KR970003151B1 - 뉴클레오티드 서열을 검출하는 방법 - Google Patents

뉴클레오티드 서열을 검출하는 방법 Download PDF

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KR970003151B1
KR970003151B1 KR1019890003001A KR890003001A KR970003151B1 KR 970003151 B1 KR970003151 B1 KR 970003151B1 KR 1019890003001 A KR1019890003001 A KR 1019890003001A KR 890003001 A KR890003001 A KR 890003001A KR 970003151 B1 KR970003151 B1 KR 970003151B1
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nucleotide
diagnostic
primer
nucleotides
complementary
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Expired - Lifetime
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Korean (ko)
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KR890014750A (ko
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로버트 뉴톤 클라이브
프레드 마르크함 알렉산더
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제네카 리미티드
조앤 마가렛 칠턴
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Priority claimed from GB888805692A external-priority patent/GB8805692D0/en
Priority claimed from GB888814170A external-priority patent/GB8814170D0/en
Application filed by 제네카 리미티드, 조앤 마가렛 칠턴 filed Critical 제네카 리미티드
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/686Polymerase chain reaction [PCR]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6858Allele-specific amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nonwoven Fabrics (AREA)
  • Communication Cables (AREA)
  • Suspension Of Electric Lines Or Cables (AREA)
KR1019890003001A 1988-03-10 1989-03-10 뉴클레오티드 서열을 검출하는 방법 Expired - Lifetime KR970003151B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB8805692 1988-03-10
GB888805692A GB8805692D0 (en) 1988-03-10 1988-03-10 Method of detecting nucleotide sequences
GB8814170.0 1988-06-15
GB881470.0 1988-06-15
GB888814170A GB8814170D0 (en) 1988-06-15 1988-06-15 Method of detecting nucleotide sequences

Publications (2)

Publication Number Publication Date
KR890014750A KR890014750A (ko) 1989-10-25
KR970003151B1 true KR970003151B1 (ko) 1997-03-14

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KR1019890003001A Expired - Lifetime KR970003151B1 (ko) 1988-03-10 1989-03-10 뉴클레오티드 서열을 검출하는 방법

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US (1) US5595890A (enExample)
EP (1) EP0332435B2 (enExample)
JP (1) JP2853864B2 (enExample)
KR (1) KR970003151B1 (enExample)
CN (1) CN1034673C (enExample)
AT (1) ATE75262T1 (enExample)
AU (1) AU614584B2 (enExample)
BG (1) BG87585A (enExample)
BR (1) BR8901136A (enExample)
CA (1) CA1323592C (enExample)
DE (1) DE68901285D1 (enExample)
DK (1) DK175527B1 (enExample)
ES (1) ES2039294T5 (enExample)
FI (1) FI891126L (enExample)
GR (2) GR3004442T3 (enExample)
HU (1) HUT52565A (enExample)
IE (1) IE61148B1 (enExample)
IL (1) IL89545A (enExample)
MY (1) MY104957A (enExample)
NO (1) NO174825B (enExample)
NZ (1) NZ228266A (enExample)
PL (1) PL162338B1 (enExample)
PT (1) PT89980B (enExample)
TN (1) TNSN89026A1 (enExample)
YU (1) YU49789A (enExample)
ZW (1) ZW3388A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE41590E1 (en) 1999-08-24 2010-08-24 Lg Electronics, Inc. Method for matching rate in mobile communication system

Families Citing this family (270)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4038804A1 (de) 1990-10-09 1992-04-16 Boehringer Mannheim Gmbh Verfahren zur genus- oder/und spezies-spezifischen detektion von bakterien in einer probenfluessigkeit
DE68916671T2 (de) * 1988-03-18 1995-03-02 Baylor College Medicine Mutationsnachweis durch kompetitiven Oligonukleotid-Priming.
FR2650840B1 (fr) * 1989-08-11 1991-11-29 Bertin & Cie Procede rapide de detection et/ou d'identification d'une seule base sur une sequence d'acide nucleique, et ses applications
GB8920097D0 (en) * 1989-09-06 1989-10-18 Ici Plc Amplification processes
JPH03123500A (ja) * 1989-10-06 1991-05-27 Canon Inc 核酸の分別方法
GB9001181D0 (en) * 1990-01-18 1990-03-21 Imp Cancer Res Tech Genetic assay
IL97222A (en) * 1990-02-16 1995-08-31 Orion Yhtymae Oy Method and reagent for determining specific nucleotide variations
US6013431A (en) 1990-02-16 2000-01-11 Molecular Tool, Inc. Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators
GB9006924D0 (en) * 1990-03-28 1990-05-23 Imperial College Prognosis of hepatitis infection
US5844108A (en) * 1990-06-22 1998-12-01 Roche Molecular Systems, Inc. Primers targeted to NAT2 gene for detection of poor metabolizers of drugs
DE69126064T2 (de) * 1990-06-22 1997-08-28 Hoffmann La Roche Nachweis von schwachen Metabolisierungsreagentien von Drogen
GB9019512D0 (en) * 1990-09-06 1990-10-24 Ici Plc Assay method
FR2668162B1 (fr) * 1990-10-17 1993-01-22 Eurobio Lab Fragments d'adn, procede et coffret de diagnostic pour la detection des porteurs de la mutation delta-f-508 responsable de la mucoviscidose.
