EA200300482A1 - Ингаляционная композиция в виде раствора с солью тиотропия - Google Patents

Ингаляционная композиция в виде раствора с солью тиотропия

Info

Publication number
EA200300482A1
EA200300482A1 EA200300482A EA200300482A EA200300482A1 EA 200300482 A1 EA200300482 A1 EA 200300482A1 EA 200300482 A EA200300482 A EA 200300482A EA 200300482 A EA200300482 A EA 200300482A EA 200300482 A1 EA200300482 A1 EA 200300482A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tiotropy
salt
solution
inhalation composition
propellant
Prior art date
Application number
EA200300482A
Other languages
English (en)
Other versions
EA007604B1 (ru
Inventor
Барбара Никлаус-Хумке
Кристель Шмельцер
Петра Барт
Карин Дрексель
Original Assignee
Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг filed Critical Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг
Publication of EA200300482A1 publication Critical patent/EA200300482A1/ru
Publication of EA007604B1 publication Critical patent/EA007604B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)

Abstract

В заявке описаны не содержащая пропеллент ингаляционная композиция на основе растворенного в воде или в смеси воды с этанолом тиотропийбромида, соответственно моногидрата тиотропийбромида и получаемые из нее без использования пропеллента ингаляционные аэрозоли.Отчет о международном поиске был опубликован 2002.08.01.
EA200300482A 2000-10-31 2001-10-24 Ингаляционная композиция в виде раствора с солью тиотропия EA007604B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10054036 2000-10-31
PCT/EP2001/012292 WO2002036104A2 (de) 2000-10-31 2001-10-24 Inhalative lösungsformulierung mit einem tiotropiumsalz

Publications (2)

Publication Number Publication Date
EA200300482A1 true EA200300482A1 (ru) 2003-12-25
EA007604B1 EA007604B1 (ru) 2006-12-29

Family

ID=7661723

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300482A EA007604B1 (ru) 2000-10-31 2001-10-24 Ингаляционная композиция в виде раствора с солью тиотропия

Country Status (39)

Country Link
EP (2) EP1333819B1 (ru)
JP (1) JP4344135B2 (ru)
KR (1) KR100853107B1 (ru)
CN (2) CN101292964A (ru)
AR (1) AR038764A1 (ru)
AT (1) ATE373473T1 (ru)
AU (2) AU2173802A (ru)
BG (1) BG66315B1 (ru)
BR (1) BRPI0115076B8 (ru)
CA (1) CA2426074C (ru)
CY (1) CY1107825T1 (ru)
CZ (1) CZ300794B6 (ru)
DE (2) DE50113037D1 (ru)
DK (1) DK1333819T3 (ru)
EA (1) EA007604B1 (ru)
EC (1) ECSP034541A (ru)
EE (1) EE05314B1 (ru)
ES (1) ES2294045T3 (ru)
HK (1) HK1060524A1 (ru)
HR (1) HRP20030338B1 (ru)
HU (1) HU229411B1 (ru)
IL (2) IL155538A0 (ru)
ME (1) ME00244B (ru)
MX (1) MXPA03003742A (ru)
MY (1) MY138940A (ru)
NO (1) NO332519B1 (ru)
NZ (1) NZ526023A (ru)
PE (1) PE20030092A1 (ru)
PL (1) PL203316B1 (ru)
PT (1) PT1333819E (ru)
RS (1) RS50859B (ru)
SA (1) SA01220482B1 (ru)
SI (1) SI1333819T1 (ru)
SK (1) SK286027B6 (ru)
TW (1) TWI293885B (ru)
UA (1) UA78690C2 (ru)
UY (1) UY26989A1 (ru)
WO (1) WO2002036104A2 (ru)
ZA (1) ZA200302922B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10216036A1 (de) * 2002-04-11 2003-10-23 Boehringer Ingelheim Pharma Aerosolformulierung für die Inhalation enthaltend ein Tiotropiumsalz
CN1292748C (zh) * 2003-03-05 2007-01-03 南昌弘益科技有限公司 噻托溴铵吸入粉雾剂及其制备工艺
SI2067779T1 (sl) * 2003-11-03 2013-08-30 Boehringer Ingelheim International Gmbh Tiotropijeve soli, postopek za njihovo pripravo in formulacije zdravil, ki jih vsebujejo
RS20060293A (en) * 2003-11-03 2008-08-07 Boehringer Ingelheim International Gmbh., Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same
DK1881980T3 (da) 2005-05-02 2012-10-01 Boehringer Ingelheim Int Nye krystalline former af tiotropiumbromid
EP2044967A1 (de) * 2007-10-01 2009-04-08 Boehringer Ingelheim Pharma GmbH & Co. KG Zerstäuber
CN104306361A (zh) * 2014-09-24 2015-01-28 万特制药(海南)有限公司 一种含噻托溴铵的吸入性溶液
CN111374963A (zh) * 2018-12-31 2020-07-07 天津药业研究院有限公司 一种用于吸入的噻托铵溶液剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
SG45171A1 (en) * 1990-03-21 1998-01-16 Boehringer Ingelheim Int Atomising devices and methods
DE19536902A1 (de) * 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
DE19653969A1 (de) * 1996-12-20 1998-06-25 Boehringer Ingelheim Kg Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole
DE19847968A1 (de) * 1998-10-17 2000-04-20 Boehringer Ingelheim Pharma Verschlußkappe und Behälter als Zweikammer-Kartusche für Vernebler zur Erzeugung von Aerosolen

