|
ZA859574B
(en)
*
|
1984-12-21 |
1986-08-27 |
Hoffmann La Roche |
Process for the manufacture of oxetanones
|
|
CA1270837A
(en)
*
|
1984-12-21 |
1990-06-26 |
Hoffmann-La Roche Limited |
Oxetanones
|
|
CA1328881C
(en)
*
|
1984-12-21 |
1994-04-26 |
Pierre Barbier |
Process for the manufacture of oxetanones
|
|
JPH0618793Y2
(ja)
*
|
1986-06-13 |
1994-05-18 |
パイオニア株式会社 |
作業台
|
|
US4806564A
(en)
*
|
1987-05-26 |
1989-02-21 |
Merck & Co., Inc. |
Antihypercholesterolemic beta-lactones
|
|
US4816477A
(en)
*
|
1987-05-26 |
1989-03-28 |
Merck & Co., Inc. |
Antihypercholesterolemic β-lactones
|
|
US5484777A
(en)
*
|
1989-04-20 |
1996-01-16 |
Lange, Iii; Louis G. |
Pancreatic cholesterol esterase inhibitor
|
|
US5063210A
(en)
*
|
1989-04-20 |
1991-11-05 |
Lange Iii Louis G |
Use of sulfated polysaccharides to decrease cholesterol and fatty acid absorption
|
|
US5017565A
(en)
*
|
1989-04-20 |
1991-05-21 |
Lange Iii Louis G |
Use of sulfated polysaccharides to inhibit pancreatic cholesterol esterase
|
|
US5376640A
(en)
*
|
1989-12-25 |
1994-12-27 |
Nisshin Flour Milling Co., Ltd. |
Lipolytic enzyme inhibitors
|
|
JP2960947B2
(ja)
*
|
1989-12-25 |
1999-10-12 |
日清製粉株式会社 |
脂質分解酵素阻害剤
|
|
CA2098167C
(en)
*
|
1992-06-24 |
2006-12-19 |
Dorothea Isler |
Foodstuffs and feedstuffs containing a lipase inhibitor
|
|
CA2128044C
(en)
*
|
1993-08-05 |
2007-02-20 |
Klaus-Dieter Bremer |
Pharmaceutical compositions comprising a glucosidase and/or amylase inhibitor, and a lipase inhibitor
|
|
US6262277B1
(en)
|
1994-09-13 |
2001-07-17 |
G.D. Searle And Company |
Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
|
|
US6268392B1
(en)
|
1994-09-13 |
2001-07-31 |
G. D. Searle & Co. |
Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
|
|
US6642268B2
(en)
|
1994-09-13 |
2003-11-04 |
G.D. Searle & Co. |
Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
|
|
MY116591A
(en)
*
|
1996-04-26 |
2004-02-28 |
Hoffmann La Roche |
Process for the production of lipstatin and tetrahydrolipstatin
|
|
US6004996A
(en)
*
|
1997-02-05 |
1999-12-21 |
Hoffman-La Roche Inc. |
Tetrahydrolipstatin containing compositions
|
|
PL191222B1
(pl)
*
|
1997-02-05 |
2006-03-31 |
Hoffmann La Roche |
Zastosowanie tetrahydrolipstatyny do wytwarzania doustnego farmaceutycznego preparatu do leczenia cukrzycy typu II
|
|
US7344713B1
(en)
*
|
1997-07-07 |
2008-03-18 |
Pimentel Julio L |
Decreased fat absorption with an anti-lipase antibody
|
|
GB9727131D0
(en)
*
|
1997-12-24 |
1998-02-25 |
Knoll Ag |
Therapeutic agents
|
|
RU2234917C2
(ru)
*
|
1997-12-24 |
2004-08-27 |
Кнолль Акциенгезелльшафт |
Терапевтические средства
|
|
US6264937B1
(en)
*
|
1998-01-09 |
2001-07-24 |
Geltex Pharmaceuticals, Inc. |
Fat-binding polymers
|
|
US7048917B1
(en)
|
1998-01-09 |
2006-05-23 |
Genzyme Corporation |
Fat-binding polymers
|
|
US6299868B1
(en)
|
1999-07-14 |
2001-10-09 |
Geltex Pharmaceuticals, Inc. |
Fat-binding polymers
|
|
ATE293970T1
(de)
|
1998-08-14 |
2005-05-15 |
Hoffmann La Roche |
Lipasehemmer enthaltende pharmazeutische zusammensetzungen
|
|
DE69916288T2
(de)
*
|
1998-08-14 |
2005-03-24 |
F. Hoffmann-La Roche Ag |
Lipasehemmer und chitosan enthaltende arzneimittel
|
|
WO2000038722A1
(en)
|
1998-12-23 |
2000-07-06 |
G.D. Searle & Co. |
COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS
|
|
HK1044292A1
(zh)
|
1998-12-23 |
2002-10-18 |
G‧D‧瑟尔有限公司 |
适用於心血管疾病的回肠胆汁酸转运抑制剂和胆汁酸螯合剂组合
|
|
AU776664B2
(en)
|
1998-12-23 |
2004-09-16 |
G.D. Searle Llc |
Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
|
|
ES2203239T3
(es)
|
1998-12-23 |
2004-04-01 |
G.D. Searle Llc |
Combinaciones de inhibidores de la proteina de transferencia de ester de colesterilo y de agentes secuestrantes de acidos biliares para indicaciones cardiovasculares.