IE66125B1 (en) * 1991-01-31 1995-12-13 Zeneca Ltd Detection method for variant nucleotides
US6004744A (en) 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer
NZ244089A (en) * 1991-08-27 1995-01-27 Zeneca Ltd Characterising genomic dna samples into individual sample codes using amplification and type specific primers to form a database of individual sample codes
US5853989A (en) * 1991-08-27 1998-12-29 Zeneca Limited Method of characterisation of genomic DNA
DE4129653A1 (de) * 1991-09-06 1993-03-11 Boehringer Mannheim Gmbh Verfahren zum nachweis aehnlicher nukleinsaeuren
IL103935A0 (en) * 1991-12-04 1993-05-13 Du Pont Method for the identification of microorganisms by the utilization of directed and arbitrary dna amplification
US5541060A (en) * 1992-04-22 1996-07-30 Arch Development Corporation Detection of glucokinase-linked early-onset non-insulin-dependent diabetes mellitus
US6207368B1 (en) 1992-08-04 2001-03-27 Beckman Coulter, Inc. Methods and reagents for controlling chain extension and ligation chain reactions
US6180338B1 (en) * 1992-08-04 2001-01-30 Beckman Coulter, Inc. Method, reagent and kit for the detection and amplification of nucleic acid sequences
WO1994008047A1 (en) * 1992-09-25 1994-04-14 Abbott Laboratories Ligase chain reaction method for detecting small mutations
EP0710296A4 (en) * 1993-07-23 1999-05-26 Bio Rad Laboratories LINEAR AMPLIFICATION OF NUCLEIC ACIDS
US6335184B1 (en) 1993-07-23 2002-01-01 Bio-Rad Laboratories, Inc. Linked linear amplification of nucleic acids
AU1911395A (en) * 1994-02-04 1995-08-21 Beckman Instruments, Inc. Method, reagent and kit for the detection and amplification of nucleic acid sequences
AU691958B2 (en) 1994-08-12 1998-05-28 Myriad Genetics, Inc. 17q-linked breast and ovarian cancer susceptibility gene
PT705903E (pt) 1994-08-12 2001-11-30 Myriad Genetics Inc Mutacoes no gene de susceptibilidade para o cancro da mama e do ovario ligado a 17q
FR2737732B1 (fr) * 1995-08-07 1997-10-10 Ass Francaise Contre La Myopat Test co-dominant de diagnostic genetique
US5837492A (en) 1995-12-18 1998-11-17 Myriad Genetics, Inc. Chromosome 13-linked breast cancer susceptibility gene
JP3455228B2 (ja) 1995-12-18 2003-10-14 ミリアド・ジェネティックス・インコーポレイテッド 第13染色体連鎖−乳癌感受性遺伝子
EP2085478A1 (en) 1995-12-22 2009-08-05 University Of Utah Research Foundation A long QT syndrome gene which encodes KVLQT1 and its association with minK
NO960163D0 (no) * 1996-01-15 1996-01-15 Thomas Berg Mutasjonsdeteksjon av bovin
US5612473A (en) * 1996-01-16 1997-03-18 Gull Laboratories Methods, kits and solutions for preparing sample material for nucleic acid amplification
AU2320597A (en) 1996-03-19 1997-10-10 Molecular Tool, Inc. Method for determining the nucleotide sequence of a polynucleotide
GB9609441D0 (en) * 1996-05-04 1996-07-10 Zeneca Ltd Process
US6361940B1 (en) 1996-09-24 2002-03-26 Qiagen Genomics, Inc. Compositions and methods for enhancing hybridization and priming specificity
IL119342A0 (en) * 1996-10-02 1997-01-10 Yeda Research And Development C Methods for priming and DNA sequencing
US5888778A (en) * 1997-06-16 1999-03-30 Exact Laboratories, Inc. High-throughput screening method for identification of genetic mutations or disease-causing microorganisms using segmented primers
US6566101B1 (en) 1997-06-16 2003-05-20 Anthony P. Shuber Primer extension methods for detecting nucleic acids
GB9721240D0 (en) * 1997-10-08 1997-12-03 Zeneca Ltd Assay
US6794133B1 (en) 1997-12-11 2004-09-21 The General Hospital Corporation Broad range PCR amplification techniques
WO1999044045A1 (en) * 1998-02-27 1999-09-02 Massachusetts Institute Of Technology Single molecule detection with surface-enhanced raman scattering and applications in dna or rna sequencing
GB9812768D0 (en) 1998-06-13 1998-08-12 Zeneca Ltd Methods
US6207379B1 (en) 1998-09-11 2001-03-27 One Lambda Method for amplification of DNA
NZ512088A (en) 1998-12-08 2004-01-30 Children S Hospital And Region Polymorphic loci that differentiate escherichia coli 0157:H7 from other strains
US6503718B2 (en) 1999-01-10 2003-01-07 Exact Sciences Corporation Methods for detecting mutations using primer extension for detecting disease
US6280947B1 (en) 1999-08-11 2001-08-28 Exact Sciences Corporation Methods for detecting nucleotide insertion or deletion using primer extension
HK1048339A1 (zh) * 1999-03-18 2003-03-28 埃克西库恩公司 利用特异性lna引物检测基因突变
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US20030207295A1 (en) * 1999-04-20 2003-11-06 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
EP1061134A3 (en) * 1999-06-17 2003-01-08 Becton Dickinson and Company Oligonucleotides for amplification and detection of hemochromatosis genes
US20020025519A1 (en) * 1999-06-17 2002-02-28 David J. Wright Methods and oligonucleotides for detecting nucleic acid sequence variations
US20030165913A1 (en) * 1999-06-17 2003-09-04 Sha-Sha Wang Methods for detecting nucleic acid sequence variations
CA2377707A1 (en) 1999-06-22 2000-12-28 Invitrogen Corporation Improved primers and methods for the detection and discrimination of nucleic acids
