ATE75262T1 - Verfahren zum nachweis von nukleotid-sequenzen. - Google Patents

Verfahren zum nachweis von nukleotid-sequenzen.

Info

Publication number
ATE75262T1
ATE75262T1 AT89302331T AT89302331T ATE75262T1 AT E75262 T1 ATE75262 T1 AT E75262T1 AT 89302331 T AT89302331 T AT 89302331T AT 89302331 T AT89302331 T AT 89302331T AT E75262 T1 ATE75262 T1 AT E75262T1
Authority
AT
Austria
Prior art keywords
diagnostic
nucleotide sequences
detecting
methods
nucleotide
Prior art date
Application number
AT89302331T
Other languages
English (en)
Inventor
Clive Robert Newton
Alexander Fred Markham
Original Assignee
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26293607&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE75262(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB888805692A external-priority patent/GB8805692D0/en
Priority claimed from GB888814170A external-priority patent/GB8814170D0/en
Application filed by Ici Plc filed Critical Ici Plc
Application granted granted Critical
Publication of ATE75262T1 publication Critical patent/ATE75262T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Nonwoven Fabrics (AREA)
  • Communication Cables (AREA)
  • Suspension Of Electric Lines Or Cables (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT89302331T 1988-03-10 1989-03-09 Verfahren zum nachweis von nukleotid-sequenzen. ATE75262T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB888805692A GB8805692D0 (en) 1988-03-10 1988-03-10 Method of detecting nucleotide sequences
GB888814170A GB8814170D0 (en) 1988-06-15 1988-06-15 Method of detecting nucleotide sequences
EP89302331A EP0332435B2 (de) 1988-03-10 1989-03-09 Verfahren zum Nachweis von Nukleotid-Sequenzen

Publications (1)

Publication Number Publication Date
ATE75262T1 true ATE75262T1 (de) 1992-05-15

Family

ID=26293607

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89302331T ATE75262T1 (de) 1988-03-10 1989-03-09 Verfahren zum nachweis von nukleotid-sequenzen.

Country Status (26)

Country Link
US (1) US5595890A (de)
EP (1) EP0332435B2 (de)
JP (1) JP2853864B2 (de)
KR (1) KR970003151B1 (de)
CN (1) CN1034673C (de)
AT (1) ATE75262T1 (de)
AU (1) AU614584B2 (de)
BG (1) BG87585A (de)
BR (1) BR8901136A (de)
CA (1) CA1323592C (de)
DE (1) DE68901285D1 (de)
DK (1) DK175527B1 (de)
ES (1) ES2039294T5 (de)
FI (1) FI891126A (de)
GR (2) GR3004442T3 (de)
HU (1) HUT52565A (de)
IE (1) IE61148B1 (de)
IL (1) IL89545A (de)
MY (1) MY104957A (de)
NO (1) NO174825B (de)
NZ (1) NZ228266A (de)
PL (1) PL162338B1 (de)
PT (1) PT89980B (de)
TN (1) TNSN89026A1 (de)
YU (1) YU49789A (de)
ZW (1) ZW3388A1 (de)

