KR950700923A - 암치료에 유용한 17-치환된 스테로이드(17-substituted steroids useful in cancer treatment) - Google Patents

암치료에 유용한 17-치환된 스테로이드(17-substituted steroids useful in cancer treatment)

Info

Publication number
KR950700923A
KR950700923A KR1019940703426A KR19940703426A KR950700923A KR 950700923 A KR950700923 A KR 950700923A KR 1019940703426 A KR1019940703426 A KR 1019940703426A KR 19940703426 A KR19940703426 A KR 19940703426A KR 950700923 A KR950700923 A KR 950700923A
Authority
KR
South Korea
Prior art keywords
carbon atoms
useful
beta
hydrogen atom
cancer treatment
Prior art date
Application number
KR1019940703426A
Other languages
English (en)
Other versions
KR100235135B1 (ko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26300621&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR950700923(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB929207057A external-priority patent/GB9207057D0/en
Priority claimed from GB929224880A external-priority patent/GB9224880D0/en
Application filed filed Critical
Publication of KR950700923A publication Critical patent/KR950700923A/ko
Application granted granted Critical
Publication of KR100235135B1 publication Critical patent/KR100235135B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
KR1019940703426A 1992-03-31 1993-03-15 암치료에 유용한 17-치환된 스테로이드 KR100235135B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB929207057A GB9207057D0 (en) 1992-03-31 1992-03-31 Steroids
GB9207057.2 1992-03-31
GB9224880.6 1992-11-27
GB929224880A GB9224880D0 (en) 1992-11-27 1992-11-27 Steroids
PCT/GB1993/000531 WO1993020097A1 (en) 1992-03-31 1993-03-15 17-substituted steroids useful in cancer treatment

Publications (2)

Publication Number Publication Date
KR950700923A true KR950700923A (ko) 1995-02-20
KR100235135B1 KR100235135B1 (ko) 2000-01-15

Family

ID=26300621

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940703426A KR100235135B1 (ko) 1992-03-31 1993-03-15 암치료에 유용한 17-치환된 스테로이드

Country Status (16)

