LT4864B - Sapropelio trąšos ir jų gavimo būdas - Google Patents

Sapropelio trąšos ir jų gavimo būdas Download PDF

Info

Publication number
LT4864B
LT4864B LT2001004A LT2001004A LT4864B LT 4864 B LT4864 B LT 4864B LT 2001004 A LT2001004 A LT 2001004A LT 2001004 A LT2001004 A LT 2001004A LT 4864 B LT4864 B LT 4864B
Authority
LT
Lithuania
Prior art keywords
sapropel
peat
fertilizer
mixture
fertilizers
Prior art date
Application number
LT2001004A
Other languages
English (en)
Other versions
LT2001004A (lt
Inventor
Evaldas Gei�Toraitis
Antanas Ci�Nys
Original Assignee
Evaldas Gei�Toraitis
Antanas Ci�Nys
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evaldas Gei�Toraitis, Antanas Ci�Nys filed Critical Evaldas Gei�Toraitis
Publication of LT2001004A publication Critical patent/LT2001004A/lt
Publication of LT4864B publication Critical patent/LT4864B/lt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14Nitrogen atoms
    • C07D261/16Benzene-sulfonamido isoxazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)

Description

Išradimas priklauso trąšų gamybos sričiai, būtent organinių trąšų mišiniams, į kurių sudėtį įeina sapropelis ir jų gavimo būdui. Šiuo būdu gautos trąšos naudojamos efektyviam dirvų tręšimui.
Sapropelis - tai ežerų dugne, esant deguonies trūkumui, iš tirpių ir kietų nuosėdų, veikiant biologiniamš procesams, per kelis tūkstantmečius susiformavusi organinė medžiaga. Seniai yra žinomas organinio sapropelio panaudojimas žemės ūkyje (L. Katkevičius, A. Ciūnys, E. Bakšienė Ežerų sapropelis žemės ūkiui”, Vilnius, 1998).
Žinomas organmineralinių sapropelio trąšų gavimo būdas, kai sapropelio pulpą sutirština nusodintuve, pašalina pagrindinę nuskaidrinto vandens masę ir į sutirštintą sapropelio pulpą deda mineralinius priedus, būtent skalūnų pelenus (buv. TSRS a.l. Nr. 1724657).
Aprašyto sapropelio trąšų gavimo būdo trūkumas yra ilgai trunkantis šių trąšų paruošimas, o šiuo būdu gautos trąšos lėtai mineralizuojasi ir maisto medžiagas atiduoda palaipsniui, be to, šiose trąšose yra mažai hidrolizuojamų medžiagų.
Žinomos sapropelio trąšos, susidedančios iš sapropelio ir organinių ir/arba mineralinių priedų, kaip organiniai priedai gali būti durpės ir/arba skiedros, ir/arba pjuvenos, ir u.oa mėšlas, o kaip mineraliniai priedai gali būti ceolitas ir/arba mineralinės trąšos, ir/arba šlakas, ir/arba karbonatinis sapropelis. Sapropelio trąšose priedai sudaro nurodytus masės % : durpės su drėgminiu imlumu 1000% 30;Fosforo trąšos 0,4
Kalio trąšos 0,2
Azoto trąšos 0,25
Likusi dalis: Karbonatinis sapropelis (Rusijos patentas Nr. 2041866, 1994 01 20, C05F 7/00).
Žinomas sapropelio trąšų gavimo būdas, kai išimtą iš ežero sapropelį aikštelėje paskleidžia sluoksniu ir periodiškai maišant džiovina pridedant priedų. Žiemą sapropelį šaldo ir sudeda į m aukščio krūvas, kad pavasarį po šalčių sapropelio masės drėgnis būtų apie 40 %
Maišymo metu į sapropelį įveda mineralinius ir/arba organinius priedus, tokius kaip durpes, 2 LT 4864 B ir/arba skiedras, ir/arba pjuvenas, ir/arba ceolitą, ir/arba mineralines trąšas, ir/arba šlaką, ir/arba karbonatinį sapropelį. Po to sapropelį valo nuo pašalinių priemaišų, mala, džiovina iki jo drėgnis siekia 10-40% bei granuliuoja (Rusijos patentas Nr. 2041866, 1994 01 20, C05F 7/00).
Žinomose sapropelio trąšose dedama 30 masės % durpių su drėgminiu imlumu 1000%, tai atitinka sausosios medžiagos durpių 9 masės %. Žinomo sapropelio trąšų gavimo būdas ilgas ir brangus, nes šiuo būdu gautų trąšų kompozicijoje esantis mineralinių ir organinių medžiagų masių santykis neužtikrina greito sapropelio trąšų džiovinimo proceso, be to, reikalinga įranga trąšų malimui, granuliavimui bei jų pergabenimui nuo vienos apdorojimo operacijos prie kitos. Gautos šiuo būdu trąšos nepakankamai efektyvios, nes granulėse esančios maisto medžiagos lėtai atiduodamos dėl mažo granulių vandens imlumo.
Išradimu siekiama supaprastinti sapropelio trąšų gavimo būdą bei pagerinti sapropelio trąšų efektyvumą.
Uždavinio sprendimo esmė yra ta, kad sapropelio trąšose, susidedančiose iš sapropelio ir durpių mišinio, nauja yra tai, kad sapropelio ir durpių sausųjų medžiagų masių santykis mišinyje yra ribose nuo 1 : 1 iki 1 : 0,5.
Sapropelio gavimo būde, apimančiame sapropelio išėmimą iš ežero, jo paskleidimą sluoksniu aikštelėje, džiovinimą ir džiovinimo metu periodiškai maišant organinių priedų, pavyzdžiui, durpių į sapropelį įvedimą, nauja yra tai, kad sapropelio ir durpių sausųjų medžiagų masių santykį mišinyje palaiko ribose nuo 1 : 1 iki 1 : 0,5.
Sapropelio džiovinimo metu jo sumaišymas su durpėmis užtikrinant sausųjų medžiagų masių santykį nuo 1 : 1 iki 1 : 0,5 pagreitina sapropelio džiovinimą, tuo pačiu ir sapropelio trąšų gavimą bei pagerina gautų trąšų efektyvumą. Gauta mišinio masė puri, biri, struktūringa, pasižymi geromis absorbcinėmis sąvybėmis. Šis trąšų gamybos būdas yra pigus, jo realizavimas nereikalauja sudėtingos įrangos. Gautose trąšose esanti durpių dalis pagreitina sapropelio mineralizaciją, padidina lengvai hidrolizuojamų medžiagų bei humusinių rūgščių kiekį, o esanti sapropelio dalis sulėtina durpių mineralizaciją, neleidžia išgaruoti išsiskiriančioms augalų maisto medžiagoms
Trąšų optimalus džiovinimo laikas ir trąšų efektyvumas buvo nustatytas įvertinus žemiau aprašytus bandymus.
Bandymais buvo nustatyti sapropelio, durpių bei šių medžiagų mišinių džiovinimo duomenys, kurie pateikti 1 lentelėje.
lentelė
Bandymų variantai Būklė Džiovinimo laikas paromis' ir medžiagos drėgnis %
Šviežias 5 paros 10 parų 20 parų 30 parų 40
parų
1. Sapropelis (S) Tešlos 92 91 86 79 72 64
Konsist.
2. Durpės (D) Puri 73 69 47 34 27 28
3. S+D 1:1 Tirštos 89 87 81 69 56 51
tesi. kons.
4. S+D 1:2 Biri 87 84 70 62 54 48
5. S+D 1:3 Puri 82 79 63 55 49 36
6. S+D 1:0,5 Tirštos 90 89 84 73 66 58
Tešlos
konsist.
lentelės duomenys rodo, kad sumaišytas sapropelis su durpėmis greičiau džiūsta ir jo struktūra pasidaro puri. Greičiausiai džiūsta durpės ir tas mišinys, kur durpių daugiausiai, t.y. S+D 1:3. Tačiau šis sapropelio ir durpių santykis nėra efektyviausias augalams. Siekiant įvertinti sapropelio ir durpių bei jų mišinio kaip trąšų vertingumą, buvo atlikti bandymai, nustatant šių medžiagų toksiškumą. Kuo mažesnis trąšų toksiškumas, tuo didesni augalų dygimo energija, daigumas ir augimas. Pagal Valstybinį standartąNr.5055-56 buvo nustatyta agurkų veislės “Alfa” sėklų dygimo energija ir daigumas. Escherichia coli bakterinė kultūra buvo įvesta į vandeninę tiriamosios medžiagos ištrauką santykiu (1 : 1). Bandymo rezultatai pateikti 2 lentelėje.
lentelė. Sapropelio - durpių trąšų vertingumo nustatymas
Bandymų variantai Dygimo energija % Daigumas % Augimas pagal E.c.
1. Sapropelis (S) +9 +12 +2
2. Durpės (D) +3 1 -2 -2
3. S + D 1:1 +6 +5 +4
4. S + D 1:2 +3 +3 +3
5. S + D 1:3 +2 +1 +1
6. S + D 1:0,5 +8 +7 +5
lentelės duomenys rodo, kad efektyviausia trąša yra sapropelio ir durpių mišinys 1 : 0,5, tačiau šios trąšos lėtokai džiūsta. Įvertinus abiejų lentelių duomenis buvo nustatyta, kad geriausias trąšų efektyvumas ir palygint neilgas džiovinimo laikas pasiekiam·- Yiant sapropelį su durpėmis sausųjų medžiagų masės santykiu apie 1:1. Toks mišinys gerai išdžiūsta ir gaunama efektyvi trąša.
Pasiūlytos sapropelio trąšos susideda iš sapropelio ir durpių mišinio, kuriame sapropelio ir durpių sausųjų medžiagų masių santykis mišinyje yra nuo 1 : 1 iki 1 : 0,5.
Trąšų gavimo būdas. Nustatomas pradinių medžiagų t.y. sapropelio ir durpių, iš kurių bus gaminamos trąšos, drėgnis. Žinomais literatūroje aprašytais būdais (payzdžiui, sapropelio sausųjų medžiagų kiekis, esant skirtingam žaliavos drėgniui, yra pateiktas grafiko pavidale knygoje L. Katkevičius, A. Ciūnys, E. Bakšienė “Ežerų sapropelis žemės ūkiui”, Vilnius, 1998, 50 psl.) nustatomas santykis tarp atitinkamo drėgnio žaliavos ir sausųjų medžiagų kiekio. Sis santykis pateikiamas 3 lentelėje.
lentelė.
Žaliavos drėgnis, %. Sausųjų medžiagų kiekis, kg/mJ
90% 100 kg/m3
80% 220 kg/m3
70% 360 kg/m3
65% 590 kg/m3
50% 670 kg/m3
40% 820 kg/ m3
30% . 960 kg/m3
Pagal pateiktą lentelę, esant sapropelio drėgniui 70%, sausųjų medžiagų kiekis yra 360 kg/m3, o durpių drėgniui esant apie 40%, sausųjų medžiagų kiekis yra 820 kg/m3, todėl, norint pasiekti minėtų sausųjų medžiagų santykį 1:1, sapropelio kiekį reikia padidinti ne mažiau kaip dvigubai. Esant nurodytam pradinių medžiagų drėgmiui dedama 1 m3 durpių ir 2 m3 sapropelio, po to nurodytu santykiu sudėtos medžiagos mechaniškai sumaišomos. Vėliau mišinys džiovinamas apie 15 parų, kol mišinio drėgnis pasiekia apie 50%.
Pasiūlytų sapropelio trąšų gavimo būdas detaliau paiškintas pateiktuoses pavyzdžiuose.
pavyzdys. Valant užpelkėjusius ežerus iškasamos durpės, kurios būna susiformavusios ežerų pakraščiuose. Durpės vienkaušiu ekskavatoriumi supilamos ant kranto į 2 - 3 m aukščio krūvas. Durpės krūvose greitai išdžiūsta (po 20 dienų jų drėgnis siekia 30 — 4u ir gali būti naudojamos trąšoms gaminti.
Sapropelis kuopiamas atskirai, dažniausiai pulpos pavidale siurbiamas žemsiurbe .> ir plastmasiniais vamzdžiais arba polietileninėmis rankovėmis (žarnomis) transportuojamas į sėsdintuvus, kur supilamas 0,5 m storio sluoksniu. Nuleidus iš sėsdintuvo vandenį sapropelio drėgnis siekia 80 - 85%.
Išdžiūvusios durpės vežamos prie sėsdintuvų, pilamos 0,3 - 0,4 m storio sluoksniu ant sapropelio sluoksnio ir ekskavatoriumi su juo sumaišomos. Po to mišinys dar džiovinamas apie 15 parų. Kai jo drėgnis siekia apie 50%, trąšų mišinys gali būti fasuojamas arba išvežamas autotransportu laukams tręšti.
pavyzdys. Sapropelio ir durpių gavyba vykdoma analogiškai aprašytam pirmajame pavyzdyje. Sapropelis sėsdintuve paliekamas džiūti 15-18 parų, kol jo paviršius sutrūkinėja (jo drėgnis siekia apie 70%). Prie sėsdintuvo atvežamos sausos durpės. Sapropelio ir durpių 6 LT 4864 B maišymas vykdomas betono (ar panašia) maišykle (apie 2/3 tūrio sudaro sapropelis, 1/3 durpės, kad sausųjų medžiagos santykis išliktų 1:1). Mišinio drėgnis siekia 50 - 45%. Po kelių (5-8) parų drėgmė dar sumažėja, mišinys pasidaro purus, birus, jo granulių dydis 0,3 0,8 cm. Mišinys fasuojamas į maišelius.
pavyzdys. Užpelkėjusioje ežero pakrantėje pradžioje vienkaušiu ekskavatoriumi kasamos durpės ir supilamos į 2 - 3 m aukščio krūvas. Po to iš gilesnių sluoksnių kasamos žemiau esantis sapropelis, kraunamas į traktorines priekabas ir išvežamas į sandėliavimo aikštelę, kur paskleidžiamas 0,5 m storio sluoksniu. Po 10 parų sapropelio paviršius sutrūkinėja, jo drėgnis siekia apie 70 %. Tuomet atvežamos išdžiūvusios durpės ir maišomos su sapropeliu pirmajame arba antrajame pavyzdžiuose aprašytu būdu.