Families Citing this family (253)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4038804A1 (de) 1990-10-09 1992-04-16 Boehringer Mannheim Gmbh Verfahren zur genus- oder/und spezies-spezifischen detektion von bakterien in einer probenfluessigkeit
ATE108491T1 (de) * 1988-03-18 1994-07-15 Baylor College Medicine Mutationsnachweis durch kompetitiven oligonukleotid-priming.
FR2650840B1 (fr) * 1989-08-11 1991-11-29 Bertin & Cie Procede rapide de detection et/ou d'identification d'une seule base sur une sequence d'acide nucleique, et ses applications
GB8920097D0 (en) * 1989-09-06 1989-10-18 Ici Plc Amplification processes
JPH03123500A (ja) * 1989-10-06 1991-05-27 Canon Inc 核酸の分別方法
GB9001181D0 (en) * 1990-01-18 1990-03-21 Imp Cancer Res Tech Genetic assay
US6013431A (en) 1990-02-16 2000-01-11 Molecular Tool, Inc. Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators
IL97222A (en) * 1990-02-16 1995-08-31 Orion Yhtymae Oy Method and Responder for Determining Special Changes to Nucleotide
GB9006924D0 (en) * 1990-03-28 1990-05-23 Imperial College Prognosis of hepatitis infection
US5844108A (en) * 1990-06-22 1998-12-01 Roche Molecular Systems, Inc. Primers targeted to NAT2 gene for detection of poor metabolizers of drugs
DE69126064T2 (de) * 1990-06-22 1997-08-28 Hoffmann La Roche Nachweis von schwachen Metabolisierungsreagentien von Drogen
GB9019512D0 (en) * 1990-09-06 1990-10-24 Ici Plc Assay method
FR2668162B1 (fr) * 1990-10-17 1993-01-22 Eurobio Lab Fragments d'adn, procede et coffret de diagnostic pour la detection des porteurs de la mutation delta-f-508 responsable de la mucoviscidose.
IE66125B1 (en) * 1991-01-31 1995-12-13 Zeneca Ltd Detection method for variant nucleotides
US6004744A (en) 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer
US5853989A (en) * 1991-08-27 1998-12-29 Zeneca Limited Method of characterisation of genomic DNA
ES2143680T3 (es) * 1991-08-27 2000-05-16 Zeneca Ltd Metodo para caracterizar dna genomico.
DE4129653A1 (de) * 1991-09-06 1993-03-11 Boehringer Mannheim Gmbh Verfahren zum nachweis aehnlicher nukleinsaeuren
IL103935A0 (en) * 1991-12-04 1993-05-13 Du Pont Method for the identification of microorganisms by the utilization of directed and arbitrary dna amplification
US5541060A (en) * 1992-04-22 1996-07-30 Arch Development Corporation Detection of glucokinase-linked early-onset non-insulin-dependent diabetes mellitus
US6207368B1 (en) 1992-08-04 2001-03-27 Beckman Coulter, Inc. Methods and reagents for controlling chain extension and ligation chain reactions
US6180338B1 (en) * 1992-08-04 2001-01-30 Beckman Coulter, Inc. Method, reagent and kit for the detection and amplification of nucleic acid sequences
WO1994008047A1 (en) * 1992-09-25 1994-04-14 Abbott Laboratories Ligase chain reaction method for detecting small mutations
JPH09500539A (ja) * 1993-07-23 1997-01-21 バイオ−ラッド・ラボラトリーズ・インコーポレーテッド 核酸のリンクされた線形増幅
US6335184B1 (en) 1993-07-23 2002-01-01 Bio-Rad Laboratories, Inc. Linked linear amplification of nucleic acids
AU1911395A (en) * 1994-02-04 1995-08-21 Beckman Instruments, Inc. Method, reagent and kit for the detection and amplification of nucleic acid sequences
AU691331B2 (en) 1994-08-12 1998-05-14 Myriad Genetics, Inc. Method for diagnosing a predisposition for breast and ovarian cancer
AU686004B2 (en) 1994-08-12 1998-01-29 Myriad Genetics, Inc. In vivo mutations and polymorphisms in the 17q-linked breast and ovarian cancer susceptibility gene
FR2737732B1 (fr) * 1995-08-07 1997-10-10 Ass Francaise Contre La Myopat Test co-dominant de diagnostic genetique
NZ326525A (en) 1995-12-18 1999-11-29 Endorecherche Inc Chromosome 13-linked breast cancer susceptibility gene
US5837492A (en) 1995-12-18 1998-11-17 Myriad Genetics, Inc. Chromosome 13-linked breast cancer susceptibility gene
ES2325820T3 (es) 1995-12-22 2009-09-18 University Of Utah Research Foundation Gen del sindrome qt largo que codifica kvlqt1 y su asociacion con mink.
NO960163D0 (no) * 1996-01-15 1996-01-15 Thomas Berg Mutasjonsdeteksjon av bovin
US5612473A (en) * 1996-01-16 1997-03-18 Gull Laboratories Methods, kits and solutions for preparing sample material for nucleic acid amplification
AU2320597A (en) 1996-03-19 1997-10-10 Molecular Tool, Inc. Method for determining the nucleotide sequence of a polynucleotide
GB9609441D0 (en) * 1996-05-04 1996-07-10 Zeneca Ltd Process
US6361940B1 (en) 1996-09-24 2002-03-26 Qiagen Genomics, Inc. Compositions and methods for enhancing hybridization and priming specificity
IL119342A0 (en) * 1996-10-02 1997-01-10 Yeda Research And Development C Methods for priming and DNA sequencing
US5888778A (en) * 1997-06-16 1999-03-30 Exact Laboratories, Inc. High-throughput screening method for identification of genetic mutations or disease-causing microorganisms using segmented primers
US6566101B1 (en) 1997-06-16 2003-05-20 Anthony P. Shuber Primer extension methods for detecting nucleic acids
GB9721240D0 (en) * 1997-10-08 1997-12-03 Zeneca Ltd Assay
US6794133B1 (en) 1997-12-11 2004-09-21 The General Hospital Corporation Broad range PCR amplification techniques
WO1999044045A1 (en) * 1998-02-27 1999-09-02 Massachusetts Institute Of Technology Single molecule detection with surface-enhanced raman scattering and applications in dna or rna sequencing
GB9812768D0 (en) * 1998-06-13 1998-08-12 Zeneca Ltd Methods
US6207379B1 (en) 1998-09-11 2001-03-27 One Lambda Method for amplification of DNA
EP1147196A4 (de) 1998-12-08 2002-10-16 Childrens Hosp Medical Center Polymorphe loci die escherichia coli 0157:h7 von anderen stämmen unterscheiden
US6280947B1 (en) 1999-08-11 2001-08-28 Exact Sciences Corporation Methods for detecting nucleotide insertion or deletion using primer extension
US6503718B2 (en) 1999-01-10 2003-01-07 Exact Sciences Corporation Methods for detecting mutations using primer extension for detecting disease
CA2368169C (en) 1999-03-18 2012-07-10 Exiqon A/S Detection of mutations in genes by specific lna primers
