LV12150B - Farneziltransferāzes inhibitori - Google Patents

Farneziltransferāzes inhibitori Download PDF

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LV12150B
LV12150B LVP-98-129A LV980129A LV12150B LV 12150 B LV12150 B LV 12150B LV 980129 A LV980129 A LV 980129A LV 12150 B LV12150 B LV 12150B
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tetrahydro
imidazol
ylmethyl
benzodiazepine
phenyl
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Charles Z. Ding
John T. Hunt
Soong-Hoon Kim
Toomas Mitt
Raheev Bhide
Katerina Leftheris
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Bristol-Myers Squibb Company
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Claims (17)

1LV 12150 Izgudrojuma formula . Savienojums ar formulu (I), (II), (III) vai (IV) r4,rs Γ^ρ A„ <££-Rr-Ss-T,-^-N , N-2-R8 ' \R7^N V/ v7m w R,R,R a1 d2 d3 Vc *Ol»x r1,r2,r3 2 JQLRr.Ss-T,-^(ln N-r5,rj/n ΧάΛm 'T*®" N—Z—R8 r\r2,r3 I-2-R8 J&*rs.^rr-K% r6r7/N V/ W R1,R2,R3 2 tā enantiomēri, diastereomēri un farmaceitiski pieņemamās sālīs, zāļu priekštečvielas un solvāti, kas inhibē farnezilproteīntransferāzi, fermentu, kurš piedalās ras onkogēna ekspresijā, ar šādām augstāk minēto apzīmējumu nozīmēm: m, n, r, s un t ir 0 vai 1; V, W un X ņemti no rindas, kas ietver skābekļa atomu, ūdeņraža atomu, R1, R2 un R3; Z un Y ņemti no rindas, kas ietver CHR9, SO2, S03, CO, C02, O, NR10, so2nr1Vconr12, n-cn n-cn 0 II II II —C— / —C-N— R13 / —N—C— / —N-S02— / R14 R1® 0 II —C-N-N— r16r17 - / -so2-ņ-ņ— / o^m20 R21N NR22 r18r19 -S- / —S — pie kam Z nav obligāts; R® D7 D® r12 q13 p14 p16 p1? R^® p19 p20 p21 p22 p24 p25 Γ\ ] Γ\ ι Γ\ ļ Γλ ι Γ\ ι i\ j Γλ ļ Γ\ ļ η ļ γ> ι Γλ ι ι% ι γ\ ι ι\ ι Γ\ ι ι\ f η y r% ι R26, R27, R28, R29, R30, R31, R32, R33, R34, R35, R36, R37 un R38 ņemti no rindas, kas ietver ūdeņraža atomu, zemāko alkilgrupu, aizvietotu alkilgrupu, arilgrupu un aizvietotu arilgrupu; R4 un R5 ir ņemti no rindas kas ietver ūdeņraža atomu, halogēna atomu, nitrogrupu, ciāngrupu un U-R , U ir ņemts no rindas, kas ietver sēra atomu, skābekļa atomu, NR24, CO, SO, S02, C02l NR25C02, nr2Sconr27, nr28šo2, nr29so2nr30, S02NR31, NR32CO, CONR33, PO2R34 un PO3R35, pie kam U nav obligāts; R1, R2 un R3 ir ņemti no rindas, kas ietver ūdeņraža atomu, alkilgrupu, alkoksikarbonilgrupu, aizvietotu alkilgrupu, alkenilgrupu, aizvietotu alkenilgrupu, alkinilgrupu, aizvietotu alkinilgrupu, aralkilgrupu, cikloalkilgrupu, arilgrupu, aizvietotu arilgrupu, heterociklisku grupu, aizvietotu heterociklisku grupu, ciāngrupu, karboksilgrupu, karbamilgrupu (proti, CONH2) un aizvietotu karbamilgrupu, kas var būt alkilkarbamilgrupa, arilkarbamilgrupu, aralkilkarbamilgrupa vai divaizvietota karbamilgrupa, kuras aizvietotāji ņemti no rindas: alkilgrupa, arilgrupa un aralkilgrupa; R8 un R23 ir ņemti no rindas, kas ietver ūdeņraža atomu, alkilgrupu, alkenilgrupu, aizvietotu alkenilgrupu, alkinilgrupu, aizvietotu alkinilgrupu, aralkilgrupu, cikloalkilgrupu, arilgrupu, aizvietotu arilgrupu, heterociklisku grupu un aizvietotu heterociklisku grupu; 3 LV 12150 pie tam jebkuri divi no aizvietotājiem R1, R2 un R1 var but savienoti, veidojot cikloalkilgrupu; R, S un T ir ņemti no rindas, kas ietver CH2, CO un CH(CH2)PQ, kur Q ir NR36R37, OR38 vai CN; A, B, C un D ir oglekļa, skābekļa, sēra vai slāpekļa atomi; ar tādu noteikumu: 1. kad m ir 0, tad V un W abi vienlaikus nav skābekļa atoms; 2. formulās (I) un (II) V un W abi vienlaikus var būt skābekļa atoms tikai tad, kad Z nav, vai tas ir O, NR10, CHR9, o 11 —n—c—- / vai —N-S02- R14 R15 formulās (III) un (IV) V un X abi vienlaikus var būt skābekļa atoms tikai tad, kad Y ir 0, NR10, CHR9, o 11 —n—c— / vai —Ņ’S02— R14 R15 -N-S 02 R15 O NR20 / ->sČ- R21N NR22 / -$>*-
2. Savienojums pēc 1. punkta, kas ņemts no rindas r2,rs
OR r4,rs
Π N-Z-m w / R1,RZ,R1 1 R23 nevar būt ūdeņraža atoms tad, kad U ir SO, S02, NR25C02 vai NR28S02; 2 R8 nevar būt ūdeņraža atoms tad, kad Z ir S02, C02 vai 4
3. Savienojums pēc 2. punkta, kurā m ir nulle un ABCD ir karbocikls.
4. Savienojums pēc 3. punkta, kurā karbocikls ir benzola gredzens.
5. Savienojums pēc 1. punkta, ar formulu (I),
kurā m ir nulle un ABCD ir karbocikls.
6. Savienojums pēc 5. punkta, kurā karbocikls ir benzola gredzens.
7. Savienojums pēc 1. punkta, kas ņemts no rindas: 2,3,4,5-tetrahidro-1 -(1 H-imidazol-4-ilmetil)-4-(1 -naftoil)-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 8-hlor-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(1-naftoil)-1H-1,4-benzo-diazepīna hidrogēnhlorīds; 1.2.3.4- tetrahidro-4-(3H-imidazol-4-ilmetil)-1-(1-naftoil)hinoksalīna dihidrogēn-hlorīds; 2.3.4.5- tetrahidro-4-(1 H-imidazol-4-ilmetil)-1-(1-naftoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-iimetil)-2-metil-4-(1-naftoil)-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 2.3.4.5- tetrahidro-4-(1-naftoil)-1-(1-fenilmetil-1H-imidazol-5-ilmetil)-1,4-benzo-diazepīna hidrogēnhlorīds; 2.3.4.5- tetrahidro-(1 H-imidazol-4-ilmetil)-4-(1-naftalīnsulfonil)-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (S)-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-2-(metiltioetii)-4-(1-naftoil)-1H-1,4-benzodiazepīna hidrogēnhlorīds; 5 LV 12150 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-N-metil-N-fenil-4H-1,4-benzo-diazepīn-4-karboksamīda hidrogēnhlorīds; 2-[2,3,4,5-tetrahidro-1 -(1 H-imidazol-4-ilmetil)-1 H-1,4-benzodiazepin-4-il]-sulfonil)benzoskābes metilestera hidrogēnhlorīds; 7-brom-2,3,4l5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(1-naftoil)-1H-1,4-benzo-diazepīna hidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-2-ilmetil)-4-(1-naftoil)-7-fenif-1 H-1,4-benzo-diazepīna hidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-2-ilmetil)-4-(1-naftoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-[3-(1 H-imidazol-2-il)propil]-4-(1-naftoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 1-[3-amino-3-(1 H-imidazol-2-il)propil]-2,3,4,5-tetrahidro-4-(1-naftoil)-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-3-metil-4-(1-naftoil)-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (S)-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-[2-(metiltio)etil]-4-(1-naftoil)-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-9-metil-4-(1-naftoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-4-(1 H-imidazol-4-ilmetil)-9-metil-1-(1 -naftoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 1{[2-(2-aminoetii)-1 H-imidazol-4-il]metil}-2,3,4,5-tetrahidro-4(1-naftoil)-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 1 {[(2-aminometil)-1 H-imidazol-4-il]metil}-2,3,4,5-tetrahidro-4(1-naftoil)-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; N-[2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-1 H-1,4-benzo-diazepin-8-il]acetamīda dihidrohlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-1 H-pirido[2,3-e]-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-1 H-nafto[2,3-e]-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-8-nitro-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 213.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-8-amino-1 H-1,4-benzo-diazepīna dihidrogēnhlorīds; N-[2,3l4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(1-naftoil)-1H-1,4-benzo-diazepin-8-il]benzamīda dihidrohlorīds; N-[2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(1-naftoil)-1H-1,4-benzo-diazepin-8-il]cikloheksānkarboksamīda dihidrohlorīds; 2.3.4.5- tetrahidro-1-[2-(1H-imidazol-4-il)etil]-4-(1-naftoil)-1H-1,4-benzo-diazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-[2-(1 H-imidazol-4-il)etil]-4-(1-naftoil)-7-fenil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 7-brom-2,3,4,5-tetrahidro-1-[2-(1H-imidazol-4-il)etil]-4-(1-naftoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 1{[(2-aminometil)-1H-imidazol-5-il]metil}-2,3,4,5-tetrahidro-4(1-naftoil)-7-fenil-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 6 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-1H-1,4-benzo-diazepīn-4-karbonskābes fenilmetilesteris; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilrnetil)-7-fenil-4-(2-trifluormetoksibenzoii)-1H-1,4-benzodiazepīns; 1.2.3.5- tetrahidro-1-{1 H-imidazol-4-ilmetil)-N-metil-N,7-difenil-4H-1,4-benzo-diazepīn-4-karboksamīda dihidrogēnhlorīds; 2,3A5-tetrahidro-1-(1H-imidazol-4-ilrnetil)-4-(1-naftoil)-7-(1-piperidinilsulfonil)-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-7-piridin-2-ii-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 