|
|
CN1342090A
(zh)
|
1998-12-23 |
2002-03-27 |
G·D·瑟尔有限公司 |
适用于心血管疾病的回肠胆汁酸转运抑制剂和贝酸衍生物的组合
|
|
EP1340508A1
(en)
|
1998-12-23 |
2003-09-03 |
G.D. Searle LLC. |
Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications
|
|
EP1342475A1
(en)
|
1998-12-23 |
2003-09-10 |
G.D. Searle LLC. |
Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
|
|
EP1028115B1
(en)
*
|
1999-01-29 |
2002-11-20 |
F. Hoffmann-La Roche Ag |
Purification of lipstatin
|
|
HK1046092A1
(zh)
*
|
1999-07-14 |
2002-12-27 |
Genzyme Corporation |
可與脂解酶抑制劑任意配合的脂肪結合聚合物
|
|
AR025587A1
(es)
*
|
1999-09-13 |
2002-12-04 |
Hoffmann La Roche |
Formulaciones en dispersion que contienen inhibidores de lipasa
|
|
AR025609A1
(es)
|
1999-09-13 |
2002-12-04 |
Hoffmann La Roche |
Formulaciones lipidas solidas
|
|
EP1132389A1
(en)
|
2000-03-06 |
2001-09-12 |
Vernalis Research Limited |
New aza-indolyl derivatives for the treatment of obesity
|
|
US6794544B2
(en)
|
2000-03-10 |
2004-09-21 |
Pharmacia Corporation |
Method for the preparation of tetrahydrobenzothiepines
|
|
EP1142572A1
(de)
*
|
2000-04-04 |
2001-10-10 |
Volker Dr. Helmstädter |
Oxetanon-enthaltende Präparate zur Behandlung von Darmerkrankungen
|
|
DE10021618A1
(de)
*
|
2000-05-04 |
2001-11-15 |
Volker Helmstaedter |
Präparat für Darmerkrankungen und dessen Verwendung
|
|
RU2244542C2
(ru)
|
2000-06-27 |
2005-01-20 |
Ф.Хоффманн-Ля Рош Аг |
Способ приготовления композиции
|
|
EP1307264B1
(en)
|
2000-07-28 |
2004-10-20 |
F. Hoffmann-La Roche Ag |
New pharmaceutical composition
|
|
WO2002009814A2
(en)
*
|
2000-07-28 |
2002-02-07 |
F. Hoffmann-La Roche Ag |
New use of lipase inhibitors
|
|
PT1311260E
(pt)
|
2000-08-09 |
2008-05-02 |
Hoffmann La Roche |
Utilização de inibidores de lipase para o tratamento da dispepsia
|
|
US6900226B2
(en)
|
2000-09-06 |
2005-05-31 |
Hoffman-La Roche Inc. |
Neuropeptide Y antagonists
|
|
EP1328515B1
(en)
|
2000-10-16 |
2008-08-06 |
F. Hoffmann-La Roche AG |
Indoline derivatives and their use as 5-ht2 receptor ligands
|
|
GB0030710D0
(en)
*
|
2000-12-15 |
2001-01-31 |
Hoffmann La Roche |
Piperazine derivatives
|
|
WO2002051844A1
(en)
|
2000-12-27 |
2002-07-04 |
F. Hoffmann-La Roche Ag |
Indole derivatives and their use as 5-ht2b and 5-ht2c receptor ligands
|
|
GB0106177D0
(en)
*
|
2001-03-13 |
2001-05-02 |
Hoffmann La Roche |
Piperazine derivatives
|
|
US20030091610A1
(en)
*
|
2001-03-19 |
2003-05-15 |
The Procter & Gamble Company |
Use of non-digestible polymeric foams to sequester ingested materials thereby inhibiting their absorption by the body
|
|
US20030072804A1
(en)
*
|
2001-03-19 |
2003-04-17 |
The Procter & Gamble Company |
Use of non-digestible polymeric foams to sequester ingested materials thereby inhibiting their absorption by the body
|
|
WO2002094789A1
(en)
|
2001-05-21 |
2002-11-28 |
F. Hoffmann-La Roche Ag |
Quinoline derivatives as ligands for the neuropeptide y receptor
|
|
US6730319B2
(en)
|
2001-06-06 |
2004-05-04 |
Hoffmann-La Roche Inc. |
Pharmaceutical compositions having depressed melting points
|
|
US20030027786A1
(en)
|
2001-06-06 |
2003-02-06 |
Karsten Maeder |
Lipase inhibiting composition
|
|
US7041280B2
(en)
*
|
2001-06-29 |
2006-05-09 |
Genzyme Corporation |
Aryl boronate functionalized polymers for treating obesity
|
|
US7049345B2
(en)
*
|
2001-06-29 |
2006-05-23 |
Genzyme Corporation |
Fat-binding polymers
|
|
MXPA04001922A
(es)
|
2001-08-30 |
2005-03-07 |
Alizyme Therapeutics Ltd |
Tieno-(1,3)-oxazin-4-onas con actividad inhibidora de lipasa.