Claims (2)

  1. IŠRADIMO APIBRĖŽTIS
    1. Sapropelio trąšos, susidedančios iš sapropelio ir durpių mišinio, besiskiriančios tuo, kad sapropelio ir durpių sausųjų medžiagų masių santykis mišinyje yra nuo 1 : 1 iki
    1 : 0,5.
  2. 2. Sapropelio trąšų pagal 1 punktą gavimo būdas, apimantis sapropelio išėmimą iš ežero, jo paskleidimą sluoksniu aikštelėje, džiovinimą ir džiovinimo metu, periodiškai maišant, durpių įvedimą į sapropelį, besiskiriantis tuo, kad sapropelio ir durpių sausųjų medžiagų masių santykį mišinyje palaiko nuo 1 : 1 iki 1 : 0,5.
LT2001004A 1998-07-06 2001-01-16 Sapropelio trąšos ir jų gavimo būdas LT4864B (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9184798P 1998-07-06 1998-07-06

Publications (2)

Publication Number Publication Date
LT2001004A LT2001004A (lt) 2001-07-25
LT4864B true LT4864B (lt) 2001-11-26

Family

ID=22229932

Family Applications (2)

Application Number Title Priority Date Filing Date
LT2000123A LT4854B (lt) 1998-07-06 2000-12-22 Bifenilsulfonamidai kaip dvigubi angiotenzino ir endotelino receptorių antagonistai
LT2001004A LT4864B (lt) 1998-07-06 2001-01-16 Sapropelio trąšos ir jų gavimo būdas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LT2000123A LT4854B (lt) 1998-07-06 2000-12-22 Bifenilsulfonamidai kaip dvigubi angiotenzino ir endotelino receptorių antagonistai

Country Status (29)

Country Link
EP (2) EP1094816B1 (lt)
JP (2) JP2002519380A (lt)
KR (1) KR20010083092A (lt)
CN (1) CN1149196C (lt)
AT (1) ATE416772T1 (lt)
AU (1) AU767456B2 (lt)
BG (1) BG65404B1 (lt)
BR (1) BR9911621A (lt)
CA (1) CA2336714A1 (lt)
CZ (1) CZ200172A3 (lt)
DE (1) DE69940063D1 (lt)
DK (1) DK1094816T3 (lt)
EE (1) EE200100006A (lt)
ES (1) ES2318899T3 (lt)
GE (1) GEP20033114B (lt)
HU (1) HUP0104634A3 (lt)
ID (1) ID26984A (lt)
IL (1) IL140622A0 (lt)
LT (2) LT4854B (lt)
LV (1) LV12639B (lt)
NO (1) NO20010062L (lt)
NZ (1) NZ508118A (lt)
PL (2) PL203771B1 (lt)
PT (1) PT1094816E (lt)
RU (1) RU2001103044A (lt)
SK (1) SK18822000A3 (lt)
TR (1) TR200100149T2 (lt)
WO (1) WO2000001389A1 (lt)
ZA (1) ZA200006772B (lt)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT6043B (lt) 2012-08-27 2014-06-25 Uab "Mibarsas" Organinės trąšos sapropelio pagrindu ir jų gamybos būdas
LT7101B (lt) 2024-01-16 2024-10-25 Steponavičius Petras Organinės trąšos sapropelio pagrindu ir jų gamybos būdas, panaudojant susmulkintus šiaudus, aukštapelkines durpes ir hidrogelį