US6830902B1 (en) 1999-07-02 2004-12-14 Invitrogen Corporation Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
EP1072679A3 (en) * 1999-07-20 2002-07-31 Agilent Technologies, Inc. (a Delaware corporation) Method of producing nucleic acid molecules with reduced secondary structure
US6528066B1 (en) * 1999-09-14 2003-03-04 University Of Iowa Research Foundation Variant varicella-zoster viruses and methods of use
AU2000278349A1 (en) * 1999-09-28 2001-04-30 Genaissance Pharmaceuticals, Inc. Drug target isogenes: polymorphisms in the interleukin 13 gene
US20030190644A1 (en) 1999-10-13 2003-10-09 Andreas Braun Methods for generating databases and databases for identifying polymorphic genetic markers
US20030148301A1 (en) * 1999-12-10 2003-08-07 Toshiya Aono Method of detecting nucleotide polymorphism
WO2003074738A1 (en) * 2000-01-18 2003-09-12 Quantom Dot Corporation Oligonucleotide-tagged semiconductor nanocrystals for microarray and fluorescence in situ hybridization
US7582420B2 (en) * 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US20050214825A1 (en) * 2000-02-07 2005-09-29 John Stuelpnagel Multiplex sample analysis on universal arrays
US7955794B2 (en) * 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US8076063B2 (en) * 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US7659054B1 (en) * 2000-05-23 2010-02-09 Nuvelo, Inc. Methods for genetic analysis of DNA to detect sequence variances
US7435541B2 (en) * 2000-05-23 2008-10-14 Sequenom, Inc. Restriction enzyme genotyping
AU2000257122A1 (en) * 2000-07-12 2002-01-21 Bionex, Inc. Method for detecting sequence variation of nucleic acid
JP3638516B2 (ja) * 2000-09-28 2005-04-13 株式会社日立製作所 核酸検出方法および核酸検出キット
US6428964B1 (en) 2001-03-15 2002-08-06 Exact Sciences Corporation Method for alteration detection
EP1373574A4 (en) * 2001-03-30 2007-01-03 Ge Healthcare Bio Sciences Ab BIOPUCES ANALYSIS OF SIMPLE POLYMORPHISMS NUCL OTIDE
CN1186456C (zh) * 2001-04-30 2005-01-26 曹卫 通用模板核酸检测方法和试剂盒
US7888324B2 (en) 2001-08-01 2011-02-15 Genzyme Corporation Antisense modulation of apolipoprotein B expression
US7407943B2 (en) 2001-08-01 2008-08-05 Isis Pharmaceuticals, Inc. Antisense modulation of apolipoprotein B expression
EP1430150B1 (en) 2001-09-24 2015-08-19 One Lambda, Inc. Diagnostic probe detection system
US20030165859A1 (en) 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
ATE412068T1 (de) * 2002-02-08 2008-11-15 Olympus Corp Spezifische multiplex-analyse von nukleinsäuren
WO2003071252A2 (en) 2002-02-15 2003-08-28 Exact Sciences Corporation Methods for analysis of molecular events
JP3752466B2 (ja) * 2002-04-24 2006-03-08 株式会社日立製作所 遺伝子検査方法
EP1576174A4 (en) 2002-08-02 2007-07-25 Orchid Cellmark Inc METHOD AND COMPOSITIONS FOR GENOTYPING
US7192700B2 (en) 2002-12-20 2007-03-20 Orchid Cellmark Inc. Methods and compositions for conducting primer extension and polymorphism detection reactions
US9394332B2 (en) * 2002-08-29 2016-07-19 Epigenomics Ag Method for bisulfite treatment
US20040121374A1 (en) * 2002-10-02 2004-06-24 Yoshihide Iwaki Method for detecting single nucleotide polymorphisms
US20040259105A1 (en) * 2002-10-03 2004-12-23 Jian-Bing Fan Multiplex nucleic acid analysis using archived or fixed samples
ATE399882T1 (de) * 2002-11-07 2008-07-15 Yoichi Matsubara Verfahren zum genmutationsnachweis
US7511131B2 (en) 2002-11-13 2009-03-31 Genzyme Corporation Antisense modulation of apolipoprotein B expression
US7820378B2 (en) 2002-11-27 2010-10-26 Sequenom, Inc. Fragmentation-based methods and systems for sequence variation detection and discovery
EP1590362B8 (en) * 2003-01-29 2015-06-03 Epigenomics AG Improved method for bisulfite treatment
WO2004081224A2 (en) * 2003-03-11 2004-09-23 Gene Check, Inc. Reca-assisted allele specific oligonucleotide extension method
CA2520538C (en) 2003-03-31 2014-04-29 F. Hoffmann-La Roche Ag Compositions and methods for detecting certain flaviviruses, including members of the japanese encephalitis virus serogroup
US20040219532A1 (en) * 2003-04-30 2004-11-04 Sampson Jeffrey R. Internal references measurements
US20050181394A1 (en) * 2003-06-20 2005-08-18 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US20040259100A1 (en) * 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
WO2005003304A2 (en) 2003-06-20 2005-01-13 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
GB0317592D0 (en) 2003-07-26 2003-08-27 Astrazeneca Ab Method
ES2743420T3 (es) * 2003-08-29 2020-02-19 Instituto Nac De Tecnologia Agropecuaria Plantas de arroz que tienen tolerancia incrementada frente a herbicidas de imidazolinona
US9394565B2 (en) 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis
CA2547743C (en) 2003-12-02 2011-06-28 F. Hoffmann-La Roche Ag Improved method for bisulfite treatment
US7129049B2 (en) 2003-12-22 2006-10-31 Regents Of The University Of Minnesota Method of detecting equine glycogen storage disease IV
US7432082B2 (en) 2004-03-22 2008-10-07 Basf Ag Methods and compositions for analyzing AHASL genes
