LU83945A1 - Ammoniumsalz einer substituierten carbonsaeure,verfahren zu seiner herstellung,seine verwendung und pharmazeutische praeparate - Google Patents
Ammoniumsalz einer substituierten carbonsaeure,verfahren zu seiner herstellung,seine verwendung und pharmazeutische praeparate Download PDFInfo
- Publication number
- LU83945A1 LU83945A1 LU83945A LU83945A LU83945A1 LU 83945 A1 LU83945 A1 LU 83945A1 LU 83945 A LU83945 A LU 83945A LU 83945 A LU83945 A LU 83945A LU 83945 A1 LU83945 A1 LU 83945A1
- Authority
- LU
- Luxembourg
- Prior art keywords
- methyl
- active ingredient
- dichloroanilino
- salt
- acid
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 22
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 19
- 238000004519 manufacturing process Methods 0.000 title claims description 9
- 150000003863 ammonium salts Chemical class 0.000 title description 6
- 150000004649 carbonic acid derivatives Chemical class 0.000 title description 2
- 150000003839 salts Chemical class 0.000 claims description 33
- 239000004480 active ingredient Substances 0.000 claims description 28
- 239000000243 solution Substances 0.000 claims description 19
- 239000002253 acid Substances 0.000 claims description 17
- 238000002360 preparation method Methods 0.000 claims description 15
- 238000002347 injection Methods 0.000 claims description 10
- 239000007924 injection Substances 0.000 claims description 10
- IPBVNPXQWQGGJP-UHFFFAOYSA-N acetic acid phenyl ester Natural products CC(=O)OC1=CC=CC=C1 IPBVNPXQWQGGJP-UHFFFAOYSA-N 0.000 claims description 8
- 238000007911 parenteral administration Methods 0.000 claims description 8
- 229940049953 phenylacetate Drugs 0.000 claims description 8
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims description 6
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 6
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims description 6
- 241001465754 Metazoa Species 0.000 claims description 5
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- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 claims description 2
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- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 4
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- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
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- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000010512 hydrogenated peanut oil Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
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- 229920000609 methyl cellulose Polymers 0.000 description 1
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- 150000007522 mineralic acids Chemical class 0.000 description 1
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- 150000002763 monocarboxylic acids Chemical class 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
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- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
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- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
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- ANBFRLKBEIFNQU-UHFFFAOYSA-M potassium;octadecanoate Chemical compound [K+].CCCCCCCCCCCCCCCCCC([O-])=O ANBFRLKBEIFNQU-UHFFFAOYSA-M 0.000 description 1
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- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- GGHPAKFFUZUEKL-UHFFFAOYSA-M sodium;hexadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCOS([O-])(=O)=O GGHPAKFFUZUEKL-UHFFFAOYSA-M 0.000 description 1
- NWZBFJYXRGSRGD-UHFFFAOYSA-M sodium;octadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCCCOS([O-])(=O)=O NWZBFJYXRGSRGD-UHFFFAOYSA-M 0.000 description 1