Families Citing this family (226)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6541498B2 (en) 1993-05-20 2003-04-01 Texas Biotechnology Benzenesulfonamides and the use thereof to modulate the activity of endothelin
RU2001103044A (ru) * 1998-07-06 2003-08-10 Бристол-Маерс Сквибб Ко. (Us) Бенилсульфонамиды в качестве двойных антагонистов ангиотензиновых эндотелиновых рецепторов
MY125533A (en) 1999-12-06 2006-08-30 Bristol Myers Squibb Co Heterocyclic dihydropyrimidine compounds
ES2273739T3 (es) * 1999-12-15 2007-05-16 Bristol-Myers Squibb Company Bifenil sulfonamidas como dobles antagonistas de receptores de endotelina y angiotensina.
WO2001049289A1 (en) * 1999-12-31 2001-07-12 Texas Biotechnology Corporation Pharmaceutical and veterinary uses of endothelin antagonists
US6271228B1 (en) * 2000-04-28 2001-08-07 Pfizer Inc. Blood pressure stabilization during hemodialysis
US7622503B2 (en) 2000-08-24 2009-11-24 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
CA2430924A1 (en) * 2000-12-01 2002-06-06 Novartis Ag Angiotensin receptor antagonist composition for the treatment of sexual dysfunction associated with hypertension and another condition
ES2329881T3 (es) 2001-09-21 2009-12-02 Bristol-Myers Squibb Company Compuestos que contienen lactama y derivados de los mismos como inhibidores del factor xa.
EP1572892A4 (en) 2001-10-18 2007-08-22 Bristol Myers Squibb Co HUMAN GLUCAGON-LIKE-PEPTIDE-1 MIMICS AND THEIR USE IN THE TREATMENT OF DIABETES AND RELATED CONDITIONS
US7238671B2 (en) 2001-10-18 2007-07-03 Bristol-Myers Squibb Company Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
US8853266B2 (en) 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
US6831102B2 (en) 2001-12-07 2004-12-14 Bristol-Myers Squibb Company Phenyl naphthol ligands for thyroid hormone receptor
TWI328007B (en) * 2002-01-16 2010-08-01 Astrazeneca Ab Novel compounds
TW200307539A (en) 2002-02-01 2003-12-16 Bristol Myers Squibb Co Cycloalkyl inhibitors of potassium channel function
TW200403058A (en) 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
US7435824B2 (en) 2002-04-19 2008-10-14 Bristol-Myers Squibb Company Prodrugs of potassium channel inhibitors
US7405234B2 (en) 2002-05-17 2008-07-29 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
US7057046B2 (en) 2002-05-20 2006-06-06 Bristol-Myers Squibb Company Lactam glycogen phosphorylase inhibitors and method of use
MY139563A (en) 2002-09-04 2009-10-30 Bristol Myers Squibb Co Heterocyclic aromatic compounds useful as growth hormone secretagogues
WO2004037181A2 (en) 2002-10-23 2004-05-06 Bristol-Myers Squibb Company Glycinenitrile-based inhibitors of dipeptidyl peptidase iv and methods
US7098235B2 (en) 2002-11-14 2006-08-29 Bristol-Myers Squibb Co. Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds
TW200504021A (en) 2003-01-24 2005-02-01 Bristol Myers Squibb Co Substituted anilide ligands for the thyroid receptor
US7557143B2 (en) 2003-04-18 2009-07-07 Bristol-Myers Squibb Company Thyroid receptor ligands
US6846836B2 (en) 2003-04-18 2005-01-25 Bristol-Myers Squibb Company N-substituted phenylurea inhibitors of mitochondrial F1F0 ATP hydrolase
US6995183B2 (en) 2003-08-01 2006-02-07 Bristol Myers Squibb Company Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
US7820702B2 (en) 2004-02-04 2010-10-26 Bristol-Myers Squibb Company Sulfonylpyrrolidine modulators of androgen receptor function and method
US7378426B2 (en) 2004-03-01 2008-05-27 Bristol-Myers Squibb Company Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US7625923B2 (en) 2004-03-04 2009-12-01 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
US7696241B2 (en) 2004-03-04 2010-04-13 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
US7772232B2 (en) 2004-04-15 2010-08-10 Bristol-Myers Squibb Company Quinazolinyl compounds as inhibitors of potassium channel function
US7550499B2 (en) 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
US9884038B2 (en) 2004-06-07 2018-02-06 University Of Tennessee Research Foundation Selective androgen receptor modulator and methods of use thereof
US9889110B2 (en) 2004-06-07 2018-02-13 University Of Tennessee Research Foundation Selective androgen receptor modulator for treating hormone-related conditions
TW200611704A (en) 2004-07-02 2006-04-16 Bristol Myers Squibb Co Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions
US7145040B2 (en) 2004-07-02 2006-12-05 Bristol-Myers Squibb Co. Process for the preparation of amino acids useful in the preparation of peptide receptor modulators
US7534763B2 (en) 2004-07-02 2009-05-19 Bristol-Myers Squibb Company Sustained release GLP-1 receptor modulators
US7572805B2 (en) 2004-07-14 2009-08-11 Bristol-Myers Squibb Company Pyrrolo(oxo)isoquinolines as 5HT ligands
US7754755B2 (en) 2004-09-23 2010-07-13 Bristol-Myers Squibb Company Inhibitors of 15-lipoxygenase
AR051446A1 (es) 2004-09-23 2007-01-17 Bristol Myers Squibb Co Glucosidos de c-arilo como inhibidores selectivos de transportadores de glucosa (sglt2)
US7429611B2 (en) 2004-09-23 2008-09-30 Bristol-Myers Squibb Company Indole inhibitors of 15-lipoxygenase
US7517991B2 (en) 2004-10-12 2009-04-14 Bristol-Myers Squibb Company N-sulfonylpiperidine cannabinoid receptor 1 antagonists
US8143425B2 (en) 2004-10-12 2012-03-27 Bristol-Myers Squibb Company Heterocyclic aromatic compounds useful as growth hormone secretagogues
AU2005299693B2 (en) 2004-10-26 2012-07-05 Janssen Pharmaceutica, N.V. Factor Xa compounds
US7589088B2 (en) 2004-12-29 2009-09-15 Bristol-Myers Squibb Company Pyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
US7635699B2 (en) 2004-12-29 2009-12-22 Bristol-Myers Squibb Company Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
US7368458B2 (en) 2005-01-12 2008-05-06 Bristol-Myers Squibb Company Bicyclic heterocycles as cannabinoid receptor modulators
US7361766B2 (en) 2005-01-12 2008-04-22 Bristol-Myers Squibb Company Bicyclic heterocycles as cannabinoid receptor modulators
WO2006076598A2 (en) 2005-01-12 2006-07-20 Bristol-Myers Squibb Company Bicyclic heterocycles as cannabinoid receptor modulators
US7459564B2 (en) 2005-01-13 2008-12-02 Bristol-Myers Squibb Company Substituted biaryl compounds as factor XIa inhibitors
WO2006078697A1 (en) 2005-01-18 2006-07-27 Bristol-Myers Squibb Company Bicyclic heterocycles as cannabinoid receptor modulators
AU2006206611A1 (en) 2005-01-19 2006-07-27 Bristol-Myers Squibb Company 2-phenoxy-N- (1, 3 , 4-thiadizol-2-yl) pyridin-3-amine derivatives and related compounds as P2Y1 receptor inhibitors for the treatment of thromboembolic disorders
WO2006086464A2 (en) 2005-02-10 2006-08-17 Bristol-Myers Squibb Company Dihydroquinazolinones as 5ht modulators
WO2006113261A2 (en) 2005-04-14 2006-10-26 Bristol-Myers Squibb Company Inhibitors of 11-beta hydroxysteroid dehydrogenase type i
