MD3519401T2 - Modulator al regulatorului de conductanță transmembranară în fibroza chistică, compoziții farmaceutice, metode de tratament și procedeu pentru fabricarea modulatorului - Google Patents

Modulator al regulatorului de conductanță transmembranară în fibroza chistică, compoziții farmaceutice, metode de tratament și procedeu pentru fabricarea modulatorului Download PDF

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Publication number
MD3519401T2
MD3519401T2 MDE20190875T MDE20190875T MD3519401T2 MD 3519401 T2 MD3519401 T2 MD 3519401T2 MD E20190875 T MDE20190875 T MD E20190875T MD E20190875 T MDE20190875 T MD E20190875T MD 3519401 T2 MD3519401 T2 MD 3519401T2
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MD
Moldova
Prior art keywords
compound
formula
independently
salt
pharmaceutically acceptable
Prior art date
Application number
MDE20190875T
Other languages
English (en)
Romanian (ro)
Inventor
Timothy Alcacio
Minson Baek
Peter Grootenhuis
Ruah Sara Sabina Hadida
Robert M Hughes
Ali Keshavarz-Shokri
Rachel Mcauley-Aoki
Jason Mccartney
Mark Thomas Miller
Goor Fredrick Van
Beili Zhang
Corey Anderson
Thomas Cleveland
Bryan A Frieman
Haripada Khatuya
Pramod Virupax Joshi
Paul John Krenitsky
Vito Melillo
Fabrice Jean Denis Pierre
Andreas P Termin
Johnny Uy
Jinglan Zhou
Alexander Russell Abela
Brett Bradley Busch
Prasuna Paraselli
David Andrew Siesel
Original Assignee
Vertex Pharma
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=61757799&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD3519401(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MD3519401T2 publication Critical patent/MD3519401T2/ro

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/12Mucolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002Heterocyclic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
MDE20190875T 2016-09-30 2017-09-29 Modulator al regulatorului de conductanță transmembranară în fibroza chistică, compoziții farmaceutice, metode de tratament și procedeu pentru fabricarea modulatorului MD3519401T2 (ro)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662402838P 2016-09-30 2016-09-30
US201662410353P 2016-10-19 2016-10-19
US201662415409P 2016-10-31 2016-10-31
US201662419935P 2016-11-09 2016-11-09
PCT/US2017/054611 WO2018064632A1 (en) 2016-09-30 2017-09-29 Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator

Publications (1)

Publication Number Publication Date
MD3519401T2 true MD3519401T2 (ro) 2022-02-28

Family

ID=61757799

Family Applications (1)

Application Number Title Priority Date Filing Date
MDE20190875T MD3519401T2 (ro) 2016-09-30 2017-09-29 Modulator al regulatorului de conductanță transmembranară în fibroza chistică, compoziții farmaceutice, metode de tratament și procedeu pentru fabricarea modulatorului

Country Status (39)

Country Link
US (3) US10570115B2 (OSRAM)
EP (1) EP3519401B1 (OSRAM)
JP (1) JP7061115B2 (OSRAM)
KR (1) KR102531491B1 (OSRAM)
CN (1) CN109803962B (OSRAM)
AU (1) AU2017336156B2 (OSRAM)
BR (1) BR112019006213A2 (OSRAM)
CA (1) CA3037986C (OSRAM)
CL (1) CL2019000827A1 (OSRAM)
CO (1) CO2019004065A2 (OSRAM)
CY (1) CY1124862T1 (OSRAM)
DK (1) DK3519401T3 (OSRAM)
DO (1) DOP2019000081A (OSRAM)
EC (1) ECSP19028690A (OSRAM)
ES (1) ES2900263T3 (OSRAM)
GE (2) GEP20217329B (OSRAM)
HR (1) HRP20211683T1 (OSRAM)
HU (1) HUE056716T2 (OSRAM)
IL (1) IL265627B (OSRAM)
JO (1) JOP20190042B1 (OSRAM)
LT (1) LT3519401T (OSRAM)
MA (1) MA46357B1 (OSRAM)
MD (1) MD3519401T2 (OSRAM)
MX (1) MX387060B (OSRAM)
NZ (1) NZ752486A (OSRAM)
PE (1) PE20191147A1 (OSRAM)
PL (1) PL3519401T3 (OSRAM)
PT (1) PT3519401T (OSRAM)
RS (1) RS62670B1 (OSRAM)
SA (1) SA519401446B1 (OSRAM)
SG (1) SG10201913595YA (OSRAM)
SI (1) SI3519401T1 (OSRAM)
SM (1) SMT202100646T1 (OSRAM)
TN (1) TN2019000079A1 (OSRAM)
TW (1) TWI766886B (OSRAM)
UA (1) UA124708C2 (OSRAM)
UY (1) UY37428A (OSRAM)
WO (1) WO2018064632A1 (OSRAM)
ZA (1) ZA201902124B (OSRAM)