|
|
US6787558B2
(en)
|
2001-09-28 |
2004-09-07 |
Hoffmann-La Roche Inc. |
Quinoline derivatives
|
|
US8603514B2
(en)
|
2002-04-11 |
2013-12-10 |
Monosol Rx, Llc |
Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
|
|
US8900497B2
(en)
|
2001-10-12 |
2014-12-02 |
Monosol Rx, Llc |
Process for making a film having a substantially uniform distribution of components
|
|
US20110033542A1
(en)
|
2009-08-07 |
2011-02-10 |
Monosol Rx, Llc |
Sublingual and buccal film compositions
|
|
US20190328679A1
(en)
|
2001-10-12 |
2019-10-31 |
Aquestive Therapeutics, Inc. |
Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
|
|
US8765167B2
(en)
|
2001-10-12 |
2014-07-01 |
Monosol Rx, Llc |
Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
|
|
US10285910B2
(en)
|
2001-10-12 |
2019-05-14 |
Aquestive Therapeutics, Inc. |
Sublingual and buccal film compositions
|
|
US11207805B2
(en)
|
2001-10-12 |
2021-12-28 |
Aquestive Therapeutics, Inc. |
Process for manufacturing a resulting pharmaceutical film
|
|
US7357891B2
(en)
|
2001-10-12 |
2008-04-15 |
Monosol Rx, Llc |
Process for making an ingestible film
|
|
US8900498B2
(en)
|
2001-10-12 |
2014-12-02 |
Monosol Rx, Llc |
Process for manufacturing a resulting multi-layer pharmaceutical film
|
|
US20070281003A1
(en)
|
2001-10-12 |
2007-12-06 |
Fuisz Richard C |
Polymer-Based Films and Drug Delivery Systems Made Therefrom
|
|
GB0125659D0
(en)
*
|
2001-10-25 |
2001-12-19 |
Ssl Int Plc |
Spermicides
|
|
MXPA04003524A
(es)
|
2001-11-02 |
2004-07-23 |
Searle Llc |
Compuestos de benzotiepina monofluorados y difluorados novedosos como inhibidores de transporte de acido biliar co-dependiente de sodio apical (asbt) y captacion de taurocolato.
|
|
IL162323A0
(en)
*
|
2001-12-04 |
2005-11-20 |
Biogal Pharmaceutical Co |
Preparation of orlistat and orlistat crystalline forms
|
|
AU2002359601A1
(en)
|
2001-12-04 |
2003-06-17 |
Biogal Gyogyszergyar Rt |
A fermentation process for lipstatin and method of extracting lipstatin from a fermentation broth
|
|
WO2003053944A1
(en)
|
2001-12-20 |
2003-07-03 |
Osi Pharmaceuticals, Inc. |
Pancreatic lipase inhibitor compounds, their synthesis and use
|
|
CA2471639A1
(en)
|
2002-01-17 |
2003-07-31 |
Pharmacia Corporation |
Novel alkyl/aryl hydroxy or keto thiepines.
|
|
GB0202015D0
(en)
*
|
2002-01-29 |
2002-03-13 |
Hoffmann La Roche |
Piperazine Derivatives
|
|
CA2473181A1
(en)
*
|
2002-02-04 |
2003-08-14 |
F. Hoffmann-La Roche Ag |
Quinoline derivatives as npy antagonists
|
|
JP2005526732A
(ja)
|
2002-02-28 |
2005-09-08 |
エフ.ホフマン−ラ ロシュ アーゲー |
Npy受容体拮抗剤としてのチアゾール誘導体
|
|
US7728153B2
(en)
*
|
2002-04-17 |
2010-06-01 |
The Burnham Institute For Medical Research |
Method for the asymmetric synthesis of beta-lactone compounds
|
|
WO2003088975A1
(en)
*
|
2002-04-17 |
2003-10-30 |
The Burnham Institute |
Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation
|
|
AU2003222814B2
(en)
*
|
2002-04-26 |
2006-08-24 |
Cheplapharm Arzneimittel Gmbh |
Pharmaceutical composition comprising a lipase inhibitor and glucomannan
|
|
US7105526B2
(en)
|
2002-06-28 |
2006-09-12 |
Banyu Pharmaceuticals Co., Ltd. |
Benzimidazole derivatives
|
|
MXPA05000131A
(es)
*
|
2002-07-05 |
2005-04-11 |
Hoffmann La Roche |
Derivados de quinazolina.