7-(2-furanil)-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetii)-4-(1-naftoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-7-(2-tienil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1 -(1 H-imidazol-4-ilmetil)-4-(1 -naftoil)-7-(4-piridinil)-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-[3-(1H-imidazol-2-il)propil]-4-{1-naftoil)-7-fenil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 7- brom-2,3,4,5-tetrahidro-4-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 8- hlor-2,3,4,5-tetrahidro-4-(1 H-imidazol-4-iImetil)-4-(1-naftoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-4-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-7-fenil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 2.3.4.5- tetrahidro-1,4-bis(1 H-imidazol-4-ilmetil)-7-fenil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-4-(1 H-imidazol-4-Hmetil)-4-(1-naftilmetil)-7-fenil-1 H-1,4-benzodiazepīna trifluoracetāts; 2.3.4.5- tetrahidro-4-(1 H-imidazol-4-ilmetil)-7-metoksi-4-(1-naftoil)-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-7-fenil-1 H-1,4-benzo-diazepīn-7-karbonskābes dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-5-ilmetil)-4-(1-naftoil)-7-cikloheksil-1 H-1,4-benzodiazepīns.2,5 HCI; 7-butil-2,3,4,5-tetrahidro-4-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 1{[(2-aminoetil)-1H-imidazol-4-il]metil}-2,3,4,5-tetrahidro-4-(1-naftoil)-7-fenil-1H-1,4-benzodiazepīna trihidrogēnhlorīds; 1{[(2-aminometil)-1H-imidazol-4-il]metil}-2,3,4,5-tetrahidro-4-(1-naftoil)-7-fenil-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(1-naftoil)-8-[N,N-bis(fenilmetil)-amino]-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; N-[2,3,4,5-tetrahidro-1-(1 H-irnidazol-4-ilmetil)-4-(1-naftoil)-1 H-1,4-benzo-diazepin-8-il]fenilsuifonamīda dihidrogēnhlorīds; N-fenil-2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-1 H-1,4-benzo-diazepīn-7-karboksamīda dihidrogēnhlorīds; N-[2,3,4,5-tetrahidro-1 -(1 H-imidazol-4-ilmetil)-4-(1 -naftoil)-1 H-1,4-benzo-diazepin-8-il]-3-metilbenzamīda dihidrogēnhlorīds; 7 LV 12150 N-[2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(1-naftoil)-1H-1,4-benzo-diazepin-8-il]-4-metilbenzamīda dihidrogēnhlorīds; 3- hlor-N-[2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-1 H-1,4-benzo-diazepin-8-il]benzamīda dihidrogēnhlorīds; 7-brom-2,3,4,5-tetrahidro-1-{[2-(dimetilaminometil)-1H-imidazol-4-il]metil}-4-(1-naftoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 7-(4-hlorfenil)-2,3,4,5-tetrahidro-4-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 7-(3-aminofenil)-2,3,4,5-tetrahidro-4-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 1 -metil-N-[2,3,4,5-tetrahidro-1 -(1 H-imidazol-4-ilmeti 1)-4-(1 -naftoil)-1 H-1,4-benzodiazepin-8-il]-1H-pirol-2-karboksamīda trihidrogēnhlorīds; N-[2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-1 H-1,4-benzo-diazepin-8-il]-furān-3-karboksamīda dihidrogēnhlorīds; 7-(3-hlorfenil)-2,3,4,5-tetrahidro-4-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2-metil-N-[2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-1 H-1,4-benzodiazepin-8-il]benzamīda dihidrogēnhlorīds; N-fenil-N’-[2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-1 H-1,4-benzodiazepin-8-il]urīnvielas dihidrogēnhlorīds; 7-(3-piridinil)-2,3,4,5-tetrahidro-4-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-4-(1 H-imidazol-4-ilmetil)-9-metoksi-4-(1 -naftoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-4-(1 H-imidazol-4-ilmetil)-4-(1 -naftoil)-7-fenil-1 H-pirido[2,3-e]- 1.4- diazepīna trihidrogēnhlorīds; (R) -2,3,4,5-tetrahidro-1-{1H-imidazol-4-ilmetil)-3-(2-metiltioetil)-4-(1-naftoil)-1H- 1.4- benzodiazepīna hidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(1-naftoil)-3-fenilmetil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-3-(2-hidroksietil)-1 H-1,4-benzodiazepīna trifluoracetāts; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-3-(2-metiltioetil)-4-(1-naftoil)-1 H-1,4-benzodiazepīna trifluoracetāts; (S) -2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-3-fenilmetil-1 H-1,4-benzodiazepīna trifluoracetāts; 4- acetil-7-brom-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(1-naftoil)-3-fenilmetii-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 2.3.4.5- tetrahidro-4-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-3-fenilmetil-1 H-1,4-benzodiazepīns.1,5 HCI; 7-brom-1,2,3,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-3-fenilmetiI-4H-1,4-benzo-diazepīn-4-karboksamīda trifluoracetāts; 7-brom-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-metilsulfonil-3-fenilmetil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 4-acetil-2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-3-fenilmetil-1 H-1,4-benzodiazepīna trifluoracetāts; 4-acetil-7-brom-2,3,4,5-tetrahidro-1-(1H-imidazol-4-iimetii)-3-[(4-hlorfenil)metil]-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 8 4-aceti 1-2,3,4,5-tetra h id ro-1 -(1 H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,4-nafto-[2,3-e]-1,4-diazepīna hidrogēnhlorīds; N-cikloheksil-N’-[2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-1 H-1,4-benzodiazepin-8-il]urīnvielas dihidrogēnhloffds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-4-metilsulfonil-3-fenilmetil-1H-1,4-nafto[2,3-e]-1,4-diazepTna hidrogēnhlorīds; 2,2-dimetil-N-[2,3,4,5-tetrahidro-1 -(1 H-imidazol-4-ilmetil)-4-(1 -naftoil)-1 H-1,4-benzodiazepin-8-il]propānamīda dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-(1-naftafīnsūlfonil)-7-fenil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 4-acetil-7-brom-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-(2-naftilmetil)-1H- 1.4- benzodiazepīna dihidrogēnhlorīds; 4-acetil-7-brom-2,3,4,5-tetrahidro-1-(1H-imidazol-4-iimetil)-3-(1-naftilmetil)-1H- 1.4- benzodiazepīna dihidrogēnhlorīds; 7- (2-hlorfenil)-2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetiI)-4-(1-naftoiI)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 1-metil-N-[2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(1-naftoil)-1H-1,4-benzodiazepin8-il]-2-piperidīnkarboksamīda trihidrogēnhlorīds; N-[2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-1 H-1,4-benzo-diazepin-8-il]-4-morfofīnkarboksamīda dihidrogēnhlorīds; N-[2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-1 H-1,4-benzo-diazepin-8-il]-3-metilbutānamīda dihidrogēnhlorīds; 1.2.3.4- tetrahidro-4-(1H-imidazol-4-ilmetil)-1-(naftalīn-1-sulfonil)hinoksafīna dihidrogēnhlorīds; 1.2.3.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-N,N,7-trifenil-4H-1,4-benzodiazepīn-4-karboksamīda dihidrogēnhlorīds; 1.2.3.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-3-fenilmetil-4H-nafto[2,3-e]-1,4-diazepīn-4-karbonskābes metilestera hidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-[(4-fenil-1,2,3-tiadiazol-5-il)karbonil]-1 H-1,4-benzodiazepīna trifluoracetāts; 8- [(cikloheksilaminokarbonil)amino]-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)- 3- fenilmetil-1 H-1,4-benzodiazepīn-4-karbonskābes 1,1 -dimetiletilesteris; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-8-[(4-metilfenil)sulfonilamino]-3-fenilmetil-1 H-1,4-benzodiazepīn-4-karbonskābes 1,1 -dimetiletilesteris; 7-brom-1,2,3,4-tetrahidro-1-(1 H-imidazol-4-ilmetil)-3-fenilmetil-5H-1,4-benzo-diazepin-5-ona dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-4-[1-okso-3-(1-piperidinil)propil]-7-fenil-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetra h id ro-1 -(1 H-imidazol-4-ilmetil)-7-fenil-4-(4-hinolinilkarbonil)-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 4- [(5-brom-3-piridinil)karbonil]-2,3r4,5-tetrahidro-1-(1H-imidazol-4-iImetil)-7-fenil-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; (S)-4-(2-dimetilamino-1-okso-3-fenilpropil)-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-4-[4-hidroksi-3-(4-morfolinilmetil)benzoil]-1-(1H-imidazol-4-ilmetil)-7-fenil-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 9 LV 12150 (S)-2,3>4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-[(1-metil-2-pirolīdinil)karbonil]-7-fenil-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-{[2-(propiltio)-3-piridinilļ-karbonil}-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 4-[(2-hlor-6-metil-4-piridinil)karbonil]-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-[(2-feniltio-3-piridinil)-karbonil]-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-4-{[2-(4-metilfenoksi)-3-piridinil]-karbonil}-7-fenil-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-4-[(2-metoksi-3-piridinii)karbonil]-7-fenil-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-4-[(4-fenil-5-oksazolil)karbonil]-7-fenil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 