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US20030207295A1 (en) * 1999-04-20 2003-11-06 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
US20020025519A1 (en) * 1999-06-17 2002-02-28 David J. Wright Methods and oligonucleotides for detecting nucleic acid sequence variations
EP1061134A3 (de) * 1999-06-17 2003-01-08 Becton Dickinson and Company Oligonukleotide zur Amplifizierung und zum Nachweis von hemochromatosis Genen
US20030165913A1 (en) * 1999-06-17 2003-09-04 Sha-Sha Wang Methods for detecting nucleic acid sequence variations
CA2377707A1 (en) 1999-06-22 2000-12-28 Invitrogen Corporation Improved primers and methods for the detection and discrimination of nucleic acids
US6830902B1 (en) * 1999-07-02 2004-12-14 Invitrogen Corporation Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
EP1072679A3 (de) * 1999-07-20 2002-07-31 Agilent Technologies, Inc. (a Delaware corporation) Methode zur Herstelung von Nucleinsäuremolekülen mit einer reduzierten Sekundärstruktur
DE10038229B4 (de) 1999-08-24 2011-06-09 LG Electronics Inc., Kangnam-gu Verfahren und Vorrichtung zur Ratenanpassung in einem Mobilkommunikationssystem
US6528066B1 (en) 1999-09-14 2003-03-04 University Of Iowa Research Foundation Variant varicella-zoster viruses and methods of use
AU2000278349A1 (en) * 1999-09-28 2001-04-30 Genaissance Pharmaceuticals, Inc. Drug target isogenes: polymorphisms in the interleukin 13 gene
US20030148301A1 (en) * 1999-12-10 2003-08-07 Toshiya Aono Method of detecting nucleotide polymorphism
WO2003074738A1 (en) * 2000-01-18 2003-09-12 Quantom Dot Corporation Oligonucleotide-tagged semiconductor nanocrystals for microarray and fluorescence in situ hybridization
US20050214825A1 (en) * 2000-02-07 2005-09-29 John Stuelpnagel Multiplex sample analysis on universal arrays
US8076063B2 (en) * 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US7955794B2 (en) * 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7659054B1 (en) * 2000-05-23 2010-02-09 Nuvelo, Inc. Methods for genetic analysis of DNA to detect sequence variances
US7435541B2 (en) * 2000-05-23 2008-10-14 Sequenom, Inc. Restriction enzyme genotyping
AU2000257122A1 (en) * 2000-07-12 2002-01-21 Bionex, Inc. Method for detecting sequence variation of nucleic acid
JP3638516B2 (ja) * 2000-09-28 2005-04-13 株式会社日立製作所 核酸検出方法および核酸検出キット
US6428964B1 (en) 2001-03-15 2002-08-06 Exact Sciences Corporation Method for alteration detection
US6986992B2 (en) * 2001-03-30 2006-01-17 Amersham Biosciences Ab P450 single nucleotide polymorphism biochip analysis
CN1186456C (zh) * 2001-04-30 2005-01-26 曹卫 通用模板核酸检测方法和试剂盒
US7407943B2 (en) 2001-08-01 2008-08-05 Isis Pharmaceuticals, Inc. Antisense modulation of apolipoprotein B expression
US7888324B2 (en) 2001-08-01 2011-02-15 Genzyme Corporation Antisense modulation of apolipoprotein B expression
CA2460759C (en) 2001-09-24 2011-05-31 One Lambda Diagnostic probe detection system
US20030165859A1 (en) * 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
DK1474529T3 (da) * 2002-02-08 2009-02-23 Olympus Corp Specifik multipleksanalyse af nucleinsyrer
US7776524B2 (en) 2002-02-15 2010-08-17 Genzyme Corporation Methods for analysis of molecular events
JP3752466B2 (ja) * 2002-04-24 2006-03-08 株式会社日立製作所 遺伝子検査方法
CA2497570A1 (en) 2002-08-02 2004-02-12 Orchid Biosciences, Inc. Methods and compositions for genotyping
US7192700B2 (en) 2002-12-20 2007-03-20 Orchid Cellmark Inc. Methods and compositions for conducting primer extension and polymorphism detection reactions
AU2003236461B2 (en) * 2002-08-29 2009-05-28 Epigenomics Ag Improved method for bisulfite treatment
US20040121374A1 (en) * 2002-10-02 2004-06-24 Yoshihide Iwaki Method for detecting single nucleotide polymorphisms
US20040259105A1 (en) * 2002-10-03 2004-12-23 Jian-Bing Fan Multiplex nucleic acid analysis using archived or fixed samples
WO2004042057A1 (ja) * 2002-11-07 2004-05-21 Daiichi Pure Chemicals Co., Ltd. 遺伝子変異検出法
US7511131B2 (en) 2002-11-13 2009-03-31 Genzyme Corporation Antisense modulation of apolipoprotein B expression
AU2003298733B2 (en) 2002-11-27 2009-06-18 Agena Bioscience, Inc. Fragmentation-based methods and systems for sequence variation detection and discovery
JP2006516391A (ja) * 2003-01-29 2006-07-06 エフ．ホフマン−ラ　ロシュ　アーゲー 重亜硫酸塩処理の改良された方法
CA2518452A1 (en) * 2003-03-11 2004-09-23 Gene Check, Inc. Reca-assisted allele specific oligonucleotide extension method for detecting mutations, snps and specific sequences
JP4782668B2 (ja) 2003-03-31 2011-09-28 エフ．ホフマン−ラ ロシュ アーゲー 日本脳炎ウィルス血清グループのメンバーを包含する一定のフラビウィルスを検出するための組成物及び方法
US20040219532A1 (en) * 2003-04-30 2004-11-04 Sampson Jeffrey R. Internal references measurements
US20040259100A1 (en) * 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US20050181394A1 (en) * 2003-06-20 2005-08-18 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
EP1636337A4 (de) * 2003-06-20 2007-07-04 Illumina Inc Verfahren und zusammensetzungen zur ganzgenomischen amplifikation und genotypisierung
GB0317592D0 (en) 2003-07-26 2003-08-27 Astrazeneca Ab Method
ES2743420T3 (es) * 2003-08-29 2020-02-19 Instituto Nac De Tecnologia Agropecuaria Plantas de arroz que tienen tolerancia incrementada frente a herbicidas de imidazolinona
WO2005024068A2 (en) 2003-09-05 2005-03-17 Sequenom, Inc. Allele-specific sequence variation analysis
US7501240B2 (en) 2003-12-02 2009-03-10 Roche Molecular Systems, Inc. Method for bisulfite treatment
US7129049B2 (en) 2003-12-22 2006-10-31 Regents Of The University Of Minnesota Method of detecting equine glycogen storage disease IV
US7432082B2 (en) 2004-03-22 2008-10-07 Basf Ag Methods and compositions for analyzing AHASL genes
WO2005098050A2 (en) 2004-03-26 2005-10-20 Sequenom, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
US20050287558A1 (en) 2004-05-05 2005-12-29 Crooke Rosanne M SNPs of apolipoprotein B and modulation of their expression