|
|
EP1539722A1
(en)
*
|
2002-08-07 |
2005-06-15 |
F. Hoffmann-La Roche Ag |
Thiazole derivatives
|
|
WO2004024726A1
(en)
*
|
2002-09-12 |
2004-03-25 |
F. Hoffmann-La Roche Ag |
N-substituted-1h-indol-5-propionic acid compounds as ppar agonists useful for the treatment of diabetes
|
|
CN100343250C
(zh)
*
|
2002-11-25 |
2007-10-17 |
霍夫曼-拉罗奇有限公司 |
吲哚衍生物
|
|
US8372430B2
(en)
|
2002-12-17 |
2013-02-12 |
The Procter & Gamble Company |
Compositions, methods, and kits useful for the alleviation of gastrointestinal effects
|
|
US7772188B2
(en)
|
2003-01-28 |
2010-08-10 |
Ironwood Pharmaceuticals, Inc. |
Methods and compositions for the treatment of gastrointestinal disorders
|
|
US20040178058A1
(en)
*
|
2003-03-10 |
2004-09-16 |
Hsueh-Chung Chen |
Electro-chemical deposition apparatus and method of preventing cavities in an ECD copper film
|
|
EP1457206A1
(en)
*
|
2003-03-13 |
2004-09-15 |
Fournier Laboratories Ireland Limited |
Combined use of a fibrate and orlistat for the treatment of obesity
|
|
EA009646B1
(ru)
*
|
2003-05-30 |
2008-02-28 |
Рэнбакси Лабораториз Лтд. |
Замещённые производные пиррола и их применение в качестве ингибиторов hmg-coa
|
|
WO2004113314A1
(en)
*
|
2003-06-23 |
2004-12-29 |
Biocon Limited |
Novel boronate esters
|
|
GB0314967D0
(en)
*
|
2003-06-26 |
2003-07-30 |
Hoffmann La Roche |
Piperazine derivatives
|
|
US20060025337A1
(en)
*
|
2003-07-01 |
2006-02-02 |
President And Fellows Of Harvard College |
Sirtuin related therapeutics and diagnostics for neurodegenerative diseases
|
|
WO2005007639A1
(en)
*
|
2003-07-17 |
2005-01-27 |
Biocon Limited |
Preparation of tetrahydrolipstatin by hydrogenation of lipstatin, solvent extraction and purification
|
|
AU2004263312A1
(en)
*
|
2003-08-12 |
2005-02-17 |
F. Hoffmann-La Roche Ag |
Thiazole derivatives as NPY antagonists
|
|
BRPI0413500A
(pt)
*
|
2003-08-12 |
2006-10-10 |
Hoffmann La Roche |
compostos, processos para a sua preparação, composição farmacêutica que compreende os mesmos, utilização de um composto, métodos para o tratamento e profilaxia de artrite, diabetes, distúrbios alimentares e obesidade
|
|
US20050239859A2
(en)
*
|
2003-09-03 |
2005-10-27 |
Solvay Pharmaceuticals Gmbh |
Novel medical uses of 4,5-dihydro-1h-pyrazole derivatives having cb1- antagonistic activity
|
|
ATE547404T1
(de)
|
2003-09-22 |
2012-03-15 |
Msd Kk |
Piperidinderivate
|
|
US20050124660A1
(en)
*
|
2003-10-27 |
2005-06-09 |
Jochen Antel |
Novel medical uses of compounds showing CB1-antagonistic activity and combination treatment involving said compounds
|
|
US20050143441A1
(en)
*
|
2003-10-27 |
2005-06-30 |
Jochen Antel |
Novel medical combination treatment of obesity involving 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity
|
|
WO2005051298A2
(en)
|
2003-11-19 |
2005-06-09 |
Metabasis Therapeutics, Inc. |
Novel phosphorus-containing thyromimetics
|
|
CN101247793B
(zh)
*
|
2003-12-29 |
2013-04-10 |
哈佛大学校长及研究员协会 |
治疗或预防肥胖和胰岛素抗性病症的组合物
|
|
US8017634B2
(en)
|
2003-12-29 |
2011-09-13 |
President And Fellows Of Harvard College |
Compositions for treating obesity and insulin resistance disorders
|
|
PL209905B1
(pl)
|
2004-01-15 |
2011-11-30 |
Bringwell Internat Ab |
Preparat do leczenia otyłości i związanego z nią syndromu metabolicznego
|
|
EP2298293A1
(en)
|
2004-01-16 |
2011-03-23 |
Fuji Oil Company, Limited |
Lipase inhibitor
|
|
US7074822B2
(en)
|
2004-02-23 |
2006-07-11 |
Solvay Pharmaceuticals Gmbh |
Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them
|
|
EP1734963A4
(en)
|
2004-04-02 |
2008-06-18 |
Merck & Co Inc |
METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER
|
|
AU2005239788A1
(en)
|
2004-05-10 |
2005-11-17 |
University Of Copenhagen |
Flaxseeds for body weight management
|
|
US7879866B2
(en)
*
|
2004-07-19 |
2011-02-01 |
Dorte Xenia Gram |
Inhibition of the activity of the capsaicin receptor in the treatment of obesity or obesity-related diseases and disorders
|
|
JP2008517976A
(ja)
|
2004-10-25 |
2008-05-29 |
ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Cb1カンナビノイド受容体拮抗薬及びカリウムチャンネルオープナーから成る、真性糖尿病1型、肥満及び関連症状の治療用の医薬組成物