4-acetil-2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-1 H-1,4-benzo-diazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-[(tetrahidro-3-furanil)-karbonil]-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-4-[(2-metoksietoksi)acetil]-7-fenil-1H- 1.4- benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-4-[4-(4-morfolinilmetil)benzoil]-7-fenil-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilrnetil)-4-(4-metilsulfonilbenzoil)-7-fenil-1H- 1.4- benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(1-okso-3-feniIsulfonilpropil)-7-fenil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1 -(1 H-imidazol-4-ilmetil)-7-fenil-4-(3-piridinilacetil)-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.314.5- tetrahidro-1-(1H-iimidazol-4-ilmetil)-7-fenil-4-(2-hinoksalinilkarbonil)-1H- 1.4- benzodiazepīna tetrahidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-(4-izohinolinilkarbonil)-1H- 1.4- benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-[(2-hlor-3-piridinil)karbonil]-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(3-piridinilkarbonil)-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-[(2,6-dimetoksi-3-piridinil)-karbonil]-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1 -(1 H-imidazol-4-ilmetil)-7-fenil-4-(2-pirazinilkarbonil)-1 H-1,4-benzodiazepīna tetrahidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(2-etoksibenzoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-(3-dimetilaminobenzoil)-1H- 1.4- benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-iimetil)-7-feni!-4-[(1 -feniiciklopropil)-karbonil]-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-[(biciklo[4.2.0]okta-1,3,5-trien-7-il)karbonil]-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 10 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-benzoil-1 H-1,4-benzo-diazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(2-hlorbenzoil)-1 H-1,4-benzodiazepma dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-(2,3-dihlorbenzoil)-1H-1,4-benzodiazepTna dihidrogēnhlorīds; N-(2-{[2,3,4,5-tetrahidro-1 -(1 H-imidazol-4-ilmetil)-7-fenil-1 H-1,4-benzodiazepin-4-il]karbonil}fenil)acetamīda dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(2-fenoksibenzoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1 -(1 H-imidazol-4-ilmetil)-7-fenil-4-{2-metoksibenzoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-(2,3-dimetoksibenzoil)-1H- 1.4- benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil~4-(2,4-dimetoksibenzoil)-1H- 1.4- benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-(2,5-dimetoksibenzoil)-1H- 1.4- benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1 -(1 H-imidazol-4-ilmetil)-7-fenil-4-(2,6-dimetoksibenzoil)-1 H- 1.4- benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-(2,3-dihidroksibenzoil)-1H- 1.4- benzodiazepīna dihidrogēnhlorīds; 4-[(1,1 '-bifenil)-2-ilkarbonilļ-2,3,4,5-tetrahidro-1 -(1 H-imidazol-4-ilmetil)-7-fenil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(2-metilbenzoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(2,3-dimetilbenzoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(3-ciānbenzoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(3-hlorbenzoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1 -(1 H-imidazol-4-ilmetil)-7-fenil-4-(3-fenoksibenzoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(3-metoksibenzoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-{3,4-dimetoksibenzoil)-1H- 1.4- benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-(3,5-dimetoksibenzoil)-1H- 1.4- benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-feniI-4-(3-metilbenzoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(1,2-diokso-2-feniletil)-1 H- 1.4- benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(2-etoksi-1-naftoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(2-naftoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(4-fluorfenilacetil)-1 H-1,4-benzodiazepma dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-difenilacetil-1 H-1,4-benzo-diazepīna dihidrogēnhlorīds; 2.314.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-(2-hidroksi-1-okso-2-fenil-propil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(1 H-indol-2-ilkarbonil)-1 H- 1.4- benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-(1H-indol-3-ilkarbonil)-1H- 1.4- benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-(1H-indol-5-ilkarbonil)-1H- 1.4- benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-[(1-metil-1H-indol-2-il)karbonil]-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1 -(1 H-imidazol-4-ilmetil)-7-fenil-4-(2-benzofuranilkarbonil)-1 H- 1.4- benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1 -(1 H-imidazol-4-ilmetil)-7-fenil-4-(3-piridinilkarbonil)-1 H-1,4-benzodiazepīna N-oksīda dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-(2-piridinilkarbonil)-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-iimetil)-7-fenil-4-(2-hinolinilkarbonil)-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-(1-izčhinolinilkarbonil)-1H- 1.4- benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-(3-hlor-2-nitrobenzoil)-1H- 1.4- benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(2-nitrobenzoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-(3-metoksi-2-nitrobenzoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1 -(1 H-imidazol-4-ilmetil)-7-fenil-4-(1 H-indol-4-ilkarbonil)-1 H- 1.4- benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1 -(1 H-imidazol-4-ilmetil)-7-fenil-4-(2,6-dihidroksi-3-naftoil)-1 H- 1.4- benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1 -(1 H-imidazol-4-ilmetil)-7-fenil-4-(1 H-benzimidazol-5-ilkarbo-nil)-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-{1H-benzotriazol-5-ilkarbo-nil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-[(4-metoksi-2-hinolinil)-karbonil]-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; N-^-tP.SAS-tetrahidro-l-O H-imidazol-4-ilmetil)-7-fenil-1 H-1,4-benzodiazepin-4-il]karbonil}fenil)acetamīda dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-(2-metil-1-okso-2-fenil-propil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-(2-dimetilaminobenzoil)-1H- 1.4- benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(3-etoksibenzoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 12 4-[2-hidroksi-(1 .l’-bifeniO-S-ilkarbonin-Ž.S^.S-tetrahidro-l^l H-imidazol-4-ilmetil)-7-fenil-1 H-1,4-benzodiazepTna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-{2-[(2-hidroksietil)tio]-benzoil}-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(2-metoksi-1 -naftoil)-1 H- 1.4- benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-[(4-hidroksi-2-hinolinil)-karbonil]-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2-{[2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-1 H-1,4-benzodiazepin-4-il]karbonil}benzamīda dihidrogēnhlorīds; N-(1,1-dimetiletil)-2-{[2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-1H-1,4-benzodiazepin-4-il]karbonil}benzamīda dihidrogēnhlorīds; N-(4-fluorfenil)-N’-(3-{[2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-1 H-1,4-benzodiazepin-4-il]karbonil}fenil)urīnvielas dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-[(3-metil-4-okso-2-fenil-4H-benzopiran-8-il)karbonil]-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-(3-trifluormetoksibenzoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(2-ciānbenzoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-(2-{[(4-metilfenil)sulfonil]-amino}benzoil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(6-hinolinilkarbonil)-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-{8-hinolinilkarbonil)-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-(benzo[b]tiofen-2-ilkarbonil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1 -(1 H-imidazol-4-ilmetil)-7-fenil-4-<4-dimetilamino-1 -naftoil)-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-{1 H-purin-6-ilkarbonil)-1 H- 1.4- benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1 -(1 H-imidazol-4-ilmetil)-7-fenil-4-(4-metoksifenilacetil)-1 H- 1.4- benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-[(5-metil-1-fenil-1H-pirazol-4-il)karbonilļ-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-iImetil)-7-fenil-4-[2-(2-metilfenil)-1-okso-propiI]-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-[(4-fenil-2H-tetrahidropiran-4-il)karbonil]-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-[2-(metilfenilamino)benzoil]-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(4-hinolinilkarbonil)-1 