Country Link
EP (1) EP0633893B1 (ko)
JP (1) JP2742331B2 (ko)
KR (1) KR100235135B1 (ko)
AT (1) ATE186913T1 (ko)
AU (1) AU668144B2 (ko)
CA (1) CA2132449C (ko)
CZ (1) CZ287434B6 (ko)
DE (2) DE69327096T2 (ko)
DK (1) DK0633893T3 (ko)
ES (1) ES2138618T3 (ko)
GB (1) GB2265624B (ko)
IL (1) IL105078A (ko)
LU (1) LU91911I2 (ko)
MX (1) MX9301525A (ko)
NZ (1) NZ249911A (ko)
WO (1) WO1993020097A1 (ko)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU676088B2 (en) * 1993-09-30 1997-02-27 British Technology Group Limited Synthesis of 17-(3-pyridyl) steroids
US5677293A (en) * 1993-10-27 1997-10-14 Merrell Pharmaceuticals Inc. 16 unsaturated C17 heterocyclic steroids useful as steroid C17-20 lyase inhibitors
DE60119963T2 (de) 2000-11-17 2006-10-05 Takeda Pharmaceutical Co. Ltd. Imidazol derivate, ihre herstellung und ihre verwendung
DE60144246D1 (de) 2000-11-20 2011-04-28 Takeda Pharmaceutical Imidazolderivate, verfahren zu deren herstellung und deren verwendung
DE60139639D1 (de) 2000-12-08 2009-10-01 Takeda Pharmaceutical Substituierte thiazolderivate mit 3-pyridylgruppen, verfahren zu deren herstellung und deren verwendung
AU2002353147A1 (en) * 2001-12-13 2003-06-30 Abbott Laboratories 3-(phenyl-alkoxy)-5-(phenyl)-pyridine derivatives and related compounds as kinase inhibitors for the treatment of cancer
US8569275B2 (en) 2002-08-28 2013-10-29 Harbor Therapeutics, Inc. Steroids having 7-oxgen and 17-heteroaryl substitution
AU2003278744B2 (en) * 2002-08-28 2010-07-29 Harbor Biosciences, Inc. Therapeutic treatment methods
GB0418900D0 (en) 2004-08-24 2004-09-29 Btg Int Ltd Novel salt forms
WO2006021777A1 (en) 2004-08-24 2006-03-02 Btg International Limited Process fot the preparation of 17-0-vinyl- triflates as intermediates
DE102006008074B4 (de) * 2006-02-22 2013-08-14 RUHR-UNIVERSITäT BOCHUM Behandlung von Krebs mit Geruchsrezeptor-Liganden
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
PT2061561E (pt) 2006-08-25 2013-10-09 Janssen Oncology Inc Composições para tratar o cancro
WO2009009132A1 (en) * 2007-07-12 2009-01-15 Cougar Biotechnology, Inc. Use of 17alpha-hydroxylase/c17, 20-lyase inhibitors for the treatment of cancer
US20100048912A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
US20110312916A1 (en) * 2009-02-05 2011-12-22 Tokai Pharmaceuticals, Inc. Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
DK2445903T3 (da) 2009-06-26 2014-06-23 Novartis Ag 1,3-Disubstituerede imidazolidin-2-on-derivater som CYP17-inhibitorer
AU2010319697B2 (en) * 2009-11-13 2016-05-19 Tokai Pharmaceuticals, Inc. Mammalian metabolites of steroids
WO2011088160A2 (en) * 2010-01-15 2011-07-21 Biomarin Pharmaceutical Inc. Novel cyp17 inhibitors
WO2012018948A2 (en) 2010-08-04 2012-02-09 Pellficure Pharmaceuticals, Inc. Novel treatment of prostate carcinoma
WO2012035078A1 (en) 2010-09-16 2012-03-22 Novartis Ag 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS
CN102558274B (zh) * 2010-12-08 2014-10-15 深圳万乐药业有限公司 一种适合工业化生产醋酸阿比特龙的合成方法
EP2651916A2 (en) * 2010-12-16 2013-10-23 BioMarin Pharmaceutical Inc. C-17-heteroaryl steroidal compounds as inhibitors of cyp11b, cyp17, and/or cyp21
CN102558275A (zh) * 2010-12-20 2012-07-11 天津药物研究院 α型多晶型醋酸阿比特龙结晶、其制备方法、用途和药物组合物
ES2656218T3 (es) 2011-04-28 2018-02-26 Novartis Ag Inhibidores de 17 alfa-hidroxilasa/C17,20-liasa
CN102321142A (zh) * 2011-09-29 2012-01-18 重庆医药工业研究院有限责任公司 一种醋酸阿比特龙晶型及其制备方法
DE102011083725A1 (de) * 2011-09-29 2013-04-04 Bayer Pharma AG Estra-1,3,5(10),16-tetraen-3-carboxamid-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
ES2590753T3 (es) 2011-10-10 2016-11-23 Zach System Proceso para la preparación de esteroides 17-sustituidos