US7608394B2 (en) 2004-03-26 2009-10-27 Sequenom, Inc. Methods and compositions for phenotype identification based on nucleic acid methylation
AU2005230936B2 (en) 2004-03-26 2010-08-05 Agena Bioscience, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
US20050287558A1 (en) 2004-05-05 2005-12-29 Crooke Rosanne M SNPs of apolipoprotein B and modulation of their expression
US7939251B2 (en) 2004-05-06 2011-05-10 Roche Molecular Systems, Inc. SENP1 as a marker for cancer
EP2592155B2 (en) 2004-06-04 2019-09-11 Genentech, Inc. EGFR mutations
US20060029954A1 (en) * 2004-06-30 2006-02-09 Applera Corporation Compositions and methods for identifying nucleotides in polynucleotide sequences
EP1776457A1 (en) * 2004-07-30 2007-04-25 BASF Agrochemical Products, B.V. Herbicide-resistant sunflower plants, polynucleotides encoding herbicide-resistant acetohydroxy acid synthase large subunit proteins, and methods of use
WO2006026654A2 (en) 2004-08-27 2006-03-09 Exact Sciences Corporation Method for detecting a recombinant event
EP1632578A1 (en) 2004-09-03 2006-03-08 Roche Diagnostics GmbH DNA decontamination method
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence
JP2006129811A (ja) * 2004-11-08 2006-05-25 Hitachi Ltd 試料核酸の分析方法、分析装置および分析キット
US20060275792A1 (en) * 2004-11-15 2006-12-07 Lee Jun E Enhancement of nucleic acid amplification using double-stranded DNA binding proteins
US20060105348A1 (en) * 2004-11-15 2006-05-18 Lee Jun E Compositions and methods for the detection and discrimination of nucleic acids
GB0428255D0 (en) 2004-12-23 2005-01-26 Health Prot Agency Detection of nucleic acid mutations
MX2007010552A (es) * 2005-03-02 2009-02-19 Inst Nac De Tecnologia Agropec Plantas de arroz resistentes a herbicidas, polinucleotidos que codifican proteinas de subunidad grande de acido acetohidroxi sintasa resistentes a herbicidas, y sus metodos de uso.
GB2424886A (en) 2005-04-04 2006-10-11 Dxs Ltd Polynucleotide primers against epidermal growth factor receptor and method of detecting gene mutations
US20090054320A1 (en) 2005-04-20 2009-02-26 Protemix Discovery Limited Vesiculins
US9777314B2 (en) 2005-04-21 2017-10-03 Esoterix Genetic Laboratories, Llc Analysis of heterogeneous nucleic acid samples
BRPI0612384B1 (pt) * 2005-07-01 2021-10-13 Basf Se Método para controlar ervas daninhas na vizinhança de planta de girassol, molécula isolada de polinucleotídeo, cassete de expressão, vetor de transformação, e, polipeptídeo isolado
GB0514913D0 (en) * 2005-07-20 2005-08-24 Univ Birmingham Polymorphism
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
WO2007136989A2 (en) 2006-05-05 2007-11-29 Isis Pharmaceuticals, Inc. Compounds and methods for modulating expression of dgat2
US7759062B2 (en) 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
KR100812259B1 (ko) * 2006-06-12 2008-03-10 주식회사 씨젠 기지의 서열에 인접한 미지의 dna 서열을 증폭하는 방법
EP2041311A4 (en) 2006-06-23 2010-07-07 Myriad Genetics Inc VARIANTS OF THE DPYD GENE AND THEIR USE
CN101512017A (zh) 2006-09-07 2009-08-19 阿斯利康(瑞典)有限公司 评价用靶向ret受体酪氨酸激酶的药物治疗的患者的方法
US8580945B2 (en) * 2006-11-02 2013-11-12 University Of Utah Oligonucleotides for use in allele-specific PCR
UA108733C2 (uk) 2006-12-12 2015-06-10 Толерантна до гербіциду рослина соняшника
US9938641B2 (en) * 2006-12-18 2018-04-10 Fluidigm Corporation Selection of aptamers based on geometry
EP2097448A4 (en) 2006-12-22 2010-07-21 Univ Utah Res Found PROCEDURE FOR THE EVIDENCE OF EYE DISEASES AND SUFFERINGS AND THEIR TREATMENT
US8314220B2 (en) * 2007-01-26 2012-11-20 Agilent Technologies, Inc. Methods compositions, and kits for detection of microRNA
RU2559536C2 (ru) 2007-03-24 2015-08-10 Джензим Корпорейшн Введение антисмысловых олигонуклеотидов, комплементарных человеческому аполипопротеину в
US10017827B2 (en) 2007-04-04 2018-07-10 Nidera S.A. Herbicide-resistant sunflower plants with multiple herbicide resistant alleles of AHASL1 and methods of use
EP2851091B1 (en) 2007-04-13 2017-12-27 Dana-Farber Cancer Institute, Inc. Methods for treating cancer resistant to ERBB therapeutics
CA2686211C (en) 2007-05-03 2018-08-21 One Lambda Inc. Methods of screening for binding interaction using sets of microparticles and unique probes
AU2008254582A1 (en) 2007-05-21 2008-11-27 Genentech, Inc. Methods and compositions for identifying and treating lupus
CN101801992A (zh) * 2007-05-31 2010-08-11 孟山都技术公司 大豆多态性与基因分型方法
AU2008255641B2 (en) 2007-05-31 2014-03-13 Board Of Regents Of The University Of Texas System Diagnostic markers for ankylosing spondylitis and uses thereof
ES2453108T3 (es) 2007-08-06 2014-04-04 Orion Genomics, Llc Nuevos polimorfismos de un único nucleótido y combinaciones de polimorfismos nuevos y conocidos para determinar la expresión específica de alelo del gen IGF2
CL2008002553A1 (es) 2007-08-29 2009-09-04 Monsanto Technology Llc Metodo de mejoramiento de plantas mediante la introduccion de loci de caracteristicas cuantitativas asociadas con resistencia a la mancha foliar gris.
