GB2093693B - Pharmaceutical preparations for topical application which contain salts of alkanecarboxylic acids novel carboxylic acid salts and the production thereof - Google Patents

Pharmaceutical preparations for topical application which contain salts of alkanecarboxylic acids novel carboxylic acid salts and the production thereof

Info

Publication number
GB2093693B
GB2093693B GB8105822A GB8105822A GB2093693B GB 2093693 B GB2093693 B GB 2093693B GB 8105822 A GB8105822 A GB 8105822A GB 8105822 A GB8105822 A GB 8105822A GB 2093693 B GB2093693 B GB 2093693B
Authority
GB
United Kingdom
Prior art keywords
salts
production
carboxylic acid
topical application
pharmaceutical preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8105822A
Other languages
English (en)
Other versions
GB2093693A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10519933&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB2093693(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to AT0070981A priority Critical patent/AT370721B/de
Priority to SE8101064A priority patent/SE448088B/sv
Priority to CA000371271A priority patent/CA1180008A/en
Priority to US06/236,097 priority patent/US4407824A/en
Priority to GB8105822A priority patent/GB2093693B/en
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Priority to NL8100917A priority patent/NL193216C/nl
Priority to FR8103932A priority patent/FR2500751A1/fr
Priority to FR8119055A priority patent/FR2514348A1/fr
Priority to LU83945A priority patent/LU83945A1/de
Priority to AT136582A priority patent/AT380166B/de
Priority to SE8203228A priority patent/SE8203228L/xx
Publication of GB2093693A publication Critical patent/GB2093693A/en
Priority to US06/517,606 priority patent/US4551475A/en
Priority to GB08418021A priority patent/GB2143528B/en
Priority to US06/765,416 priority patent/US4619926A/en
Publication of GB2093693B publication Critical patent/GB2093693B/en
Application granted granted Critical
Priority to US07/156,770 priority patent/US4784808A/en
Priority to SG33388A priority patent/SG33388G/en
Priority to KE3820A priority patent/KE3820A/xx
Priority to KE382188A priority patent/KE3821A/xx
Priority to HK83988A priority patent/HK83988A/xx
Priority to HK838/88A priority patent/HK83888A/xx
Priority to CY1444A priority patent/CY1444A/en
Priority to CY1443A priority patent/CY1443A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
GB8105822A 1981-02-16 1981-02-24 Pharmaceutical preparations for topical application which contain salts of alkanecarboxylic acids novel carboxylic acid salts and the production thereof Expired GB2093693B (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
AT0070981A AT370721B (de) 1981-02-24 1981-02-16 Verfahren zur herstellung von neuen salzen der 2- (2,6-dichloranilino)-phenylessigsaeure, der
SE8101064A SE448088B (sv) 1981-02-24 1981-02-17 Nya salter av 2-(2,6-di-kloranilino)-fenylettiksyra, forfarande for framstellning av dessa samt anvendning av dessa for framstellning av lokalt applicerbara farmaceutiska preparat
CA000371271A CA1180008A (en) 1981-02-24 1981-02-19 Process for the production of salts of alkanecarboxylic acids and of pharmaceutical preparations
US06/236,097 US4407824A (en) 1981-02-24 1981-02-20 Pharmaceutical preparations for topical application which contain salts of alkanecarboxylic acids, novel carboxylic acid salts and the production thereof
GB8105822A GB2093693B (en) 1981-02-24 1981-02-24 Pharmaceutical preparations for topical application which contain salts of alkanecarboxylic acids novel carboxylic acid salts and the production thereof
NL8100917A NL193216C (nl) 1981-02-24 1981-02-25 Diethylammonium-2-(2,6-dichlooranilino)-fenylacetaat en topicaal toepasbaar preparaat dat het bevat.
FR8103932A FR2500751A1 (fr) 1981-02-24 1981-02-27 Compositions pharmaceutiques anti-inflammatoires topiques a base de sels d'acides carboxyliques, nouveaux sels d'acides carboxyliques et leur preparation
FR8119055A FR2514348A1 (fr) 1981-02-24 1981-10-09 Nouveaux sels d'acides carboxyliques, procede pour leur preparation et compositions pharmaceutiques les contenant
LU83945A LU83945A1 (de) 1981-02-24 1982-02-15 Ammoniumsalz einer substituierten carbonsaeure,verfahren zu seiner herstellung,seine verwendung und pharmazeutische praeparate
AT136582A AT380166B (de) 1981-02-16 1982-04-06 Verfahren zur herstellung topisch applizierbarer pharmazeutischer praeparate, enthaltend salze von alkancarbonsaeuren
SE8203228A SE8203228L (sv) 1981-02-24 1982-05-25 Lokala farmaceutiska preparat innehallande salter av alkankarbonsyror samt nya karbonsyrasalter och forfarande for framstellning derav
US06/517,606 US4551475A (en) 1981-02-24 1983-07-27 Pharmaceutical preparations for topical application which contain salts of alkanecarboxylic acids
GB08418021A GB2143528B (en) 1981-02-24 1984-07-16 Salts of 2-(2-6-dichloroanilino)-phenyl acetic acid
US06/765,416 US4619926A (en) 1981-02-24 1985-08-14 Pharmaceutical preparations for topical application which contain salts of alkanecarboxylic acids, novel carboxylic acid salts and the production thereof
US07/156,770 US4784808A (en) 1981-02-24 1988-02-18 Diethylammonium-2-(2,6-dichloroanilino)phenylacetate
SG33388A SG33388G (en) 1981-02-24 1988-05-27 Salts of 2(2,6-dichloroanilino) phenylacetic acid and their production
KE3820A KE3820A (en) 1981-02-24 1988-06-07 Pharmaceutical preparations for topical application which contain salts of alkanecarboxylic acids,novel carboxylic acid salts and the production thereof
KE382188A KE3821A (en) 1981-02-24 1988-06-07 Salts of 2-(2,6-dichloroanilino)phenylacetic acid and their production
HK83988A HK83988A (en) 1981-02-24 1988-10-13 Salts of 2-(2,6-dichloroanilino) phenylacetic acid and their production
HK838/88A HK83888A (en) 1981-02-24 1988-10-13 Pharmaceutical preparations for topical application which contain salts of alkanecarboxylic acids, novel carboxylic acid salts and the production thereof
CY1444A CY1444A (en) 1981-02-24 1989-03-10 Salts of 2-(2,6-dichloroanilino)phenylacetic acit and their production
CY1443A CY1443A (en) 1981-02-24 1989-03-10 Pharmaceutical preparations for topical application which contain salts jof alkanecarboxylic acids,novel carboxylic acid salts and the production thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8105822A GB2093693B (en) 1981-02-24 1981-02-24 Pharmaceutical preparations for topical application which contain salts of alkanecarboxylic acids novel carboxylic acid salts and the production thereof