US7521557B2 (en) 2005-05-20 2009-04-21 Bristol-Myers Squibb Company Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods
US7452892B2 (en) 2005-06-17 2008-11-18 Bristol-Myers Squibb Company Triazolopyrimidine cannabinoid receptor 1 antagonists
US7317012B2 (en) 2005-06-17 2008-01-08 Bristol-Myers Squibb Company Bicyclic heterocycles as cannabinoind-1 receptor modulators
US7572808B2 (en) 2005-06-17 2009-08-11 Bristol-Myers Squibb Company Triazolopyridine cannabinoid receptor 1 antagonists
US7629342B2 (en) 2005-06-17 2009-12-08 Bristol-Myers Squibb Company Azabicyclic heterocycles as cannabinoid receptor modulators
US7632837B2 (en) 2005-06-17 2009-12-15 Bristol-Myers Squibb Company Bicyclic heterocycles as cannabinoid-1 receptor modulators
WO2007002634A1 (en) 2005-06-27 2007-01-04 Bristol-Myers Squibb Company Carbocycle and heterocycle antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
ES2352796T3 (es) 2005-06-27 2011-02-23 Bristol-Myers Squibb Company Antagonistas cíclicos unidos a c del receptor p2y1 útiles en el tratamiento de afecciones trombóticas.
ATE502924T1 (de) 2005-06-27 2011-04-15 Bristol Myers Squibb Co Lineare harnstoffmimetika-antagonisten des p2y1- rezeptors zur behandlung von thromboseleiden
KR20080027890A (ko) 2005-06-27 2008-03-28 브리스톨-마이어스 스큅 컴퍼니 혈전성 증상의 치료에 유용한 p2y1 수용체의 n-연결헤테로시클릭 길항제
WO2007005967A2 (en) * 2005-07-05 2007-01-11 Teva Pharmaceutical Industries Ltd. Process for preparing valsartan
EP1757290A1 (en) 2005-08-16 2007-02-28 Zentaris GmbH Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors
US7534804B2 (en) 2005-08-24 2009-05-19 Bristol-Myers Squibb Company Benzoxazole inhibitors of 15-lipoxygenase
US7795436B2 (en) 2005-08-24 2010-09-14 Bristol-Myers Squibb Company Substituted tricyclic heterocycles as serotonin receptor agonists and antagonists
DK2425715T3 (da) 2005-08-31 2014-04-28 Univ Tennessee Res Foundation Behandling af symptomer på nyresygdom med selektive, androgenreceptor modulatorer (SARM)
AR056155A1 (es) 2005-10-26 2007-09-19 Bristol Myers Squibb Co Antagonistas del receptor 1 de la hormona de concentracion de melanina no basica
WO2007053819A2 (en) 2005-10-31 2007-05-10 Bristol-Myers Squibb Company Pyrrolidinyl beta-amino amide-based inhibitors of dipeptidyl peptidase iv and methods
US7553836B2 (en) 2006-02-06 2009-06-30 Bristol-Myers Squibb Company Melanin concentrating hormone receptor-1 antagonists
BRPI0708507A2 (pt) * 2006-03-03 2011-05-31 Torrent Pharmaceuticals Ltd Novos antagonistas de receptores de dupla ação (dara) para os receptores at1 eta
WO2007109456A2 (en) * 2006-03-16 2007-09-27 Pharmacopeia, Inc. Substituted biphenyl isoxazole sulfonamides as dual angiotensin endothelin receptor antagonists
WO2007139589A1 (en) 2006-05-26 2007-12-06 Bristol-Myers Squibb Company Sustained release glp-1 receptor modulators
US7919598B2 (en) 2006-06-28 2011-04-05 Bristol-Myers Squibb Company Crystal structures of SGLT2 inhibitors and processes for preparing same
MX2009000385A (es) 2006-07-12 2009-04-06 Univ Tennessee Res Foundation Acil-anilidas sustituidas y metodos de uso de las mismas.
US7727978B2 (en) 2006-08-24 2010-06-01 Bristol-Myers Squibb Company Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors
WO2008043087A2 (en) 2006-10-05 2008-04-10 Cv Therapeutics, Inc. Bicyclic nitrogen-containing heterocyclic compounds for use as stearoyl coa desaturase inhibitors
US7960569B2 (en) 2006-10-17 2011-06-14 Bristol-Myers Squibb Company Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
US9604931B2 (en) 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents
EA201692214A1 (ru) 2007-01-22 2017-11-30 ДЖиТиЭкс, ИНК. Вещества, связывающие ядерные рецепторы
US9623021B2 (en) 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
TW200838501A (en) 2007-02-02 2008-10-01 Theravance Inc Dual-acting antihypertensive agents
PE20090185A1 (es) 2007-03-22 2009-02-28 Bristol Myers Squibb Co Formulaciones farmaceuticas que contienen un inhibidor sglt2
US20080255161A1 (en) * 2007-04-11 2008-10-16 Dmitry Koltun 3-HYDROQUINAZOLIN-4-ONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS
WO2008130951A1 (en) 2007-04-17 2008-10-30 Bristol-Myers Squibb Company Fused heterocyclic 11-beta-hydroxysteroid dehydrogenase type i inhibitors
PE20090696A1 (es) 2007-04-20 2009-06-20 Bristol Myers Squibb Co Formas cristalinas de saxagliptina y procesos para preparar las mismas
WO2008128647A1 (en) 2007-04-23 2008-10-30 Sanofi-Aventis Quinoline-carboxamide derivatives as p2y12 antagonists
TWI448284B (zh) 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
JP2010526146A (ja) 2007-05-04 2010-07-29 ブリストル−マイヤーズ スクイブ カンパニー [6,5]−二環式gpr119gタンパク質結合受容体アゴニスト
JP2010526145A (ja) 2007-05-04 2010-07-29 ブリストル−マイヤーズ スクイブ カンパニー [6,6]および[6,7]−二環式gpr119gタンパク質結合受容体アゴニスト
TWI406850B (zh) 2007-06-05 2013-09-01 Theravance Inc 雙效苯并咪唑抗高血壓劑
US20090011994A1 (en) 2007-07-06 2009-01-08 Bristol-Myers Squibb Company Non-basic melanin concentrating hormone receptor-1 antagonists and methods
EA016595B1 (ru) 2007-07-17 2012-06-29 Бристол-Маерс Сквибб Компани Способ модулирования рецептора gpr119, сопряженного с g-белком, и используемые при этом соединения
CN101808995A (zh) 2007-07-27 2010-08-18 百时美施贵宝公司 新颖的葡糖激酶激活剂及其使用方法
EP2200975A1 (en) 2007-09-07 2010-06-30 Theravance, Inc. Dual-acting antihypertensive agents
US7968603B2 (en) 2007-09-11 2011-06-28 University Of Tennessee Research Foundation Solid forms of selective androgen receptor modulators
BRPI0817211A2 (pt) 2007-09-20 2017-05-16 Irm Llc composto composições como moduladores da atividade de gpr119
ATE555099T1 (de) 2007-12-11 2012-05-15 Theravance Inc Dual wirkende benzimidazol-derivate und deren verwendung als blutdrucksenkende mittel
EP2238128B1 (en) 2007-12-26 2012-08-22 Sanofi Heterocyclic pyrazole-carboxamides as p2y12 antagonists
EP2103602A1 (en) 2008-03-17 2009-09-23 AEterna Zentaris GmbH Novel 1,2,4-triazole derivatives and process of manufacturing thereof
US7989484B2 (en) 2008-04-29 2011-08-02 Theravance, Inc. Dual-acting antihypertensive agents
WO2009143039A2 (en) 2008-05-19 2009-11-26 Schering Corporation Heterocyclic compounds as factor ixa inhibitors
PE20091928A1 (es) 2008-05-29 2009-12-31 Bristol Myers Squibb Co Tienopirimidinas hidroxisustituidas como antagonistas de receptor-1 de hormona concentradora de melanina no basicos
WO2009155448A1 (en) * 2008-06-20 2009-12-23 Ligand Pharmaceuticals Inc. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
TW201006821A (en) 2008-07-16 2010-02-16 Bristol Myers Squibb Co Pyridone and pyridazone analogues as GPR119 modulators
JP2011529072A (ja) 2008-07-24 2011-12-01 セラヴァンス, インコーポレーテッド 二重作用血圧降下薬