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- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8105822A GB2093693B (en) | 1981-02-24 | 1981-02-24 | Pharmaceutical preparations for topical application which contain salts of alkanecarboxylic acids novel carboxylic acid salts and the production thereof |
| GB8105822 | 1981-02-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU83945A1 true LU83945A1 (de) | 1982-12-13 |
Family
ID=10519933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU83945A LU83945A1 (de) | 1981-02-24 | 1982-02-15 | Ammoniumsalz einer substituierten carbonsaeure,verfahren zu seiner herstellung,seine verwendung und pharmazeutische praeparate |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US4407824A (en, 2012) |
| AT (1) | AT370721B (en, 2012) |
| CA (1) | CA1180008A (en, 2012) |
| CY (2) | CY1443A (en, 2012) |
| FR (2) | FR2500751A1 (en, 2012) |
| GB (2) | GB2093693B (en, 2012) |
| HK (1) | HK83888A (en, 2012) |
| KE (1) | KE3820A (en, 2012) |
| LU (1) | LU83945A1 (en, 2012) |
| NL (1) | NL193216C (en, 2012) |
| SE (2) | SE448088B (en, 2012) |
| SG (1) | SG33388G (en, 2012) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU83138A1 (de) * | 1981-02-16 | 1981-09-11 | T Eckert | Topische pharmazeutische praeparate,enthaltend salze von alkancarbonsaeuren sowie neue carbonsaeuresalze und verfahren zu ihrer herstellung |
| FR2526427A1 (fr) * | 1982-05-04 | 1983-11-10 | Bouchara Emile | Nouveau sel d'indometacine, son procede de preparation et les compositions pharmaceutiques en renfermant |
| US4437053A (en) * | 1982-05-10 | 1984-03-13 | Diasonics (Nmr) Inc. | Gradient power supply |
| CH655656B (en, 2012) * | 1982-10-07 | 1986-05-15 | ||
| ES8407042A1 (es) * | 1982-10-08 | 1984-09-01 | Espinos & Bofill Lab Sa | Procedimiento para la obtencion de un nuevo derivado del sulpiride. |
| JPS59137408A (ja) * | 1983-01-27 | 1984-08-07 | Taisho Pharmaceut Co Ltd | 軟膏 |
| JPS59139315A (ja) * | 1983-01-31 | 1984-08-10 | Taisho Pharmaceut Co Ltd | クリ−ム剤 |
| CH643138A5 (de) * | 1983-08-29 | 1984-05-30 | Mepha Ag | Indomethacin enthaltende, gelartige salbe. |
| DE3381733D1 (de) * | 1983-12-08 | 1990-08-16 | Toko Yakuhin Kogyo Kk | Gelpraeparate zur externen applikation. |
| US4670254A (en) * | 1983-12-09 | 1987-06-02 | Toko Yakuhin Industry Co., Ltd. | Gel preparations for topical application of diclofenac sodium |
| DE3423589A1 (de) * | 1984-06-27 | 1986-01-09 | Wella Ag, 6100 Darmstadt | Oxidationshaarfaerbemittel auf basis einer niedrigviskosen traegermasse |
| IT1178411B (it) * | 1984-09-06 | 1987-09-09 | Sigma Tau Ind Farmaceuti | Sale di d,l-lisina dell'acido 1-(4-clorobenzoil)-5-metossi-2-metil-1h-indol-3 acetico, procedimento per la sua preparazione e composizioni farmaceutiche che lo contengono |
| CA1265288A (en) * | 1984-11-22 | 1990-01-30 | E. I. Du Pont De Nemours And Company | Curable fluoroelastomer composition |
| US4980084A (en) * | 1985-09-11 | 1990-12-25 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Water rinsable petroleum jelly compositions |
| US4690774A (en) * | 1985-09-11 | 1987-09-01 | Chesebrough Pond's Inc. | Novel translucent water in oil emulsions |
| US4832858A (en) * | 1987-02-19 | 1989-05-23 | Chesebrough-Pond's Inc. | Water dispersible petroleum jelly compositions |
| US4960892A (en) * | 1988-06-10 | 1990-10-02 | American Home Products Corporation | Naphthalenepropionic acid derivatives as anti-inflammatory/anti-allergic agents |
| TW225536B (en, 2012) * | 1990-08-23 | 1994-06-21 | Ciba Geigy Ag | |
| US5444076A (en) * | 1990-11-26 | 1995-08-22 | Roemmers S.A.I.C.F. | Pharmaceutical preparation for topical application |
| AU2259692A (en) * | 1991-07-03 | 1993-02-11 | Sano Corporation | Composition and method for transdermal delivery of diclofenac |
| US6117907A (en) * | 1993-04-14 | 2000-09-12 | Sher; Neal A. | Topical treatment of ocular pain after corneal surgery |
| JP3526887B2 (ja) * | 1993-04-23 | 2004-05-17 | 帝國製薬株式会社 | 消炎鎮痛外用貼付剤 |
