ES2138618T3 - Esteroides 17-sustituidos utiles en el tratamiento del cancer. - Google Patents
Esteroides 17-sustituidos utiles en el tratamiento del cancer.Info
- Publication number
- ES2138618T3 ES2138618T3 ES93906670T ES93906670T ES2138618T3 ES 2138618 T3 ES2138618 T3 ES 2138618T3 ES 93906670 T ES93906670 T ES 93906670T ES 93906670 T ES93906670 T ES 93906670T ES 2138618 T3 ES2138618 T3 ES 2138618T3
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- beta
- hydrogen atom
- pyridyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
Abstract
SE PRESENTAN COMPUESTOS DE LA FORMULA GENERAL (I) EN LA QUE X REPRESENTA EL RESIDUO DE LOS ANILLOS A, B Y C DE UN ESTEROIDE, R REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO DE ALQUILO DE ENTRE 1 Y 4 ATOMOS DE CARBONO, R14 REPRESENTA UN ATOMO DE HIDROGENO Y R15 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO DE ALQUIL O DE ALCOXIDO DE ENTRE 1 Y 4 ATOMOS DE CARBONO, O UN GRUPO DE HIDROXIDO O DE ALQUILCARBONILOXIDO DE ENTRE 2 Y 5 ATOMOS DE CARBONO O R14 Y R15 JUNTAS REPRESENTAN UN DOBLE ENLACE Y R16 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO DE ALQUIL DE ENTRE 1 Y 4 ATOMOS DE CARBONO EN FORMA DE BASES LIBRES O DE SALES DE ADICION ACIDA FARMACOLOGICAMENTE ACEPTABLES, CON LA SALVEDAD DE QUE EL 17-(3-PIRIDIL)ANDROSTA-5,14,16TRIEN-3(BETA)-OL Y 15(BETA)-ACETOXI-17-(3-PIRIDIL)ANDROSTA-5,16-DIEN-3(BETA)-OL Y SUS 3-ACETATOS Y EL 3(BETA)-METOXI-17-(3-PIRIDIL)ANDROS-16-ENE SON RECLAMADOS SOLAMENTE PARA SU USO EN LA TERAPIA, LOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES DEPENDIENTES DE LOS ANDROGENOS, ESPECIALMENTE DEL CANCER PROSTATICO, Y TAMBIEN DE LAS ENFERMEDADES DEPENDIENTES DE LOS ESTROGENOS TALES COMO EL CANCER DE PULMON.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929207057A GB9207057D0 (en) | 1992-03-31 | 1992-03-31 | Steroids |
GB929224880A GB9224880D0 (en) | 1992-11-27 | 1992-11-27 | Steroids |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2138618T3 true ES2138618T3 (es) | 2000-01-16 |
Family
ID=26300621
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93906670T Expired - Lifetime ES2138618T3 (es) | 1992-03-31 | 1993-03-15 | Esteroides 17-sustituidos utiles en el tratamiento del cancer. |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0633893B1 (es) |
JP (1) | JP2742331B2 (es) |
KR (1) | KR100235135B1 (es) |
AT (1) | ATE186913T1 (es) |
AU (1) | AU668144B2 (es) |
CA (1) | CA2132449C (es) |
CZ (1) | CZ287434B6 (es) |
DE (2) | DE69327096T2 (es) |
DK (1) | DK0633893T3 (es) |
ES (1) | ES2138618T3 (es) |
GB (1) | GB2265624B (es) |
IL (1) | IL105078A (es) |
LU (1) | LU91911I2 (es) |
MX (1) | MX9301525A (es) |
NZ (1) | NZ249911A (es) |
WO (1) | WO1993020097A1 (es) |
Families Citing this family (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU676088B2 (en) * | 1993-09-30 | 1997-02-27 | British Technology Group Limited | Synthesis of 17-(3-pyridyl) steroids |
WO1995011914A1 (en) * | 1993-10-27 | 1995-05-04 | Merrell Pharmaceuticals Inc. | Δ16 unsaturated c¿17? heterocyclic steroids useful as steroid c17-20 lyase inhibitors |