US8557983B2 (en) 2008-12-04 2013-10-15 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US20100160322A1 (en) 2008-12-04 2010-06-24 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8563735B2 (en) 2008-12-05 2013-10-22 Abbvie Inc. Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
US8586754B2 (en) 2008-12-05 2013-11-19 Abbvie Inc. BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
NZ595723A (en) * 2009-03-17 2012-10-26 Daiichi Sankyo Co Ltd Amide derivative
CN102448456A (zh) 2009-03-27 2012-05-09 百时美施贵宝公司 用dpp-iv抑制剂预防重度有害心血管事件的方法
ES2811342T3 (es) * 2009-03-31 2021-03-11 Ligand Pharm Inc Antagonista de receptores de endotelina y angiotensina II de bifenilsulfonamida para tratar glomeruloesclerosis y nefropatía inducida por IgA
US20220315555A1 (en) 2009-05-26 2022-10-06 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
KR102001418B1 (ko) 2009-05-26 2019-07-19 애브비 아일랜드 언리미티드 컴퍼니 암,면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제
LT2442791T (lt) 2009-06-16 2020-02-25 Pfizer Inc. Apiksabano vaisto formos
EP2451782B1 (en) 2009-07-07 2016-11-09 Theravance Biopharma R&D IP, LLC Dual-acting pyrazole antihypertensive agents
EP2456762B1 (en) 2009-07-22 2013-10-16 Theravance, Inc. Dual-acting oxazole antihypertensive agents
WO2011014520A2 (en) 2009-07-29 2011-02-03 Irm Llc Compounds and compositions as modulators of gpr119 activity
TWI393716B (zh) 2009-08-04 2013-04-21 Merck Sharp & Dohme 作為ixa因子抑制劑之雜環化合物
US8575168B2 (en) 2009-10-09 2013-11-05 Irm Llc Compounds and compositions as modulators of GPR119 activity
AU2010319377B2 (en) 2009-11-13 2014-10-23 Astrazeneca Ab Immediate release tablet formulations
MX2012005425A (es) 2009-11-13 2012-06-14 Astrazeneca Uk Ltd Formulaciones de metformina de masa reducida.
DK2498758T3 (en) 2009-11-13 2018-10-15 Astrazeneca Ab TWO-LAYER TABLET FORMULATIONS
CN101921265B (zh) * 2009-11-25 2012-07-04 北京理工大学 联苯酰胺四唑类化合物、合成方法及用途
CN101891735B (zh) * 2009-11-25 2012-07-18 北京理工大学 联苯磺胺异噁唑类化合物、合成方法及用途
US8394858B2 (en) 2009-12-03 2013-03-12 Novartis Ag Cyclohexane derivatives and uses thereof
US8481549B2 (en) 2010-01-19 2013-07-09 Theravance, Inc. Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents
TWI562775B (en) 2010-03-02 2016-12-21 Lexicon Pharmaceuticals Inc Methods of using inhibitors of sodium-glucose cotransporters 1 and 2
US8415367B2 (en) 2010-04-08 2013-04-09 Bristol-Myers Squibb Company Pyrimidinylpiperidinyloxypyridinone analogues as GPR119 modulators
ES2559209T3 (es) 2010-04-14 2016-02-11 Bristol-Myers Squibb Company Nuevos activadores de la glucocinasa y métodos de uso de los mismos
EP2566862B1 (en) 2010-05-06 2015-09-16 Bristol-Myers Squibb Company Benzofuranyl analogues as gpr119 modulators
BR112012028445A2 (pt) 2010-05-06 2016-07-19 Bristol Myers Squibb Co compostos de heteroarila bicíclica como moduladores de gpr119
US8697739B2 (en) 2010-07-29 2014-04-15 Novartis Ag Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof
EP2431035A1 (en) 2010-09-16 2012-03-21 Æterna Zentaris GmbH Novel Triazole Derivatives with Improved Receptor Activity and Bioavailability Properties as Ghrelin Antagonists of Growth Hormone Secretagogue Receptors
BR112013009093B1 (pt) 2010-10-29 2022-04-19 Abbvie Inc Processo para a preparação de uma dispersão sólida contendo um agente indutor de apoptose
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
US8722657B2 (en) 2010-11-23 2014-05-13 Abbvie Inc. Salts and crystalline forms of an apoptosis-inducing agent
KR20190109590A (ko) 2010-11-23 2019-09-25 애브비 아일랜드 언리미티드 컴퍼니 선택적인 bcl­2 억제제를 사용하는 치료 방법
CN103327969A (zh) 2010-12-23 2013-09-25 普渡制药公司 抗篡改固体口服剂型
TWI631963B (zh) 2011-01-05 2018-08-11 雷西肯製藥股份有限公司 包含鈉-葡萄糖共同輸送體1與2之抑制劑的組合物與應用方法
BR112014011254A2 (pt) 2011-11-11 2017-05-16 Pfizer 2-tiopirimidinonas
MX2014011373A (es) 2012-04-06 2014-10-14 Pfizer Inhibidores de diacilglicerol aciltransferasa 2.
US9174965B2 (en) 2012-05-16 2015-11-03 Bristol-Myers Squibb Company Pyrimidinylpiperidinyloxypyridone analogues as GPR119 modulators
AU2013274619B2 (en) 2012-06-11 2017-09-28 Bristol-Myers Squibb Company Phosphoramidic acid prodrugs of 5 - [5 - phenyl- 4 - (pyridin- 2 - ylmethylamino) quinazolin- 2 - yl] pyridine- 3 - sulfonamide
US9969683B2 (en) 2012-07-13 2018-05-15 Gtx, Inc. Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
US9744149B2 (en) 2012-07-13 2017-08-29 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10258596B2 (en) 2012-07-13 2019-04-16 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9622992B2 (en) 2012-07-13 2017-04-18 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
PT2872482T (pt) 2012-07-13 2020-09-22 Oncternal Therapeutics Inc Método de tratamento de cancro de mama com modulador seletivo do recetor de andrógeno (sarm)
US10314807B2 (en) 2012-07-13 2019-06-11 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US10987334B2 (en) 2012-07-13 2021-04-27 University Of Tennessee Research Foundation Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)
EP2892897A1 (en) 2012-09-05 2015-07-15 Bristol-Myers Squibb Company Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists
EP2892896B1 (en) 2012-09-05 2016-06-29 Bristol-Myers Squibb Company Pyrrolone or pyrrolidinone melanin concentrating hormore receptor-1 antagonists
WO2014052619A1 (en) 2012-09-27 2014-04-03 Irm Llc Piperidine derivatives and compositions as modulators of gpr119 activity
KR102165224B1 (ko) 2012-11-20 2020-10-13 렉시컨 파마슈티컬스 인코퍼레이티드 나트륨 글루코스 공동수송체 1의 억제제
WO2014143606A1 (en) 2013-03-11 2014-09-18 Bristol-Myers Squibb Company Pyrrolotriazines as potassium ion channel inhibitors
US9050345B2 (en) 2013-03-11 2015-06-09 Bristol-Myers Squibb Company Pyrrolotriazines as potassium ion channel inhibitors
WO2014143609A1 (en) 2013-03-11 2014-09-18 Bristol-Myers Squibb Company Isoquinolines as potassium ion channel inhibitors
US9458164B2 (en) 2013-03-11 2016-10-04 Bristol-Myers Squibb Company Pyrrolopyridazines as potassium ion channel inhibitors
US9242966B2 (en) 2013-03-11 2016-01-26 Bristol-Myers Squibb Company Phthalazines as potassium ion channel inhibitors
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
NZ712479A (en) * 2013-03-15 2019-01-25 Univ Southern California Methods, compounds, and compositions for the treatment of angiotensin-related diseases
ES2665153T3 (es) 2013-10-09 2018-04-24 Pfizer Inc. Antagonistas del receptor EP3 de prostaglandina
US9580422B2 (en) 2013-10-22 2017-02-28 Bristol-Myers Squibb Company Isotopically labeled triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
SI3119757T1 (en) 2014-03-17 2018-08-31 Pfizer Inc. DIACILGLICEROL-ACILTRANSFERAZE 2 BINDERS FOR THE USE IN THE TREATMENT OF PRECIOUS AND RELATED DISEASES
ME03599B (me) 2014-04-04 2020-07-20 Pfizer Biciklički kondenzirani heteroarilni ili arilni spojevi i njihova upotreba kao inhibitora irak4
EP3131897B8 (en) 2014-04-16 2022-08-03 Merck Sharp & Dohme LLC Factor ixa inhibitors
