MX2007000631A - Tienopirimidinas utiles como inhibidores de aurora cinasa. - Google Patents
Tienopirimidinas utiles como inhibidores de aurora cinasa.Info
- Publication number
- MX2007000631A MX2007000631A MX2007000631A MX2007000631A MX2007000631A MX 2007000631 A MX2007000631 A MX 2007000631A MX 2007000631 A MX2007000631 A MX 2007000631A MX 2007000631 A MX2007000631 A MX 2007000631A MX 2007000631 A MX2007000631 A MX 2007000631A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- aryl
- heteroaryl
- carbon atoms
- hydrogen
- Prior art date
Links
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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Landscapes
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58871804P | 2004-07-16 | 2004-07-16 | |
| US63256804P | 2004-12-01 | 2004-12-01 | |
| PCT/US2005/025340 WO2006036266A1 (en) | 2004-07-16 | 2005-07-15 | Thienopyrimidines useful as aurora kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
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| MX2007000631A true MX2007000631A (es) | 2007-03-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| MX2007000631A MX2007000631A (es) | 2004-07-16 | 2005-07-15 | Tienopirimidinas utiles como inhibidores de aurora cinasa. |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7601725B2 (enExample) |
| EP (1) | EP1768984B1 (enExample) |
| JP (1) | JP2008506714A (enExample) |
| KR (1) | KR20070057792A (enExample) |
| AT (1) | ATE485300T1 (enExample) |
| AU (1) | AU2005290226A1 (enExample) |
| BR (1) | BRPI0513405A (enExample) |
| CA (1) | CA2573999A1 (enExample) |
| DE (1) | DE602005024274D1 (enExample) |
| IL (1) | IL180722A0 (enExample) |
| MX (1) | MX2007000631A (enExample) |
| NZ (1) | NZ552751A (enExample) |
| SG (1) | SG156650A1 (enExample) |
| WO (1) | WO2006036266A1 (enExample) |
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| WO2006010264A1 (en) | 2004-07-30 | 2006-02-02 | Methylgene, Inc. | Inhibitors of vegf receptor and hgf receptor signaling |
| BRPI0610322B8 (pt) | 2005-05-20 | 2021-05-25 | Methylgene Inc | inibidores de sinalização de receptor de vegf e de receptor de hgf e composição farmacêutica |
| EP1904504B1 (en) | 2005-05-20 | 2014-03-19 | MethylGene Inc. | Inhibitors of vegf receptor and hgf receptor signaling |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| JP2009530342A (ja) * | 2006-03-20 | 2009-08-27 | エフ．ホフマン−ラ ロシュ アーゲー | Ｂｔｋおよびｓｙｋ蛋白キナーゼを阻害する方法 |
| BRPI0719883A2 (pt) | 2006-10-09 | 2015-05-05 | Takeda Pharmaceutical | Inibidores de quinase |
| NZ582349A (en) * | 2007-06-29 | 2012-06-29 | Sunesis Pharmaceuticals Inc | Heterocyclic compounds useful as raf kinase inhibitors |
| EP2014663A1 (de) * | 2007-07-12 | 2009-01-14 | Bayer Schering Pharma AG | Thienopyrimidylamine als Modulatoren des EP2-Rezeptors |
| BRPI0923670A2 (pt) | 2008-03-05 | 2013-07-30 | Methylgene Inc | inibidores da atividade de proteÍna tirosina quinase e seu uso, bem como composiÇço compreendendo os mesmos |