KR100809899B1 (ko) | 2000-11-17 | 2008-03-10 | 다케다 야쿠힌 고교 가부시키가이샤 | 신규 이미다졸 유도체, 이의 제조 방법 및 이의 용도 |
AU2002214320A1 (en) | 2000-11-20 | 2002-05-27 | Takeda Chemical Industries Ltd. | Imidazole derivatives, process for their preparation and their use |
EP1348706B1 (en) | 2000-12-08 | 2009-08-19 | Takeda Pharmaceutical Company Limited | Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof |
CA2470214A1 (en) * | 2001-12-13 | 2003-06-26 | Abbott Laboratories | 3-(phenyl-alkoxy)-5-(phenyl)-pyridine derivatives and related compounds as kinase inhibitors for the treatment of cancer |
US8569275B2 (en) | 2002-08-28 | 2013-10-29 | Harbor Therapeutics, Inc. | Steroids having 7-oxgen and 17-heteroaryl substitution |
EP2298315A1 (en) * | 2002-08-28 | 2011-03-23 | Harbor BioSciences, Inc. | Therapeutic treatment methods |
GB0418900D0 (en) | 2004-08-24 | 2004-09-29 | Btg Int Ltd | Novel salt forms |
ES2377074T3 (es) * | 2004-08-24 | 2012-03-22 | Btg International Limited | Procedimiento para la preparación de 17-vinil-triflatos como intermedios |
US20100047338A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
DE102006008074B4 (de) * | 2006-02-22 | 2013-08-14 | RUHR-UNIVERSITäT BOCHUM | Behandlung von Krebs mit Geruchsrezeptor-Liganden |
US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
ES2428634T3 (es) | 2006-08-25 | 2013-11-08 | Janssen Oncology, Inc. | Composiciones para el tratamiento del cáncer |
WO2009009132A1 (en) * | 2007-07-12 | 2009-01-15 | Cougar Biotechnology, Inc. | Use of 17alpha-hydroxylase/c17, 20-lyase inhibitors for the treatment of cancer |
CA2761389A1 (en) | 2009-02-05 | 2010-08-12 | Tokai Pharmaceuticals, Inc. | Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens |
SG176105A1 (en) | 2009-06-26 | 2011-12-29 | Novartis Ag | 1, 3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp 17 |
US20120282331A1 (en) * | 2009-11-13 | 2012-11-08 | Tokai Pharmaceuticals, Inc. | Mammalian metabolites of steroids |
WO2011088160A2 (en) * | 2010-01-15 | 2011-07-21 | Biomarin Pharmaceutical Inc. | Novel cyp17 inhibitors |
MX345788B (es) | 2010-08-04 | 2017-02-15 | Pellficure Pharmaceuticals Inc * | Nuevo tratamiento del carcinoma de prostata. |
CN103108871B (zh) | 2010-09-16 | 2014-09-10 | 诺华股份有限公司 | 17α-羟化酶/C17,20-裂合酶抑制剂 |
CN102558274B (zh) * | 2010-12-08 | 2014-10-15 | 深圳万乐药业有限公司 | 一种适合工业化生产醋酸阿比特龙的合成方法 |
TW201307378A (zh) * | 2010-12-16 | 2013-02-16 | Biomarin Pharm Inc | Cyp11b、cyp17及/或cyp21抑制劑 |
CN102558275A (zh) * | 2010-12-20 | 2012-07-11 | 天津药物研究院 | α型多晶型醋酸阿比特龙结晶、其制备方法、用途和药物组合物 |
MX359399B (es) | 2011-04-28 | 2018-09-27 | Novartis Ag | Inhibidores de 17alfa-hidroxilasa/c17-20-liasa. |
CN102321142A (zh) * | 2011-09-29 | 2012-01-18 | 重庆医药工业研究院有限责任公司 | 一种醋酸阿比特龙晶型及其制备方法 |
DE102011083725A1 (de) * | 2011-09-29 | 2013-04-04 | Bayer Pharma AG | Estra-1,3,5(10),16-tetraen-3-carboxamid-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