KR20160147007A (ko) 2014-05-30 2016-12-21 화이자 인코포레이티드 선택적인 안드로겐 수용체 조절제로서의 카보니트릴 유도체
EP3237401B1 (en) 2014-12-22 2019-03-06 Pfizer Inc Antagonists of prostaglandin ep3 receptor
CN104761548B (zh) * 2015-04-27 2017-09-12 梯尔希(南京)药物研发有限公司 一种稳定同位素标记的二苯基磺酰胺类药物的制备方法
SG11201708407TA (en) 2015-05-05 2017-11-29 Pfizer 2-thiopyrimidinones
WO2016193844A1 (en) 2015-05-29 2016-12-08 Pfizer Inc. Novel heterocyclic compounds as inhibitors of vanin-1 enzyme
US11472805B2 (en) 2015-06-17 2022-10-18 Pfizer, Inc. Tricyclic compounds and their use as phosphodiesterase inhibitors
WO2016203335A1 (en) 2015-06-18 2016-12-22 Pfizer Inc. Novel pyrido[2,3-b]pyrazinones as bet-family bromodomain inhibitors
CA2995153A1 (en) 2015-08-13 2017-02-16 Pfizer Inc. Bicyclic-fused heteroaryl or aryl compounds
BR112018001650A2 (pt) 2015-08-27 2018-09-18 Pfizer compostos de heteroarila ou arila fundidos bicíclicos como moduladores de irak4
WO2017037567A1 (en) 2015-09-03 2017-03-09 Pfizer Inc. Regulators of frataxin
CN105481844A (zh) * 2015-12-08 2016-04-13 梁彦云 一种治疗高血压的药物组合物
RU2696269C1 (ru) 2015-12-29 2019-08-01 Пфайзер Инк. Замещенные 3-азабицикло[3.1.0]гексаны в качестве ингибиторов кетогексокиназы
CN106188115A (zh) * 2016-07-13 2016-12-07 北京理工大学 廉价高效合成2‑二羟硼基‑n‑二甲异噁唑基‑n‑甲氧乙氧甲基苯磺酰胺的新方法
BR112019000589A2 (pt) 2016-07-14 2019-04-24 Pfizer Inc. pirimidina carboxamidas como inibidores da enzima vanina-1
JP7072557B2 (ja) 2016-07-22 2022-05-20 ブリストル-マイヤーズ スクイブ カンパニー グルコキナーゼ活性化剤およびその使用方法
AR109179A1 (es) 2016-08-19 2018-11-07 Pfizer Inhibidores de diacilglicerol aciltransferasa 2
KR102528435B1 (ko) * 2016-10-13 2023-05-03 트래비어 테라퓨틱스, 인코포레이티드 신장 질환 또는 장애의 치료를 위한 비페닐 설폰아미드 화합물
US10703723B2 (en) 2017-03-09 2020-07-07 Truly Translational Sweden Ab Prodrugs of sulfasalazine, pharmaceutical compositions thereof and their use in the treatment of autoimmune disease
PL3630188T3 (pl) 2017-05-31 2022-01-03 Amplio Pharma Ab Kompozycja farmaceutyczna zawierająca kombinację metotreksatu i nowobiocyny oraz zastosowanie wspomnianej kompozycji w terapii
EP3489222A1 (en) 2017-11-23 2019-05-29 medac Gesellschaft für klinische Spezialpräparate mbH Sulfasalazine salts, production processes and uses
ES2965337T3 (es) 2017-11-23 2024-04-12 Medac Ges Fuer Klinische Spezialpraeparate Mbh Composición farmacéutica para administración oral que contiene sulfasalazina y/o una sal orgánica de sulfasalazina, proceso de producción y uso
WO2019119673A1 (zh) 2017-12-19 2019-06-27 北京吉源生物科技有限公司 一种双基因修饰的干细胞及其用途
WO2019133445A1 (en) 2017-12-28 2019-07-04 Inception Ibd, Inc. Aminothiazoles as inhibitors of vanin-1
MX2021000601A (es) 2018-07-19 2021-04-13 Astrazeneca Ab Metodos de tratamiento de hfpef empleando dapagliflozina y composiciones que comprenden la misma.
MA53496A (fr) 2018-08-31 2021-12-08 Pfizer Combinaisons pour le traitement de la stéatohépatite non alcoolique (nash)/maladie du foie gras non alcoolique (nafld) et de maladies associées
CA3113037A1 (en) 2018-09-26 2020-04-02 Lexicon Pharmaceuticals, Inc. Crystalline forms of n-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oopropan-2-yl)-4-(4-(2-methyl-5-(2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2h-pyran-2-yl)benzyl)phenl)butanamide and methods of their synthesis
CN113286587A (zh) 2018-10-04 2021-08-20 特拉维尔治疗公司 用于治疗iv型胶原病的联苯磺酰胺化合物
WO2020102575A1 (en) 2018-11-16 2020-05-22 Inception Ibd, Inc. Heterocyclic aminothiazoles and uses thereof
US20220387402A1 (en) 2019-05-20 2022-12-08 Pfizer Inc. Combinations comprising benzodioxol as glp-1r agonists for use in the treatment of nash/nafld and related diseases
US20220363673A1 (en) 2019-06-28 2022-11-17 Pfizer Inc. 5-(Thiophen-2-YL)-1 H-Tetrazole Derivative as BCKDK Inhibitors Useful for Treating Various Diseases
TW202115086A (zh) 2019-06-28 2021-04-16 美商輝瑞大藥廠 Bckdk抑制劑
TWI771766B (zh) 2019-10-04 2022-07-21 美商輝瑞股份有限公司 二醯基甘油醯基轉移酶2 抑制劑
JP2022058085A (ja) 2020-02-24 2022-04-11 ファイザー・インク ジアシルグリセロールアシルトランスフェラーゼ2阻害剤とアセチル-CoAカルボキシラーゼ阻害剤との組合せ
PE20231215A1 (es) 2020-06-09 2023-08-17 Pfizer Compuestos espiro como antagonistas del receptor de melanocortina 4 y usos de los mismos
TW202220672A (zh) 2020-07-27 2022-06-01 瑞典商阿斯特捷利康公司 用達格列淨治療慢性腎臟病之方法
WO2022266370A1 (en) 2021-06-17 2022-12-22 Aria Pharmaceuticals, Inc. Sparsentan for treating idiopathic pulmonary fibrosis
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators
WO2023026180A1 (en) 2021-08-26 2023-03-02 Pfizer Inc. Amorphous form of (s)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-n-(tetrahydrofuran-3- yl)pyrimidine-5-carboxamide
CA3229397A1 (en) * 2021-08-26 2023-03-02 Hualing XIAO Aromatic ring-containing biological antagonist, and preparation method therefor and use thereof
JP2024539270A (ja) 2021-10-21 2024-10-28 ニコヤ セラピューティクス(シャンハイ)カンパニー リミテッド 二重アンタゴニスト及びその使用
IL312296A (en) 2021-12-01 2024-06-01 Pfizer 3-PHENYL-1-BENZOTHIOPEN-2-CARBOXYLIC ACID DERIVATIVES AS INHIBITORS OF BRANCHED ALPHA KETO ACID DEHYDROGENSIS KINASE FOR THE TREATMENT OF DIABETES, KIDNEY DISEASES, NASH AND HEART
CA3241470A1 (en) 2021-12-06 2023-06-15 Pfizer Inc. Melanocortin 4 receptor antagonists and uses thereof
WO2023144722A1 (en) 2022-01-26 2023-08-03 Astrazeneca Ab Dapagliflozin for use in the treatment of prediabetes or reducing the risk of developing type 2 diabetes
WO2023169456A1 (en) 2022-03-09 2023-09-14 Gasherbrum Bio , Inc. Heterocyclic glp-1 agonists
WO2023198140A1 (en) 2022-04-14 2023-10-19 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
WO2023224963A1 (en) * 2022-05-16 2023-11-23 Aria Pharmaceuticals, Inc. Dual-acting angiotensin and endothelin receptor antagonists
WO2024075051A1 (en) 2022-10-07 2024-04-11 Pfizer Inc. Hsd17b13 inhibitors and/or degraders
US20240182468A1 (en) 2022-10-18 2024-06-06 Pfizer Inc. Compounds for the activation of ampk
WO2024084360A1 (en) 2022-10-18 2024-04-25 Pfizer Inc. Patatin-like phospholipase domain-containing protein 3 (pnpla3) modifiers
CN115745983A (zh) * 2022-11-23 2023-03-07 深圳信立泰药业股份有限公司 一种血管紧张肽和内皮肽受体拮抗剂及其应用
WO2024125602A1 (en) 2022-12-15 2024-06-20 Gasherbrum Bio, Inc. Salts and solid forms of a compound having glp-1 agonist activity
WO2024127297A1 (en) 2022-12-16 2024-06-20 Pfizer Inc. 3-fluoro-4-hydroxybenzmide-containing inhibitors and/or degraders and uses thereof
WO2024175082A1 (zh) * 2023-02-24 2024-08-29 江苏豪森药业集团有限公司 含芳环类衍生物拮抗剂的盐、其制备方法和应用
WO2024214038A1 (en) 2023-04-14 2024-10-17 Pfizer Inc. Glucose-dependent insulinotropic polypeptide receptor antagonists and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1724657A1 (ru) 1990-02-26 1992-04-07 Научно-Производственный Кооператив "Охрана Природы" Способ приготовлени сапропелевого удобрени
RU2041866C1 (ru) 1994-01-20 1995-08-20 Акционерное предприятие "Сапропель-Неро" Способ добычи и получения сапропелевого удобрения

