NO20031911L - Inhalasjonslösningsformulering med et tiotropiumsalt - Google Patents

Inhalasjonslösningsformulering med et tiotropiumsalt

Info

Publication number
NO20031911L
NO20031911L NO20031911A NO20031911A NO20031911L NO 20031911 L NO20031911 L NO 20031911L NO 20031911 A NO20031911 A NO 20031911A NO 20031911 A NO20031911 A NO 20031911A NO 20031911 L NO20031911 L NO 20031911L
Authority
NO
Norway
Prior art keywords
solution formulation
inhalation solution
tiotropium salt
propellant
water
Prior art date
Application number
NO20031911A
Other languages
English (en)
Other versions
NO332519B1 (no
NO20031911D0 (no
Inventor
Barbara Niklaus-Humke
Christel Schmelzer
Petra Barth
Karin Drechsel
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of NO20031911L publication Critical patent/NO20031911L/no
Publication of NO20031911D0 publication Critical patent/NO20031911D0/no
Publication of NO332519B1 publication Critical patent/NO332519B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Foreliggende oppfinnelse angår en drivmiddelfri inhalerbar formulering av tiotropiumbromid eller tiotropiumbromidmonohydrat oppløst i vann eller i en blanding av vann og etanol og drivmiddelfrie, inhalerbare aerosol-formuleringer resulterende derfra.
NO20031911A 2000-10-31 2003-04-29 Inhalasjonslosningsformulering med et tiotropiumsalt, fremgangsmate for fremstilling av slike samt slike formuleringer for behandling av sykdom NO332519B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10054036 2000-10-31
PCT/EP2001/012292 WO2002036104A2 (de) 2000-10-31 2001-10-24 Inhalative lösungsformulierung mit einem tiotropiumsalz

Publications (3)

Publication Number Publication Date
NO20031911L true NO20031911L (no) 2003-04-29
NO20031911D0 NO20031911D0 (no) 2003-04-29
NO332519B1 NO332519B1 (no) 2012-10-08

Family

ID=7661723

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20031911A NO332519B1 (no) 2000-10-31 2003-04-29 Inhalasjonslosningsformulering med et tiotropiumsalt, fremgangsmate for fremstilling av slike samt slike formuleringer for behandling av sykdom

Country Status (39)

Country Link
EP (2) EP1333819B1 (no)
JP (1) JP4344135B2 (no)
KR (1) KR100853107B1 (no)
CN (2) CN100396285C (no)
AR (1) AR038764A1 (no)
AT (1) ATE373473T1 (no)
AU (2) AU2002221738B2 (no)
BG (1) BG66315B1 (no)
BR (1) BRPI0115076B8 (no)
CA (1) CA2426074C (no)
CY (1) CY1107825T1 (no)
CZ (1) CZ300794B6 (no)
DE (2) DE50113037D1 (no)
DK (1) DK1333819T3 (no)
EA (1) EA007604B1 (no)
EC (1) ECSP034541A (no)
EE (1) EE05314B1 (no)
ES (1) ES2294045T3 (no)
HK (1) HK1060524A1 (no)
HR (1) HRP20030338B1 (no)
HU (1) HU229411B1 (no)
IL (2) IL155538A0 (no)
ME (1) ME00244B (no)
MX (1) MXPA03003742A (no)
MY (1) MY138940A (no)
NO (1) NO332519B1 (no)
NZ (1) NZ526023A (no)
PE (1) PE20030092A1 (no)
PL (1) PL203316B1 (no)
PT (1) PT1333819E (no)
RS (1) RS50859B (no)
SA (1) SA01220482B1 (no)
SI (1) SI1333819T1 (no)
SK (1) SK286027B6 (no)
TW (1) TWI293885B (no)
UA (1) UA78690C2 (no)
UY (1) UY26989A1 (no)
WO (1) WO2002036104A2 (no)
ZA (1) ZA200302922B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10216036A1 (de) * 2002-04-11 2003-10-23 Boehringer Ingelheim Pharma Aerosolformulierung für die Inhalation enthaltend ein Tiotropiumsalz
CN1292748C (zh) * 2003-03-05 2007-01-03 南昌弘益科技有限公司 噻托溴铵吸入粉雾剂及其制备工艺
PT1682541E (pt) * 2003-11-03 2010-04-14 Boehringer Ingelheim Int Processo para a preparação de sais de tiotrópio
PL2083007T3 (pl) * 2003-11-03 2013-09-30 Boehringer Ingelheim Int Sole tiotropium, sposoby ich wytwarzania oraz zawierające je kompozycje farmaceutyczne
EP1881980B1 (en) 2005-05-02 2012-08-22 Boehringer Ingelheim International GmbH Novel crystalline forms of tiotropium bromide
EP2044967A1 (de) * 2007-10-01 2009-04-08 Boehringer Ingelheim Pharma GmbH & Co. KG Zerstäuber
CN104306361A (zh) * 2014-09-24 2015-01-28 万特制药(海南)有限公司 一种含噻托溴铵的吸入性溶液
CN111374963A (zh) * 2018-12-31 2020-07-07 天津药业研究院有限公司 一种用于吸入的噻托铵溶液剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
SG45171A1 (en) * 1990-03-21 1998-01-16 Boehringer Ingelheim Int Atomising devices and methods
DE19536902A1 (de) * 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
DE19653969A1 (de) * 1996-12-20 1998-06-25 Boehringer Ingelheim Kg Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole
DE19847968A1 (de) * 1998-10-17 2000-04-20 Boehringer Ingelheim Pharma Verschlußkappe und Behälter als Zweikammer-Kartusche für Vernebler zur Erzeugung von Aerosolen