JP2009077712A (ja) 2007-09-11 2009-04-16 F Hoffmann La Roche Ag B−Rafキナーゼ阻害剤に対する感受性についての診断試験
GB2453173A (en) 2007-09-28 2009-04-01 Dxs Ltd Polynucleotide primers
CA2704809A1 (en) 2007-11-01 2009-05-07 University Of Iowa Research Foundation Rca locus analysis to assess susceptibility to amd and mpgnii
WO2009059199A2 (en) * 2007-11-02 2009-05-07 Hunch Inc. Interactive machine learning advice facility
CA2704487A1 (en) * 2007-11-02 2009-06-18 Luminex Molecular Diagnostics, Inc. One-step target detection assay
JP5188789B2 (ja) * 2007-11-29 2013-04-24 株式会社日立製作所 核酸の定量方法
WO2009098998A1 (ja) 2008-02-05 2009-08-13 Olympus Corporation 核酸検出方法及び核酸検出用キット
CN102098909B (zh) 2008-04-24 2014-12-31 孟山都技术有限公司 鉴定大豆中亚洲大豆锈病抗性数量性状基因座的方法和其组合物
EP2113574A1 (en) 2008-04-28 2009-11-04 Biotype AG Substances and methods for a DNA based profiling assay
US8911948B2 (en) * 2008-04-30 2014-12-16 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
EP2644707B1 (en) 2008-04-30 2015-06-03 Integrated Dna Technologies, Inc. RNase-H-based assays utilizing modified RNA monomers
KR20100080621A (ko) 2008-07-02 2010-07-09 아크레이 가부시키가이샤 표적 핵산 서열의 증폭 방법, 그것을 사용한 변이의 검출 방법, 및, 그것에 사용하는 시약
JP5590781B2 (ja) 2008-07-10 2014-09-17 オリンパス株式会社 標的核酸比率推定方法
EP2337865B1 (en) * 2008-10-20 2014-11-19 Roche Diagnostics GmbH Allele-specific amplification using a primer with a modified nucleotide
EP2186907A1 (en) 2008-11-11 2010-05-19 Deutsches Primatenzentrum GmbH X-chromosomal variation as a diagnostic and therapeutic marker for the progression to AIDS
CA2751758A1 (en) 2009-02-11 2010-08-19 Orion Genomics Llc Combinations of polymorphisms for determining allele-specific expression of igf2
EP3722810A3 (en) 2009-02-11 2021-01-13 Caris MPI, Inc. Molecular profiling of tumors
US9347092B2 (en) * 2009-02-25 2016-05-24 Roche Molecular System, Inc. Solid support for high-throughput nucleic acid analysis
JP5457222B2 (ja) 2009-02-25 2014-04-02 エフ.ホフマン−ラ ロシュ アーゲー 小型化ハイスループット核酸分析
US9107933B2 (en) 2009-03-16 2015-08-18 Isis Pharmaceuticals, Inc. Compositions and methods of targeting apolipoprotein B for the reduction of apolipoprotein C-III
AU2010229994B2 (en) 2009-03-25 2016-08-18 Genentech, Inc. Anti-FGFR3 antibodies and methods using same
WO2010112033A2 (en) 2009-03-31 2010-10-07 Østjysk Innovation A/S Method for estimating the risk of having or developing multiple sclerosis using sequence polymorphisms in a specific region of chromosome x
US20100299773A1 (en) * 2009-05-20 2010-11-25 Monsanto Technology Llc Methods and compositions for selecting an improved plant
CN102686728B (zh) 2009-06-29 2018-09-18 卢米耐克斯公司 具有发夹构象的嵌合引物及其使用方法
CN113025703A (zh) 2009-10-07 2021-06-25 弗·哈夫曼-拉罗切有限公司 用于治疗、诊断和监控狼疮的方法
WO2011056688A2 (en) 2009-10-27 2011-05-12 Caris Life Sciences, Inc. Molecular profiling for personalized medicine
EP2494066B1 (en) * 2009-10-27 2017-04-05 Swift Biosciences, Inc. Bimolecular primers
US8614071B2 (en) 2009-12-11 2013-12-24 Roche Molecular Systems, Inc. Preferential amplification of mRNA over DNA using chemically modified primers
US9238832B2 (en) 2009-12-11 2016-01-19 Roche Molecular Systems, Inc. Allele-specific amplification of nucleic acids
KR101649179B1 (ko) 2010-01-21 2016-08-19 아크레이 가부시키가이샤 표적 서열의 증폭 방법, 다형 검출 방법 및 그것에 사용하는 시약
WO2011128096A1 (en) 2010-04-16 2011-10-20 Roche Diagnostics Gmbh Polymorphism markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
US9340833B2 (en) 2010-04-30 2016-05-17 Arkray, Inc. Method for adjusting amplification efficiency of target polynucleotide
JP5830268B2 (ja) * 2010-04-30 2015-12-09 アークレイ株式会社 標的ポリヌクレオチドの増幅効率の調節方法
GB201008125D0 (en) 2010-05-14 2010-06-30 Biofortuna Ltd Tissue typing assays and kits
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
WO2012071096A2 (en) 2010-09-03 2012-05-31 The Johns Hopkins University Arid1a and ppp2r1a mutations in cancer
WO2012052758A1 (en) 2010-10-22 2012-04-26 Astrazeneca Ab Response biomarkers for iap antagonists in human cancers
US9528157B2 (en) 2011-01-14 2016-12-27 Genefirst Limited Methods, compositions, and kits for determing the presence/absence of a variant nucleic acid sequence
GB201101200D0 (en) 2011-01-24 2011-03-09 King S College Method