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
US5240928A (en) * 1989-07-03 1993-08-31 Merck & Co., Inc. Substituted quinazolinones as angiotensin II antagonists
CA2020073A1 (en) * 1989-07-03 1991-01-04 Eric E. Allen Substituted quinazolinones as angiotensin ii antagonists
JPH05503530A (ja) 1990-02-13 1993-06-10 メルク・エンド・カムパニー・インコーポレーテツド 置換ベンジル成分を含むアンギオテンシン2拮抗物質
DE122007000050I1 (de) * 1990-02-19 2007-11-08 Novartis Ag Acylverbindungen
FR2681067B1 (fr) 1991-09-10 1993-12-17 Elf Sanofi Derives heterocycliques n-substitues, leur preparation, les compositions pharmaceutiques en contenant.
IE912956A1 (en) * 1990-09-10 1992-03-11 Abbott Lab Angiotensin ii receptor antagonists
US5250548A (en) * 1990-09-10 1993-10-05 Abbott Laboratories Angiotensin II receptor antagonists
CA2057089A1 (en) 1990-12-07 1992-06-08 Eric E. Allen Substituted pyrazolopyrimidines and imidazopyridazines as angiotensin ii antagonists
TW274551B (lt) 1991-04-16 1996-04-21 Takeda Pharm Industry Co Ltd
CA2079982A1 (en) * 1991-10-07 1993-04-08 Stephen E. De Laszlo Substituted pyrazino (2,3-d)-pyrimidinones as angiotensin ii antagonists
US5674883A (en) * 1992-02-07 1997-10-07 Roussel Uclaf Derivatives of pyridone, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions containing them
US5326776A (en) 1992-03-02 1994-07-05 Abbott Laboratories Angiotensin II receptor antagonists
GB2264710A (en) * 1992-03-04 1993-09-08 Merck & Co Inc Quinoline and azaquinoline angiotensin ii antagonists incorporating a substituted biphenyl element
DE4208304A1 (de) * 1992-03-16 1993-09-23 Merck Patent Gmbh 2-oxochinolinderivate
US5514696A (en) * 1992-05-06 1996-05-07 Bristol-Myers Squibb Co. Phenyl sulfonamide endothelin antagonists
DE4300912A1 (de) 1993-01-15 1994-07-21 Merck Patent Gmbh Chinazolinderivate
US5256658A (en) 1993-01-15 1993-10-26 Ortho Pharmaceutical Corporation Angiotensin II inhibitors
ES2126061T3 (es) 1993-03-24 1999-03-16 American Home Prod Piridopirimidinas substituidas como antihipertensores.
DE4320432A1 (de) 1993-06-21 1994-12-22 Bayer Ag Substituierte Mono- und Bipyridylmethylderivate
ZA945190B (en) 1993-07-30 1995-02-24 Kotobuki Seiyaku Co Ltd Carboxymethylidenecycloheptimidazole derivatives method or manufacturing the same and therapeutic agents containing these compounds
US5674879A (en) 1993-09-24 1997-10-07 G.D. Searle & Co. Compositions including and methods of using conformationally restricted angiotensin II antagonist
US5438136A (en) 1993-11-02 1995-08-01 Merck & Co., Inc. Benzo-fused macrocycles promote release of growth hormone
US5612359A (en) * 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
FR2725987B1 (fr) 1994-10-19 1997-01-10 Sanofi Sa Procede pour la preparation d'un derive de tetrazole sous deux formes cristallines et nouvelle forme cristalline de ce derive
US5760038A (en) * 1995-02-06 1998-06-02 Bristol-Myers Squibb Company Substituted biphenyl sulfonamide endothelin antagonists
IL116916A (en) * 1995-02-06 2000-09-28 Bristol Myers Squibb Co Substituted biphenyl sulfonamide derivatives and pharmaceutical compositions containing the same
EP1048657A1 (en) * 1995-04-04 2000-11-02 Texas Biotechnology Corporation Thienyl-, furyl-, pyrrolyl- and biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
GB9512697D0 (en) * 1995-06-22 1995-08-23 Zeneca Ltd Heterocyclic compounds
US5846990A (en) * 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
CN1211183A (zh) 1996-02-20 1999-03-17 布里斯托尔-迈尔斯斯奎布公司 联苯基异噁唑磺酰胺的制备方法
AU2074297A (en) * 1996-03-12 1997-10-01 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
US5939446A (en) * 1996-04-09 1999-08-17 Bristol-Myers Squibb Co. Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists
IT1283620B1 (it) 1996-04-19 1998-04-22 Luso Farmaco Inst "pirimidin-4-oni n-3 sostituiti ad attivita' aii antagonista"
JPH09291078A (ja) 1996-04-25 1997-11-11 Kyorin Pharmaceut Co Ltd オルトメトキシフェニルピペラジニルアルコキシアリール基を有する新規イミダゾール誘導体及びその製造法
TW536540B (en) 1997-01-30 2003-06-11 Bristol Myers Squibb Co Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
US5846985A (en) * 1997-03-05 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
RU2001103044A (ru) * 1998-07-06 2003-08-10 Бристол-Маерс Сквибб Ко. (Us) Бенилсульфонамиды в качестве двойных антагонистов ангиотензиновых эндотелиновых рецепторов