WO2013053691A1 (en) | 2011-10-10 | 2013-04-18 | Zach System | Process for preparing 17-substituted steroids |
CN103059090B (zh) * | 2011-10-20 | 2016-06-22 | 连云港润众制药有限公司 | 醋酸阿比特龙草酸盐以及醋酸阿比特龙的纯化方法 |
LT2785349T (lt) | 2011-11-30 | 2019-12-10 | Astrazeneca Ab | Kombinuotas vėžio gydymas |
EP2607371A1 (en) | 2011-12-23 | 2013-06-26 | Crystal Pharma, S.A.U. | Processes for the preparation of abiraterone and related compouds |
CN103172690B (zh) * | 2011-12-23 | 2016-08-24 | 重庆医药工业研究院有限责任公司 | 醋酸阿比特龙及其中间体的制备方法 |
CN105461777B (zh) * | 2012-01-04 | 2017-07-18 | 连云港润众制药有限公司 | 一种醋酸阿比特龙的纯化方法 |
CN103254265B (zh) | 2012-02-21 | 2016-07-13 | 上海希迈医药科技有限公司 | 醋酸阿比特龙三氟乙酸盐及其制备方法和应用 |
CN102627681B (zh) * | 2012-03-23 | 2016-04-13 | 山东新时代药业有限公司 | 一种醋酸阿比特龙的制备方法 |
AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
WO2013159225A1 (en) * | 2012-04-23 | 2013-10-31 | Alphora Research Inc. | Process for preparation of 17-substituted steroids |
JP2015518888A (ja) | 2012-06-06 | 2015-07-06 | ノバルティス アーゲー | 腫瘍疾患を治療するための17−アルファ−ヒドロキシラーゼ(c17,20−リアーゼ)インヒビターと特定のpi−3kインヒビターとの組み合わせ |
CN102731605B (zh) * | 2012-06-19 | 2016-04-13 | 鲁南制药集团股份有限公司 | 一种醋酸阿比特龙的纯化方法 |
JP6196302B2 (ja) * | 2012-07-10 | 2017-09-13 | バイエル・ファルマ・アクティエンゲゼルシャフト | 3−置換エストラ−1,3,5(10),16−テトラエン誘導体、その調製法、これらを含む医薬製剤および医薬を調製するためのその使用 |
WO2014009437A1 (en) | 2012-07-11 | 2014-01-16 | Sandoz Ag | Oxidation stability of abiraterone acetate |
WO2014009436A1 (en) | 2012-07-11 | 2014-01-16 | Sandoz Ag | Nanosuspension of abiraterone acetate |
WO2014009434A1 (en) | 2012-07-11 | 2014-01-16 | Sandoz Ag | Self-microemulsifying drug delivery system of abiraterone or abiraterone acetate |
WO2014016830A1 (en) * | 2012-07-25 | 2014-01-30 | Mapi Pharma Ltd. | Process and intermediates for the preparation of abiraterone acetate |
WO2014058785A1 (en) | 2012-10-10 | 2014-04-17 | Novartis Ag | Combination therapy |
ITMI20121788A1 (it) | 2012-10-22 | 2014-04-23 | Olon Spa | Procedimento per la purificazione di abiraterone acetato |
EP2917226A1 (en) | 2012-11-09 | 2015-09-16 | Synthon BV | Process for making the 17-triflate intermediate of abiraterone-3-acetate |
EP2917225A1 (en) | 2012-11-09 | 2015-09-16 | Synthon BV | Process for making abiraterone-3-acetate |
TWI570131B (zh) * | 2012-11-13 | 2017-02-11 | 賽克系統公司 | 製備17-經取代類固醇之方法 |
WO2014075978A1 (en) | 2012-11-16 | 2014-05-22 | Synthon B.V. | Process for the production of abiraterone-3-acetate involving an enol trliflation reaction in the presence of an alkoxy-pyridine compound |
CN103059091B (zh) * | 2012-11-22 | 2017-04-19 | 常州靶点医药科技有限公司 | 一种避免重金属残留的醋酸阿比特龙的制备方法 |
CN103864878A (zh) * | 2012-12-12 | 2014-06-18 | 天津大学 | 阿比特龙醋酸酯的制备方法 |
WO2014102833A2 (en) | 2012-12-31 | 2014-07-03 | Hetero Research Foundation | Process for abiraterone acetate |
EP2968219B1 (en) | 2013-03-14 | 2019-04-24 | Pellficure Pharmaceuticals, Inc. | Novel therapy for prostate carcinoma |
EP4066841A1 (en) | 2013-03-14 | 2022-10-05 | University of Maryland, Baltimore | Androgen receptor down-regulating agents and uses thereof |