BR112013020220B1 (pt) 2011-02-09 2020-03-17 Natera, Inc. Método para determinar o estado de ploidia de um cromossomo em um feto em gestação
WO2012135053A2 (en) 2011-03-25 2012-10-04 Integrated Dna Technologies, Inc. Rnase h-based assays utilizing modified rna monomers
EP2694959B8 (en) 2011-04-01 2019-12-25 Genentech, Inc. Biomarkers for predicting sensitivity to cancer treatments
WO2012149193A2 (en) 2011-04-29 2012-11-01 Monsanto Technology Llc Diagnostic molecular markers for seed lot purity traits in soybeans
EP2704554B1 (en) 2011-05-02 2019-04-10 The Board of Regents of the University of Nebraska Plants with useful traits and related methods
KR20140064924A (ko) 2011-08-31 2014-05-28 에프. 호프만-라 로슈 아게 항-혈관신생 치료와 연관된 고혈압 위험성의 예측 방법
SG10201607224PA (en) 2011-08-31 2016-10-28 Hoffmann La Roche Responsiveness to Angiogenesis Inhibitors
WO2013033611A1 (en) 2011-08-31 2013-03-07 Monsanto Technology Llc Methods and compositions for watermelon firmness
KR20140064971A (ko) 2011-09-19 2014-05-28 제넨테크, 인크. c-met 길항제 및 B-raf 길항제를 포함하는 조합 치료
PE20141562A1 (es) 2011-10-14 2014-11-12 Genentech Inc Anticuerpos anti-htra1 y metodos de uso
CN106011243A (zh) 2011-11-10 2016-10-12 霍夫曼-拉罗奇有限公司 用于治疗、诊断和监测阿尔茨海默病的方法
MX2014006186A (es) 2011-11-23 2014-07-14 Hoffmann La Roche Capacidad de respuesta a los inhibidores de la angiogenesis.
SG11201402510TA (en) 2011-11-30 2014-06-27 Genentech Inc Erbb3 mutations in cancer
CN104114714A (zh) 2011-12-14 2014-10-22 阿斯利康(瑞典)有限公司 Gabr-a2诊断
EP2607495A1 (en) 2011-12-23 2013-06-26 Genomica S.A.U. Method for detection of KRAS mutations
US10294529B2 (en) 2012-04-10 2019-05-21 Life Sciences Research Partners Vzw Microsatellite instability markers in detection of cancer
US10633707B2 (en) 2012-04-10 2020-04-28 Vib Vzw Markers for detecting microsatellite instability in cancer and determining synthetic lethality with inhibition of the DNA base excision repair pathway
WO2013159035A2 (en) 2012-04-19 2013-10-24 Medical College Of Wisconsin, Inc. Highly sensitive surveillance using detection of cell free dna
US10077474B2 (en) 2012-05-29 2018-09-18 Abbott Molecular, Inc. Method of designing primers, method of detecting single nucleotide polymorphisms (SNPs), method of distinguishing SNPs, and related primers, detectable oligonucleotides, and kits
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
EP2711432A1 (en) 2012-09-21 2014-03-26 Genomica S.A.U. Method for detection of BRAF and PI3K mutations
US10314253B2 (en) 2012-12-04 2019-06-11 Seminis Vegetable Seeds, Inc. Methods and compositions for watermelon sex expression
JP6669500B2 (ja) 2013-02-25 2020-03-18 ジェネンテック, インコーポレイテッド 薬物耐性akt変異体を検出し治療するための方法及び組成物
US10294489B2 (en) 2013-03-15 2019-05-21 Board Of Trustees Of Southern Illinois University Soybean resistant to cyst nematodes
WO2014150300A2 (en) 2013-03-15 2014-09-25 Abbott Molecular Inc. Method for amplification and assay of rna fusion gene variants, method of distinguishing same and related primers, probes, and kits
WO2014149356A1 (en) 2013-03-15 2014-09-25 Abbott Molecular Inc. Detection of bisulfite converted nucleotide sequences
EP2977464A4 (en) 2013-03-19 2016-10-19 Toppan Printing Co Ltd PROCEDURE FOR PREDICTING SENSITIVITY TO EGFR HEMMER
US10059999B2 (en) 2013-06-10 2018-08-28 Monsanto Technology Llc Molecular markers associated with soybean tolerance to low iron growth conditions
US10767188B2 (en) 2013-09-25 2020-09-08 Nutech Ventures Methods and compositions for obtaining useful plant traits
NZ630628A (en) 2013-10-08 2015-04-24 Seminis Vegetable Seeds Inc Methods and compositions for peronospora resistance in spinach
JP2015096049A (ja) 2013-11-15 2015-05-21 凸版印刷株式会社 Vegf阻害剤長期奏功性予測方法
NZ630717A (en) 2013-11-27 2016-04-29 Seminis Vegetable Seeds Inc Disease resistance loci in onion
EA202091497A3 (ru) 2014-02-21 2020-12-30 Зингента Партисипейшнс Аг Генетические локусы, связанные с повышенной фертильностью у маиса
NZ630710A (en) 2014-02-27 2016-03-31 Seminis Vegetable Seeds Inc Compositions and methods for peronospora resistance in spinach
JP2017516463A (ja) 2014-03-31 2017-06-22 デバイオファーム インターナショナル エスエイ Fgfr融合体