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1724657A1 (ru) 1990-02-26 1992-04-07 Научно-Производственный Кооператив "Охрана Природы" Способ приготовлени сапропелевого удобрени
RU2041866C1 (ru) 1994-01-20 1995-08-20 Акционерное предприятие "Сапропель-Неро" Способ добычи и получения сапропелевого удобрения

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
L. KATKEVIČIUS, A.CIŪNYS, E.BAKŠIENĖ: "Ežerų sapropelis žemės ūkiui", pages: 30 - 50

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT6043B (lt) 2012-08-27 2014-06-25 Uab "Mibarsas" Organinės trąšos sapropelio pagrindu ir jų gamybos būdas
LT7101B (lt) 2024-01-16 2024-10-25 Steponavičius Petras Organinės trąšos sapropelio pagrindu ir jų gamybos būdas, panaudojant susmulkintus šiaudus, aukštapelkines durpes ir hidrogelį

Also Published As

Publication number Publication date
LV12639B (lv) 2001-09-20
EP1094816A4 (en) 2001-12-19
GEP20033114B (en) 2003-11-25
PL203771B1 (pl) 2009-11-30
CZ200172A3 (cs) 2001-08-15
NZ508118A (en) 2003-07-25
ES2318899T3 (es) 2009-05-01
LT4854B (lt) 2001-11-26
ID26984A (id) 2001-02-22
ZA200006772B (en) 2002-02-20
WO2000001389A1 (en) 2000-01-13
BG105205A (en) 2001-09-28
RU2001103044A (ru) 2003-08-10
PL201048B1 (pl) 2009-03-31
NO20010062L (no) 2001-03-05
SK18822000A3 (sk) 2001-12-03
DK1094816T3 (da) 2009-04-06
AU767456B2 (en) 2003-11-13
CA2336714A1 (en) 2000-01-13
BR9911621A (pt) 2001-10-16
IL140622A0 (en) 2002-02-10
EE200100006A (et) 2002-06-17
TR200100149T2 (tr) 2001-10-22
KR20010083092A (ko) 2001-08-31
EP1094816A1 (en) 2001-05-02
HUP0104634A3 (en) 2002-11-28
EP1094816B1 (en) 2008-12-10
LT2000123A (lt) 2001-07-25
ATE416772T1 (de) 2008-12-15
EP2002837A1 (en) 2008-12-17
PT1094816E (pt) 2009-03-10
JP2010209096A (ja) 2010-09-24
HUP0104634A2 (en) 2002-10-28
AU5088899A (en) 2000-01-24
BG65404B1 (bg) 2008-06-30
LT2001004A (lt) 2001-07-25
PL346443A1 (en) 2002-02-11
CN1308536A (zh) 2001-08-15
NO20010062D0 (no) 2001-01-05
LV12639A (lv) 2001-04-20
DE69940063D1 (de) 2009-01-22
JP2002519380A (ja) 2002-07-02
CN1149196C (zh) 2004-05-12

Similar Documents

Publication Publication Date Title
LT4864B (lt) Sapropelio trąšos ir jų gavimo būdas
US5501718A (en) Method to produce substitute for peat moss
CN101390468B (zh) 红层砂岩边坡创面人工土壤的制备方法
CN102173920B (zh) 含有微生物菌剂的红层砂泥岩互层边坡创面人工土壤的制备方法
Joost et al. Revegetation and minesoil development of coal refuse amended with sewage sludge and limestone
CN106045783A (zh) 一种酸性土壤改良剂及其制备方法
WO2008133488A1 (es) Proceso de composteo semi -estático mejorado para la producción de un sustrato humectante de baja densidad, para su uso en viveros e invernaderos
US9382166B1 (en) Plant nutrient composition
DK166580B1 (da) Fremgangsmaade til omdannelse af ammoniumholdig gylle eller lignende
KR102308209B1 (ko) 친환경 절개지사면 녹화용 조성물의 제조방법
RU2041866C1 (ru) Способ добычи и получения сапропелевого удобрения
PL236167B1 (pl) Sposób wytwarzania nawozów organicznych i nawóz organiczny wytworzony tym sposobem
RU2423812C1 (ru) Способ улучшения агрофизических свойств почвы
SU1599356A1 (ru) Способ получени искусственной почвы
KR100852358B1 (ko) 임목 폐기물 등의 식물 발생재를 재활용한 식물 생육보조재조성물
KR100612767B1 (ko) 폐자원의 재활용을 통한 식물 생육보조재 조성물
KR100353923B1 (ko) 수화반응물질을 이용한 사면 녹화재 조성물 및 그 제조방법
CN112020927A (zh) 一种滨海盐渍土土壤结构改良的方法
JP4892196B2 (ja) 緑化用土壌および緑化用土壌の製造方法ならびに緑化用土壌を用いた緑化方法
RU2786219C1 (ru) Способ получения биопрепаратов
KR100792170B1 (ko) 질소질 구아노를 주성분으로 하는 친환경 유기질 비료
Johnson Peat and Its Uses: As Fertilizer and Fuel
RU2808737C1 (ru) Способ получения техногенного почвогрунта
RU2239619C2 (ru) Композиция органоминеральной смеси для озеленения на основе сапропеля и способ ее получения
RU2818839C1 (ru) Техногенный почвогрунт

Legal Events

Date Code Title Description
MM9A Lapsed patents

Effective date: 20030116