H-1,4-benzodiazepīna N-oksīda dihidrogēnhlorīds; N-metil-N-(2-piridinilmetil)-2-{[2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-1 H-1,4-benzodiazepin-4-il]karbonil}benzamīda trihidrogēnhlorīds; 13 LV 12150 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-(3-izohinolinilkarbonil)-1H- 1.4- benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1 -(1 H-imidazol-4-ilmetil)-7-fenil-4-[(3-naftiltio)acetil]-1 H-1,4-benzodiazepīna trifluoracetāts (1:2); 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-[(1,1 ’-bifenil)-4-ilacetil]-1 H- 1.4- benzodiazepīna trifluoracetāts (1:2); 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(2-naftililacetil)-1 H-1,4-benzodiazepīna trifluoracetāts (1:2); 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilrnetil)-7-fenil-4-[(1,1’-bifenil)-2-karbonil]-1H- 1.4- benzodiazepīna trifluoracetāts (1:2); 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-[(2-fenil-4-hinolinil)karbonil]-1 H-1,4-benzodiazepīna trifluoracetāts (1:3); 2.3.4.5- tetrah id ro-1 -(1 H-imidazol-4-ilmetil)-7-fenil-4-(3-piridinilacetil)-1 H-1,4-benzodiazepīna trifluoracetāts (1:3); 2.3.4.5- tetrahidro-1-(1H-imidazol-4-iJmetil)-7-fenil-4-(9H-fluoren-9-ilacetil)-1H- 1.4- benzodiazepīna trifluoracetāts (1:2); (S)-4-(2-dimetilamino-1-okso-3-fenilpropil)-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-1 H-1,4-benzodiazepīna trifluoracetāts (1:3); (S)-4-[(2-okso-4-fenil-3-oksazolidinil)acetil]-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-1 H-1,4-benzodiazepīna trifluoracetāts (1:3); 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(9-akridinilkarbonil)-1 H-1,4-benzodiazepīna trifluoracetāts (1:3); 2.3.4.5- tetrahidro-1 -(1 H-imidazol-4-ilmetil)-7-fenil-4-(3-fenoksibenzoil)-1 H-1,4-benzodiazepīna trifluoracetāts (1:2); 2.3.4.5- tetrahidro-1 -(1 H-imidazol-4-ilmetil)-7-fenil-4-[(4’-trifluomnetil-1,1 ’-bifenil)-2-karbonil]-1 H-1,4-benzodiazepīna trifluoracetāts (1:2); 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(4-fenoksibenzoil)-1 H-1,4-benzodiazepīna trifluoracetāts (1:2); 2.3.4.5- tetrahidro-1-(1 H-imidazo(-4-ilmetil)-7-fenil-4-(2-naftoil)-1 H-1,4-benzodiazepīna trifluoracetāts (1:2); 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(1-okso-4-fenilbutil)-1 H-1,4-benzodiazepīna trifluoracetāts (1:2); 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-[(2-fenoksifenil)acetil]-1H- 1.4- benzodiazepīna trifluoracetāts (1:2); 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-{2-[(4-metilfenil)sulfinil]-benzoil}-1 H-1,4-benzodiazepīna trifluoracetāts (1:2); 2.3.4.5- tetrahidro-1 -(1 H-imidazol-4-ilmetil)-7-fenil-4-{2-[(fenilmetil)aminoļbenzoil}-1 H-1,4-benzodiazepīna trifluoracetāts (1:3); 1.2.3.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-N,N-difenil-4H-1,4-benzodiazepīn-4-karboksamīda hidrogēnhlorīds; 1.2.3.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-a,7-difenil-4H-1,4-benzodiazepīn-4-etiķskābes metilestera hidrogēnhlorīds; 4-acetil-2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-brom-4-metilsulfonil-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenil-metil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-ciān-4-metilsulfonil-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 14 (R)-4-acetil-2,3,4,5-tetrahidro-1-(1H-imidazoi-4-ilmetil)-3-fenilmetil-7-fenil-1H-1,4-benzodiazepīna hidrogēnhlorīds; 7- brom-4-[(2-dimetilaminoetil)sulfonil]-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-1H-1,4-benzodiazepTna trifluoracetāts (1:2); 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-[(1,2,3,4-tetrahidro-1-hinolinil)karbonil]-1 H-1,4-benzodiazepTna hidrogēnhlorīds; N-etil-1,2,3,5-tetrah id ro-1 -(1 H-imidazol-4-ilmetil)-N,7-difenil-4H-1,4-benzo-diazepīn-4-karboksamīda hidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilrnetil)-7-fenil-4-[(2,3-dihidro-1H-indol-4-il)karbonil]-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-4-metilsulfonil-3-fenilmetil-7-(4-piri-dinil)-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; (R)-4-[(2-dimetilaminoetil)sulfonil]-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-7-fenil-1 H-1,4-benzodiazepīna trifluoracetāts (1:1); [2,3,4,5-tetrahidro-1 -(1 H-imidazol-4-ilmetil)-4-(1 -naftoil)-1 H-1,4-benzodiazepin- 8- il]karbamīskābes cikloheksilestera dihidrogēnhlorīds; (R)-7-brom-4-metilsulfonil-2,3,4,5-tetrahidro-1 -(1 -metil-1 H-imidazol-5-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-ciān-4-metilsulfonil-2,3,4,5-tetrahidro-1-(1-metil-1H-imidazol-5-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-fenil-4-metilsulfonil-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-1 H-pirido[3,2-e]-1,4-diazepīna hidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-[1,2-dioksoetil-2-(4-hlor-fenil)]-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4-(1,2-dioksopropil)-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-[1,2-dioksoetil-2-(4-nitro-fenil)]-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-[1,2-dioksoetil-2-(4-metoksi-fenil)]-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-7-fenil-4-(1,2-diokso-3,3,3-trifluor-propil)-1 H-1,4-benzodiazepīna trifluoracetāts (1:2); (R)-7-hlor-4-metilsulfonil-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-1 H-pirido[3,2-e]-1,4-diazepīna hidrogēnhlorīds; 6,7,8,9-tetrahidro-5-(1H-imidazol-4-ilmetil)-8-(1-naftoil)-2-fenil-5H-pirimido-[5,4-e][1,4]diazepīna hidrogēnhlorīds; (R)-7-brom-4-metilsulfonil-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilacetil)-3-fenil-metil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-brom-4-metilsulfonil-2,3,4,5-tetrahidro-1-(1H-imidazol-4-iletil)-3-fenilmetil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 8-cikloheksilkarbonilamino-1,2,3,5-tetrahidro-1-(1H-i’midazol-4-ilmetii)-3-fenii-metil-4H-1,4-benzodiazepīn-4-karbonskābes metilestera dihidrogēnhlorīds; N-[2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-1 H-1,4-benzo-diazepin-8-il]-1 -piperidīnkarboksamīda dihidrogēnhlorīds; (R)-7-ciān-1,2,3,5-tetrahidro-1-(1 H-imidazol-4-iImetil)-3-fenilmetil-4H-1,4-benzo-diazepīn-4-karbonskābes etilestera hidrogēnhlorīds; N-[2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-3-fenilmetil-4-metilsulfonil-1 H-1,4-benzodiazepin-8-il]cikloheksānkarboksamīda dihidrogēnhlorīds; 15 LV 12150 (R)-7-ciān-4-[(2-dimetilaminoetil)sulfonil]-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepTna dihidrogēnhlorīds; (R)-7-ciān-4-{[2-(4-morfolinil)etil]sulfonil}-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; N-[2,3,4,5-tetrahidro-1 -(1 H-imidazol-4-ilmetil)-4-(2-metoksi-3-metilbenzoil)-1 H- 1.4- benzodiazepin-8-il]cikloheksānkarboksamīda dihidrogēnhlorīds; 8-cikloheksilkarbonilamino-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-N-fenil-1 H-1,4-benzodiazepīn-karboksamīda dihidrogēnhlorīds; N-[2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-[(2-metilfenil)sulfonil]-1 H-1,4-benzodiazepin-8-il]cikloheksānkarboksamīda dihidrogēnhlorīds; N-[2,3,4,5-tetrahidro-1 -(1 H-imidazol-4-ilmetil)-4-[(2-metoksifenil)karbonil]-1 H- 1.4- benzodiazepin-8-il]cikloheksānkarboksamīda dihidrogēnhlorīds; (R)-7-ciān-1 ,2,3,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-3-fenilmetii-4H-1,4-benzo-diazepīn-4-sulfonskābes etilestera hidrogēnhlorīds; (3R)-7-brom-4-metilsulfonil-2,3,4,5-tetrahidro-1-[ciān-(1H-imidazol-4-il)metil]-3-fenilmetil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (3R)-1 -[2-amino-1 -(1 H-imidazoM-iOetil^.S^.S-tetrahidro^-metilsulfonil-S-fenilmetil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (3R)-1-[2-dimetilamino-1-(1H-imidazol-4-il)etil]-2,3,4,5-tetrahidro-4-metilsulfonil-3-fenilmetil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (3R)-1-[2-amino-1-(1H-imidazol-4-il)etil]-2,3,4,5-tetrahidro-4-metilsulfonil-3-fenilmetil-7-brom-1H-1,4-benzodiazepīna dihidrogēnhlorīds; (3R)-1-[2-dimetilamino-1-(1H-imidazol-4-il)etil]-2,3,4,5-tetrahidro-4-metilsulfonil- 3- fenilmetil-7-brom-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 7-ciān-1,3,4)5-tetrahidro-1-(1-metil-1H-imidazol-5-ilmetil)-3-fenilmetil-4-fenil-sulfonil-2H-1,4-benzodiazepin-2-ona hidrogēnhlorīds; 7-ciān-1,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-fenilsulfonil-2H- 1.4- benzodiazepin-2-ona hidrogēnhlorīds; 7-brom-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-(2-feniletil)-4-metilsulfonil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 