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
TW201620526A (zh) * 2014-06-17 2016-06-16 愛羅海德研究公司 用於抑制α-1抗胰蛋白酶基因表現之組合物及方法
US10316369B2 (en) 2014-06-27 2019-06-11 Seminis Vegetable Seeds, Inc. Methods and assays for male sterile watermelon
WO2016049531A1 (en) 2014-09-26 2016-03-31 Purecircle Usa Inc. Single nucleotide polymorphism (snp) markers for stevia
EP3005862A1 (en) 2014-10-10 2016-04-13 Seminis Vegetable Seeds, Inc. Melon plants with improved disease tolerance
CN107108740B (zh) 2014-11-05 2021-09-17 豪夫迈·罗氏有限公司 抗fgfr2/3抗体及其使用方法
CN107109494B (zh) 2014-11-10 2023-10-27 豪夫迈·罗氏有限公司 Il-33介导型疾病的治疗方法和诊断方法
US9909169B2 (en) 2014-12-17 2018-03-06 Roche Molecular Systems, Inc. Allele-specific amplification of nucleic acids using blocking oligonucleotides for wild type suppression
HUE053541T2 (hu) 2015-04-28 2021-07-28 Monsanto Technology Llc Eljárások és készítmények brachitikus kukoricanövények elõállítására
CA2981819A1 (en) 2015-04-30 2016-11-03 Monsanto Technology Llc Methods for producing canola plants with clubroot resistance and compositions thereof
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
WO2017031059A1 (en) 2015-08-18 2017-02-23 Monsanto Technology Llc Methods for producing cotton plants with enhanced drought tolerance and compositions thereof
US10448595B2 (en) 2015-09-03 2019-10-22 Seminis Vegetable Seeds, Inc. Downy mildew resistant lettuce plants
US10858709B2 (en) 2015-09-10 2020-12-08 Monsanto Technology Llc Methods for producing corn plants with downy mildew resistance and compositions thereof
SI3368578T1 (sl) 2015-10-30 2021-08-31 F. Hoffmann-La Roche Ag Protitelesa proti HtrA1 in postopki uporabe
BR112018012039A2 (pt) 2015-12-18 2018-12-04 Monsanto Technology Llc métodos para produção de plantas de milho com resistência à helmintosporiose e composições dos mesmos
RU2760913C2 (ru) 2016-04-15 2021-12-01 Натера, Инк. Способы выявления рака легкого
EP3496528A4 (en) 2016-08-11 2020-03-18 Monsanto Technology LLC METHODS AND COMPOSITIONS FOR PRODUCING CORN PLANTS WITH RESISTANCE TO LATE FAILURE
CN109803977B (zh) * 2016-08-17 2023-03-17 菲克特生物科学股份有限公司 核酸产品及其施用方法
AU2017232187B2 (en) 2016-09-30 2023-11-09 Seminis Vegetable Seeds, Inc. Xanthomonas resistant brassica oleracea plants
CA3042722A1 (en) * 2016-11-02 2018-05-11 The Medical College Of Wisconsin, Inc. Methods for assessing risk using mismatch amplification and statistical methods
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
US11031099B2 (en) 2016-11-09 2021-06-08 Roche Molecular Systems, Inc. Detection of sequence variants
WO2018118808A1 (en) 2016-12-19 2018-06-28 The Broad Institute, Inc. Methods of treating autism spectrum disorders
WO2018170436A1 (en) 2017-03-16 2018-09-20 Jacobs Farm Del Cabo Basil with high tolerance to downy mildew
KR20190140952A (ko) 2017-04-24 2019-12-20 제넨테크, 인크. 막관통 및 인접막 도메인에서의 erbb2/her2 돌연변이
IL270723B2 (en) 2017-05-17 2025-01-01 Microbio Pty Ltd Biomarkers and uses thereof
CA3067637A1 (en) 2017-06-20 2018-12-27 The Medical College Of Wisconsin, Inc. Assessing transplant complication risk with total cell-free dna
JP6986299B2 (ja) 2017-07-12 2021-12-22 ジーンキャスト カンパニー リミテッドGenecast Co., Ltd. 遺伝子変異特異性が増加したdna重合酵素およびその活性増加用pcrバッファー組成物
US11648551B2 (en) 2017-12-12 2023-05-16 Essenlix Corporation Sample manipulation and assay with rapid temperature change
US12084720B2 (en) 2017-12-14 2024-09-10 Natera, Inc. Assessing graft suitability for transplantation
PE20211304A1 (es) 2018-02-09 2021-07-20 Genentech Inc Metodos terapeuticos y diagnosticos para enfermedades inflamatorias mediadas por mastocitos
US12024738B2 (en) 2018-04-14 2024-07-02 Natera, Inc. Methods for cancer detection and monitoring
US11268102B2 (en) 2018-05-16 2022-03-08 University Of Florida Research Foundation, Incorporated Compositions and methods for identifying and selecting brachytic locus in solanaceae
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
IL311084A (en) 2018-11-30 2024-04-01 Caris Mpi Inc New generation molecular characterization
CA3145881A1 (en) 2019-01-15 2020-07-23 Seminis Vegetable Seeds, Inc. Green bean plants with improved resistance to sclerotinia sclerotiorum and genetic markers therefor
