MX2016008551A - Moleculas artificiales de acido nucleico. - Google Patents
Moleculas artificiales de acido nucleico.Info
- Publication number
- MX2016008551A MX2016008551A MX2016008551A MX2016008551A MX2016008551A MX 2016008551 A MX2016008551 A MX 2016008551A MX 2016008551 A MX2016008551 A MX 2016008551A MX 2016008551 A MX2016008551 A MX 2016008551A MX 2016008551 A MX2016008551 A MX 2016008551A
- Authority
- MX
- Mexico
- Prior art keywords
- nucleic acid
- utr
- artificial nucleic
- acid sequence
- acid molecules
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La invención se refiere a una molécula artificial de ácido nucleico que comprende al menos un marco de lectura abierto y al menos un elemento de región no traducida 3´ (3´ -UTR) que comprende una secuencia que se deriva de la 3´ -UTR de un gen de proteína ribosómica. La invención se refiere adicionalmente al uso de tal molécula artificial de ácido nucleico en la terapia génica y/o vacunación genética. Adicionalmente, la invención se refiere al uso de un elemento 3´ -UTR que comprende una secuencia de ácido nucleico que se deriva de la 3´ -UTR de un gen de proteína ribosómica para mejorar, estabilizar y/o prolongar la expresión de proteínas de una secuencia de ácido nucleico que comprende tal elemento 3´ -UTR.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2013003946 | 2013-12-30 | ||
| PCT/EP2014/003480 WO2015101414A2 (en) | 2013-12-30 | 2014-12-30 | Artificial nucleic acid molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016008551A true MX2016008551A (es) | 2016-09-26 |
Family
ID=49920310
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016008551A MX2016008551A (es) | 2013-12-30 | 2014-12-30 | Moleculas artificiales de acido nucleico. |
| MX2020003245A MX2020003245A (es) | 2013-12-30 | 2016-06-27 | Moleculas artificiales de acido nucleico. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020003245A MX2020003245A (es) | 2013-12-30 | 2016-06-27 | Moleculas artificiales de acido nucleico. |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10047375B2 (es) |
| JP (2) | JP6704850B2 (es) |
| KR (1) | KR102399799B1 (es) |
| CN (2) | CN111304231A (es) |
| AU (1) | AU2014375402B2 (es) |
| BR (1) | BR112016014462A2 (es) |
| CA (1) | CA2927862C (es) |
| DK (1) | DK3090053T3 (es) |
| ES (1) | ES2712092T3 (es) |
| MX (2) | MX2016008551A (es) |
| RU (1) | RU2717986C2 (es) |
| SG (2) | SG11201603144QA (es) |
| WO (1) | WO2015101414A2 (es) |
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| US20220136001A1 (en) | 2022-05-05 |
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