|
|
CA2590533C
(en)
*
|
2004-11-23 |
2010-09-07 |
Warner-Lambert Company Llc |
7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for the treatment of lipidemia
|
|
US20060246141A1
(en)
*
|
2005-04-12 |
2006-11-02 |
Elan Pharma International, Limited |
Nanoparticulate lipase inhibitor formulations
|
|
JP2008540368A
(ja)
*
|
2005-05-03 |
2008-11-20 |
エフ.ホフマン−ラ ロシュ アーゲー |
5−ht2リガンドとしての四環式アザピラジノインドリン
|
|
RU2417985C2
(ru)
|
2005-05-30 |
2011-05-10 |
Баниу Фармасьютикал Ко., Лтд. |
Новые производные пиперидина
|
|
WO2006138418A2
(en)
*
|
2005-06-14 |
2006-12-28 |
President And Fellows Of Harvard College |
Improvement of cognitive performance with sirtuin activators
|
|
US20070149466A1
(en)
*
|
2005-07-07 |
2007-06-28 |
Michael Milburn |
Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders
|
|
US20100216758A1
(en)
|
2005-08-10 |
2010-08-26 |
Makoto Ando |
Pyridone Compounds
|
|
DE602006006712D1
(de)
*
|
2005-08-18 |
2009-06-18 |
Hoffmann La Roche |
Thiazolylpiperidin-derivate nützlich als h3 rezeptor modulatoren
|
|
JPWO2007024004A1
(ja)
|
2005-08-24 |
2009-03-05 |
萬有製薬株式会社 |
フェニルピリドン誘導体
|
|
AU2006288153A1
(en)
|
2005-09-07 |
2007-03-15 |
Msd K.K. |
Bicyclic aromatic substituted pyridone derivative
|
|
US7355055B2
(en)
*
|
2005-09-08 |
2008-04-08 |
Reliance Life Sciences Pvt. Ltd. |
Compounds for treatment of lipase-mediated diseases
|
|
US7741317B2
(en)
|
2005-10-21 |
2010-06-22 |
Bristol-Myers Squibb Company |
LXR modulators
|
|
EP2332526A3
(en)
|
2005-10-21 |
2011-10-12 |
Novartis AG |
Combination of a renin-inhibitor and an anti-dyslipidemic agent and/or an antiobesity agent
|
|
US8163770B2
(en)
|
2005-10-27 |
2012-04-24 |
Msd. K. K. |
Benzoxathiin derivative
|
|
JP2009514851A
(ja)
*
|
2005-11-08 |
2009-04-09 |
ランバクシー ラボラトリーズ リミテッド |
(3r,5r)−7−[2−(4−フルオロフェニル)−5−イソプロピル−3−フェニル−4−[(4−ヒドロキシメチルフェニルアミノ)カルボニル]−ピロール−1−イル]−3,5−ジヒドロキシ−ヘプタン酸ヘミカルシウム塩の製法
|
|
BRPI0618354B8
(pt)
|
2005-11-10 |
2021-05-25 |
Banyu Pharma Co Ltd |
composto e seu uso, composição farmacêutica, preventivo ou remédio
|
|
US7888376B2
(en)
|
2005-11-23 |
2011-02-15 |
Bristol-Myers Squibb Company |
Heterocyclic CETP inhibitors
|
|
RU2412182C2
(ru)
*
|
2005-11-30 |
2011-02-20 |
Ф.Хоффманн-Ля Рош Аг |
Производные 1,1-диоксотиоморфолинилиндолилметанона для применения в качестве модуляторов гистамина 3 (н3)
|
|
AU2006319234B2
(en)
*
|
2005-11-30 |
2012-01-19 |
F. Hoffmann-La Roche Ag |
1,5-substituted indol-2-yl amide derivatives
|
|
BRPI0619233A2
(pt)
*
|
2005-11-30 |
2011-09-20 |
Hoffmann La Roche |
compostos, processo para a sua manufatura, método para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, uso dos compostos e método para o tratamento ou prevenção de obesidade e de diabetes do tipo ii em um ser humano ou animal
|
|
AU2006324089A1
(en)
*
|
2005-12-09 |
2007-06-14 |
F. Hoffmann-La Roche Ag |
Tricyclic amide derivatives useful for treating obesity
|
|
ES2334580T3
(es)
*
|
2005-12-15 |
2010-03-12 |
F. Hoffmann-La Roche Ag |
Derivados de pirrolo(2,3-c)piridina.
|
|
CN101331131A
(zh)
*
|
2005-12-16 |
2008-12-24 |
霍夫曼-拉罗奇有限公司 |
用作H3受体调节剂的吡咯并[2,3-b]吡啶衍生物
|
|
SK22006A3
(sk)
*
|
2006-01-03 |
2007-08-02 |
Biotika, A. S. |
Kmeň Streptomyces toxytricini produkujúci lipstatín a príprava lipstatínu s uvedeným kmeňom
|
|
US20080021092A1
(en)
*
|
2006-01-06 |
2008-01-24 |
Deepak Murpani |
Stable pharmaceutical compositions of orlistat
|
|
JP2009523150A
(ja)
*
|
2006-01-13 |
2009-06-18 |
エフ.ホフマン−ラ ロシュ アーゲー |
シクロヘキシルピペラジニルメタノン誘導体及びh3受容体調節剤としてのそれらの使用
|
|
RU2008134315A
(ru)
*
|
2006-01-23 |
2010-02-27 |
Ф.Хоффманн-Ля Рош Аг (Ch) |
Производные циклогексилсульфонамида, обладающие н3 рецепторной активностью
|
|
TW200744583A
(en)
*
|
2006-03-14 |
2007-12-16 |
Ranbaxy Lab Ltd |
Statin stabilizing dosage formulations
|
|
KR101252635B1
(ko)
|
2006-04-20 |
2013-04-10 |
(주)아모레퍼시픽 |
리파아제 저해제 및 친유성 오일흡수제를 포함하는 약학조성물 및 이로부터 제조된 경구 투여용 제제
|
|
US7432255B2
(en)
*
|
2006-05-16 |
2008-10-07 |
Hoffmann-La Roche Inc. |
1H-indol-5-yl-piperazin-1-yl-methanone derivatives
|
|
CN101448820A
(zh)