US11931674B2 (en) 2019-04-04 2024-03-19 Natera, Inc. Materials and methods for processing blood samples
CN114341187A (zh) 2019-07-12 2022-04-12 中外制药株式会社 抗突变型fgfr3抗体及其用途
US11542513B2 (en) 2019-09-26 2023-01-03 Seminis Vegetable Seeds, Inc. Lettuce plants having resistance to Nasonovia ribisnigri biotype Nr:1
WO2021112918A1 (en) 2019-12-02 2021-06-10 Caris Mpi, Inc. Pan-cancer platinum response predictor
WO2021183529A1 (en) 2020-03-11 2021-09-16 Seagen Inc. Methods of treating her2 mutant cancers with tucatinib
US20230110203A1 (en) 2020-03-13 2023-04-13 Medimmune Limited Therapeutic methods for the treatment of subjects with risk alelles in il33
AU2021204717A1 (en) 2020-07-15 2022-02-03 Seminis Vegetable Seeds, Inc. Green Bean Plants with Improved Disease Resistance
EP4217400A1 (en) 2020-09-28 2023-08-02 Seagen Inc. Methods of treating solid tumors driven by her2 alterations with tucatinib in combination with an anti-her2 antibody
MX2023005528A (es) 2020-11-17 2023-06-23 Seagen Inc Metodos de tratamiento del cancer con una combinacion de tucatinib y un anticuerpo anti-pd-1/anti-pd-l1.
US20230193310A1 (en) 2021-12-10 2023-06-22 Seminis Vegetabe Seeds, Inc. Lettuce plants having resistance to downy mildew
US20230404003A1 (en) 2022-06-21 2023-12-21 Seminis Vegetable Seeds, Inc. Novel qtls conferring resistance to cucumber mosaic virus
US20240344079A1 (en) 2023-04-14 2024-10-17 Seminis Vegetable Seeds, Inc. Methods and compositions for peronospora resistance in spinach
WO2024231499A1 (en) 2023-05-10 2024-11-14 Vib Vzw Combinations of short genetic variants in the diagnosis of alzheimer disease

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8311018D0 (en) * 1983-04-22 1983-05-25 Amersham Int Plc Detecting mutations in dna
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
CA1284931C (en) * 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US4851331A (en) * 1986-05-16 1989-07-25 Allied Corporation Method and kit for polynucleotide assay including primer-dependant DNA polymerase
GB8612087D0 (en) * 1986-05-19 1986-06-25 Ici Plc Hybridisation probes
GB8709652D0 (en) * 1987-04-23 1987-05-28 Williamson R Diagnosis of cystic fibrosis
US4994368A (en) * 1987-07-23 1991-02-19 Syntex (U.S.A.) Inc. Amplification method for polynucleotide assays
EP0317239A3 (en) * 1987-11-13 1990-01-17 Native Plants Incorporated Method and device for improved restriction fragment length polymorphism analysis
AU613989B2 (en) * 1987-11-24 1991-08-15 Gen-Probe Incorporated Means and method for enhancing nucleic acid hybridization
AU2735988A (en) * 1987-12-21 1989-07-13 Amoco Corporation Target and background capture methods with amplification for affinity assays
US4999290A (en) * 1988-03-31 1991-03-12 The Board Of Regents, The University Of Texas System Detection of genomic abnormalities with unique aberrant gene transcripts
WO1989010414A1 (en) * 1988-04-28 1989-11-02 Robert Bruce Wallace AMPLIFIED SEQUENCE POLYMORPHISMS (ASPs)
AU629845B2 (en) * 1988-08-30 1992-10-15 Abbott Laboratories Detection and amplification of target nucleic acid sequences
CA1339731C (en) * 1988-10-12 1998-03-17 Charles T. Caskey Multiplex genomic dna amplification for deletion detection
CA2011818A1 (en) * 1989-03-17 1990-09-17 Fred T. Oakes Methods for purification, amplification and detection of a nucleic acid
AU5640090A (en) * 1989-03-21 1990-11-05 Collaborative Research Inc. A dna diagnostic test using an exonuclease activity
CA2013317A1 (en) * 1989-04-17 1990-10-17 Fred T. Oakes Diagnostic kit, primer composition and their use for replication or detection of nucleic acids
US5137806A (en) * 1989-12-11 1992-08-11 Board Of Regents, The University Of Texas System Methods and compositions for the detection of sequences in selected DNA molecules
US6004744A (en) * 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE41590E1 (en) 1999-08-24 2010-08-24 Lg Electronics, Inc. Method for matching rate in mobile communication system
USRE41753E1 (en) 1999-08-24 2010-09-21 Lg Electronics, Inc. Method for matching rate in mobile communication system

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