7-brom-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3[(3-hlorfenil)metil]-4-metil-sulfonil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (R) -7-brom-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-cikloheksilmetil-4-metil-sulfonil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 7-brom-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3[(2-hlorfenil)metil]-4-metil-sulfonil-1H-1,4-benzodiazepīna dihidrogēnhlorīds; (S) -7-brom-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-cikloheksilmetil-4-metil-sulfonil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 7-brom-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3[(4-metoksifenil)metil]-4-metilsulfonil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 4- acetil-7-brom-2,3,4,5-tetrahidro-1-(1H-imidazol-4-iimetil)-3[(2-hlorfenil)metil]-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 4-acetil-7-brom-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3[(3-hlorfenil)metil]-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 7-brom-2,3,4,5-tetrahidro-1-{1H-imidazol-4-ilmetil)-3[(4-hidroksifenil)metil]-4-metilsulfonil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (R)-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-metilsulfonil-3-(3-piridinilmetil)-7-fenil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 16 2.3.4.5- tetra h īd ro-8-h id ro ksi metil-1 -(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-1 H-1,4-benzodiazepTna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-8-fenoksimetil-1-{1H-imidazol-4-ilmetil)-4-(1-naftoil)-1H-1,4-benzodiazepīna dihidrogēnhlorīds; N-cikloheksil-2,3,4,5-tetrahidro-1-{1 H-imidazol-4-ilmetil)-4-(1-naftoil)-1 H-1,4-benzodiazepīn-8-karboksamīda dihidrogēnhlorīds; N-cikloheksilmetil-2,3,4,5-tetrahidro-1 -(1 H-imidazol-4-iimetil)-4-(1 -naftoil)-1 H- 1.4- benzodiazepīn-8-karboksamīda dihidrogēnhlorīds; N-fenilmetil-2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-(1-naftoil)-1 H-1,4-benzodiazepīn-8-karboksamīda dihidrogēnhlorīds; (R)-4-acetil-7-[2-(dimetilaminometil)fenil]-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (R)-4-acetil-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-1H- 1.4- benzodiazepīna hidrogēnhlorīds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-(1-okso-butil)-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-ciān-2,3,4,5-tetrahidro-1 -(1 H-imidazol-4-ilmetil)-3-fenilmetil-4-(2-metil-1-oksopropil)-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-ciān-2,3l4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-(2-piridinil-acetil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-(2-tienil-sulfonil)-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-ciān-2,3,4,5-tetrahidro-1 -(1 H-imidazol-4-ilmetil)-3-fenilmetil-4-[(1 -metiletil)-sulfonil]-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-trifluormetil-sulfonil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-brom-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-propilsulfo-nil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-brom-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-fenilsulfo-nil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-fenil-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-fenilsulfonil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-fenil-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetii)-3-fenilmetil-4-propilsulfo-nil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-[(4-fluor-fenil)sulfonil]-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetit)-3-fenilmetil-4-[(3-ciān-fenil)sulfonil]-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-[(1-metil-1H-imidazoi-2-il)sulfonil]-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-[(3-brom-fenil)sulfonil]-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-N-(5-{[7-ciān-2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepin-4-ilļsulfonil}-4-metil-2-tiazolil)acetamīda dihidrogēnhlorīds; 4-acetil-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-7-(4-piridinil)-1H- 1.4- benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazoi-4-ilmeti!)-4-(2-fenil-2,2-dioksoetil)-7-(4-piridin-il)-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 17 LV 12150 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(2-trifluormetoksibenzoil)-7-(4-piri-dinil)-1 H-1,4-benzodiazepTna trihidrogēnhlorīds; (R)-7-fenil-2,3,4,5-tetrahidro-1-{1-metil-1H-imidazol-5-ilrnetil)-3-fenilmetil-4-metilsulfonil-1 H-1,4-benzodiazepīns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-fenilacetil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 4-(2-benzotiazolil)-2,3,4,5-tetrahidro-1 -(1 H-imidazol-4-ilmetil)-7-fenil-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetii-7-(3-piridinil)-4-trifluor-acetil-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-7-(3-piridinil)-4-metil-sulfonil-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 7-brom-3-[(1,1-dimetiletoksi)metil]-1,2,3,4-tetrahidro-1-(1 H-imidazol-4-ilmetil)-5H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenoksimetil-7-brom-4-metilsulfonil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-3-oksimetil-7-brom-4-metilsulfonil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 7-brom-3-[(1,1-dimetiletoksi)metil]-1,2,3,4-tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-metilsulfonil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; [7-brom-2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,4-benzo-diazepin-8-il]karbamīnskābes 2-metilpropilesteris; N-[4-acetil-2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,4-benzo-diazepi-8-ii]cikloheksānkarbonamīda dihidrogēnhlorīds; [7-brom-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-metilsulfonil-3-fenilmetil-1 H-1,4-benzodiazepin-8-il]karbamīnskābes 2-metilpropilesteris; (R)-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-fenilsulfonil-3-fenilmetil-7-ciān-1 H-1,4-benzodiazepīna hidrogēnhlorīds 2.3.4.5- tetrahidro-1 -(1 H-imidazol-4-ilmetil)-3-fenilmetil-7-brom-1 H-1,4-benzo-diazepīn-4-acetamīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-dimetilaminoacetil-7-brom-1 H-1,4-benzodiazepīns; (R)-7-brom-4-(1,2-dioksopropil)-2)3I4,5-tetrahidro-1-(1H-imidazol-4-iimetil)-3-fenilmetil-1 H-1,4-benzodiazepīna trifluoracetāts; (R)-7-brom-4-ciklopropilkarbonil-2,3I4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepīna trifluoracetāts; (R)-7-brom-4-propilsulfonil-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenil-metil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 7-brom-2,3,4,5-1,4-bis(1 H-imidazol-4-i!metil)-3-fenilmetil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 7-brom-1,2,3,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-N,N-dimetil-3-fenilmetil-4H-1,4-benzodiazepīn-4-sulfonamīda hidrogēnhlorīds; 7-ciān-4-propilsulfonil-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-ciān-1,2,3,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-N,N-dimetil-3-feniImetil-4H-1,4-benzodiazepīn-4-karboksamīda hidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1H-imidazol-4-ilrnetil)-NlN-dietil-3-fenilrnetil-4-metilsulfonil-1 H-1,4-benzodiazepīn-7-karboksamīda hidrogēnhlorīds; 18 2,3,4,5-tetrah id ro-1 -(1 H-imidazol-4-ilmetil)-7-fenil-4-(1-fenil-1 H-tetrazol-5-il)-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-(2-pirazinil-karbonii)-4H-1,4-benzodiazepTna hidrogēnhlorīds; (R)-4-[7-brom-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4H-1,4-benzodiazepin-4-il]-4-oksobutānskābes metilestera hidrogēnhlorīds; (R)-7-ciān-2,3,4,5-tetrahidro-1(1H-imidazol-4-ilmetil)-4-(4-morfolinilkarbonil)-3-fenilmetil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R) -7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-{[2-(1-piroli-dinil)etil]sulfonil}-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (S) -2,3,4,5-tetrah!dro-1-(1H-imidazol-4-ilmetil)-4-metiIsulfonil-3-{3-piridinilmetil)-7-fenil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (R)-7-fenil-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-(3-piridinilmetil)-4-(2-tienilsulfonil)-1H-1,4-benzodiazepīna dihidrogēnhlorīds; (R)-7-fenil-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-(3-piridinilmetil)-4-propil-sulfonil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-brom-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-(2-piridinilmetil)-4-metilsulfonil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 