EP2792682B1 (en) | 2013-04-19 | 2016-11-09 | Zach System | Process for producing a solid form of abiraterone acetate |
IN2013MU02133A (es) * | 2013-06-24 | 2015-06-05 | Sun Pharmaceutical Ind Ltd | |
ITMI20131861A1 (it) * | 2013-11-08 | 2015-05-09 | Ind Chimica Srl | Processo per la preparazione di abiraterone e abiraterone acetato |
US9676815B2 (en) | 2013-07-29 | 2017-06-13 | Industriale Chimica S.R.L. | Process for the preparation of abiraterone or abiraterone acetate |
EP3027638B1 (en) | 2013-07-29 | 2017-12-27 | Industriale Chimica S.R.L. | Process for the preparation of abiraterone and abiraterone acetate |
AU2014306698A1 (en) | 2013-08-12 | 2016-01-28 | Tokai Pharmaceuticals, Inc. | Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies |
CN104558091B (zh) * | 2013-10-16 | 2017-07-28 | 天津金耀集团有限公司 | 一种醋酸阿比特龙的合成方法 |
CA2938023C (en) | 2014-01-28 | 2022-03-08 | Olon S.P.A. | Procedure for the preparation of abiraterone acetate and intermediates thereof |
CN103965282B (zh) | 2014-04-21 | 2016-01-20 | 武汉百科药物开发有限公司 | 一种醋酸阿比特龙的制备方法 |
US9315541B2 (en) | 2014-05-20 | 2016-04-19 | Olon S.P.A. | Process for the preparation of unsaturated trifluoromethanesulfonate steroid derivatives |
EP3160450A1 (en) | 2014-06-30 | 2017-05-03 | Galenicum Health S.L. | Stable pharmaceutical compositions in the form of immediate release tablets |
CZ2014475A3 (cs) | 2014-07-09 | 2016-01-20 | Zentiva, K.S. | Způsob přípravy Abirateron acetátu o vysoké čistotě aplikovatelný v průmyslovém měřítku |
CA2960750A1 (en) | 2014-09-12 | 2016-03-17 | Pellficure Pharmaceuticals, Inc. | Compositions and methods for treatment of prostate carcinoma |
CA2969675C (en) | 2014-12-05 | 2023-06-06 | Aragon Pharmaceuticals, Inc. | Anticancer compositions |
US10722527B2 (en) | 2015-04-10 | 2020-07-28 | Capsugel Belgium Nv | Abiraterone acetate lipid formulations |
US10519193B2 (en) | 2016-02-02 | 2019-12-31 | Shenzhen Targetrx, Inc. | Steroidal compound, composition containing the same and use thereof |
WO2017209939A1 (en) | 2016-06-03 | 2017-12-07 | Aragon Pharmaceuticals, Inc. | Anticancer compositions |
CA3044812A1 (en) | 2016-10-24 | 2018-05-03 | Pellficure Pharmaceuticals Inc. | Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1,4-dione |
EP3784218A1 (en) | 2018-04-26 | 2021-03-03 | Synthon B.V. | Tablet compositions comprising abiraterone acetate |
HU231297B1 (hu) | 2018-07-31 | 2022-09-28 | Richter Gedeon Nyrt | Stabil gyógyszerkészítmények és eljárás az előállításukra |
CN110272465A (zh) * | 2019-07-15 | 2019-09-24 | 成都贝诺科成生物科技有限公司 | 阿比特龙衍生物、其制备方法与应用 |
MX2022001450A (es) | 2019-08-08 | 2022-04-20 | Laekna Ltd | Metodo de tratamiento del cancer. |
EP3854384A1 (en) | 2020-01-27 | 2021-07-28 | Adamed Pharma S.A. | Pharmaceutical formulation comprising abiraterone acetate |
CA3177123A1 (en) | 2020-05-08 | 2021-11-11 | Janssen Pharmaceutica Nv | Pharmaceutical formulations of abiraterone acetate and niraparib |
EP3944860A1 (en) | 2020-07-30 | 2022-02-02 | Galenicum Health S.L.U. | Abiraterone for use in a method of treating cancer |
