LU83376A1 - Nouveaux derives d'imidazo-rifamycine a activite antibacterienne - Google Patents
Nouveaux derives d'imidazo-rifamycine a activite antibacterienne Download PDFInfo
- Publication number
- LU83376A1 LU83376A1 LU83376A LU83376A LU83376A1 LU 83376 A1 LU83376 A1 LU 83376A1 LU 83376 A LU83376 A LU 83376A LU 83376 A LU83376 A LU 83376A LU 83376 A1 LU83376 A1 LU 83376A1
- Authority
- LU
- Luxembourg
- Prior art keywords
- carbon atoms
- group
- hydrogen atom
- singlet
- doublet
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT03429/80A IT1154655B (it) | 1980-05-22 | 1980-05-22 | Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica |
IT342980 | 1980-05-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
LU83376A1 true LU83376A1 (fr) | 1981-09-11 |
Family
ID=11107198
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LU83376A LU83376A1 (fr) | 1980-05-22 | 1981-05-20 | Nouveaux derives d'imidazo-rifamycine a activite antibacterienne |
Country Status (25)
Country | Link |
---|---|
US (1) | US4341785A (zh) |
JP (1) | JPS5711987A (zh) |
AR (1) | AR226212A1 (zh) |
AT (1) | AT373599B (zh) |
AU (1) | AU537093B2 (zh) |
BE (1) | BE888895A (zh) |
CA (1) | CA1142518A (zh) |
CH (1) | CH648037A5 (zh) |
DE (1) | DE3120460A1 (zh) |
DK (1) | DK157876C (zh) |
EG (1) | EG14891A (zh) |
ES (1) | ES8203388A1 (zh) |
FI (1) | FI69467C (zh) |
FR (1) | FR2482967A1 (zh) |
GB (1) | GB2079270B (zh) |
GR (1) | GR75640B (zh) |
IE (1) | IE51204B1 (zh) |
IT (1) | IT1154655B (zh) |
LU (1) | LU83376A1 (zh) |
NL (1) | NL187022C (zh) |
NO (1) | NO155622C (zh) |
PH (2) | PH17207A (zh) |
PT (1) | PT73064B (zh) |
SE (1) | SE453089B (zh) |
ZA (1) | ZA813430B (zh) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1199374B (it) * | 1984-05-15 | 1988-12-30 | Alfa Farmaceutici Spa | Processo per la preparazione di pirido-imidazo-rifamicine |
IT1264494B1 (it) * | 1993-03-23 | 1996-09-24 | Alfa Wassermann Spa | Uso di rifaximin e di formulazioni che la contengono nel trattamento delle dispepsie gastriche originate da helicobacter |
US6861053B1 (en) | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
US5981522A (en) * | 1995-09-01 | 1999-11-09 | Kaneka Corporation | Treatment of disease caused by infection of Helicobacter |
CA2230649C (en) * | 1997-02-28 | 2007-11-06 | Kaneka Corporation | Medicine for a disease caused by infection of helicobacter |
AU2002360416A1 (en) * | 2001-11-21 | 2003-06-10 | Activbiotics, Inc. | Targeted therapeutics and uses thereof |
US7078399B2 (en) * | 2001-12-13 | 2006-07-18 | Activbiotics, Inc. | Sulfhydryl rifamycins and uses thereof |
ES2385477T3 (es) * | 2002-11-05 | 2012-07-25 | Fadim S.R.L. | Liberación continua y controlada de rifaximina |
US7820652B2 (en) * | 2003-09-24 | 2010-10-26 | Activbiotics Pharma, Llc | Regimen for the administration of rifamycin-class antibiotics |
US7923553B2 (en) * | 2003-11-07 | 2011-04-12 | Alfa Wassermann, S.P.A. | Processes for the production of polymorphic forms of rifaximin |
US20080262024A1 (en) * | 2003-11-07 | 2008-10-23 | Giuseppe Claudio Viscomi | Rifaximin compositions and method of use |
US7906542B2 (en) * | 2004-11-04 | 2011-03-15 | Alfa Wassermann, S.P.A. | Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin |
ITMI20032144A1 (it) * | 2003-11-07 | 2005-05-08 | Alfa Wassermann Spa | Forme polimorfe di rifaximina, processi per ottenerle e |