*
|
2006-05-30 |
2009-06-03 |
霍夫曼-拉罗奇有限公司 |
哌啶基嘧啶衍生物
|
|
TW200811101A
(en)
*
|
2006-07-14 |
2008-03-01 |
Ranbaxy Lab Ltd |
Polymorphic forms of an HMG-CoA reductase inhibitor and uses thereof
|
|
US7514433B2
(en)
|
2006-08-03 |
2009-04-07 |
Hoffmann-La Roche Inc. |
1H-indole-6-yl-piperazin-1-yl-methanone derivatives
|
|
JPWO2008038692A1
(ja)
|
2006-09-28 |
2010-01-28 |
萬有製薬株式会社 |
ジアリールケチミン誘導体
|
|
TW200831497A
(en)
*
|
2006-10-12 |
2008-08-01 |
Epix Delaware Inc |
Carboxamide compounds and their use
|
|
ES2382009T3
(es)
|
2006-12-01 |
2012-06-04 |
Bristol-Myers Squibb Company |
Derivados de N-((3-bencil)-2,2-(bis-fenil-)-propan-1-amina como inhibidores de CETP para el tratamiento de aterosclerosis y enfermedades cardiovasculares
|
|
US20080146559A1
(en)
|
2006-12-08 |
2008-06-19 |
Li Chen |
4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives
|
|
US20080200422A1
(en)
*
|
2007-01-09 |
2008-08-21 |
Cavener Douglas R |
Methods for reduction of adipose tissue mass
|
|
EP2145884B1
(en)
|
2007-04-02 |
2014-08-06 |
Msd K.K. |
Indoledione derivative
|
|
CN101795684A
(zh)
*
|
2007-04-09 |
2010-08-04 |
赛多斯有限责任公司 |
他汀类化合物与抗肥胖药的组合
|
|
US20080249156A1
(en)
*
|
2007-04-09 |
2008-10-09 |
Palepu Nageswara R |
Combinations of statins and anti-obesity agent and glitazones
|
|
IN2009KN04568A
(Direct)
|
2007-06-01 |
2015-08-28 |
Univ Princeton |
|
|
EP2527360B1
(en)
|
2007-06-04 |
2015-10-28 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
|
US8969514B2
(en)
|
2007-06-04 |
2015-03-03 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
|
|
WO2008149321A2
(en)
*
|
2007-06-06 |
2008-12-11 |
Ranbaxy Laboratories Limited |
Process for the preparation of orlistat
|
|
WO2009033483A1
(en)
|
2007-09-12 |
2009-03-19 |
Københavns Universitet |
Compositions and methods for increasing the suppression of hunger and reducing the digestibility of non-fat energy satiety
|
|
US20100196464A1
(en)
*
|
2007-09-17 |
2010-08-05 |
Dr. Reddy's Laboratories Limited |
Orlistat pharmaceutical formulations
|
|
WO2009044380A2
(en)
|
2007-10-05 |
2009-04-09 |
Ranbaxy Laboratories Limited |
Formulations containing orlistat particles having controlled particle size
|
|
US20100317642A1
(en)
*
|
2007-10-15 |
2010-12-16 |
Inventis Dds Pvt Limited |
Pharmaceutical composition of orlistat
|
|
US8298583B2
(en)
|
2007-10-19 |
2012-10-30 |
Monosol Rx, Llc |
Film delivery system for tetrahydrolipstatin
|
|
CN101925383A
(zh)
|
2007-12-11 |
2010-12-22 |
赛特帕斯凡德株式会社 |
甲酰胺化合物及其作为趋化因子受体激动剂的应用
|
|
US20090214682A1
(en)
*
|
2008-02-22 |
2009-08-27 |
Heuer Marvin A |
Composition and methods for weight loss in a subject
|
|
US20110015181A1
(en)
|
2008-03-06 |
2011-01-20 |
Makoto Ando |
Alkylaminopyridine derivative
|
|
US8501444B2
(en)
|
2008-03-26 |
2013-08-06 |
Biocon Limited |
Fermentation process for higher yield coefficient of lipase-inhibitor with respect to consumed fatty acid
|
|
CN101981025A
(zh)
|
2008-03-28 |
2011-02-23 |
万有制药株式会社 |
具有黑色素浓缩激素受体拮抗作用的二芳基甲基酰胺衍生物
|
|
EP3239170B1
(en)
|
2008-06-04 |
2019-03-20 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
|
US20110071129A1
(en)
|
2008-06-19 |
2011-03-24 |
Makoto Ando |
Spirodiamine-diaryl ketoxime derivative
|
|
EP2141236A1
(en)
*
|
2008-07-03 |
2010-01-06 |
KRKA, D.D., Novo Mesto |
Process for production of lipstatin and microorganisms therefore
|
|
AU2009270833B2
(en)
|
2008-07-16 |
2015-02-19 |
Bausch Health Ireland Limited |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
|
|
JPWO2010013595A1
(ja)
|
2008-07-30 |
2012-01-12 |
Msd株式会社 |
5員−5員又は5員−6員縮環シクロアルキルアミン誘導体
|
|
WO2010039019A1
(es)
|
2008-10-03 |
2010-04-08 |
Sigma Alimentos, S.A. De C.V. |
Composición para promover el control de colesterol total y ldl y/o la pérdida de peso y/o la termogénesis
|
|
US8309107B2
(en)
*
|
2008-10-06 |
2012-11-13 |
Banner Pharmacaps, Inc. |
Stable solutions of orlistat for pharmaceutical dosage forms
|
|
WO2010043592A1
(en)
*
|
2008-10-15 |
2010-04-22 |
Revotar Biopharmaceuticals Ag |
Lipase inhibitors for use for the treatment of obesity
|
|
EP2348857B1
(en)
|
2008-10-22 |
