MEP40408A - Inhalative solution formulation containing a tiotropium salt - Google Patents

Inhalative solution formulation containing a tiotropium salt

Info

Publication number
MEP40408A
MEP40408A MEP-404/08A MEP40408A MEP40408A ME P40408 A MEP40408 A ME P40408A ME P40408 A MEP40408 A ME P40408A ME P40408 A MEP40408 A ME P40408A
Authority
ME
Montenegro
Prior art keywords
formulation containing
solution formulation
tiotropium salt
inhalative solution
inhalative
Prior art date
Application number
MEP-404/08A
Other languages
English (en)
Croatian (hr)
Inventor
Barbara Niklaus-Humke
Christel Schmelzer
Petra Barth
Karin Drechsel
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of MEP40408A publication Critical patent/MEP40408A/xx
Publication of ME00244B publication Critical patent/ME00244B/me

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)

Abstract

Predmetni pronalazak se odnosi na formulaciju za inhalaciju bez pogonskog gasa sa tiotropijum bromidom odn. tiotropijum bromid monohidratom koji je rastvoren u vodi ili u smješi vode i etanola i na aerosol za inhalaciju bez pogonskog gasa koji se dobija od nje.
MEP-2008-404A 2000-10-31 2001-10-24 Formulacija rastvora za inhalaciju sa soli tiotropijma ME00244B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10054036 2000-10-31
YUP-330/03A RS50859B (sr) 2000-10-31 2001-10-24 Formulacija rastvora za inhalaciju sa soli tiotropijuma
PCT/EP2001/012292 WO2002036104A2 (de) 2000-10-31 2001-10-24 Inhalative lösungsformulierung mit einem tiotropiumsalz

Publications (2)

Publication Number Publication Date
MEP40408A true MEP40408A (en) 2011-02-10
ME00244B ME00244B (me) 2011-05-10

Family

ID=7661723

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2008-404A ME00244B (me) 2000-10-31 2001-10-24 Formulacija rastvora za inhalaciju sa soli tiotropijma

Country Status (38)

Country Link
EP (2) EP1333819B1 (bs)
JP (1) JP4344135B2 (bs)
KR (1) KR100853107B1 (bs)
CN (2) CN101292964A (bs)
AR (1) AR038764A1 (bs)
AT (1) ATE373473T1 (bs)
AU (2) AU2002221738B2 (bs)
BG (1) BG66315B1 (bs)
BR (1) BRPI0115076B8 (bs)
CA (1) CA2426074C (bs)
CY (1) CY1107825T1 (bs)
CZ (1) CZ300794B6 (bs)
DE (2) DE10152521A1 (bs)
DK (1) DK1333819T3 (bs)
EA (1) EA007604B1 (bs)
EC (1) ECSP034541A (bs)
EE (1) EE05314B1 (bs)
ES (1) ES2294045T3 (bs)
HR (1) HRP20030338B1 (bs)
HU (1) HU229411B1 (bs)
IL (2) IL155538A0 (bs)
ME (1) ME00244B (bs)
MX (1) MXPA03003742A (bs)
MY (1) MY138940A (bs)
NO (1) NO332519B1 (bs)
NZ (1) NZ526023A (bs)
PE (1) PE20030092A1 (bs)
PL (1) PL203316B1 (bs)
PT (1) PT1333819E (bs)
RS (1) RS50859B (bs)
SA (1) SA01220482B1 (bs)
SI (1) SI1333819T1 (bs)
SK (1) SK286027B6 (bs)
TW (1) TWI293885B (bs)
UA (1) UA78690C2 (bs)
UY (1) UY26989A1 (bs)
WO (1) WO2002036104A2 (bs)
ZA (1) ZA200302922B (bs)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10216036A1 (de) * 2002-04-11 2003-10-23 Boehringer Ingelheim Pharma Aerosolformulierung für die Inhalation enthaltend ein Tiotropiumsalz
CN1292748C (zh) * 2003-03-05 2007-01-03 南昌弘益科技有限公司 噻托溴铵吸入粉雾剂及其制备工艺
UA82414C2 (uk) * 2003-11-03 2008-04-10 Бёрингер Ингельхайм Интернациональ Гмбх Солі тіотропію, спосіб їх одержання, а також лікарські композиції, які їх містять
ES2342468T3 (es) * 2003-11-03 2010-07-07 Boehringer Ingelheim International Gmbh Procedimiento para la preparacion de sales de tiotropio.
SI1881980T1 (sl) 2005-05-02 2012-12-31 Boehringer Ingelheim International Gmbh Nove kristalinične oblike tiotropijevega bromida
EP2044967A1 (de) * 2007-10-01 2009-04-08 Boehringer Ingelheim Pharma GmbH & Co. KG Zerstäuber
CN104306361A (zh) * 2014-09-24 2015-01-28 万特制药(海南)有限公司 一种含噻托溴铵的吸入性溶液
CN111374963A (zh) * 2018-12-31 2020-07-07 天津药业研究院有限公司 一种用于吸入的噻托铵溶液剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
SG45171A1 (en) * 1990-03-21 1998-01-16 Boehringer Ingelheim Int Atomising devices and methods
DE19536902A1 (de) * 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
DE19653969A1 (de) * 1996-12-20 1998-06-25 Boehringer Ingelheim Kg Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole
DE19847968A1 (de) * 1998-10-17 2000-04-20 Boehringer Ingelheim Pharma Verschlußkappe und Behälter als Zweikammer-Kartusche für Vernebler zur Erzeugung von Aerosolen

