 Corning Incorporated Cell culture media extending materials and methods
EA036178B1 (ru) 2014-12-01 2020-10-09 Эмджен Инк. Процесс контроля уровня содержания гликанов в составе гликопротеинов
EP3294053A4 (en) * 2015-05-08 2019-03-06 Flownamics Analytical Instruments, Inc. METHOD AND APPARATUS FOR AUTOMATED CONTINUOUS INFUSION SYSTEM EXTRACTING IN SITU FILTERING PROBE
US20230287335A1 (en) 2020-07-30 2023-09-14 Amgen Inc. Cell culture media and methods of making and using the same
CN112553044A (zh) * 2020-12-10 2021-03-26 上海奥浦迈生物科技股份有限公司 一种生物反应器细胞培养进样口用防堵塞装置

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629202A (en) * 1994-07-19 1997-05-13 Development Center For Biotechnology Computer-controlled bioreactor system for enzymatic synthesis of L-tryptophan
KR100447374B1 (ko) * 1996-03-13 2004-11-03 델타 바이오테크놀로지 리미티드 발효조절방법
US6156570A (en) 1997-03-20 2000-12-05 Regents Of The University Of Minnesota Process for the continuous culture of cells
AU2003268201A1 (en) * 2002-08-27 2004-03-19 Vanderbilt University Capillary perfused bioreactors with multiple chambers
DE102004007658B4 (de) * 2004-02-17 2008-12-18 Bioceuticals Arzneimittel Ag Verfahren zur Herstellung von rekombinanten Proteinen in eukaryontischen Wirtszellen
CN1778903A (zh) 2005-09-29 2006-05-31 华东理工大学 一种动物细胞高密度连续灌注培养方法
WO2007071072A1 (en) 2005-12-22 2007-06-28 Corporation De L'ecole Polytechnique De Montreal High-rate perfusion bioreactor
JP2007202500A (ja) * 2006-02-03 2007-08-16 Hitachi Ltd 培養槽の運転制御装置
TWI601823B (zh) 2007-04-26 2017-10-11 Chugai Pharmaceutical Co Ltd Cell culture methods using media containing high concentrations of amino acids

Also Published As

Publication number Publication date
TW201326387A (zh) 2013-07-01
KR101710766B1 (ko) 2017-02-27
IL231032A0 (en) 2014-03-31
JP2022058710A (ja) 2022-04-12
TWI583788B (zh) 2017-05-21
CN103946366A (zh) 2014-07-23
JP2020022492A (ja) 2020-02-13
JP2014526265A (ja) 2014-10-06
EP2756069A1 (en) 2014-07-23
JP2017029162A (ja) 2017-02-09
ZA201401655B (en) 2014-12-23
US9803166B2 (en) 2017-10-31
EA201490502A1 (ru) 2014-06-30
SG11201400656SA (en) 2014-04-28
CN103946366B (zh) 2017-08-11
WO2013040444A1 (en) 2013-03-21
US20140295545A1 (en) 2014-10-02
BR112014008303A2 (pt) 2017-04-11
AU2012308335A1 (en) 2014-03-13
MX2014003134A (es) 2014-04-25
EP2756069B1 (en) 2021-01-27
KR20140044396A (ko) 2014-04-14
CA2846905A1 (en) 2013-03-21
ES2862576T3 (es) 2021-10-07

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