CN103059090B (zh) * 2011-10-20 2016-06-22 连云港润众制药有限公司 醋酸阿比特龙草酸盐以及醋酸阿比特龙的纯化方法
CA2856646C (en) 2011-11-30 2020-01-14 Astrazeneca Ab Combination treatment of cancer
EP2607371A1 (en) 2011-12-23 2013-06-26 Crystal Pharma, S.A.U. Processes for the preparation of abiraterone and related compouds
CN103172690B (zh) * 2011-12-23 2016-08-24 重庆医药工业研究院有限责任公司 醋酸阿比特龙及其中间体的制备方法
CN105461777B (zh) * 2012-01-04 2017-07-18 连云港润众制药有限公司 一种醋酸阿比特龙的纯化方法
CN103254265B (zh) 2012-02-21 2016-07-13 上海希迈医药科技有限公司 醋酸阿比特龙三氟乙酸盐及其制备方法和应用
CN102627681B (zh) * 2012-03-23 2016-04-13 山东新时代药业有限公司 一种醋酸阿比特龙的制备方法
AU2013204533B2 (en) 2012-04-17 2017-02-02 Astrazeneca Ab Crystalline forms
CA2871314A1 (en) * 2012-04-23 2013-10-31 Alphora Research Inc. Process for preparation of 17-substituted steroids
CN104349771A (zh) 2012-06-06 2015-02-11 诺华股份有限公司 用于治疗肿瘤疾病的17α-羟化酶(C17,20-裂解酶)抑制剂和特定PI-3K抑制剂的组合
CN102731605B (zh) * 2012-06-19 2016-04-13 鲁南制药集团股份有限公司 一种醋酸阿比特龙的纯化方法
MX2015000347A (es) * 2012-07-10 2015-04-14 Bayer Pharma AG Derivados de estra-1,3,5(10),16-tetraeno 3-sustituidos, metodos para su preparacion, preparaciones farmaceuticas que los contienen, asi como su uso para la preparacion de medicamentos.
WO2014009437A1 (en) 2012-07-11 2014-01-16 Sandoz Ag Oxidation stability of abiraterone acetate
WO2014009434A1 (en) 2012-07-11 2014-01-16 Sandoz Ag Self-microemulsifying drug delivery system of abiraterone or abiraterone acetate
WO2014009436A1 (en) 2012-07-11 2014-01-16 Sandoz Ag Nanosuspension of abiraterone acetate
EP2877482A4 (en) * 2012-07-25 2016-04-06 Mapi Pharma Ltd PROCESS AND INTERMEDIATES USED IN THE PREPARATION OF ABIRATERONE ACETATE
WO2014058785A1 (en) 2012-10-10 2014-04-17 Novartis Ag Combination therapy
ITMI20121788A1 (it) 2012-10-22 2014-04-23 Olon Spa Procedimento per la purificazione di abiraterone acetato
WO2014071983A1 (en) 2012-11-09 2014-05-15 Synthon Bv Process for making the 17-triflate intermediate of abiraterone-3-acetate
WO2014071984A1 (en) 2012-11-09 2014-05-15 Synthon Bv Process for making abiraterone-3-acetate
TWI570131B (zh) * 2012-11-13 2017-02-11 賽克系統公司 製備１７－經取代類固醇之方法
WO2014075978A1 (en) 2012-11-16 2014-05-22 Synthon B.V. Process for the production of abiraterone-3-acetate involving an enol trliflation reaction in the presence of an alkoxy-pyridine compound
CN103059091B (zh) * 2012-11-22 2017-04-19 常州靶点医药科技有限公司 一种避免重金属残留的醋酸阿比特龙的制备方法
CN103864878A (zh) * 2012-12-12 2014-06-18 天津大学 阿比特龙醋酸酯的制备方法
EP2938625B1 (en) 2012-12-31 2018-02-21 Hetero Research Foundation Process for the preparation of abiraterone acetate
SG11201507093WA (en) 2013-03-14 2015-10-29 Univ Maryland Baltimore Office Of Technology Transfer Androgen receptor down-regulating agents and uses thereof
AU2014241816B9 (en) 2013-03-14 2019-02-14 Pellficure Pharmaceuticals Inc. Novel therapy for prostate carcinoma
EP2792682B1 (en) 2013-04-19 2016-11-09 Zach System Process for producing a solid form of abiraterone acetate
JP2016527213A (ja) * 2013-06-24 2016-09-08 サン・ファーマシューティカル・インダストリーズ・リミテッドＳｕｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｉｎｄｕｓｔｒｉｅｓ Ｌｔｄ． アビラテロン酢酸エステルの製造方法
WO2015014686A1 (en) 2013-07-29 2015-02-05 Industriale Chimica S.R.L. Process for the preparation of abiraterone or abiraterone acetate
ITMI20131861A1 (it) * 2013-11-08 2015-05-09 Ind Chimica Srl Processo per la preparazione di abiraterone e abiraterone acetato
WO2015015246A1 (en) 2013-07-29 2015-02-05 Industriale Chimica S.R.L. Process for the preparation of abiraterone and abiraterone acetate