| FI100692B (fi) * | 1994-05-24 | 1998-02-13 | Leiras Oy | Menetelmä farmaseuttisten koostumusten valmistamiseksi, jolloin koostu mukset pohjautuvat mikroemulsiogeeleihin sekä uusia mikroemulsioihin p ohjautuvia geelejä |
| ATE178884T1 (de) * | 1994-06-29 | 1999-04-15 | Novartis Erfind Verwalt Gmbh | Salze von 2-((2,6- dichlorophenyl)amin>phenylacetoxyessigsäure mit organischen basischen kationen |
| RU2128989C1 (ru) * | 1997-03-05 | 1999-04-20 | Закрытое акционерное общество "Химмедсинтез" | Композиция антимикробного, противовоспалительного и регенерационного действия |
| US20030060657A1 (en) * | 1998-04-28 | 2003-03-27 | Russinsky Limited | Process for the preparation of Aceclofenac |
| RU2177314C2 (ru) * | 2000-03-22 | 2001-12-27 | Кривошеин Юрий Семенович | Состав с антисептическими, репаративными и болеутоляющими свойствами |
| TWI290464B (en) | 2000-09-01 | 2007-12-01 | Novartis Consumer Health Sa | Treatment of burns |
| DE10114561A1 (de) * | 2001-03-24 | 2002-09-26 | Wella Ag | Verwendung von Mitteln enthaltend Kreatin, Kreatin und/oder deren Derivaten zur Verstärkung und Strukturverbesserung von keratinischen Fasern |
| ITMI20020986A1 (it) * | 2002-05-10 | 2003-11-10 | Acraf | Composizione a base di diclofenac per il trattamento topico di affezioni del cavo orofaringeo |
| AR042206A1 (es) | 2002-11-26 | 2005-06-15 | Novartis Ag | Acidos fenilaceticos y derivados |
| ITMI20030269A1 (it) * | 2003-02-14 | 2004-08-15 | Advance Holdings Ltd | Sale di cetilpiridino di un agente antiinfiammatorio |
| FR2854802B1 (fr) * | 2003-05-12 | 2005-06-24 | Galderma Res & Dev | Procede de preparation d'une formulation contenant un principe actif microdose |
| EP2055298A1 (en) | 2007-10-30 | 2009-05-06 | Novartis AG | Topical composition |
| US11000495B2 (en) | 2014-09-10 | 2021-05-11 | GSK Consumer Healthcare S.A. | Topical diclofenac sodium compositions |
| CN116143647A (zh) * | 2023-03-03 | 2023-05-23 | 长沙晶易医药科技股份有限公司 | 双氯芬酸二乙胺的新晶型及其制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US514839A (en) * | 1894-02-13 | sergeant | ||
| GB971700A (en) * | 1961-02-02 | 1964-09-30 | Boots Pure Drug Co Ltd | Anti-Inflammatory Agents |
| AT290523B (de) * | 1962-01-05 | 1971-06-11 | Merck & Co Inc | Verfahren zur Herstellung neuer α-(3-Indolyl)-carbonsäuren |
| US3558690A (en) * | 1965-04-08 | 1971-01-26 | Gelgy Chemical Corp | Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation |
| CH470349A (de) * | 1966-10-07 | 1969-03-31 | Geigy Ag J R | Verfahren zur Herstellung von neuen substituierten Phenylessigsäuren |
| US3896157A (en) * | 1967-01-13 | 1975-07-22 | Syntex Corp | Dihydo 2-naphthylacetic acid derivatives |
| US4048330A (en) * | 1967-01-13 | 1977-09-13 | Syntex Corporation | Compositions containing 2-(6'-substituted-2'-naphthyl)acetic acid esters used for treating inflammation, pain or pyrexia |
| CA960689A (en) * | 1967-01-13 | 1975-01-07 | Syntex Corporation | 2-naphthyl acetic acid derivatives and compositions |
| FR1546478A (fr) * | 1967-01-27 | 1968-11-22 | Rhone Poulenc Sa | Nouveaux dérivés de l'acide benzoyl-3 phénylacétique et leur préparation |
| US3592902A (en) * | 1967-04-13 | 1971-07-13 | Sumitomo Chemical Co | Injection |
| NL6817965A (en, 2012) * | 1967-12-20 | 1969-06-24 | ||
| US3641040A (en) * | 1968-03-27 | 1972-02-08 | Ciba Geigy Corp | Tertiary amino phenyl acetic acids |
| US3637767A (en) * | 1968-07-30 | 1972-01-25 | Syntex Corp | 2-(6'-methoxynaphth-2'-yl)propylene oxide and 5'-halo derivatives |
| BR6915470D0 (pt) * | 1969-03-24 | 1973-03-13 | Syntex Corp | Processo para preparar derivados de acido 2-(6'substituido 2'naftil)propionico e de seus sais |
| US3752826A (en) * | 1970-01-26 | 1973-08-14 | Mcneilab Inc | Aroyl substituted pyrroles |
| US3647858A (en) * | 1970-05-01 | 1972-03-07 | Merck & Co Inc | Process for preparing 1-benzylidene-3-indenyl acetic acids |