7-(2-pirimidinil)-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-(2-piridinilmetil)-4-metilsulfonil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (R)-7-brom-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetii)-3-fenilmetil-4-trifiuor-metilsulfonil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-fenil-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-trifluoracetil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-(4-piridinil)-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-metil-sulfonil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (R)-7-(4-piridinil)-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-(2-tienilsulfonil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (R)-7-(4-piridinil)-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-fenil-sulfonil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (R)-7-(4-piridinil)-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-propil-sulfonil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-[(3,5-dimetil-izoksazol-4-il)sulfonil]-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-feniimetil-4-[(4-ciān-fenil)sulfonilj-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-(2,2,2-trifluoretilsulfonil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetii-4-(2,2,2-trifluoretilsulfonil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (R)-4-[(5-brom-2-tienil)sulfonil]-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-il-metil)-3-fenilmetil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-feniImetil-4-(4-metoksi-fenilsulfonil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; N-{[7-brom-2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-metiIsulfonil-1 H-1,4-benzodiazepin-3-il]metil}benzamīda dihidrogēnhlorīds; (R)-7-ciān-1,2,3,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-N,N-dimetil-3-fenilmetil-4H-1,4-benzodiazepīn-4-sulfonamīda hidrogēnhlorīds; 19 LV 12150 (R)-7-ciān-1,2,3,5-tetrahidro-1-(1-metil-1H-imidazol-5-ilmetil)-N,N-dimetil-3-fenilmetil-4H-1,4-benzodiazepīn-4-sulfonamīda hidrogēnhlorTds; (R)-7-hlor-2,3,4,5-tetrahidro-1 -(1 -metil-1 H-imidazol-5-ilmetil)-3-fenilmetii-4-metilsulfonii-1 H-1,4-benzodiazepTna hidrogēnhlorTds; (R)-7-hlor-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-metilsulfonil-1 H-1,4-benzodiazepīna hidrogēnhlorTds; (R)-7-hlor-2,3,4,5-tetrahidro-1-(1-metil-1 H-imidazol-5-ilmetil)-3-fenilmetil-4-fenilsulfonil-1 H-1,4-benzodiazepTna hidrogēnhlorTds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-(piridin3-ilmetil)-4-metilsulfonil-1 H-1,4-benzodiazepTna tetrahidrogēnhlorīds; (R)-7-brom-2,3,4,5-tetrahidro-1-(1H-imidazol-2-ilmetil)-3-fenilmetil-4-metil-sulfonil-1 H-1,4-benzodiazepTna dihidrogēnhlorTds; (R)-7-brom-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-[(1-metil-1 H-imidazol-4-il)sulfonil]-1 H-1,4-benzodiazepTna trihidrogēnhlorTds; (R)-7-hlor-2,3,4,5-tetrahydro-1-(1-metilimidazol-5-ilmetil)-4-[(2-morfolin-4-iletil)-sulfonil]-3-fenilmetil-1 H-1,4-benzodiazepTna dihidrogēnhlorTds; (R)-7-hlor-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ilmetil)-4-[(2-morfolin-4-iletil)-sulfonil]-3-fenilmetil-1 H-1,4-benzodiazepīna dihidrogēnhlorTds; (R)-7-hlor-4-dimetilaminosulfonil-1-(1-metil-1 H-imidazol-5-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepTna hidrogēnhlorTds; (R)-7-hlor-2,3,4,5-tetrahydro-1-(1-metilimidazol-5-ilmetil)-4-[(4-metilpiperidin-4-iietil)sulfonilj-3-fenilmetil-1 H-1,4-benzodiazepTna dihidrogēnhlorTds; (R)-7-brom-2,3,4,5-tetrahydro-1-(1-metilimidazol-5-ilmetil)-4-[(4-metilpiperidin-4-iletil)sulfonil]-3-fenilmetil-1 H-1,4-benzodiazepTna dihidrogēnhlorTds; (R)-7-ciān-1,2,3,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-3-fenilmetil-4H-1,4-benzo-diazepm-4-karbonskābes 2-metiletilestera hidrogēnhlorTds; (R)-7-brom-2,3,4,5-tetrahidro-4-{[2-(1 H-imidazol-1 -il)etil]sulfonil}-1 -(1 H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepīna dihidrogēnhlorTds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-propilsulfonil-3-(3-piri-dinilmetil)-1 H-1,4-benzodiazepTna hidrogēnhlorTds; 7-brom-2,3,4,5-tetrahydro-1-(1 H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,4-benzo-diazepin-5-ona hidrogēnhlorTds; (R)-7-brom-2,3,4,5-tetrahydro-1 -(1 H-imidazol-1 -ilacetil)-4-metilsulfonil-3-fenil-metil-1 H-1,4-benzodiazepTna trifluoracetāts; 1.2.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-2-(2-feniletil)-3H-1,4-benzodiazepin- 3- ons; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-ilmetil)-4-metilsulfonil-2-(2-feniletil)-1 H-1,4-benzodiazepTna hidrogēnhlorTds; (R)-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-metilsulfonil-7-fenil-3-(4-piridin-ilmetil)-1 H-1,4-benzodiazepTna dihidrogēnhlorTds; (R)-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-fenilsulfonil-7-ciān-3-(4-piridin-ilmetil)-1H-1,4-benzodiazepTna hidrogēnhlorTds; (R)-7-ciān-1,2,3,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-N,N-dimetil-3-(3-piridinil-metil)-4H-1,4-benzodiazepīn-4-karboksamīda dihidrogēnhlorTds; (R)-7-ciān-1,2,3,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-N,N-dimetil-3-(3-piridinil-metil)-4H-1,4-benzodiazepTn-4-sulfonamTda dihidrogēnhlorTds; 4- (4-fluorfenilsulfonil)-2,3,4,5-tetrahidro-1-[(1-metii-1H-imidazol-5-il)-3-fenilmetil-1H-tieno[2,3-e]-1,4-diazepīna hidrogēnhlorTds; 20 (R)-2,3,4,5-tetrahidro-1 -[1-(4-ciānfenilmetif)-imidazol-5-iImetil]-4-metilsulfonil-3-fenilmetil-7-ciān-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R^.SAS-tetrahidro-HI-A-ciānfenilrnetilHmidazoM-ilmetillA-metilsulfonil-S-fenilmetil-7-ciān-1 H-1,4-benzodiazepTna hidrogēnhlorīds; (R)A-benzoil-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazolA-ilmetil)-3-fenilmetil-1H- 1.4- benzodiazepīna hidrogēnhlorīds; (R)-7-ciān-2,3A5-tetrahidro-1-(1-metil-1 H-imidazol-5-ilmetil)-3-(piridin-3-ilmetil)-4-metilsulfonil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1 -metil-1 H-imidazol-5-ilmetil)-3-(piridin-3-ilmetil)-4-propilsulfonil-1H-1,4-benzodiazepīna trihidrogēnhlorīds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-(piridin-3-ilmetil)-4-fenil-sulfonil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 7-fenil-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-metilsulfonil-1H- 1.4- benzodiazepīns; 1,2,3,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-N-(1-naftil)-7-fenil-4H-1,4-benzo-diazepīn-4-karboksamīda hidrogēnhlorīds; (S^-brom^.SAS-tetrahidro-l-OH-imidazolA-ilmetiO-S-fenilmetilA-metilsuIfo-nil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; N-[2,3,4,5-tetrahidro-1 -{1 H-imidazol-4-ilmetil)-4-(2,3-dimetilbenzoil)-1 H-1,4-benzodiazepin-8-il]cikloheksānkarboksamīds dihidrogēnhlorīds; (R)-7-ciān-N-(2-dimetilaminoetil)-2,3I4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-N-metil-3-fenilmetil-1 H-1,4-benzodiazepīnA-karboksamīda trifluoracetāts (1:2); 7-brom-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-metilsulfonil-2-okso-3-fenilmetil-1 H-1,4-benzodiazepīna trifluoracetāts; (R)-7-ciān-4-(2-furanilkarbonil)-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepīna trifluoracetāts (1:1); (R)-7-ciān-4-(4-nitrofenilsulfonil)-2l3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepīna trifluoracetāts; (R)-7-ciān-4-{[(4-metil-1-piperazinil)fenil]sulfonil}-2,3,4,5-tetrahidro-1-(1H-imid-azol-4-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepīna trifluoracetāts; (R)-7-ciān-4-[(4-dimetilaminofenil)sulfonil]-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-feniīmetil-1 H-1,4-benzodiazepīna trifluoracetāts; (R)-7-brom-4-[(2-dimetilaminoetil)sulfonil]-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (R)-7-ciān-4-(3-piridinilsulfonil)-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepīna trihidrogēnhlorīds 4-metilsulfonil-2,3,4,5-tetrahidro-1 -(1 H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (R)-7-brom-4-metilsulfonil-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenil-metil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (R)-7-fenil-4-[(3-dimetilaminopropil)sulfonil]-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; 4-butil-2,3,4,5-tetrahidro-1-{1H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; (R)-7-brom-4-{[2-(4-morfolinil)etil]sulfonil}-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 21 LV 12150 (R)-7-brom-4-{[2-(4-morfolinil)etil]sulfonil}-2,3,4,5-tetrahidro-1-(1-metil-1H-imid-azol-5-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (R)-7-ciān-4-(4-morfolinilsulfonil)-1 -(1 H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (R)-7-ciān-4-(4-aminofenilsulfonil)-1-(1-imidazol-4-ilmetil)-3-fenilmetil-1H-1,4-benzodiazepīna hidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1 H-imidazol-4-iimetil)-4-[(4-piridiltio)acetiI]-7-fenil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; N-(4-hlorfeniI)-N’-ciān-1,2,3,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-7-fenil-4H-1,4-benzodiazepīn-4-imīdamīda hidrogēnhlorīds; 4-acetil-7-brom-1,2,4,5,1’,3’-heksahidro-1-(1H-imidazol-4-ilmetil)spiro[3H-1,4-benzodiazepīn-3,2’-[2H]indēna dihidrogēnhlorīds; 7-brom-4-(3-dimetilamono-1-oksopropil)-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepīna trifluoracetāts (1:1); (RJ^.S^^-tetrahidro-l-CI-metii-l H-imidazol-5-ilmetil)-4-fenilsulfoniI-3-fenilmetil-7-ciān-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 2.3.4.5- tetrahidro-1-(1-metil-1H-imidazol-5-ilmetil)-4-metilsulfonil-7-fenil-3-(piridin-3-ilmetil)-1 H-1,4-benzodiazepīna sālskābes (1:1,5) un trifluoretiķskābes (1:0,75) sāls; 4-(4-fluorfenilsulfonil)-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-2-(2-feniletiI)-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 4-metilsulfonil-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-2-(2-feniietil)-1H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-ciān-4-{[2-(4-morfolinil)etil]sulfonil}-2,3,4,5-tetrahidro-1-(1-metil-1H-imid-azol-5-ilmetil)-3-fenilmetil-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; (R)-7-brom-4-metilsulfonil-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetii)-3-(4-brom-fenil)metil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-brom-4-metilsulfonil-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-(tiazol-4-ilmetil)-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-brom-4-propilsulfonil-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-(4-bromfenilmetil)-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-brom-4-metilsulfonil-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-(3-piridinilmetil)-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; (R)-7-brom-4-metilsulfonil-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-(3-piridin-ilmetil)-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; (R)-7-brom-4-metilsulfonil-2,3,4,5-tetrahidro-1-(1H-imidazol-5-ilmetil)-(3-piridinil-metil)-1 H-1,4-benzodiazepīna dihidrogēnhlorīds; 1,2,3,4-tetrahidro-7-brom-4-(1H-imidazol-4-ilmetil)-3-fenilmetil-1-fenilmetiloksi-karbonilhinoksalīna hidrogēnhlorīds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil‘)-4-fenilsulfonil-3-(4-ciān-fenilmetil)-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetii)-4-[(N-metil-N-fenilmetil)-aminosulfonil]-3-fenilmetil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-[N-(tetrahidroizo-hinolinil)sulfonil]-3-fenilmetil-1 H-1,4-benzodiazepīna hidrogēnhlorīds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-fenilsulfonil-3-(2-tienil-metil)-1 H-1,4-benzodiazepīna hidrogēnhlorīds; 22 cis-2,3,4,5-tetrah id ro-1,5-bis(1 H-imidazol-4-ilmetil)-3-fenilmetil-1 H-1,5-benzo-diazepīn-2-karbonskābes etilestera trifluoracetāts (1:2); (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-[(N-piperidinil)sulfonil]-3-fenilmetil-1 H-1,4-benzodiazepīna hidrogēnhlorTds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-1-metilimidazol-5-ilmetil)-4-(2-tienilsulfonil)-3-fenilmetil-1 H-1,4-benzodiazepTna hidrogēnhlorTds; (R)-7-ciān-2,314I5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-[(2-dimetilaminoetil)-sulfonil]-3-(piridin-3-ilmetil)-1 H-1,4-benzodiazepīna trihidrogēnhlorīds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-1-metilimidazol-5-ilmetil)-4-propilsulfonil-3-fenilmetil-1 H-1,4-benzodiazepTna hidrogēnhlorTds; N-ciān-N’-metil-7-fenil-1,2,3,5-tetrahidro-1-(1 H-imidazol-4-ilmetil)-4H-1,4-benzo-diazepm-4-imīdamTda hidrogēnhlorTds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(2-nitrofenilsulfonil)-3-fenilmetil-1 H-1,4-benzodiazepTna hidrogēnhlorTds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(4-metilfenilsulfonil)-3-fenilmetil-1 H-1,4-benzodiazepTna hidrogēnhlorTds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-butilsulfonil-3-fenilmetil-1 H-1,4-benzodiazepTna hidrogēnhlorTds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(2-trifluormetilfenil-sulfonil)-3-fenilmetil-1 H-1,4-benzodiazepīna hidrogēnhlorTds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(2-trifluormetoksifenil-sulfonil)-3-fenilmetil-1 H-1,4-benzodiazepīna hidrogēnhlorTds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(2-metoksikarbonilfenil-sulfonil)-3-fenilmetil-1 H-1,4-benzodiazepTna hidrogēnhlorTds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-[(2-metilsulfonilfenil)-sulfonil]-3-fenilmetil-1 H-1,4-benzodiazepīna hidrogēnhlorTds; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-[(4-metilsulfonilfenil)-sulfonil]-3-fenilmetil-1 H-1,4-benzodiazepTns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(4-trifluormetilfenil-sulfonil)-3-fenilmetil-1 H-1,4-benzodiazepTns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(3-metoksipropil-sulfonil)-3-fenilmetil-1 H-1,4-benzodiazepTns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(3,4-dimetoksifenil-sulfonil)-3-fenilmetil-1 H-1,4-benzodiazepTns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-fenilsulfonil-3-(4-fluor-fenilmetil)-1 H-1,4-benzodiazepTns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-[(N-ciklopropilmetil-N-propil)sulfonil]-3-fenilmetil-1 H-1,4-benzodiazepīns; (R^-ciān^.S^.S-tetrahidro-l-ilH-imidazoM-ilmetilH-iN.N-dibutilamino-sulfonil)-3-fenilmetil-1 H-1,4-benzodiazepTns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-metānsulfonil-3-fenil-metil-1 H-pirido[3,4-e]-1,4-diazepīns; 1,2,3,4-tetrahidro-7-brom-4(1 H-imidazol-4-ilmetil)-2-fenilmetil-1 -metilsulfonil-hinoksafīns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-[(imidazol-4-iI)nnetilsulfo-n i l]-3-fe n i I meti I-1 H-1,4-benzodiazepTns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-propilsulfonil-3-(2-tienil-metil)-1 H-1,4-benzodiazepTns; 23 LV 12150 (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(2-tienilsulfonil)-3-(2-tienilmetil)-1 H-1,4-benzodiazepTns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(3-metiltiopropilsulfonil)-3-fenilmetil-1 H-1,4-benzodiazepīns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetii)-4-(3-metiltioksopropil-sulfonil)-3-fenilmetīl-1 H-1,4-benzodiazepTns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(3-metilsulfonilpropil-sulfonil)-3-fenilmetil-1 H-1,4-benzodiazepTns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(2-metilpropilsulfonil)-3-fenilmetil-1 H-1,4-benzodiazepīns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-ciklopentilsulfonil-3-fenilmetil-1 H-1,4-benzodiazepTns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilrnetil)-4-(4,4,4-trifluorbutilsulfo-nil)-3-fenilmetil-1 H-1,4-benzodiazepīns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-fenilmetilsulfonil-3-fenil-metil-1 H-1,4-benzodiazepTns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-{[2-(5-benzoilamino-metil)tienil]sulfonil}-3-fenilmetil-1 H-1,4-benzodiazepTns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-iimetil)-4-{2-[1-(3-hlor-5-metil-piridin-2-il)piroliljsulfonii}-3-fenilmetil-1 H-1,4-benzodiazepTns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(4-karboksifenilsulfonil)-3-fenilmetil-1 H-1,4-benzodiazepīns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-{[(3-metii-1,2,4-oksa-diazol-5-il)fenil]sulfonil}-3-fenilmetil-1 H-1,4-benzodiazepTns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(2,5-dimetoksifenil-sulfonii)-3-fenilmetil-1 H-1,4-benzodiazepTns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-[(N-tetrahidrohinolinil)-sulfoniI]-3-fenilmetii-1 H-1,4-benzodiazepTns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-{[N,N-bis(2-metilpropil)-amino]sulfonii}-3-fenilmetil-1 H-1,4-benzodiazepTns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(N-metil-N-fenilamino-sulfonil)-3-feni!metil-1 H-1,4-benzodiazepTns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-metilsuifonil-3-[2-(2,6-dimetiifenil)etil]-1 H-1,4-benzodiazepTns; (R)-7-ciān-2,3,4,5-tetrahidro-1-[1-(N-ftalimidoetil)imidazol-5-ilmetil)-4-metil-sulfonil-3-fenilmetil-1 H-1,4-benzodiazepTns; (R)-7-ciān-2,3,4,5-tetrahidro-1-{[2-(N,N-dimetilamino)etil]innidazol-5-ilnnetil}-4-metilsulfonil-3-fenilmetil-1 H-1,4-benzodiazepīns; (R)-7-ciān-2,3,4,5-tetrahidro-1-[(2-aminoetil)imidazol-5-ilmetil]-4-metiisulfonil-3-fenilmetil-1 H-1,4-benzodiazepTns; (R)-7-brom-2,3,4,5-tetrahidro-1-(1H-imidazol-4-iimetil)-4-metānsulfonil-3-[2-{2,6-dimetilfenil)etilļ-1 