JO1216B1 - active compounds - Google Patents

Abstract

Compounds of formula (I) Wherein One of R1 and R2 is hydrogen and the other is selected from the class of alkylcarbonyl, alkoxy-carbonyl, alkylcarbonyloxy, alkylhydroymethyl, nitro , cyano, chloro, trifluormoethyl , alkylsuphinyl, alkylsulphonyl, alkoxysulphinyl, alkoxysulphonyl, alkylcarbonylamino, alkoxycarbonylamino, or aminosulphinyl, aminosulphonyl or aminocarbonyl , the amino moiety being optionally substituted by one or two alkyl groups, or alkylsulphinylamino, alkylsulphonyl-amino, alkoxysulphinylamino or alkoxysulphonylamino, or ethylenyl terminally substituted by alkylcarbonyl, nitro or cyano or –C(alyl)NOH or –C(alkyl)NNH2, the alkyl groups or alkyl moieties of alkyl-containing groups having from 1 to 6 carbon atoms One of R3 and R4 is hydrogen or alkyl having from 1 to 4 carbon atoms and the other is alkyl having from 1 to 4 carbon atoms, or R3 and R4 together with the carbon atom to which they are attached are spiroalkyl having from 3 to 6 carbon atoms R5 is hydrogen, alkyl having from 1 to 3 carbon atoms or acyl having from 1 to 8 carbon atoms, and N is 1 or 2, the lactam group being trans to the OR5 group Have anti-hypertensive activity and are of use in the treatment of high blood pressure.