US7939251B2 (en) 2004-05-06 2011-05-10 Roche Molecular Systems, Inc. SENP1 as a marker for cancer
EP3042964A1 (de) 2004-06-04 2016-07-13 Genentech, Inc. Egfr-mutationen
WO2006005081A2 (en) * 2004-06-30 2006-01-12 Applera Corporation Compositions and methods for identifying nucleotides in polynucleotide sequences
WO2006024351A1 (en) * 2004-07-30 2006-03-09 Basf Agrochemical Products B.V. Herbicide-resistant sunflower plants, plynucleotides encoding herbicide-resistant acetohydroxy acid synthase large subunit proteins, and methods of use
US7981607B2 (en) 2004-08-27 2011-07-19 Esoterix Genetic Laboratories LLC Method for detecting recombinant event
EP1632578A1 (de) 2004-09-03 2006-03-08 Roche Diagnostics GmbH Methode zur Dekontamination der DNA
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence
JP2006129811A (ja) * 2004-11-08 2006-05-25 Hitachi Ltd 試料核酸の分析方法、分析装置および分析キット
US20060275792A1 (en) * 2004-11-15 2006-12-07 Lee Jun E Enhancement of nucleic acid amplification using double-stranded DNA binding proteins
US20060105348A1 (en) * 2004-11-15 2006-05-18 Lee Jun E Compositions and methods for the detection and discrimination of nucleic acids
GB0428255D0 (en) 2004-12-23 2005-01-26 Health Prot Agency Detection of nucleic acid mutations
ES2692594T1 (es) * 2005-03-02 2018-12-04 Instituto Nacional De Tecnologia Agropecuaria Plantas de arroz resistentes a herbicidas, polinucleótidos que codifican proteínas de la subunidad grande de la acetohidroxiácido sintasa resistentes a herbicidas y métodos para su uso
GB2424886A (en) 2005-04-04 2006-10-11 Dxs Ltd Polynucleotide primers against epidermal growth factor receptor and method of detecting gene mutations
WO2006112737A1 (en) 2005-04-20 2006-10-26 Protemix Discovery Limited Vesiculins
US9777314B2 (en) 2005-04-21 2017-10-03 Esoterix Genetic Laboratories, Llc Analysis of heterogeneous nucleic acid samples
ES2581478T3 (es) * 2005-07-01 2016-09-06 Basf Se Plantas de girasol resistentes a herbicidas, polinucleótidos que codifican para proteínas de la subunidad grande de la acetohidroxiácido sintasa resistentes a herbicidas y procedimientos de uso
GB0514913D0 (en) * 2005-07-20 2005-08-24 Univ Birmingham Polymorphism
CN103554205A (zh) 2006-05-05 2014-02-05 Isis制药公司 调节gccr的表达的化合物和方法
US7759062B2 (en) 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
KR100812259B1 (ko) * 2006-06-12 2008-03-10 주식회사 씨젠 기지의 서열에 인접한 미지의 ｄｎａ 서열을 증폭하는 방법
EP2377953A1 (de) 2006-06-23 2011-10-19 Myriad Genetics, Inc. Varianten des DPYD-Gens und ihre Verwendung
US20110028498A1 (en) 2006-09-07 2011-02-03 Anderson Joseph Ryan Method for evaluating patients for treatment with drugs targeting ret receptor tyrosine kinase
WO2008070370A2 (en) * 2006-11-02 2008-06-12 University Of Utah Research Foundation Oligonucleotides for use in allele-specific pcr
UA108733C2 (uk) 2006-12-12 2015-06-10 Толерантна до гербіциду рослина соняшника
US9938641B2 (en) * 2006-12-18 2018-04-10 Fluidigm Corporation Selection of aptamers based on geometry
EP2913341A1 (de) 2006-12-22 2015-09-02 University of Utah Research Foundation Verfahren für den Nachweis von Augenerkrankungen und leiden sowie ihre Behandlung
US8314220B2 (en) * 2007-01-26 2012-11-20 Agilent Technologies, Inc. Methods compositions, and kits for detection of microRNA
JP2010522245A (ja) 2007-03-24 2010-07-01 ゲンザイム コーポレイション ヒトアポリポタンパク質ｂと相補的なアンチセンスオリゴヌクレオチドの投与
US10017827B2 (en) 2007-04-04 2018-07-10 Nidera S.A. Herbicide-resistant sunflower plants with multiple herbicide resistant alleles of AHASL1 and methods of use
ES2529790T3 (es) 2007-04-13 2015-02-25 Dana-Farber Cancer Institute, Inc. Métodos de tratamiento de cáncer resistente a agentes terapéuticos de ERBB
BRPI0810917A2 (pt) 2007-05-03 2014-10-29 One Lambda Inc Métodos do exame para interação obrigatória usando jogos das micropartículas e de pontas de prova originais
AU2008254582A1 (en) 2007-05-21 2008-11-27 Genentech, Inc. Methods and compositions for identifying and treating lupus
CN101801992A (zh) * 2007-05-31 2010-08-11 孟山都技术公司 大豆多态性与基因分型方法
AU2008255641B2 (en) 2007-05-31 2014-03-13 Board Of Regents Of The University Of Texas System Diagnostic markers for ankylosing spondylitis and uses thereof
EP2185726B1 (de) 2007-08-06 2014-01-08 Orion Genomics, LLC Neue einzelnukleotid-polymorphismen und kombinationen neuer und bekannter polymorphismen zur bestimmung der allelspezifischen expression des igf2-gens
CL2008002553A1 (es) 2007-08-29 2009-09-04 Monsanto Technology Llc Metodo de mejoramiento de plantas mediante la introduccion de loci de caracteristicas cuantitativas asociadas con resistencia a la mancha foliar gris.
CA2639416C (en) 2007-09-11 2019-12-31 F. Hoffmann-La Roche Ag Diagnostic test for susceptibility to b-raf kinase inhibitors
GB2453173A (en) 2007-09-28 2009-04-01 Dxs Ltd Polynucleotide primers
WO2009059321A2 (en) 2007-11-01 2009-05-07 University Of Iowa Research Foundation Rca locus analysis to assess susceptibility to amd and mpgnii
CA2704487A1 (en) * 2007-11-02 2009-06-18 Luminex Molecular Diagnostics, Inc. One-step target detection assay
US7958066B2 (en) * 2007-11-02 2011-06-07 Hunch Inc. Interactive machine learning advice facility
JP5188789B2 (ja) * 2007-11-29 2013-04-24 株式会社日立製作所 核酸の定量方法
WO2009098998A1 (ja) 2008-02-05 2009-08-13 Olympus Corporation 核酸検出方法及び核酸検出用キット
US8669414B2 (en) 2008-04-24 2014-03-11 Monsanto Technology Llc Method to identify Asian soybean rust resistance quantitative trait loci in soybean and compositions thereof
EP2113574A1 (de) 2008-04-28 2009-11-04 Biotype AG Stoffe und Verfahren für Profilierungstest auf DNA-Basis
US8911948B2 (en) * 2008-04-30 2014-12-16 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
US9434988B2 (en) 2008-04-30 2016-09-06 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
EP2644710B1 (de) 2008-04-30 2016-12-21 Integrated Dna Technologies, Inc. Rnase-h-basierte assays unter verwendung von modifizierten rna monomeren