US7902206B2 (en) * | 2003-11-07 | 2011-03-08 | Alfa Wassermann, S.P.A. | Polymorphic forms α, β and γ of rifaximin |
US7265107B2 (en) * | 2004-03-10 | 2007-09-04 | Cumbre Pharmaceuticals Inc. | Rifamycin C-11 oxime cyclo derivatives effective against drug-resistant microbes |
US7256187B2 (en) * | 2004-03-10 | 2007-08-14 | Cumbre Pharmaceuticals Inc. | Rifamycin C-11 oxime derivatives effective against drug-resistant microbes |
US7202246B2 (en) * | 2004-06-09 | 2007-04-10 | Cumbre Pharmaceuticals Inc. | Spiro-rifamycin derivatives targeting RNA polymerase |
US8003118B2 (en) * | 2005-03-02 | 2011-08-23 | Kodsi Robert E | Use of rifaximin for the prevention of aspiration pneumonia and/or sepsis |
US20060210483A1 (en) * | 2005-03-02 | 2006-09-21 | Kodsi Robert E | Non-systemic antibiotic formulations and related method of use and treatment of upper respiratory infections |
US20060210492A1 (en) * | 2005-03-02 | 2006-09-21 | Kodsi Robert E | Use of rifaximin for treatment and prevention of periodontal conditions |
EP1698630B1 (en) | 2005-03-03 | 2014-09-03 | ALFA WASSERMANN S.p.A. | New polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations |
ITBO20050123A1 (it) * | 2005-03-07 | 2005-06-06 | Alfa Wassermann Spa | Formulazioni farmaceutiche gastroresistenti contenenti rifaximina |
AU2006339058B2 (en) | 2005-08-11 | 2012-09-06 | Targanta Therapeutics Inc. | Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections |
CN101594885B (zh) | 2006-03-09 | 2017-07-18 | 萨利克斯药品公司 | 利福昔明抗直肠功能障碍制剂 |
CN104382900A (zh) | 2006-08-02 | 2015-03-04 | 萨利克斯药品公司 | 治疗放射性肠炎的组合物和方法 |
ITMI20061692A1 (it) | 2006-09-05 | 2008-03-06 | Alfa Wassermann Spa | Uso di polioli per ottenere forme polimorfe stabili di rifaximina |
WO2008035109A1 (en) * | 2006-09-22 | 2008-03-27 | Cipla Limited | Rifaximin |
US20080161337A1 (en) * | 2007-01-03 | 2008-07-03 | Leonard Weinstock | Use of Rifaximin for the Treatment of Chronic Prostatitis |
US20080159987A1 (en) * | 2007-01-03 | 2008-07-03 | Leonard Weinstock | Use of Rifaximin for the Treatment of Restless Legs Syndrome |
ITMI20071241A1 (it) * | 2007-06-20 | 2008-12-21 | Solmag S P A | Processo per la preparazione di rifaximina amorfa e rifaximina amorfa cosi' ottenuta |
AU2008273699A1 (en) | 2007-07-06 | 2009-01-15 | Lupin Limited | Pharmaceutical compositions of rifaximin |
EP2837378A1 (en) | 2007-07-06 | 2015-02-18 | Lupin Limited | Pharmaceutical compositions of rifaximin |
US7709634B2 (en) * | 2007-09-20 | 2010-05-04 | Apotex Pharmachem Inc. | Amorphous form of rifaximin and processes for its preparation |
US8486956B2 (en) * | 2008-02-25 | 2013-07-16 | Salix Pharmaceuticals, Ltd | Forms of rifaximin and uses thereof |
JP5706693B2 (ja) | 2008-02-25 | 2015-04-22 | サリックス ファーマシューティカルズ リミテッド | リファキシミンの型およびその使用 |
US11779571B2 (en) | 2008-02-26 | 2023-10-10 | Salix Pharmaceuticals, Inc. | Methods for treating irritable bowel syndrome (IBS) |
EP3563850A1 (en) | 2008-02-26 | 2019-11-06 | Salix Pharmaceuticals, Ltd. | Methods for treating bowel diseases |
WO2009137672A1 (en) | 2008-05-07 | 2009-11-12 | Salix Pharmaceuticals, Ltd. | Methods of treating bowel disease by administering a bowel cleanser and an antibiotic |
WO2010019511A2 (en) | 2008-08-13 | 2010-02-18 | Targanta Therapeutics Corp. | Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections |
JP5567484B2 (ja) | 2008-09-26 | 2014-08-06 | あすか製薬株式会社 | 機能性消化管障害の予防及び/又は治療剤 |
CA2739436C (en) | 2008-10-02 | 2019-08-27 | Salix Pharmaceuticals, Ltd. | Use of rifaximin for treating hepatic encephalopathy |
US8916193B2 (en) | 2008-12-10 | 2014-12-23 | Cipla Limited | Rifaximin complexes |
IT1397617B1 (it) * | 2009-04-20 | 2013-01-18 | Alfa Wassermann Spa | Nuovi derivati della rifamicina |
EP2437603A4 (en) | 2009-06-02 | 2012-12-12 | Salix Pharmaceuticals Ltd | METHODS OF TREATING HEPATIC ENCEPHALOPATHY |
KR20120062897A (ko) | 2009-09-13 | 2012-06-14 | 샐릭스 파마슈티컬스 리미티드 | 과민성 장 증후군(ibs)의 치료방법 |
KR20190000931A (ko) | 2009-10-27 | 2019-01-03 | 루핀 리미티드 | 리팍시민의 고형 분산물 |
MX2012005883A (es) | 2009-11-23 | 2012-10-09 | Cipla Ltd | Composicion topica en espuma. |
US8952159B2 (en) | 2009-12-28 | 2015-02-10 | Silvio Massimo Lavagna | Method for the production of amorphous rifaximin |
WO2011103246A1 (en) | 2010-02-18 | 2011-08-25 | Salix Pharmaceuticals, Ltd. | Methods for treating infection |
IT1398550B1 (it) | 2010-03-05 | 2013-03-01 | Alfa Wassermann Spa | Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo |
EP2544660B1 (en) | 2010-03-10 | 2018-06-13 | Lupin Limited | Rifaximin ready-to-use suspension |
WO2012009388A1 (en) | 2010-07-12 | 2012-01-19 | Salix Pharmaceuticals, Ltd | Formulations of rifaximin and uses thereof |
WO2012035544A2 (en) | 2010-09-13 | 2012-03-22 | Sequent Scientific Ltd. | A novel polymorphic form of rifaximin and process for its preparation |
BR112013020265A2 (pt) | 2011-02-11 | 2017-07-11 | Salix Pharmaceuticals Ltd | formas de rifaximina e uso das mesmas |
EP2705042A1 (en) | 2011-05-02 | 2014-03-12 | Ranbaxy Laboratories Limited | Rifaximin dimethylformamide solvate |
ITMI20110890A1 (it) * | 2011-05-19 | 2012-11-20 | A M S A Anonima Materie Sint & Affini S P A | Polimorfo di rifaximina e processo per la sua preparazione |
ITBO20110461A1 (it) | 2011-07-29 | 2013-01-30 | Alfa Wassermann Spa | Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali. |
RU2496475C2 (ru) | 2011-10-26 | 2013-10-27 | Александр Васильевич Иващенко | Фармацевтическая композиция и набор для лечения бактериальных инфекций |
WO2013067394A1 (en) | 2011-11-02 | 2013-05-10 | Salix Pharmaceuticals, Ltd | Methods for treating irritable bowel syndrome (ibs) and infections |
CA2861104A1 (en) | 2012-01-25 | 2013-08-01 | Salix Pharmaceuticals, Ltd. | Rifaximin derivative and uses thereof |
ITBO20120368A1 (it) | 2012-07-06 | 2014-01-07 | Alfa Wassermann Spa | Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso. |
WO2014091432A1 (en) | 2012-12-12 | 2014-06-19 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of rifaximin |
CN105142636A (zh) | 2013-03-15 | 2015-12-09 | 意大利阿尔法韦士曼制药公司 | 用于治疗阴道感染的利福昔明 |
US20160047819A1 (en) | 2013-03-15 | 2016-02-18 | Alfa Wassermann S.P.A. | Method for diagnosing vaginal infections |
MX2015014307A (es) | 2013-04-12 | 2015-12-08 | Alfa Wassermann Spa | Administracion de farmacos antiinflamatorios no esteroidales y composiciones, metodos y sistemas relacionados. |
US9018225B1 (en) | 2013-07-26 | 2015-04-28 | Novel Laboratories | Rifaximin crystalline forms and methods of preparation thereof |
ES2621557T3 (es) | 2014-03-31 | 2017-07-04 | Euticals S.P.A. | Mezcla polimórfica de rifaximina y su uso para la preparación de formulaciones sólidas |