| JP5498025B2 (ja) * | 2008-03-13 | 2014-05-21 | 公益財団法人相模中央化学研究所 | 新規なチアゾール誘導体固定化マトリックス、及びその製造方法 |
| JP5455380B2 (ja) * | 2008-03-12 | 2014-03-26 | 公益財団法人相模中央化学研究所 | 新規なチアゾール誘導体、及びその製造方法 |
| WO2009113637A1 (ja) * | 2008-03-12 | 2009-09-17 | 東ソー株式会社 | 新規なチアゾール誘導体、チアゾール誘導体固定化マトリックス、及びそれらの製造方法 |
| WO2009114856A2 (en) * | 2008-03-14 | 2009-09-17 | Sunesis Pharmaceuticals, Inc. | Aurora kinase inhibitors |
| EP2257637B1 (en) * | 2008-03-25 | 2015-09-23 | Sunesis Pharmaceuticals, Inc. | Methods of chemotype evolution |
| CA2722220C (en) | 2008-04-30 | 2016-06-07 | National Health Research Institutes | Fused bicyclic pyrimidine compounds as aurora kinase inhibitors |
| MX2011002263A (es) * | 2008-09-10 | 2011-05-23 | Kalypsys Inc | Aminopirimidinas como inhibidores de receptores de histamina para el tratamiento de enfermedades. |
| CN102232071B (zh) * | 2008-09-26 | 2016-03-23 | 财团法人卫生研究院 | 作为蛋白激酶抑制剂的稠合多环化合物 |
| WO2010074724A1 (en) | 2008-12-22 | 2010-07-01 | Millennium Pharmaceuticals, Inc. | Combination of aurora kinase inhibitors and anti-cd20 antibodies |
| WO2014079545A1 (en) * | 2012-11-20 | 2014-05-30 | Ktb Tumorforschungsgesellschaft Mbh | Thioether derivatives as protein kinase inhibitors |
| CN103012428A (zh) | 2013-01-08 | 2013-04-03 | 中国药科大学 | 4-(五元杂环并嘧啶/吡啶取代)氨基-1H-3-吡唑甲酰胺类CDK/Aurora双重抑制剂及其用途 |
| JP6525474B2 (ja) | 2013-12-06 | 2019-06-05 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | オーロラキナーゼ阻害剤と抗ｃｄ３０抗体の併用 |
| FR3015483B1 (fr) * | 2013-12-23 | 2016-01-01 | Servier Lab | Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JP2018123058A (ja) * | 2015-06-08 | 2018-08-09 | 石原産業株式会社 | ジフルオロメチレン化合物 |
| EP3324976A4 (en) | 2015-07-21 | 2019-03-27 | Millennium Pharmaceuticals, Inc. | ADMINISTRATION OF KINASE AURORA INHIBITOR AND CHEMOTHERAPEUTIC AGENTS |
| GB201705263D0 (en) * | 2017-03-31 | 2017-05-17 | Probiodrug Ag | Novel inhibitors |
| WO2019195658A1 (en) | 2018-04-05 | 2019-10-10 | Dana-Farber Cancer Institute, Inc. | Sting levels as a biomarker for cancer immunotherapy |
| WO2020049208A1 (es) | 2018-09-09 | 2020-03-12 | Fundacio Privada Institut De Recerca De La Sida - Caixa | Aurora cinasa como diana para tratar, prevenir o curar una infección por vih o sida |
| WO2021041532A1 (en) | 2019-08-26 | 2021-03-04 | Dana-Farber Cancer Institute, Inc. | Use of heparin to promote type 1 interferon signaling |
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| GB1570494A (en) | 1975-11-28 | 1980-07-02 | Ici Ltd | Thienopyrimidine derivatives and their use as pesticides |
| ZA782648B (en) | 1977-05-23 | 1979-06-27 | Ici Australia Ltd | The prevention,control or eradication of infestations of ixodid ticks |
| JPS61286373A (ja) * | 1985-06-14 | 1986-12-16 | Sankyo Co Ltd | フエノキシアルキルアミン誘導体、その製法および殺虫殺ダニ剤 |
| JPH0720943B2 (ja) | 1988-08-19 | 1995-03-08 | 宇部興産株式会社 | アミノピリミジン誘導体、その製法及び殺虫・殺菌剤 |