WO2010001969A1 (ja) 2008-07-02 2010-01-07 アークレイ株式会社 標的核酸配列の増幅方法、それを用いた変異の検出方法、および、それに用いる試薬
JP5590781B2 (ja) 2008-07-10 2014-09-17 オリンパス株式会社 標的核酸比率推定方法
WO2010046067A1 (en) * 2008-10-20 2010-04-29 Roche Diagnostics Gmbh Improved allele-specific amplification
EP2186907A1 (de) 2008-11-11 2010-05-19 Deutsches Primatenzentrum GmbH X-chromosomale Variation als diagnostischer und therapeutischer Marker für den Fortschritt von AIDS
JP5748672B2 (ja) 2009-02-11 2015-07-15 オリオン ゲノミクス エルエルシー Ｉｇｆ２の対立遺伝子特異的な発現を判定するための多型の組み合わせ
EP3722810A3 (de) 2009-02-11 2021-01-13 Caris MPI, Inc. Molekulare profilierung von tumoren
US9347092B2 (en) * 2009-02-25 2016-05-24 Roche Molecular System, Inc. Solid support for high-throughput nucleic acid analysis
JP5457222B2 (ja) 2009-02-25 2014-04-02 エフ．ホフマン−ラ ロシュ アーゲー 小型化ハイスループット核酸分析
US9107933B2 (en) 2009-03-16 2015-08-18 Isis Pharmaceuticals, Inc. Compositions and methods of targeting apolipoprotein B for the reduction of apolipoprotein C-III
HUE061117T2 (hu) 2009-03-25 2023-05-28 Genentech Inc Anti-FGFR3 antitestek és eljárások alkalmazásukra
WO2010112033A2 (en) 2009-03-31 2010-10-07 Østjysk Innovation A/S Method for estimating the risk of having or developing multiple sclerosis using sequence polymorphisms in a specific region of chromosome x
US20100299773A1 (en) * 2009-05-20 2010-11-25 Monsanto Technology Llc Methods and compositions for selecting an improved plant
EP2789689B1 (de) 2009-06-29 2016-04-27 Luminex Corporation Chimäre Primer mit Haarnadel-Konformationen und Verfahren zur Verwendung davon
RU2016131167A (ru) 2009-10-07 2018-12-07 Дженентек, Инк. Способы лечения, диагностики и мониторинга волчанки
WO2011056688A2 (en) 2009-10-27 2011-05-12 Caris Life Sciences, Inc. Molecular profiling for personalized medicine
JP6147502B2 (ja) * 2009-10-27 2017-06-14 スウィフト バイオサイエンシーズ， インコーポレイテッド ポリヌクレオチドプライマー及びプローブ
US9238832B2 (en) 2009-12-11 2016-01-19 Roche Molecular Systems, Inc. Allele-specific amplification of nucleic acids
US8614071B2 (en) 2009-12-11 2013-12-24 Roche Molecular Systems, Inc. Preferential amplification of mRNA over DNA using chemically modified primers
US9284603B2 (en) 2010-01-21 2016-03-15 Arkray, Inc. Target sequence amplification method, polymorphism detection method, and reagents for use in the methods
WO2011128096A1 (en) 2010-04-16 2011-10-20 Roche Diagnostics Gmbh Polymorphism markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
JP5830268B2 (ja) * 2010-04-30 2015-12-09 アークレイ株式会社 標的ポリヌクレオチドの増幅効率の調節方法
US9340833B2 (en) 2010-04-30 2016-05-17 Arkray, Inc. Method for adjusting amplification efficiency of target polynucleotide
GB201008125D0 (en) 2010-05-14 2010-06-30 Biofortuna Ltd Tissue typing assays and kits
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
WO2012071096A2 (en) 2010-09-03 2012-05-31 The Johns Hopkins University Arid1a and ppp2r1a mutations in cancer
WO2012052758A1 (en) 2010-10-22 2012-04-26 Astrazeneca Ab Response biomarkers for iap antagonists in human cancers
US9528157B2 (en) 2011-01-14 2016-12-27 Genefirst Limited Methods, compositions, and kits for determing the presence/absence of a variant nucleic acid sequence
GB201101200D0 (en) 2011-01-24 2011-03-09 King S College Method
AU2011358564B9 (en) 2011-02-09 2017-07-13 Natera, Inc Methods for non-invasive prenatal ploidy calling
PL2694959T3 (pl) 2011-04-01 2020-05-18 Genentech, Inc. Biomarkery do przewidywania wrażliwości w leczeniu nowotworu złośliwego
WO2012149193A2 (en) 2011-04-29 2012-11-01 Monsanto Technology Llc Diagnostic molecular markers for seed lot purity traits in soybeans
CN103796508B (zh) 2011-05-02 2017-05-03 内布拉斯加大学评议会 具有有用性状的植物和相关方法
WO2013030168A1 (en) 2011-08-31 2013-03-07 F. Hoffmann-La Roche Ag Method for predicting risk of hypertension associated with anti-angiogenesis therapy
HUE059863T2 (hu) 2011-08-31 2023-01-28 Seminis Vegetable Seeds Inc Eljárás és készítmények görögdinnye keménységhez
JP2014526900A (ja) 2011-08-31 2014-10-09 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 血管新生阻害剤に対する応答性
CN103930111A (zh) 2011-09-19 2014-07-16 霍夫曼-拉罗奇有限公司 包含c-met拮抗剂和b-raf拮抗剂的组合治疗
CN103917556B (zh) 2011-10-14 2018-02-06 霍夫曼-拉罗奇有限公司 抗HtrA1抗体及使用方法
CA2854779A1 (en) 2011-11-10 2013-05-16 Genentech, Inc. Methods for treating, diagnosing and monitoring alzheimer's disease
CN104066852A (zh) 2011-11-23 2014-09-24 霍夫曼-拉罗奇有限公司 对血管发生抑制剂的响应性
RU2019103083A (ru) 2011-11-30 2019-03-22 Дженентек, Инк. МУТАЦИИ ErbB3 ПРИ РАКЕ
EP2791352A1 (de) 2011-12-14 2014-10-22 Astrazeneca AB Gabr-a2-diagnostik
EP2607495A1 (de) 2011-12-23 2013-06-26 Genomica S.A.U. Verfahren zur Erkennung von KRAS-Mutationen
US10294529B2 (en) 2012-04-10 2019-05-21 Life Sciences Research Partners Vzw Microsatellite instability markers in detection of cancer
US10633707B2 (en) 2012-04-10 2020-04-28 Vib Vzw Markers for detecting microsatellite instability in cancer and determining synthetic lethality with inhibition of the DNA base excision repair pathway
EP3741871A3 (de) 2012-04-19 2021-02-17 The Medical College of Wisconsin, Inc. Hochempfindliche überwachung mittels nachweis von zellfreier dna
US10077474B2 (en) 2012-05-29 2018-09-18 Abbott Molecular, Inc. Method of designing primers, method of detecting single nucleotide polymorphisms (SNPs), method of distinguishing SNPs, and related primers, detectable oligonucleotides, and kits
EP2711432A1 (de) 2012-09-21 2014-03-26 Genomica S.A.U. Verfahren zur Detektion von BRAF- und PI3K-Mutationen
US10314253B2 (en) 2012-12-04 2019-06-11 Seminis Vegetable Seeds, Inc. Methods and compositions for watermelon sex expression
CA2901126C (en) 2013-02-25 2022-01-25 Genentech, Inc. Methods and compositions for detecting and treating drug resistant akt mutant
WO2014150300A2 (en) 2013-03-15 2014-09-25 Abbott Molecular Inc. Method for amplification and assay of rna fusion gene variants, method of distinguishing same and related primers, probes, and kits
US10294489B2 (en) 2013-03-15 2019-05-21 Board Of Trustees Of Southern Illinois University Soybean resistant to cyst nematodes