H-tieno[2,3-e]-1,4-diazepTns; (R)-7-brom-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetii)-4-metānsuifonil-3-[2-(2,6-dimetilfenil)etil]-1 H-tieno[3,2-e]-1,4-diazepTns; (R)-4-metānsulfonil-2,3,4,5-tetrahidro-1 -(1 H-imidazol-4-ilmetil)-3-fenilmetil-1 H-8-oksopirimidino[4,5-e]-1,4-diazepīns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetii)-4-fenilsulfonil-3-[4-(2-metoksietoksi)fenilmetii]-1 H-1,4-benzodiazepTns; 24 (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-fenilsulfonil-3-[4-(2-dimetilaminoetoksi)fenilmetil]-1 H-1,4-benzodiazepīns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilsulfonii)-4-metilsulfonil-3-fenil-metil-1 H-1,4-benzodiazepTns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilsulfonil)-4-propilsulfonil-3-fenil-metil-1 H-1,4-benzodiazepTns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilsulfonil)-4-fenilsulfonil-3-fenil-metil-1 H-1,4-benzodiazepTns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilsulfonil)-4-(2-tienilsulfonil)-3-fenilmetil-1 H-1,4-benzodiazepTns; 7-ciān-2,3,4,5-tetrahidro-1 -(1 H-imidazol-4-ilmetil)-4-metiisulfonil-3-(R)-((R)-1 -feniletil)-1 H-1,4-benzodiazepTns; 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-propilsulfonil-3-(R)-((R)-1-feniletil)-1 H-1,4-benzodiazepTns; 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-feniisulfonil-3-(R)-((R)-1-feniletil)-1 H-1,4-benzodiazepTns; 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(2-tienilsulfonil)-3-(R)-((R)-1 -feniletil)-1 H-1,4-benzodiazepTns; 7-ciān-2,3,4,5-tetrahidro-1 -(1 H-imidazol-4-ilmetil)-4-metilsulfonil-3-(S)-((R)-1 -feniletil)-1 H-1,4-benzodiazepTns; 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-propilsuifonil-3-(S)-((R)-1-feniletil)-1 H-1,4-benzodiazepTns; 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-fenilsulfonil-3-(S)-((R)-1-feniletil)-1 H-1,4-benzodiazepTns; 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(2-tienilsulfonil)-3-(S)-((R)-1 feniletil)-1 H-1,4-benzodiazepTns; 7-ciān-2I3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetii)-4-metilsulfoniI-3-(R)-((S)-1-feniletil)-1 H-1,4-benzodiazepTns; 7-ciān-2,3,4,5-tetrahidro-1 -(1 H-imidazol-4-ilmetil)-4-propilsuifonil-3-(R)-((S)-1 -feniietil)-1 H-1,4-benzodiazepīns; 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-fenilsulfonil-3-(R)-((S)-1-feniletil)-1 H-1,4-benzodiazepTns; 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(2-tienilsulfonil)-3-(R)-((S)-1 feniletil)-1 H-1,4-benzodiazepTns; 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-metilsuifonil-3-(S)-((S)-1-feniletil)-1 H-1,4-benzodiazepīns; 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-iimetil)-4-propilsulfonil-3-(S)-((S)-1-feniletil)-1 H-1,4-benzodiazepTns; 7-ciān-2,3,4,5-tetrahidro-1 -(1 H-imidazol-4-ilmetil)-4-fenilsulfonil-3-(S)-((S)-1 -feniletil)-1 H-1,4-benzodiazepTns; 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(2-tieniisulfonil)-3-(S)-((S)-1 feniletil)-1 H-1,4-benzodiazepTns; 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-metiisulfonil-3-(R)-((R)-fenilciklopropil)-1 H-1,4-benzodiazepīns; 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-propilsulfonil-3-(R)-((R)-fenilciklopropil)-1 H-1,4-benzodiazepTns; 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetii)-4-feniisulfonii-3-(R)-((R)-fenilciklopropil)-1 H-1,4-benzodiazepīns; 25 LV 12150 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(2-tienilsulfonil)-3-(R)-((R)-fenilciklopropil)-1 H-1,4-benzodiazepīns; 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-metilsulfonil-3-(S)-((R)-fenilciklopropil)-1 H-1,4-benzodiazepīns; 7-ciān-2,314,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-propilsulfonil-3-(S)-((R)-fenilciklopropil)-1 H-1,4-benzodiazepīns; 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-iimetil)-4-fenilsulfonil-3-(S)-((R)-fenilciklopropil)-1 H-1,4-benzodiazepīns; 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-(2-tienilsulfonii)-3-(S)-((R)-fenilciklopropil)-1 H-1,4-benzodiazepīns; 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-metilsulfonil-3-(R)-((S)-feniiciklopropil)-1 H-1,4-benzodiazepīns; 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-propilsulfonil-3-(R)-((S)-fenilciklopropil)-1 H-1,4-benzodiazepīns; 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-fenilsulfonii-3-(R)-((S)-fenilciklopropil)-1 H-1,4-benzodiazepīns; 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetii)-4-(2-tieniisulfonii)-3-(R)-((S)-fenilciklopropil)-1 H-1,4-benzodiazepīns; ī-ciān^.S^.S-tetrahidro-l-ilH-imidazoM-ilmetilJ^-metilsulfonil-S-iSJ-iiS)-fenilciklopropil)-1 H-1,4-benzodiazepīns; 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-i!metil)-4-propilsulfonil-3-(S)-((S)-fenilciklopropii)-1 H-1,4-benzodiazepīns; 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-4-fenilsulfonil-3-(S)-((S)-fenilciklopropil)-1 H-1,4-benzodiazepīns; 7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazoi-4-ilmetil)-4-(2-tienilsulfonil)-3-(S)-((S)-fenilciklopropil)-1 H-1,4-benzodiazepīns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmeti!)-4-{2-[5-(piridin-2-il)tienil]-sulfonil}-3-fenilmetil-1 H-1,4-benzodiazepīns; (R)-7-ciān-2,3,4,5-tetrahidro-1-[3-(1H-imidazol-2-il)propil]-4-fenilsulfonil-3-fenil-metil-1 H-1,4-benzodiazepīns; (R)-7-ciān-2,3,4,5-tetrahidro-1-[3-(1H-imidazol-2-il)propil]-4-metilsulfonil-3-fenil-metil-1 H-1,4-benzodiazepīns; (R)-7-ciān-2,3,4,5-tetrahidro-1-[3-(1H-imidazol-2-il)propil]-4-propilsulfonil-3-fenil-metil-1 H-1,4-benzodiazepīns; (R)-7-ciān-2,3,4,5-tetrahidro-1-[3-(1H-imidazol-2-il)propii]-4-(2-tienilsulfonil)-3-fenilmetil-1 H-1,4-benzodiazepīns; (R)-7-ciān-2,3,4,5-tetrahidro-1-[2-(1H-imidazol-2-il)etilsulfonii]-4-fenilsulfonil-3-fenilmetil-1 H-1,4-benzodiazepīns; (R)-7-ciān-2,3,4,5-tetrahidro-1-[2-(1H-imidazol-2-il)etilsulfoniI]-4-metilsulfonil-3-fenilmetil-1 H-1,4-benzodiazepīns; (R)-7-ciān-2,3,4,5-tetrahidro-1-[2-(1H-imidazoi-2-il)etilsulfonil]-4-propiisulfonil-3-fenilmetii-1 H-1,4-benzodiazepīns; (R)-7-ciān-2,3,4,5-tetrahidro-1-[2-(1H-imidazol-2-il)etilsulfonil]-4-(2-tienilsulfonil)-3-fenilmetil-1 H-1,4-benzodiazepīns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-feniimetil-4-[(1-oksoetil)-amino]-1 H-1,4-benzodiazepīns; (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetil)-3-fenilmetil-4-metān-sulfoniIamino-1 H-1,4-benzodiazepīns; 26 (R)-7-ciān-2,3,4,5-tetrahidro-1-(1H-imidazol-4-ilmetii)-3-fenilmetil-4-fenilsulfonil-amino-1 H-1,4-benzodiazepTns.
8. Savienojuma pēc 1. punkta pielietojums zīdītāju farnezilproteīntrans-ferāzes inhibēšanai.
9. Savienojuma pēc 1. punkta pielietojums zīdītāju prenilproteīntrans-ferāzes inhibēšanai.
10. Savienojuma pēc 1. punkta pielietojums zīdītāju audzēju nomākšanai.
11. Savienojuma pēc 1. punkta pielietojums tādu zīdītāju slimību ārstēšanai, kurās iesaistīta signālu nodošana ar Ras starpniecību.
12. Savienojuma pēc 1. punkta pielietojums tādu zīdītāju slimību ārstēšanai, kurās iesaistīti proteīni, kas pēc translācijas tiek modificēti ar farnezilproteīntransferāzi.
13. Savienojuma pēc 1. punkta pielietojums tādu zīdītāju slimību ārstēšanai, kurās iesaistīti proteīni, kas pēc translācijas tiek modificēti ar geranilgeranilproteīntransferāzi.
14. Savienojums ar formulu
kurā Ri ir ņemts no rindas: Cl, Br, fenilgrupa, piridilgrupa un ciāngrupa; R2 ir aralkilgrupa vai heterociklilalkilgrupa.
15. Savienojums ar formulu
H kurā Ri ir ņemts no rindas: Cl, Br, fenilgrupa, piridilgrupa un ciāngrupa; R2 ir aralkilgrupa vai heterociklilalkilgrupa. 27 LV 12150
16. Savienojums ar formulu
kurā Rļ ņemts no rindas: Cl, Br, fenilgrupa, piridilgrupa un ciāngrupa; R2 ir aralkilgrupa vai heterociklilalkiigrupa; R3 ir ņemts no rindas: aizvietota alkilgrupa, aizvietota arilgrupa un aizvietota heterocikliska grupa; Z1 ir ņemts no rindsa CO, S02, C02, CONHR5l S03, S02NR5i C(NCN)NR5; R5 ņemts no rindas: ūdeņraža atoms, zemākā alkilgrupa, aizvietota alkilgrupa, arilgrupa, aizvietota arilgrupa.
17. Savienojums ar formulu
I Prot kurā Rļ ņemts no rindas: Cl, Br, fenilgrupa, piridilgrupa un ciāngrupa; R2 ir aralkilgrupa vai heterociklilalkiigrupa; R3 ir ņemts no rindas: aizvietota alkilgrupa, aizvietota arilgrupa un aizvietota heterocikliska grupa; Z1 ir ņemts no rindsa CO, S02, C02, CONHR5, S03, S02NR5, C(NCN)NR5; R5 ņemts no rindas: ūdeņraža atoms, zemākā alkilgrupa, aizvietota alkilgrupa, arilgrupa, aizvietota arilgrupa, Prot ir trifenilmetilgrupa vai Boc-grupa.
LVP-98-129A 1996-02-26 1998-06-04 Farneziltransferāzes inhibitori LV12150B (lv)

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