MX2016010923A - Metodo para generar celulas t compatibles para el trasplante alogenico. - Google Patents

Metodo para generar celulas t compatibles para el trasplante alogenico.

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Publication number
MX2016010923A
MX2016010923A MX2016010923A MX2016010923A MX2016010923A MX 2016010923 A MX2016010923 A MX 2016010923A MX 2016010923 A MX2016010923 A MX 2016010923A MX 2016010923 A MX2016010923 A MX 2016010923A MX 2016010923 A MX2016010923 A MX 2016010923A
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MX
Mexico
Prior art keywords
cells
ciita
expression
gene encoding
modified
Prior art date
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MX2016010923A
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English (en)
Inventor
Poirot Laurent
Duchateau Philippe
Sourdive David
Pierre CABANIOLS Jean-
Original Assignee
Cellectis
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50336023&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2016010923(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cellectis filed Critical Cellectis
Publication of MX2016010923A publication Critical patent/MX2016010923A/es

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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

Abstract

La presente invención se refiere a células T diseñadas por ingeniería, método para su preparación y su uso como medicamento, en particular para la inmunoterapia. Las células T diseñadas por ingeniería de la invención se caracterizan en que la expresión de beta 2-microglobulina (B2M) y/o transactivador complejo principal de histocompatibilidad clase II (CIITA) se inhibe, por ejemplo, mediante el uso de endonucleasas de corte inusual capaces de inactivar selectivamente por escisión de ADN el gen que codifica B2M y/o CIITA, o mediante el uso de moléculas de ácidos nucleicos que inhiben la expresión de B2M y/o CIITA. Cono el fin de hacer aún más no alorreactivas a las células T, al menos se inactiva un gen que codifica un componente del receptor de células T, por ejemplo, mediante el uso de una de las endonucleasas de corte inusual capaces de inactivar selectivamente por escisión de ADN el gen que codifica dicho componente TCR. Además, la expresión de polipéptido inmunosupresor se puede realizar en las células T modificadas con el fin de prolongar la supervivencia de estas células T modificadas en el organismo huésped. Tal célula T modificada es particularmente adecuada para trasplantes alogénicos, especialmente debido a que reduce tanto el riesgo de rechazo por el sistema inmune del huésped como el riesgo de desarrollar enfermedad de injerto contra huésped. La invención abre el camino a las estrategias de inmunoterapia adoptiva estándar y asequibles mediante el uso de células T para el tratamiento de cáncer, infecciones y enfermedades autoinmunes.
MX2016010923A 2014-03-11 2015-03-11 Metodo para generar celulas t compatibles para el trasplante alogenico. MX2016010923A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201470119 2014-03-11
PCT/EP2015/055097 WO2015136001A1 (en) 2014-03-11 2015-03-11 Method for generating t-cells compatible for allogenic transplantation

Publications (1)

Publication Number Publication Date
MX2016010923A true MX2016010923A (es) 2016-11-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016010923A MX2016010923A (es) 2014-03-11 2015-03-11 Metodo para generar celulas t compatibles para el trasplante alogenico.

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US (3) US20170016025A1 (es)
EP (3) EP4368705A2 (es)
JP (2) JP6681837B2 (es)
KR (1) KR102228828B1 (es)
CN (1) CN106103475B (es)
AU (1) AU2015228844B2 (es)
BR (1) BR112016019071A8 (es)
CA (1) CA2942113C (es)
DK (2) DK3116902T3 (es)
ES (1) ES2782125T3 (es)
HU (1) HUE048558T2 (es)
IL (1) IL247064B (es)
MX (1) MX2016010923A (es)
PL (1) PL3116902T3 (es)
PT (2) PT3116902T (es)
RU (1) RU2752933C2 (es)
WO (1) WO2015136001A1 (es)

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EP3215623A4 (en) * 2014-11-06 2018-09-26 President and Fellows of Harvard College Cells lacking b2m surface expression and methods for allogeneic administration of such cells
JP2018509148A (ja) * 2015-03-11 2018-04-05 セレクティスＣｅｌｌｅｃｔｉｓ 患者における持続性および／または生着を増加させるために同種ｔ細胞を改変する方法
US10322774B2 (en) * 2015-05-15 2019-06-18 Oru Designs, Llc Collapsible kayak with large cockpit

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