RU2016104643A (ru) 2013-08-12 2017-09-19 Токай Фармасьютикалз, Инк. Биомаркёры для лечения неопластических заболеваний с применением нацеленных на андроген методов лечения
CN104558091B (zh) * 2013-10-16 2017-07-28 天津金耀集团有限公司 一种醋酸阿比特龙的合成方法
EP3099701B1 (en) 2014-01-28 2019-07-24 OLON S.p.A. Procedure for the preparation of abiraterone acetate and intermediates thereof
CN103965282B (zh) 2014-04-21 2016-01-20 武汉百科药物开发有限公司 一种醋酸阿比特龙的制备方法
US9315541B2 (en) 2014-05-20 2016-04-19 Olon S.P.A. Process for the preparation of unsaturated trifluoromethanesulfonate steroid derivatives
WO2016001208A1 (en) 2014-06-30 2016-01-07 Galenicum Health S.L. Stable pharmaceutical compositions in the form of immediate release tablets
CZ2014475A3 (cs) 2014-07-09 2016-01-20 Zentiva, K.S. Způsob přípravy Abirateron acetátu o vysoké čistotě aplikovatelný v průmyslovém měřítku
WO2016040896A1 (en) 2014-09-12 2016-03-17 Pellficure Pharmaceuticals, Inc. Compositions and methods for treatment of prostate carcinoma
US10285948B2 (en) 2014-12-05 2019-05-14 Janssen Pharmaceutica Nv Anticancer compositions
WO2016162229A1 (en) 2015-04-10 2016-10-13 Capsugel Belgium N.V. Abiraterone acetate lipid formulations
WO2017133360A1 (zh) * 2016-02-02 2017-08-10 深圳市塔吉瑞生物医药有限公司 一种甾体类化合物及包含该化合物的组合物及其用途
AU2017275396A1 (en) 2016-06-03 2018-11-22 Aragon Pharmaceuticals, Inc. Anticancer compositions
CA3044812A1 (en) 2016-10-24 2018-05-03 Pellficure Pharmaceuticals Inc. Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1,4-dione
US11865215B2 (en) 2018-04-26 2024-01-09 Synthon B.V. Tablet compositions comprising abiraterone acetate
HU231297B1 (hu) 2018-07-31 2022-09-28 Richter Gedeon Nyrt Stabil gyógyszerkészítmények és eljárás az előállításukra
CN110272465A (zh) * 2019-07-15 2019-09-24 成都贝诺科成生物科技有限公司 阿比特龙衍生物、其制备方法与应用
KR20220047589A (ko) 2019-08-08 2022-04-18 래크나 리미티드 암 치료 방법
EP3854384A1 (en) 2020-01-27 2021-07-28 Adamed Pharma S.A. Pharmaceutical formulation comprising abiraterone acetate
CN115551506A (zh) 2020-05-08 2022-12-30 詹森药业有限公司 用醋酸阿比特龙和尼拉帕尼的组合治疗前列腺癌
EP3944860A1 (en) 2020-07-30 2022-02-02 Galenicum Health S.L.U. Abiraterone for use in a method of treating cancer
WO2023148345A1 (en) 2022-02-04 2023-08-10 Janssen Pharmaceutica Nv Niraparib and abiraterone acetate plus prednisone to improve clinical outcomes in patients with metastatic castration-resistant prostate cancer and hrr alterations
WO2023155846A1 (zh) * 2022-02-18 2023-08-24 上海醇健医药技术有限公司 17-吡啶基-10α-甲基-甾体衍生物及中间体化合物、其制备方法、其用途、以及其药物组合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1326234C (en) * 1987-04-22 1994-01-18 Michael R. Angelastro 17.beta.-(cyclopropylamino)androst-5-en-3.beta.-ol and related compoundsuseful as_c__-__ lyase inhibitors
US4966898A (en) * 1989-08-15 1990-10-30 Merrell Dow Pharmaceuticals Inc. 4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors

Also Published As

Publication number Publication date
CZ233794A3 (en) 1995-02-15
LU91911I2 (fr) 2012-02-07
CA2132449A1 (en) 1993-10-14
EP0633893A1 (en) 1995-01-18
CA2132449C (en) 2002-09-10
DE69327096D1 (de) 1999-12-30
DE122012000012I1 (de) 2012-06-14
DE69327096T2 (de) 2000-06-21
IL105078A0 (en) 1993-07-08
JP2742331B2 (ja) 1998-04-22
JPH07505377A (ja) 1995-06-15
WO1993020097A1 (en) 1993-10-14
ATE186913T1 (de) 1999-12-15
IL105078A (en) 1997-11-20
NZ249911A (en) 1996-06-25
AU668144B2 (en) 1996-04-26
EP0633893B1 (en) 1999-11-24
MX9301525A (es) 1994-02-28
CZ287434B6 (en) 2000-11-15
GB2265624B (en) 1995-04-19
GB2265624A (en) 1993-10-06
DK0633893T3 (da) 2000-04-17
GB9305269D0 (en) 1993-05-05
AU3758493A (en) 1993-11-08
ES2138618T3 (es) 2000-01-16
KR100235135B1 (ko) 2000-01-15

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