| US4033816A (en) | 1973-06-18 | 1977-07-05 | The Upjohn Company | Process for inhibiting platelet aggregation |
| US3936528A (en) * | 1974-02-13 | 1976-02-03 | Syntex Corporation | Analgesic formulations having enhanced therapeutic activity |
| ES423834A1 (es) * | 1974-03-02 | 1976-06-01 | Roger Lab | Procedimiento de obtencion de una nueva sal de piperacina del acido (1 - p - clorobenzoil - 2 - metil - 5 - metoxi - 3- indolil) acetico. |
| US4031243A (en) * | 1975-07-03 | 1977-06-21 | Juste, S.A. Quimico-Farmaceutica | 2-(4-Isobutyl phenyl)butyric acid, salts thereof, and pharmaceutical compositions containing the same |
| PT66660B (en) * | 1976-06-12 | 1978-11-13 | Ciba Geigy Ag | Process for the production of a derivative of phenylacetic |
| LU77316A1 (en, 2012) * | 1977-05-11 | 1979-01-19 | ||
| JPS549240A (en) * | 1977-06-23 | 1979-01-24 | Asahi Chem Ind Co Ltd | New derivative of phenylglycolic acid, its preparation and analgesic and antiinflammatory agent contining it as effective component |
| GB2023000B (en) * | 1978-06-17 | 1982-10-13 | Kowa Co | Antinflammatory analgesic gelled ointments |
| BE871335A (fr) * | 1978-10-18 | 1979-04-18 | Bago Sa Labor | Derives solubles des acides 2-anilino-aryl-carboxyliques substitues utiles par la voie buccale comme agents anti-inflammatoires. |
| LU83138A1 (de) * | 1981-02-16 | 1981-09-11 | T Eckert | Topische pharmazeutische praeparate,enthaltend salze von alkancarbonsaeuren sowie neue carbonsaeuresalze und verfahren zu ihrer herstellung |
-
1981
- 1981-02-16 AT AT0070981A patent/AT370721B/de not_active IP Right Cessation
- 1981-02-17 SE SE8101064A patent/SE448088B/sv not_active IP Right Cessation
- 1981-02-19 CA CA000371271A patent/CA1180008A/en not_active Expired
- 1981-02-20 US US06/236,097 patent/US4407824A/en not_active Expired - Lifetime
- 1981-02-24 GB GB8105822A patent/GB2093693B/en not_active Expired
- 1981-02-25 NL NL8100917A patent/NL193216C/nl not_active IP Right Cessation
- 1981-02-27 FR FR8103932A patent/FR2500751A1/fr active Granted
- 1981-10-09 FR FR8119055A patent/FR2514348A1/fr active Granted
-
1982
- 1982-02-15 LU LU83945A patent/LU83945A1/de unknown
- 1982-05-25 SE SE8203228A patent/SE8203228L/xx unknown
-
1983
- 1983-07-27 US US06/517,606 patent/US4551475A/en not_active Expired - Lifetime
-
1984
- 1984-07-16 GB GB08418021A patent/GB2143528B/en not_active Expired
-
1985
- 1985-08-14 US US06/765,416 patent/US4619926A/en not_active Expired - Lifetime
-
1988
- 1988-02-18 US US07/156,770 patent/US4784808A/en not_active Expired - Lifetime
- 1988-05-27 SG SG33388A patent/SG33388G/en unknown
- 1988-06-07 KE KE3820A patent/KE3820A/xx unknown
- 1988-10-13 HK HK838/88A patent/HK83888A/xx not_active IP Right Cessation
-
1989
- 1989-03-10 CY CY1443A patent/CY1443A/en unknown
- 1989-03-10 CY CY1444A patent/CY1444A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB2143528B (en) | 1985-10-02 |
| SE8203228L (sv) | 1982-08-18 |
| GB2093693B (en) | 1985-10-02 |
| SG33388G (en) | 1988-09-30 |
| CY1444A (en) | 1989-03-10 |
| FR2500751B1 (en, 2012) | 1984-12-28 |
| ATA70981A (de) | 1982-09-15 |
| FR2514348A1 (fr) | 1983-04-15 |
| KE3820A (en) | 1988-09-09 |
| US4407824A (en) | 1983-10-04 |
| CA1180008A (en) | 1984-12-27 |
| US4619926A (en) | 1986-10-28 |
| FR2514348B1 (en, 2012) | 1984-12-14 |
| NL8100917A (nl) | 1982-09-16 |
| AT370721B (de) | 1983-04-25 |
| NL193216B (nl) | 1998-11-02 |
| HK83888A (en) | 1988-10-21 |
| FR2500751A1 (fr) | 1982-09-03 |
| US4551475A (en) | 1985-11-05 |
| GB2143528A (en) | 1985-02-13 |
| GB8418021D0 (en) | 1984-08-22 |
| NL193216C (nl) | 1999-03-03 |
| SE8101064L (sv) | 1982-08-18 |
| CY1443A (en) | 1989-03-10 |
| GB2093693A (en) | 1982-09-08 |
| US4784808A (en) | 1988-11-15 |
| SE448088B (sv) | 1987-01-19 |
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