Publications (2)

Publication Number Publication Date
GB2093693A GB2093693A (en) 1982-09-08
GB2093693B true GB2093693B (en) 1985-10-02

Family

ID=10519933

Family Applications (2)

Application Number Title Priority Date Filing Date
GB8105822A Expired GB2093693B (en) 1981-02-16 1981-02-24 Pharmaceutical preparations for topical application which contain salts of alkanecarboxylic acids novel carboxylic acid salts and the production thereof
GB08418021A Expired GB2143528B (en) 1981-02-24 1984-07-16 Salts of 2-(2-6-dichloroanilino)-phenyl acetic acid

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB08418021A Expired GB2143528B (en) 1981-02-24 1984-07-16 Salts of 2-(2-6-dichloroanilino)-phenyl acetic acid

Country Status (12)

Country Link
US (4) US4407824A (en, 2012)
AT (1) AT370721B (en, 2012)
CA (1) CA1180008A (en, 2012)
CY (2) CY1444A (en, 2012)
FR (2) FR2500751A1 (en, 2012)
GB (2) GB2093693B (en, 2012)
HK (1) HK83888A (en, 2012)
KE (1) KE3820A (en, 2012)
LU (1) LU83945A1 (en, 2012)
NL (1) NL193216C (en, 2012)
SE (2) SE448088B (en, 2012)
SG (1) SG33388G (en, 2012)