MX2016014329A (es) | 2014-05-04 | 2017-02-23 | Salix Pharmaceuticals Inc | Microbiota ibs y sus usos. |
PL3546464T3 (pl) | 2014-05-12 | 2020-11-02 | Alfasigma S.P.A. | Sposób wytwarzania i zastosowanie postaci krystalicznej Tau rifaksyminy solwatowanej z DEGME |
EP2982764A1 (en) | 2014-08-05 | 2016-02-10 | ALFA WASSERMANN S.p.A. | Identification of vaginal bacteria |
US9988398B2 (en) | 2016-06-07 | 2018-06-05 | Cadila Healthcare Limited | Crystalline form of rifaximin and process for its preparation |
EP4137132A1 (en) | 2016-09-30 | 2023-02-22 | Salix Pharmaceuticals, Inc. | Solid dispersion forms of rifaximin |
IT201700091912A1 (it) * | 2017-08-08 | 2019-02-08 | Biofer Spa | Nuove pirido-imidazo rifamicine |
WO2019003076A1 (en) * | 2017-06-26 | 2019-01-03 | Biofer S.P.A. | PYRIDO-IMIDAZO-RIFAMYCIN DERIVATIVES AS ANTIBACTERIAL AGENT |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE273377C (zh) * | ||||
AT273377B (de) * | 1967-03-01 | 1969-08-11 | Lepetit Spa | Verfahren zur Herstellung von neuen Rifamycinen |
AT344898B (de) * | 1975-06-13 | 1978-08-10 | Archifar Ind Chim Trentino | Verfahren zur herstellung neuer rifamycin-verbindungen |
DK345977A (da) * | 1976-09-30 | 1978-03-31 | Archifar Ind Chim Trentino | G rifamycinforbindelser og fremgangsmaade til deres fremstillin |
CH629212A5 (it) * | 1976-10-18 | 1982-04-15 | Erba Farmitalia | Procedimento per la preparazione di composti di rifamicina. |
CH633014A5 (en) * | 1978-06-09 | 1982-11-15 | Erba Farmitalia | Rifamycin compounds |
-
1980
- 1980-05-22 IT IT03429/80A patent/IT1154655B/it active Protection Beyond IP Right Term
-
1981
- 1981-05-11 NL NLAANVRAGE8102290,A patent/NL187022C/xx not_active IP Right Cessation
- 1981-05-11 US US06/262,123 patent/US4341785A/en not_active Expired - Lifetime
- 1981-05-18 AU AU70655/81A patent/AU537093B2/en not_active Expired
- 1981-05-19 AT AT0222781A patent/AT373599B/de not_active IP Right Cessation
- 1981-05-20 PT PT73064A patent/PT73064B/pt unknown
- 1981-05-20 EG EG280/81A patent/EG14891A/xx active
- 1981-05-20 FR FR8110058A patent/FR2482967A1/fr active Granted
- 1981-05-20 GR GR65010A patent/GR75640B/el unknown
- 1981-05-20 PH PH25656A patent/PH17207A/en unknown
- 1981-05-20 LU LU83376A patent/LU83376A1/fr unknown
- 1981-05-21 FI FI811565A patent/FI69467C/fi not_active IP Right Cessation
- 1981-05-21 NO NO811731A patent/NO155622C/no unknown
- 1981-05-21 SE SE8103216A patent/SE453089B/sv not_active IP Right Cessation
- 1981-05-21 BE BE2/59169A patent/BE888895A/fr not_active IP Right Cessation
- 1981-05-21 IE IE1139/81A patent/IE51204B1/en not_active IP Right Cessation
- 1981-05-21 ZA ZA00813430A patent/ZA813430B/xx unknown
- 1981-05-21 ES ES502906A patent/ES8203388A1/es not_active Expired
- 1981-05-21 DK DK224781A patent/DK157876C/da active
- 1981-05-21 CA CA000378015A patent/CA1142518A/en not_active Expired
- 1981-05-22 JP JP7787781A patent/JPS5711987A/ja active Granted
- 1981-05-22 AR AR285424A patent/AR226212A1/es active
- 1981-05-22 GB GB8115790A patent/GB2079270B/en not_active Expired
- 1981-05-22 DE DE19813120460 patent/DE3120460A1/de active Granted
- 1981-05-22 CH CH3381/81A patent/CH648037A5/de not_active IP Right Cessation
-
1982
- 1982-02-09 PH PH26842A patent/PH18704A/en unknown
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