CN105026580A (zh) 2013-03-15 2015-11-04 雅培分子公司 重亚硫酸盐转化的核苷酸序列的检测
JP6520705B2 (ja) 2013-03-19 2019-05-29 凸版印刷株式会社 Ｅｇｆｒ阻害剤感受性予測方法
US10059999B2 (en) 2013-06-10 2018-08-28 Monsanto Technology Llc Molecular markers associated with soybean tolerance to low iron growth conditions
US10767188B2 (en) 2013-09-25 2020-09-08 Nutech Ventures Methods and compositions for obtaining useful plant traits
JP2015096049A (ja) 2013-11-15 2015-05-21 凸版印刷株式会社 Ｖｅｇｆ阻害剤長期奏功性予測方法
NZ791803A (en) 2013-11-27 2023-02-24 Seminis Vegetable Seeds Inc Disease resistance loci in onion
CA2939580C (en) 2014-02-21 2020-07-21 Syngenta Participations Ag Genetic loci associated with increased fertility in maize
NZ630710A (en) 2014-02-27 2016-03-31 Seminis Vegetable Seeds Inc Compositions and methods for peronospora resistance in spinach
SG11201607772WA (en) 2014-03-31 2016-10-28 Debiopharm Int Sa Fgfr fusions
TW201620526A (zh) * 2014-06-17 2016-06-16 愛羅海德研究公司 用於抑制α－１抗胰蛋白酶基因表現之組合物及方法
US10316369B2 (en) 2014-06-27 2019-06-11 Seminis Vegetable Seeds, Inc. Methods and assays for male sterile watermelon
WO2016049531A1 (en) 2014-09-26 2016-03-31 Purecircle Usa Inc. Single nucleotide polymorphism (snp) markers for stevia
EP3005862A1 (de) 2014-10-10 2016-04-13 Seminis Vegetable Seeds, Inc. Melonenpflanzen mit verbesserter krankheitstoleranz
CA2961439A1 (en) 2014-11-05 2016-05-12 Genentech, Inc. Anti-fgfr2/3 antibodies and methods using same
CN107109494B (zh) 2014-11-10 2023-10-27 豪夫迈·罗氏有限公司 Il-33介导型疾病的治疗方法和诊断方法
US9909169B2 (en) 2014-12-17 2018-03-06 Roche Molecular Systems, Inc. Allele-specific amplification of nucleic acids using blocking oligonucleotides for wild type suppression
CA2982495A1 (en) 2015-04-28 2016-11-03 Monsanto Technology Llc Methods and compositions for producing brachytic corn plants
CA2981819A1 (en) 2015-04-30 2016-11-03 Monsanto Technology Llc Methods for producing canola plants with clubroot resistance and compositions thereof
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
CR20180164A (es) 2015-08-18 2018-09-04 Monsanto Technology Llc Métodos para producir plantas de algodón con tolerancia mejorada a la sequía y composiciones de estas
US10448595B2 (en) 2015-09-03 2019-10-22 Seminis Vegetable Seeds, Inc. Downy mildew resistant lettuce plants
US10858709B2 (en) 2015-09-10 2020-12-08 Monsanto Technology Llc Methods for producing corn plants with downy mildew resistance and compositions thereof
EP3368578B1 (de) 2015-10-30 2021-03-17 H. Hoffnabb-La Roche Ag Anti-htra1-antikörper und verfahren zur verwendung davon
BR112018012039A2 (pt) 2015-12-18 2018-12-04 Monsanto Technology Llc métodos para produção de plantas de milho com resistência à helmintosporiose e composições dos mesmos
EP3496528A4 (de) 2016-08-11 2020-03-18 Monsanto Technology LLC Verfahren und zusammensetzungen zur erzeugung von maispflanzen mit resistenz gegen spätes verwelken
CA3033788A1 (en) * 2016-08-17 2018-02-22 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
AU2017232187B2 (en) 2016-09-30 2023-11-09 Seminis Vegetable Seeds, Inc. Xanthomonas resistant brassica oleracea plants
WO2018085597A1 (en) * 2016-11-02 2018-05-11 Medical College Of Wisconsin, Inc. Methods for assessing risk using mismatch amplification and statistical methods
US11031099B2 (en) 2016-11-09 2021-06-08 Roche Molecular Systems, Inc. Detection of sequence variants
WO2018118808A1 (en) 2016-12-19 2018-06-28 The Broad Institute, Inc. Methods of treating autism spectrum disorders
WO2018170436A1 (en) 2017-03-16 2018-09-20 Jacobs Farm Del Cabo Basil with high tolerance to downy mildew
EP3615695A1 (de) 2017-04-24 2020-03-04 Genentech, Inc. Erbb2/her2-mutationen in der transmembran- oder juxtamembran-domäne
EP3625358A4 (de) 2017-05-17 2021-02-24 Microbio Pty Ltd Biomarker und verwendungen davon
CN110945136A (zh) 2017-06-20 2020-03-31 威斯康星州立大学医学院 使用总无细胞dna评估移植并发症风险
JP6986299B2 (ja) 2017-07-12 2021-12-22 ジーンキャスト カンパニー リミテッドGenecast Co., Ltd. 遺伝子変異特異性が増加したｄｎａ重合酵素およびその活性増加用ｐｃｒバッファー組成物
US11648551B2 (en) 2017-12-12 2023-05-16 Essenlix Corporation Sample manipulation and assay with rapid temperature change
KR102417088B1 (ko) 2018-02-09 2022-07-07 제넨테크, 인크. 비만 세포 매개 염증성 질환에 대한 치료 및 진단 방법
US11268102B2 (en) 2018-05-16 2022-03-08 University Of Florida Research Foundation, Incorporated Compositions and methods for identifying and selecting brachytic locus in solanaceae
WO2020113237A1 (en) 2018-11-30 2020-06-04 Caris Mpi, Inc. Next-generation molecular profiling
AU2020208190B2 (en) 2019-01-15 2022-07-28 Seminis Vegetable Seeds, Inc. Green bean plants with improved disease resistance
US11931674B2 (en) 2019-04-04 2024-03-19 Natera, Inc. Materials and methods for processing blood samples
WO2021010326A1 (ja) 2019-07-12 2021-01-21 中外製薬株式会社 抗変異型ｆｇｆｒ３抗体およびその使用
US11542513B2 (en) 2019-09-26 2023-01-03 Seminis Vegetable Seeds, Inc. Lettuce plants having resistance to Nasonovia ribisnigri biotype Nr:1
WO2021112918A1 (en) 2019-12-02 2021-06-10 Caris Mpi, Inc. Pan-cancer platinum response predictor
IL296227A (en) 2020-03-11 2022-11-01 Seagen Inc Methods for treating her2 mutant cancer with toctinib
WO2021180858A1 (en) 2020-03-13 2021-09-16 Medimmune Limited Therapeutic methods for the treatment of subjects with risk alelles in il33
AU2021204717A1 (en) 2020-07-15 2022-02-03 Seminis Vegetable Seeds, Inc. Green Bean Plants with Improved Disease Resistance
JP2023543261A (ja) 2020-09-28 2023-10-13 シージェン インコーポレイテッド ツカチニブを抗ｈｅｒ２抗体と組み合わせて用いてｈｅｒ２変化により駆動される固形腫瘍を処置する方法
WO2022108931A2 (en) 2020-11-17 2022-05-27 Seagen Inc. Methods of treating cancer with a combination of tucatinib and an anti-pd-1/anti-pd-l1 antibody
US20230193310A1 (en) 2021-12-10 2023-06-22 Seminis Vegetabe Seeds, Inc. Lettuce plants having resistance to downy mildew
US20230404003A1 (en) 2022-06-21 2023-12-21 Seminis Vegetable Seeds, Inc. Novel qtls conferring resistance to cucumber mosaic virus