Also Published As

Publication number Publication date
CN101292964A (zh) 2008-10-29
BRPI0115076B1 (pt) 2016-07-26
PL360405A1 (en) 2004-09-06
HU229411B1 (en) 2013-12-30
YU33003A (sh) 2006-05-25
HRP20030338A2 (en) 2005-04-30
ME00244B (me) 2011-05-10
HK1060524A1 (zh) 2004-08-13
KR20030060926A (ko) 2003-07-16
WO2002036104A3 (de) 2002-08-01
DE50113037D1 (de) 2007-10-31
EP1837021A3 (de) 2008-03-19
HUP0301378A3 (en) 2005-12-28
TWI293885B (en) 2008-03-01
NO20031911D0 (no) 2003-04-29
EP1837021A2 (de) 2007-09-26
UA78690C2 (uk) 2007-04-25
ES2294045T3 (es) 2008-04-01
SK286027B6 (sk) 2008-01-07
CN100396285C (zh) 2008-06-25
EE200300203A (et) 2003-10-15
BG66315B1 (bg) 2013-04-30
AU2002221738B2 (en) 2007-01-11
CY1107825T1 (el) 2013-06-19
PE20030092A1 (es) 2003-03-24
ZA200302922B (en) 2004-04-22
CZ20031486A3 (cs) 2003-08-13
PL203316B1 (pl) 2009-09-30
HRP20030338B1 (en) 2011-09-30
WO2002036104A2 (de) 2002-05-10
DK1333819T3 (da) 2007-12-03
MXPA03003742A (es) 2004-10-15
MY138940A (en) 2009-08-28
BRPI0115076B8 (pt) 2021-05-25
SA01220482B1 (ar) 2007-07-31
JP4344135B2 (ja) 2009-10-14
NO332519B1 (no) 2012-10-08
NZ526023A (en) 2005-05-27
CA2426074C (en) 2008-12-23
AR038764A1 (es) 2005-01-26
KR100853107B1 (ko) 2008-08-21
EA007604B1 (ru) 2006-12-29
ATE373473T1 (de) 2007-10-15
PT1333819E (pt) 2007-10-29
CN1473038A (zh) 2004-02-04
BR0115076A (pt) 2003-07-29
RS50859B (sr) 2010-08-31
BG107727A (bg) 2004-11-30
AU2173802A (en) 2002-05-15
DE10152521A1 (de) 2002-07-11
EA200300482A1 (ru) 2003-12-25
IL155538A0 (en) 2003-11-23
HUP0301378A2 (hu) 2003-10-28
CZ300794B6 (cs) 2009-08-12
UY26989A1 (es) 2002-06-20
SK5272003A3 (en) 2003-10-07
EE05314B1 (et) 2010-08-16
NO20031911L (no) 2003-04-29
ECSP034541A (es) 2003-05-26
EP1333819B1 (de) 2007-09-19
CA2426074A1 (en) 2002-05-10
EP1333819A2 (de) 2003-08-13
JP2004512357A (ja) 2004-04-22
SI1333819T1 (sl) 2007-12-31
IL155538A (en) 2008-11-26

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