WO2023148345A1 (en) | 2022-02-04 | 2023-08-10 | Janssen Pharmaceutica Nv | Niraparib and abiraterone acetate plus prednisone to improve clinical outcomes in patients with metastatic castration-resistant prostate cancer and hrr alterations |
CN116917306A (zh) * | 2022-02-18 | 2023-10-20 | 上海醇健医药技术有限公司 | 17-吡啶基-10α-甲基-甾体衍生物及中间体化合物、其制备方法、其用途、以及其药物组合物 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ224288A (en) * | 1987-04-22 | 1989-12-21 | Merrell Dow Pharma | 17b-(cyclopropylamino)androst-5-en-3b-ol and related compounds and methods using these for treatment of non-humans |
US4966898A (en) * | 1989-08-15 | 1990-10-30 | Merrell Dow Pharmaceuticals Inc. | 4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
-
1993
- 1993-03-15 AT AT93906670T patent/ATE186913T1/de active
- 1993-03-15 AU AU37584/93A patent/AU668144B2/en not_active Expired
- 1993-03-15 ES ES93906670T patent/ES2138618T3/es not_active Expired - Lifetime
- 1993-03-15 CZ CZ19942337A patent/CZ287434B6/cs not_active IP Right Cessation
- 1993-03-15 DK DK93906670T patent/DK0633893T3/da active
- 1993-03-15 GB GB9305269A patent/GB2265624B/en not_active Expired - Lifetime
- 1993-03-15 JP JP5517187A patent/JP2742331B2/ja not_active Expired - Lifetime
- 1993-03-15 EP EP93906670A patent/EP0633893B1/en not_active Expired - Lifetime
- 1993-03-15 DE DE69327096T patent/DE69327096T2/de not_active Expired - Lifetime
- 1993-03-15 WO PCT/GB1993/000531 patent/WO1993020097A1/en active IP Right Grant
- 1993-03-15 KR KR1019940703426A patent/KR100235135B1/ko not_active IP Right Cessation
- 1993-03-15 NZ NZ249911A patent/NZ249911A/en not_active IP Right Cessation
- 1993-03-15 CA CA002132449A patent/CA2132449C/en not_active Expired - Lifetime
- 1993-03-16 IL IL105078A patent/IL105078A/xx active Protection Beyond IP Right Term
- 1993-03-18 MX MX9301525A patent/MX9301525A/es active IP Right Grant
-
2011
- 2011-12-07 LU LU91911C patent/LU91911I2/fr unknown
-
2012
- 2012-01-12 DE DE201212000012 patent/DE122012000012I1/de active Pending
Also Published As
Publication number | Publication date |
---|---|
ATE186913T1 (de) | 1999-12-15 |
CZ233794A3 (en) | 1995-02-15 |
AU3758493A (en) | 1993-11-08 |
CA2132449C (en) | 2002-09-10 |
DE69327096D1 (de) | 1999-12-30 |
IL105078A (en) | 1997-11-20 |
JPH07505377A (ja) | 1995-06-15 |
GB2265624A (en) | 1993-10-06 |
CA2132449A1 (en) | 1993-10-14 |
DE122012000012I1 (de) | 2012-06-14 |
LU91911I2 (fr) | 2012-02-07 |
EP0633893B1 (en) | 1999-11-24 |
DK0633893T3 (da) | 2000-04-17 |
WO1993020097A1 (en) | 1993-10-14 |
KR100235135B1 (ko) | 2000-01-15 |
MX9301525A (es) | 1994-02-28 |
EP0633893A1 (en) | 1995-01-18 |
GB2265624B (en) | 1995-04-19 |
CZ287434B6 (en) | 2000-11-15 |
GB9305269D0 (en) | 1993-05-05 |
JP2742331B2 (ja) | 1998-04-22 |
DE69327096T2 (de) | 2000-06-21 |
KR950700923A (ko) | 1995-02-20 |
IL105078A0 (en) | 1993-07-08 |
NZ249911A (en) | 1996-06-25 |
AU668144B2 (en) | 1996-04-26 |
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