2016-02-24 |
Merck Sharp & Dohme Corp. |
Novel cyclic benzimidazole derivatives useful anti-diabetic agents
|
|
EP2362731B1
(en)
|
2008-10-31 |
2016-04-06 |
Merck Sharp & Dohme Corp. |
Novel cyclic benzimidazole derivatives useful anti-diabetic agents
|
|
US20120046364A1
(en)
|
2009-02-10 |
2012-02-23 |
Metabasis Therapeutics, Inc. |
Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use
|
|
WO2010093243A1
(en)
|
2009-02-12 |
2010-08-19 |
Coöperatieve Mirzorg U.A., Arnhem |
Use of a combination of diazoxide and metformin for treating obesity or obesity related disorders
|
|
US20100215635A1
(en)
*
|
2009-02-23 |
2010-08-26 |
Zoltan Kiss |
Small molecules to induce weight loss or to reduce weight gain
|
|
WO2010112569A1
(en)
|
2009-03-31 |
2010-10-07 |
Robert Zimmermann |
Modulation of adipose triglyceride lipase for prevention and treatment of cachexia, loss of weight and muscle atrophy and methods of screening therefor
|
|
WO2010115825A2
(en)
|
2009-03-31 |
2010-10-14 |
Robert Zimmermann |
Modulation of adipose triglyceride lipase for prevention and treatment of cachexia, loss of weight and muscle atrophy and methods of screening therefor
|
|
BRPI0901602B8
(pt)
|
2009-04-03 |
2021-05-25 |
Ems S/A |
formulação farmacêuticas
|
|
RU2412713C2
(ru)
*
|
2009-05-14 |
2011-02-27 |
Открытое Акционерное Общество Завод Экологической Техники И Экопитания "Диод" |
Фармацевтическая композиция, биологически активная добавка и способ уменьшения поглощения жира из пищи
|
|
WO2011028309A1
(en)
|
2009-09-04 |
2011-03-10 |
University Of Toledo |
PROCESSES FOR PRODUCING OPTICALLY PURE β-LACTONES FROM ALDEHYDES AND COMPOSITIONS PRODUCED THEREBY
|
|
WO2011051864A1
(en)
|
2009-11-02 |
2011-05-05 |
Pfizer Inc. |
Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives
|
|
UA107369C2
(en)
|
2010-02-01 |
2014-12-25 |
Lab Bago S A |
Pharmaceutical composition with anti-obesity activity comprising a premixture of pure orlistat and preparation process
|
|
US8524909B2
(en)
|
2010-02-02 |
2013-09-03 |
Hoffmann-La Roche Inc. |
Tetrahydro-pyran derivatives
|
|
RU2441654C2
(ru)
*
|
2010-02-17 |
2012-02-10 |
Лабораториос Баго С.А. |
Фармацевтическая композиция с активностью против ожирения, включающая премикс чистого орлистата, и способ ее изготовления
|
|
JP2013520502A
(ja)
|
2010-02-25 |
2013-06-06 |
メルク・シャープ・エンド・ドーム・コーポレイション |
有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体
|
|
WO2011140190A1
(en)
|
2010-05-05 |
2011-11-10 |
Infinity Pharmaceuticals |
Tetrazolones as inhibitors of fatty acid synthase
|
|
WO2011140296A1
(en)
|
2010-05-05 |
2011-11-10 |
Infinity Pharmaceuticals |
Triazoles as inhibitors of fatty acid synthase
|
|
US20130072519A1
(en)
|
2010-05-21 |
2013-03-21 |
Edward Lee Conn |
2-phenyl benzoylamides
|
|
ES2662710T3
(es)
|
2010-05-24 |
2018-04-09 |
Swedish Oat Fiber Ab |
Dispersión acuosa que comprende galactolípidos y método de producción de la misma
|
|
EP2392327A1
(en)
|
2010-06-04 |
2011-12-07 |
Universitätsmedizin der Johannes Gutenberg-Universität Mainz |
Use of orlistat for the anti-parasitic treatment of a parasitic disease
|
|
KR20130041177A
(ko)
|
2010-07-06 |
2013-04-24 |
아스트라제네카 아베 |
치료제 976
|
|
CN101885713B
(zh)
*
|
2010-07-19 |
2011-11-30 |
大邦(湖南)生物制药有限公司 |
一种毒三素链霉菌发酵液中分离提取利普司他汀的工艺
|
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
|
CN101948450B
(zh)
*
|
2010-10-13 |
2013-04-24 |
鲁南制药集团股份有限公司 |
一种生产制备奥利司他的方法
|
|
US9149959B2
(en)
|
2010-10-22 |
2015-10-06 |
Monosol Rx, Llc |
Manufacturing of small film strips
|
|
SMT202000486T1
(it)
|
2010-11-04 |
2020-11-10 |
Albireo Ab |
Inibitori di ibat per il trattamento di malattie del fegato
|
|
KR101890960B1
(ko)
|
2010-11-08 |
2018-09-28 |
알비레오 에이비 |
Ⅰbat 억제제 및 담즙산 바인더를 포함하는 약학적 조합물
|
|
MY159058A
(en)
|
2011-02-25 |
2016-12-15 |
Merck Sharp & Dohme |
Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agent
|
|
JP2014513923A
(ja)
|
2011-03-04 |
2014-06-19 |
ファイザー・インク |
Edn3様ペプチドおよびその使用
|
|
UY34194A
(es)
|
2011-07-15 |
2013-02-28 |
Astrazeneca Ab |
?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad?