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8311018D0 (en) * 1983-04-22 1983-05-25 Amersham Int Plc Detecting mutations in dna
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
CA1284931C (en) * 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US4851331A (en) * 1986-05-16 1989-07-25 Allied Corporation Method and kit for polynucleotide assay including primer-dependant DNA polymerase
GB8612087D0 (en) * 1986-05-19 1986-06-25 Ici Plc Hybridisation probes
GB8709652D0 (en) * 1987-04-23 1987-05-28 Williamson R Diagnosis of cystic fibrosis
US4994368A (en) * 1987-07-23 1991-02-19 Syntex (U.S.A.) Inc. Amplification method for polynucleotide assays
EP0317239A3 (de) * 1987-11-13 1990-01-17 Native Plants Incorporated Verfahren und Vorrichtung zum Nachweis von Restriktionsfragmentlängenpolymorphien
AU613989B2 (en) * 1987-11-24 1991-08-15 Gen-Probe Incorporated Means and method for enhancing nucleic acid hybridization
AU2735988A (en) * 1987-12-21 1989-07-13 Amoco Corporation Target and background capture methods with amplification for affinity assays
US4999290A (en) * 1988-03-31 1991-03-12 The Board Of Regents, The University Of Texas System Detection of genomic abnormalities with unique aberrant gene transcripts
WO1989010414A1 (en) * 1988-04-28 1989-11-02 Robert Bruce Wallace AMPLIFIED SEQUENCE POLYMORPHISMS (ASPs)
AU629845B2 (en) * 1988-08-30 1992-10-15 Abbott Laboratories Detection and amplification of target nucleic acid sequences
CA1339731C (en) * 1988-10-12 1998-03-17 Charles T. Caskey Multiplex genomic dna amplification for deletion detection
CA2011818A1 (en) * 1989-03-17 1990-09-17 Fred T. Oakes Methods for purification, amplification and detection of a nucleic acid
WO1990012115A1 (en) * 1989-03-21 1990-10-18 Collaborative Research, Inc. A dna diagnostic test using an exonuclease activity
CA2013317A1 (en) * 1989-04-17 1990-10-17 Fred T. Oakes Diagnostic kit, primer composition and their use for replication or detection of nucleic acids
US5137806A (en) * 1989-12-11 1992-08-11 Board Of Regents, The University Of Texas System Methods and compositions for the detection of sequences in selected DNA molecules
US6004744A (en) * 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer

Also Published As

Publication number Publication date
GR3004442T3 (de) 1993-03-31
ES2039294T3 (es) 1993-09-16
NO891012L (no) 1989-09-11
YU49789A (sh) 1992-09-07
NO174825C (de) 1994-07-13
IE61148B1 (en) 1994-10-05
PT89980B (pt) 1999-12-31
NO174825B (no) 1994-04-05
DK175527B1 (da) 2004-11-22
BG87585A (bg) 1993-12-24
DE68901285D1 (de) 1992-05-27
EP0332435B2 (de) 1999-10-13
EP0332435A2 (de) 1989-09-13
KR970003151B1 (ko) 1997-03-14
ES2039294T5 (es) 2000-01-16
ZW3388A1 (en) 1989-11-22
NZ228266A (en) 1991-05-28
DK118089D0 (da) 1989-03-10
CA1323592C (en) 1993-10-26
US5595890A (en) 1997-01-21
TNSN89026A1 (fr) 1991-02-04
IL89545A0 (en) 1989-09-10
HUT52565A (en) 1990-07-28
CN1039618A (zh) 1990-02-14
AU3124689A (en) 1989-09-14
IE890739L (en) 1989-09-10
BR8901136A (pt) 1989-10-31
PT89980A (pt) 1989-11-10
PL162338B1 (pl) 1993-10-30
FI891126A (fi) 1989-09-11
JP2853864B2 (ja) 1999-02-03
GR3031532T3 (en) 2000-01-31
NO891012D0 (no) 1989-03-09
FI891126A0 (fi) 1989-03-09
IL89545A (en) 1994-11-11
EP0332435A3 (en) 1990-06-27
DK118089A (da) 1989-09-11
EP0332435B1 (de) 1992-04-22
JPH0242999A (ja) 1990-02-13
PL278176A1 (en) 1990-02-05
MY104957A (en) 1994-07-30
KR890014750A (ko) 1989-10-25
CN1034673C (zh) 1997-04-23
AU614584B2 (en) 1991-09-05

Similar Documents

Publication Publication Date Title
ATE75262T1 (de) Verfahren zum nachweis von nukleotid-sequenzen.
ATE142272T1 (de) Nukleinsäure-amplifikation unter verwendung eines einzelprimers
DK463089D0 (da) Fremgangsmaade og reagenssaet til detektion af en specifik nucleinsyresekvens i en proeve indeholdende en nucleinsyre
DE3785865D1 (de) Schnellverfahren zum nachweis von nukleinsaeure-sequenzen in einer probe mittels probemarkierung.
FI900602A0 (fi) Bestaemning.
SE8800864D0 (sv) Method of assaying of nucleic acids, a reagent combination and kit therefore
ATE125947T1 (de) Bestimmungsmethode unter verwendung von polynucleotidsequenzen.
ES2058112T3 (es) Sondas de hibridacion.
DK0666927T3 (da) Fremgangsmåde til påvisning af en nukleinsyresekvens.
DE69011722D1 (de) Diagnoseausrüstung, Primerzusammensetzung und ihre Verwendung zur Erwiderung oder zum Nachweis von Nukleinsäuren.
DE69003477D1 (de) Verfahren zum Nachweis von Nucleinsäuren.
ATE200108T1 (de) Verfahren zum nachweis von telomerase-aktivität
ATE184055T1 (de) Verfahren zum sensitiven nachweis von reverser transcriptase

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EELA Cancelled due to lapse of time