MX174531B - Procedimiento para preparar benzopiranos - Google Patents

Procedimiento para preparar benzopiranos

Info

Publication number
MX174531B
MX174531B MX009342A MX934282A MX174531B MX 174531 B MX174531 B MX 174531B MX 009342 A MX009342 A MX 009342A MX 934282 A MX934282 A MX 934282A MX 174531 B MX174531 B MX 174531B
Authority
MX
Mexico
Prior art keywords
alkyl
carbon atoms
hydrogen
alkylcarbonyl
cyano
Prior art date
Application number
MX009342A
Other languages
English (en)
Inventor
John Morris Evans
Robin Edwin Buckingham
Keneth Willcocks
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of MX174531B publication Critical patent/MX174531B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Glass Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invención se refiere a procedimiento para la preparación de benzopiranos de fórmula (I): donde uno de R1 y R2 es hidrógeno y el otro se selecciona de la clase de alquilcarbonilo, alcoxicarbonilo, alquilcarboniloxi, alquilhidroximetilo, nitro, ciano, cloro, trifluorometilo, alquilsulfinilo, alquilslfonilo, alcoxisulfinilo, alcoxisulfonilo, alquiolcarbonilamino, alcoxicarbonilamino o aminosulfilo, aminosulfonilo o aminocarbonilo,k donde el resto amino está opcionalmente sustituído con uno o dos grupos alquilo, o alquilsulfinilamino, alquilsulfonilamino, alcalsulfinilamino, alquilsulfonilamino, alcoxisulfinilamono o alcoxisulfonilamino, o etilenilo sustituído como uno o dos grupos alquilo, o alquilsulfinilamino, alquilsulfonilamono alcoxisulfinilamono o alcoxisulfonilamono o etileno sustituído terminalmente con alquilcarbonilo,nitro o ciano o -C (alquil)NOH o - C (alquil) NNH2, donde los grupos que contienen alquilo tienen de 1 a 6 átomos de carbono; uno de R3 y R4 es hidrógeno o alquilo que tiene de 1 a 4 átomos de carbono, o R3 y R4 junto con el átomo de carbono al que están unidos son espiroalquilo que tiene de 3 a 6 átomos de carbono o acilo que tiene de 1 a 8 átomos de carbono; y n es 1 ó 2, y el grupo lactama está en posición trans al grupo OR5; cuyo procedimiento está caracterizado por someter a ciclación un compuesto de fórmula (XIV) donde R'1 y R'2 y R3 a R5 y n se definen como antes y L3 es un grupo saliente y donde el grupo amino sustituído está en posición tras al grupo o R5; en caso de que uno de R'1 y R'2 sea un grupo o átomo convertible en uno de la clase de sustituyentes definida antes para el otro de R1 y R2, convertir el grupo o átomo en uno de la clase de sustituyentes definida y, en caso de que R5 sea hidrógeno en el compuesto de fórmula (I), alquilar o acilar opcionalmente con un agente alquilante de 1 a 3 átomos de carbono o con un agnte acilante de 1 a 8 átomos.
MX009342A 1981-09-25 1982-09-23 Procedimiento para preparar benzopiranos MX174531B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8129064 1981-09-25
GB8206400 1982-03-04
GB8210490 1982-04-08

Publications (1)

Publication Number Publication Date
MX174531B true MX174531B (es) 1994-05-24

Family

ID=27261315

Family Applications (3)

Application Number Title Priority Date Filing Date
MX009343A MX174532B (es) 1981-09-25 1982-09-23 Procedimiento para preparar benzopiranos
MX009344A MX174533B (es) 1981-09-25 1982-09-23 Procedimiento para preparar benzopiranos
MX009342A MX174531B (es) 1981-09-25 1982-09-23 Procedimiento para preparar benzopiranos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MX009343A MX174532B (es) 1981-09-25 1982-09-23 Procedimiento para preparar benzopiranos
MX009344A MX174533B (es) 1981-09-25 1982-09-23 Procedimiento para preparar benzopiranos