| US5141941A (en) | 1988-11-21 | 1992-08-25 | Ube Industries, Ltd. | Aralkylamine derivatives, and fungicides containing the same |
| JPH075569B2 (ja) | 1989-08-02 | 1995-01-25 | 宇部興産株式会社 | アラルキルアミン誘導体、その製法及び殺菌、殺虫剤 |
| US5124333A (en) | 1989-08-02 | 1992-06-23 | Ube Industries, Ltd. | Aminopyrimidine derivatives and harmful organisms preventive agent |
| JPH0717638B2 (ja) | 1989-08-02 | 1995-03-01 | 宇部興産株式会社 | アミノピリミジン誘導体、その製造方法及び殺虫、殺菌剤 |
| JPH03173872A (ja) | 1989-09-14 | 1991-07-29 | Ube Ind Ltd | アミノピリミジン誘導体、その製造方法及び殺虫・殺菌剤 |
| EP0424125A3 (en) | 1989-10-18 | 1991-10-09 | Ube Industries, Ltd. | Aralkylamine derivatives, preparation method thereof and fungicides containing the same |
| DE4008726A1 (de) | 1990-03-19 | 1991-09-26 | Basf Ag | Thieno(2,3-d)pyrimidinderivate |
| AU651337B2 (en) | 1990-03-30 | 1994-07-21 | Dowelanco | Thienopyrimidine derivatives |
| JPH04164072A (ja) | 1990-10-26 | 1992-06-09 | Ube Ind Ltd | オキシピリミジン誘導体、その製法及び有害生物防除剤 |
| JP2762430B2 (ja) | 1991-01-18 | 1998-06-04 | 宇部興産株式会社 | アラルキルアミノピリミジン類の製法 |
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-
2005
- 2005-07-15 AT AT05772519T patent/ATE485300T1/de not_active IP Right Cessation
- 2005-07-15 BR BRPI0513405-6A patent/BRPI0513405A/pt not_active IP Right Cessation
- 2005-07-15 EP EP05772519A patent/EP1768984B1/en not_active Expired - Lifetime
- 2005-07-15 WO PCT/US2005/025340 patent/WO2006036266A1/en not_active Ceased
- 2005-07-15 DE DE602005024274T patent/DE602005024274D1/de not_active Expired - Lifetime
- 2005-07-15 US US11/182,215 patent/US7601725B2/en not_active Expired - Fee Related
- 2005-07-15 AU AU2005290226A patent/AU2005290226A1/en not_active Abandoned
- 2005-07-15 SG SG200906907-1A patent/SG156650A1/en unknown
- 2005-07-15 NZ NZ552751A patent/NZ552751A/en not_active IP Right Cessation
- 2005-07-15 KR KR1020077003002A patent/KR20070057792A/ko not_active Ceased
- 2005-07-15 JP JP2007521708A patent/JP2008506714A/ja active Pending
- 2005-07-15 CA CA002573999A patent/CA2573999A1/en not_active Abandoned
- 2005-07-15 MX MX2007000631A patent/MX2007000631A/es not_active Application Discontinuation
-
2007
- 2007-01-16 IL IL180722A patent/IL180722A0/en unknown
-
2009
- 2009-10-08 US US12/575,560 patent/US20100179123A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NZ552751A (en) | 2010-11-26 |
| ATE485300T1 (de) | 2010-11-15 |
| US7601725B2 (en) | 2009-10-13 |
| WO2006036266A1 (en) | 2006-04-06 |
| IL180722A0 (en) | 2007-06-03 |
| CA2573999A1 (en) | 2006-04-06 |
| DE602005024274D1 (de) | 2010-12-02 |
| KR20070057792A (ko) | 2007-06-07 |
| US20060035908A1 (en) | 2006-02-16 |
| BRPI0513405A (pt) | 2008-05-06 |
| SG156650A1 (en) | 2009-11-26 |
| JP2008506714A (ja) | 2008-03-06 |
| AU2005290226A1 (en) | 2006-04-06 |
| US20100179123A1 (en) | 2010-07-15 |
| EP1768984A1 (en) | 2007-04-04 |
| EP1768984B1 (en) | 2010-10-20 |
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| FA | Abandonment or withdrawal |