Also Published As

Publication number Publication date
DK1333819T3 (da) 2007-12-03
ECSP034541A (es) 2003-05-26
ME00244B (me) 2011-05-10
HUP0301378A3 (en) 2005-12-28
EP1837021A2 (de) 2007-09-26
BR0115076A (pt) 2003-07-29
SI1333819T1 (sl) 2007-12-31
PL203316B1 (pl) 2009-09-30
HRP20030338A2 (en) 2005-04-30
EE200300203A (et) 2003-10-15
HRP20030338B1 (en) 2011-09-30
HU229411B1 (en) 2013-12-30
CZ300794B6 (cs) 2009-08-12
NO332519B1 (no) 2012-10-08
WO2002036104A3 (de) 2002-08-01
MXPA03003742A (es) 2004-10-15
KR100853107B1 (ko) 2008-08-21
MEP40408A (en) 2011-02-10
CZ20031486A3 (cs) 2003-08-13
IL155538A (en) 2008-11-26
EP1333819B1 (de) 2007-09-19
EA007604B1 (ru) 2006-12-29
NO20031911D0 (no) 2003-04-29
KR20030060926A (ko) 2003-07-16
NO20031911L (no) 2003-04-29
HK1060524A1 (en) 2004-08-13
RS50859B (sr) 2010-08-31
WO2002036104A2 (de) 2002-05-10
DE50113037D1 (de) 2007-10-31
DE10152521A1 (de) 2002-07-11
SK5272003A3 (en) 2003-10-07
BG66315B1 (bg) 2013-04-30
CY1107825T1 (el) 2013-06-19
AU2173802A (en) 2002-05-15
EE05314B1 (et) 2010-08-16
EP1333819A2 (de) 2003-08-13
CA2426074A1 (en) 2002-05-10
JP4344135B2 (ja) 2009-10-14
IL155538A0 (en) 2003-11-23
NZ526023A (en) 2005-05-27
PE20030092A1 (es) 2003-03-24
UA78690C2 (ru) 2007-04-25
CN1473038A (zh) 2004-02-04
BRPI0115076B1 (pt) 2016-07-26
JP2004512357A (ja) 2004-04-22
MY138940A (en) 2009-08-28
ZA200302922B (en) 2004-04-22
CN101292964A (zh) 2008-10-29
SK286027B6 (sk) 2008-01-07
PL360405A1 (en) 2004-09-06
CN100396285C (zh) 2008-06-25
AU2002221738B2 (en) 2007-01-11
ATE373473T1 (de) 2007-10-15
UY26989A1 (es) 2002-06-20
SA01220482B1 (ar) 2007-07-31
BG107727A (bg) 2004-11-30
PT1333819E (pt) 2007-10-29
TWI293885B (en) 2008-03-01
YU33003A (sh) 2006-05-25
BRPI0115076B8 (pt) 2021-05-25
AR038764A1 (es) 2005-01-26
EP1837021A3 (de) 2008-03-19
ES2294045T3 (es) 2008-04-01
CA2426074C (en) 2008-12-23
HUP0301378A2 (hu) 2003-10-28

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Legal Events

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MK4A Patent expired

Designated state(s): BY RU