|
|
CN102304105B
(zh)
*
|
2011-07-15 |
2013-07-10 |
鲁南新时代生物技术有限公司 |
一种制备高纯度奥利司他的方法
|
|
CN103030613B
(zh)
*
|
2011-09-29 |
2014-11-12 |
北大方正集团有限公司 |
一种利普司他汀的提纯方法
|
|
JP2013249293A
(ja)
*
|
2012-06-04 |
2013-12-12 |
Kao Corp |
リパーゼ活性阻害剤、抗真菌剤、及びフケ抑制剤
|
|
US9527875B2
(en)
|
2012-08-02 |
2016-12-27 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
WO2014060445A1
(en)
|
2012-10-19 |
2014-04-24 |
Akzo Nobel Chemicals International B.V. |
Method for preparing high purity orlistat
|
|
CN102936234B
(zh)
*
|
2012-11-15 |
2015-04-01 |
江苏阿尔法药业有限公司 |
一种制备脂肪酶抑制剂奥利司他的方法
|
|
CN102993134B
(zh)
*
|
2012-12-31 |
2015-08-05 |
鲁南新时代生物技术有限公司 |
一种利普司他汀的提纯方法
|
|
CA2898482A1
(en)
|
2013-02-22 |
2014-08-28 |
Linda L. Brockunier |
Antidiabetic bicyclic compounds
|
|
US9650375B2
(en)
|
2013-03-14 |
2017-05-16 |
Merck Sharp & Dohme Corp. |
Indole derivatives useful as anti-diabetic agents
|
|
HK1220611A1
(zh)
|
2013-03-15 |
2017-05-12 |
Bausch Health Ireland Limited |
用於治疗胃肠道病症的组成物
|
|
US9708367B2
(en)
|
2013-03-15 |
2017-07-18 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase and their uses
|
|
EP2986599A1
(en)
|
2013-04-17 |
2016-02-24 |
Pfizer Inc. |
N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
|
|
CN113388007A
(zh)
|
2013-06-05 |
2021-09-14 |
博士医疗爱尔兰有限公司 |
鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
|
|
WO2015051496A1
(en)
|
2013-10-08 |
2015-04-16 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
CA2959208C
(en)
|
2014-08-29 |
2023-09-19 |
Tes Pharma S.R.L. |
Pyrimidine derivatives and their use as inhibitors of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase
|
|
US10743813B2
(en)
|
2014-09-11 |
2020-08-18 |
Rattan Nath |
Diabetes control using postprandial feedback
|
|
WO2016055901A1
(en)
|
2014-10-08 |
2016-04-14 |
Pfizer Inc. |
Substituted amide compounds
|
|
US12427121B2
(en)
|
2016-05-05 |
2025-09-30 |
Aquestive Therapeutics, Inc. |
Enhanced delivery epinephrine compositions
|
|
US12433850B2
(en)
|
2016-05-05 |
2025-10-07 |
Aquestive Therapeutics, Inc. |
Enhanced delivery epinephrine and prodrug compositions
|
|
CN109310646A
(zh)
|
2016-05-05 |
2019-02-05 |
阿奎斯蒂弗医疗股份有限公司 |
增强递送的肾上腺素组合物
|
|
US11273131B2
(en)
|
2016-05-05 |
2022-03-15 |
Aquestive Therapeutics, Inc. |
Pharmaceutical compositions with enhanced permeation
|
|
CN109952292A
(zh)
|
2016-10-14 |
2019-06-28 |
Tes制药有限责任公司 |
α-氨基-β-羧基己二烯二酸半醛去羧酶的抑制剂
|
|
US11072602B2
(en)
|
2016-12-06 |
2021-07-27 |
Merck Sharp & Dohme Corp. |
Antidiabetic heterocyclic compounds
|
|
EP3558298A4
(en)
|
2016-12-20 |
2020-08-05 |
Merck Sharp & Dohme Corp. |
ANTIDIABETIC SPIROCHROMAN COMPOUNDS
|
|
AU2019385644B2
(en)
|
2018-11-20 |
2025-10-30 |
Tes Pharma S.R.L. |
Inhibitors of α-Amino-β-carboxymuconic acid semialdehyde decarboxylase
|
|
PH12021551686A1
(en)
|
2019-01-18 |
2022-05-16 |
Astrazeneca Ab |
Pcsk9 inhibitors and methods of use thereof
|
|
NL2022615B1
(en)
|
2019-02-21 |
2020-08-31 |
Patrick Alexander Unger |
Pharmaceutical composition comprising tetrahydrocannabivarin for the prevention and treatment of overweight
|
|
JP7722195B2
(ja)
|
2020-02-05 |
2025-08-13 |
日油株式会社 |
膵液瘻の予防または治療剤
|
|
US12465564B2
(en)
|
2021-10-25 |
2025-11-11 |
Aquestive Therapeutics, Inc. |
Oral and nasal compositions and methods of treatment
|