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FR2526427A1 (fr) * 1982-05-04 1983-11-10 Bouchara Emile Nouveau sel d'indometacine, son procede de preparation et les compositions pharmaceutiques en renfermant
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CH643138A5 (de) * 1983-08-29 1984-05-30 Mepha Ag Indomethacin enthaltende, gelartige salbe.
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US4670254A (en) * 1983-12-09 1987-06-02 Toko Yakuhin Industry Co., Ltd. Gel preparations for topical application of diclofenac sodium
DE3423589A1 (de) * 1984-06-27 1986-01-09 Wella Ag, 6100 Darmstadt Oxidationshaarfaerbemittel auf basis einer niedrigviskosen traegermasse
IT1178411B (it) * 1984-09-06 1987-09-09 Sigma Tau Ind Farmaceuti Sale di d,l-lisina dell'acido 1-(4-clorobenzoil)-5-metossi-2-metil-1h-indol-3 acetico, procedimento per la sua preparazione e composizioni farmaceutiche che lo contengono
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US5444076A (en) * 1990-11-26 1995-08-22 Roemmers S.A.I.C.F. Pharmaceutical preparation for topical application
CA2112751A1 (en) * 1991-07-03 1993-01-21 Charles J. Ii Betlach Composition and method for transdermal delivery of diclofenac
US6117907A (en) * 1993-04-14 2000-09-12 Sher; Neal A. Topical treatment of ocular pain after corneal surgery
JP3526887B2 (ja) * 1993-04-23 2004-05-17 帝國製薬株式会社 消炎鎮痛外用貼付剤
FI100692B (fi) * 1994-05-24 1998-02-13 Leiras Oy Menetelmä farmaseuttisten koostumusten valmistamiseksi, jolloin koostu mukset pohjautuvat mikroemulsiogeeleihin sekä uusia mikroemulsioihin p ohjautuvia geelejä
CA2192682A1 (en) * 1994-06-29 1996-01-11 Alfred Sallmann New salts of 2-¬(2,6-dichlorophenyl)amine|phenylacetoxyacetic acid with organic basic cations
RU2128989C1 (ru) * 1997-03-05 1999-04-20 Закрытое акционерное общество "Химмедсинтез" Композиция антимикробного, противовоспалительного и регенерационного действия
US20030060657A1 (en) * 1998-04-28 2003-03-27 Russinsky Limited Process for the preparation of Aceclofenac
RU2177314C2 (ru) * 2000-03-22 2001-12-27 Кривошеин Юрий Семенович Состав с антисептическими, репаративными и болеутоляющими свойствами
TWI290464B (en) 2000-09-01 2007-12-01 Novartis Consumer Health Sa Treatment of burns
DE10114561A1 (de) * 2001-03-24 2002-09-26 Wella Ag Verwendung von Mitteln enthaltend Kreatin, Kreatin und/oder deren Derivaten zur Verstärkung und Strukturverbesserung von keratinischen Fasern
ITMI20020986A1 (it) * 2002-05-10 2003-11-10 Acraf Composizione a base di diclofenac per il trattamento topico di affezioni del cavo orofaringeo
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ITMI20030269A1 (it) * 2003-02-14 2004-08-15 Advance Holdings Ltd Sale di cetilpiridino di un agente antiinfiammatorio
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Also Published As

Publication number Publication date
LU83945A1 (de) 1982-12-13
FR2514348A1 (fr) 1983-04-15
SE448088B (sv) 1987-01-19
SG33388G (en) 1988-09-30
NL193216B (nl) 1998-11-02
ATA70981A (de) 1982-09-15
FR2514348B1 (en, 2012) 1984-12-14
KE3820A (en) 1988-09-09
GB8418021D0 (en) 1984-08-22
CA1180008A (en) 1984-12-27
HK83888A (en) 1988-10-21
CY1443A (en) 1989-03-10
AT370721B (de) 1983-04-25
FR2500751A1 (fr) 1982-09-03
US4407824A (en) 1983-10-04
US4619926A (en) 1986-10-28
US4551475A (en) 1985-11-05
GB2143528A (en) 1985-02-13
CY1444A (en) 1989-03-10
GB2093693A (en) 1982-09-08
NL193216C (nl) 1999-03-03
SE8101064L (sv) 1982-08-18
SE8203228L (sv) 1982-08-18
NL8100917A (nl) 1982-09-16
FR2500751B1 (en, 2012) 1984-12-28
US4784808A (en) 1988-11-15
GB2143528B (en) 1985-10-02

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