Country Status (24)

Country Link
US (1) US4446113A (es)
EP (1) EP0076075B1 (es)
JP (4) JPH0314573A (es)
KR (1) KR880001943B1 (es)
AT (1) ATE23718T1 (es)
AU (1) AU561536B2 (es)
CA (1) CA1174682A (es)
DE (1) DE3274350D1 (es)
DK (1) DK170165B1 (es)
ES (4) ES8401061A1 (es)
FI (1) FI73675C (es)
GB (1) GB2107706A (es)
GR (1) GR76732B (es)
HK (1) HK17588A (es)
IE (1) IE53875B1 (es)
MX (3) MX174532B (es)
MY (1) MY102061A (es)
NO (4) NO159597C (es)
NZ (1) NZ201984A (es)
PH (1) PH18691A (es)
PL (4) PL141133B1 (es)
PT (1) PT75598B (es)
SG (1) SG98587G (es)
YU (4) YU43279B (es)

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Also Published As

Publication number Publication date
FI823272L (fi) 1983-03-26
EP0076075A1 (en) 1983-04-06
PL141133B1 (en) 1987-06-30
PL247746A1 (en) 1985-01-30
YU43279B (en) 1989-06-30
NZ201984A (en) 1986-04-11
JPH05310729A (ja) 1993-11-22
YU145484A (en) 1986-06-30
DE3274350D1 (en) 1987-01-08
FI73675B (fi) 1987-07-31
PL238342A1 (en) 1985-01-16
YU44768B (en) 1991-02-28
PT75598A (en) 1982-10-01
YU210182A (en) 1984-12-31
PL247747A1 (en) 1985-04-24
FI73675C (fi) 1987-11-09
ES515921A0 (es) 1983-11-16
ES8500268A1 (es) 1984-10-01
YU44766B (en) 1991-02-28
KR880001943B1 (ko) 1988-10-04
JPH05394B2 (es) 1993-01-05
NO159597C (no) 1989-01-18
PL141099B1 (en) 1987-06-30
JPH05301866A (ja) 1993-11-16
MY102061A (en) 1992-03-31
ES522937A0 (es) 1984-09-16
YU44767B (en) 1991-02-28
GB2107706A (en) 1983-05-05
YU145384A (en) 1986-06-30
NO834133L (no) 1983-03-28
ES8407490A1 (es) 1984-09-16
PT75598B (en) 1984-12-10
AU8867582A (en) 1983-03-31
EP0076075B1 (en) 1986-11-20
JP2504707B2 (ja) 1996-06-05
US4446113A (en) 1984-05-01
ATE23718T1 (de) 1986-12-15
ES8401061A1 (es) 1983-11-16
PL141134B1 (en) 1987-06-30
NO823247L (no) 1983-03-28
NO834135L (no) 1983-03-28
NO834134L (no) 1983-03-28
SG98587G (en) 1988-07-15
ES522939A0 (es) 1984-10-01
YU145284A (en) 1986-06-30
GR76732B (es) 1984-08-30
JPH0314573A (ja) 1991-01-23
MX174532B (es) 1994-05-24
PL141135B1 (en) 1987-06-30
NO159597B (no) 1988-10-10
KR840001572A (ko) 1984-05-07
FI823272A0 (fi) 1982-09-23
PH18691A (en) 1985-09-05
DK424582A (da) 1983-03-26
AU561536B2 (en) 1987-05-14
IE53875B1 (en) 1989-03-29
US4446113B1 (es) 1985-12-10
MX174533B (es) 1994-05-24
DK170165B1 (da) 1995-06-06
JP2504708B2 (ja) 1996-06-05
ES522938A0 (es) 1984-09-16
JPH0780875B2 (ja) 1995-08-30
JPH05202034A (ja) 1993-08-10
PL247748A1 (en) 1985-04-24
ES8407491A1 (es) 1984-09-16
HK17588A (en) 1988-03-11
CA1174682A (en) 1984-09-18
IE822313L (en) 1983-03-25

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