Families Citing this family (31)

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MX2017004543A (es) 2014-10-06 2017-10-04 Vertex Pharma Moduladores de regulador de conductancia transmembranal de fibrosis quística.
PL3436446T3 (pl) 2016-03-31 2023-09-11 Vertex Pharmaceuticals Incorporated Modulatory mukowiscydozowego przezbłonowego regulatora przewodnictwa
PT3519401T (pt) 2016-09-30 2021-12-27 Vertex Pharma Modulador de regulador de condutância transmembranar de fibrose quística, composições farmacêuticas, métodos de tratamento e processo para fazer o modulador
WO2018107100A1 (en) 2016-12-09 2018-06-14 Vertex Pharmaceuticals Incorporated Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
US11253509B2 (en) 2017-06-08 2022-02-22 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
AU2018304168B2 (en) 2017-07-17 2023-05-04 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
AR112467A1 (es) 2017-08-02 2019-10-30 Vertex Pharma Procesos para preparar compuestos
IL273831B2 (en) * 2017-10-19 2024-10-01 Vertex Pharma Crystalline forms and compositions of cftr modulators
EP3720849A2 (en) * 2017-12-08 2020-10-14 Vertex Pharmaceuticals Incorporated Processes for making modulators of cystic fibrosis transmembrane conductance regulator
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
ES2939775T3 (es) * 2018-02-15 2023-04-26 Vertex Pharma Macrociclos como moduladores del regulador de la conductancia transmembrana de la fibrosis quística, composiciones farmacéuticas de los mismos, su uso en el tratamiento de la fibrosis quística, y procesos para elaborarlos
US20210139514A1 (en) * 2018-04-05 2021-05-13 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
WO2019200246A1 (en) 2018-04-13 2019-10-17 Alexander Russell Abela Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
MA54227B1 (fr) 2018-11-14 2023-03-31 Vertex Pharma Méthodes de traitement de la fibrose kystique
AR118555A1 (es) 2019-04-03 2021-10-20 Vertex Pharma Agentes moduladores del regulador de la conductancia transmembrana de la fibrosis quística
WO2020214921A1 (en) 2019-04-17 2020-10-22 Vertex Pharmaceuticals Incorporated Solid forms of modulators of cftr
AU2020328028B2 (en) 2019-08-14 2025-03-06 Vertex Pharmaceuticals Incorporated Crystalline forms of CFTR modulators
TWI867024B (zh) * 2019-08-14 2024-12-21 美商維泰克斯製藥公司 囊腫纖維化跨膜傳導調節蛋白之調節劑
TWI899097B (zh) 2019-08-14 2025-10-01 美商維泰克斯製藥公司 製備cftr調節劑之方法
AU2020328568A1 (en) * 2019-08-14 2022-03-03 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
CR20230120A (es) 2020-08-07 2023-09-01 Vertex Pharma Moduladores del regulador de la conductancia transmembrana de la fibrosis quística
KR20230051216A (ko) 2020-08-13 2023-04-17 버텍스 파마슈티칼스 인코포레이티드 Cftr 조절제의 결정질 형태
IL301755A (en) * 2020-10-07 2023-05-01 Vertex Pharma Modulators of cystic fibrosis transmembrane conductance regulator
US12324802B2 (en) 2020-11-18 2025-06-10 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
JP2023549547A (ja) * 2020-11-18 2023-11-27 バーテックス ファーマシューティカルズ インコーポレイテッド 嚢胞性線維症膜コンダクタンス制御因子のモジュレーターとして使用するための1,3,4-オキサジアゾール環を含有する大環状化合物
MX2023006770A (es) 2020-12-10 2023-08-14 Vertex Pharma Metodos de tratamiento para fibrosis quistica.
EP4472983A1 (en) 2022-02-03 2024-12-11 Vertex Pharmaceuticals Incorporated Methods of preparing and crystalline forms of (6a,12a)-17-amino-12-methyl-6,15-bis(trifluoromethyl)-13,19-dioxa-3,4,18-triazatricyclo[ 12.3.1.12,5]nonadeca-1(18),2,4,14,16-pentaen-6-ol
WO2023150237A1 (en) 2022-02-03 2023-08-10 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
AU2023218262A1 (en) 2022-02-08 2024-08-22 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
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GEP20217329B (en) 2021-12-10
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PT3519401T (pt) 2021-12-27
AU2017336156B2 (en) 2021-10-21
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JP2019529490A (ja) 2019-10-17
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CY1124862T1 (el) 2022-11-25
ECSP19028690A (es) 2019-05-31
KR20190067827A (ko) 2019-06-17
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