Also Published As

Publication number Publication date
KR20030060926A (ko) 2003-07-16
ZA200302922B (en) 2004-04-22
EE05314B1 (et) 2010-08-16
ME00244B (me) 2011-05-10
EP1333819A2 (de) 2003-08-13
HUP0301378A3 (en) 2005-12-28
UA78690C2 (uk) 2007-04-25
AU2173802A (en) 2002-05-15
HRP20030338B1 (en) 2011-09-30
HUP0301378A2 (hu) 2003-10-28
BRPI0115076B1 (pt) 2016-07-26
YU33003A (sh) 2006-05-25
HRP20030338A2 (en) 2005-04-30
DE10152521A1 (de) 2002-07-11
SA01220482B1 (ar) 2007-07-31
ES2294045T3 (es) 2008-04-01
SK286027B6 (sk) 2008-01-07
ECSP034541A (es) 2003-05-26
DE50113037D1 (de) 2007-10-31
WO2002036104A2 (de) 2002-05-10
SI1333819T1 (sl) 2007-12-31
WO2002036104A3 (de) 2002-08-01
BR0115076A (pt) 2003-07-29
PL203316B1 (pl) 2009-09-30
PE20030092A1 (es) 2003-03-24
KR100853107B1 (ko) 2008-08-21
UY26989A1 (es) 2002-06-20
NZ526023A (en) 2005-05-27
MEP40408A (en) 2011-02-10
EP1837021A3 (de) 2008-03-19
CN100396285C (zh) 2008-06-25
CA2426074C (en) 2008-12-23
IL155538A0 (en) 2003-11-23
HU229411B1 (en) 2013-12-30
RS50859B (sr) 2010-08-31
CZ300794B6 (cs) 2009-08-12
MY138940A (en) 2009-08-28
CY1107825T1 (el) 2013-06-19
SK5272003A3 (en) 2003-10-07
TWI293885B (en) 2008-03-01
BG107727A (bg) 2004-11-30
ATE373473T1 (de) 2007-10-15
CZ20031486A3 (cs) 2003-08-13
HK1060524A1 (en) 2004-08-13
NO332519B1 (no) 2012-10-08
JP4344135B2 (ja) 2009-10-14
EA007604B1 (ru) 2006-12-29
EE200300203A (et) 2003-10-15
MXPA03003742A (es) 2004-10-15
CN101292964A (zh) 2008-10-29
EP1333819B1 (de) 2007-09-19
IL155538A (en) 2008-11-26
EP1837021A2 (de) 2007-09-26
JP2004512357A (ja) 2004-04-22
PT1333819E (pt) 2007-10-29
DK1333819T3 (da) 2007-12-03
AR038764A1 (es) 2005-01-26
BRPI0115076B8 (pt) 2021-05-25
AU2002221738B2 (en) 2007-01-11
BG66315B1 (bg) 2013-04-30
PL360405A1 (en) 2004-09-06
NO20031911D0 (no) 2003-04-29
CA2426074A1 (en) 2002-05-10
CN1473038A (zh) 2004-02-04
EA200300482A1 (ru) 2003-12-25

Similar Documents

Publication Publication Date Title
WO2005115406A3 (en) 8-(2-hydroxyphenoxy)octyldiethanolamine and salts thereof for delivery of active agents
HUP0400692A2 (hu) Szubsztituált 7H-pirrolo[2,3-d]pirimidin-származékok, alkalmazásuk és az ezeket tartalmazó gyógyászati készítmények
NO20053277L (no) Hurtigvirkende farmasoytisk sammensetning.
CA2359813A1 (en) Nicotine mucosal spray
HUP0301447A2 (hu) Tiotrópium- és salmeterolsókat tartalmazó kombinációs gyógyszerkészítmények
HN1999000183A (es) Preparado farmaceuticos de moxifloxacina
MXPA03010162A (es) Un inhibidor de pde4 y un agente anticolinergico en combinacion para tratar enfermedades obstructivas de vias respiratorias.
TW200630364A (en) 2-amido-4-phenylthiazole derivatives, preparation thereof and therapeutic application thereof
NO20024646D0 (no) Kombinasjonsterapier med vaskul¶r-skadende aktivitet
EA200500833A1 (ru) Получение стерильных водных суспензий, содержащих микронизированные кристаллические активные ингредиенты для ингаляции
NO20031911L (no) Inhalasjonslösningsformulering med et tiotropiumsalt
SE0102440D0 (sv) New compound
YU33103A (sh) Formulacija rastvora za inhalaciju sa soli tiotropijuma
NO20044001L (no) Aerosolformulering for inhalasjon omfattende et tiotropiumsalt
MEP54208A (en) Medicaments containing steroids and a novel anticholinesterase drug
NO965469D0 (no) Substituerte alkyldiaminderivater og deres anvendelse som tachykininantagonister
DK1581224T3 (da) Tiotropiumholdig lægemiddelsammensætning til inhalation
IT1252599B (it) Composizione farmaceutica effervescente anticefalalgica
ATE77238T1 (de) Primycin-loesungen.

Legal Events

Date Code Title Description
MK1K Patent expired