MX345788B - Nuevo tratamiento del carcinoma de prostata. - Google Patents
Nuevo tratamiento del carcinoma de prostata.Info
- Publication number
- MX345788B MX345788B MX2013001272A MX2013001272A MX345788B MX 345788 B MX345788 B MX 345788B MX 2013001272 A MX2013001272 A MX 2013001272A MX 2013001272 A MX2013001272 A MX 2013001272A MX 345788 B MX345788 B MX 345788B
- Authority
- MX
- Mexico
- Prior art keywords
- plumbagin
- treatment
- combination therapy
- prostate carcinoma
- naphthoquinone
- Prior art date
Links
- 238000002648 combination therapy Methods 0.000 title abstract 2
- 206010060862 Prostate cancer Diseases 0.000 title 1
- 201000001514 prostate carcinoma Diseases 0.000 title 1
- VCMMXZQDRFWYSE-UHFFFAOYSA-N plumbagin Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1O VCMMXZQDRFWYSE-UHFFFAOYSA-N 0.000 abstract 8
- ZMOIGGHUSNHCAB-UHFFFAOYSA-N Isoplumbagin Natural products C1=CC(O)=C2C(=O)C(C)=CC(=O)C2=C1 ZMOIGGHUSNHCAB-UHFFFAOYSA-N 0.000 abstract 4
- 229930192627 Naphthoquinone Natural products 0.000 abstract 4
- ALPCEXCHMFUSAN-UHFFFAOYSA-N beta-Dihydroplumbagin Natural products C1=CC=C2C(=O)C(C)CC(=O)C2=C1O ALPCEXCHMFUSAN-UHFFFAOYSA-N 0.000 abstract 4
- 150000002791 naphthoquinones Chemical class 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000001794 hormone therapy Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
- A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
Abstract
En este documento se dan a conocer análogos de naftoquinona, tales como plumbagina, una composición farmacéutica que incluye análogos de naftoquinona tales como plumbagina, y métodos de tratamiento de enfermedades y/o afecciones tales como cáncer con análogos de naftoquinona, tales como plumbagina. Además son incluidas combinaciones de terapias en donde un análogo de naftoquinona, tal como plumbagina, y un agente de terapia hormonal son proporcionados a un sujeto que padece de una afección tal como el cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37053410P | 2010-08-04 | 2010-08-04 | |
PCT/US2011/046474 WO2012018948A2 (en) | 2010-08-04 | 2011-08-03 | Novel treatment of prostate carcinoma |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013001272A MX2013001272A (es) | 2013-05-22 |
MX345788B true MX345788B (es) | 2017-02-15 |
Family
ID=44504259
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013001272A MX345788B (es) | 2010-08-04 | 2011-08-03 | Nuevo tratamiento del carcinoma de prostata. |
Country Status (11)
Country | Link |
---|---|
US (5) | US9132105B2 (es) |
EP (1) | EP2600855A2 (es) |
JP (1) | JP5998137B2 (es) |
KR (3) | KR101926320B1 (es) |
CN (1) | CN103124563B (es) |
AU (1) | AU2011285724B2 (es) |
BR (1) | BR112013002655A2 (es) |
CA (1) | CA2807149C (es) |
IL (1) | IL224370B (es) |
MX (1) | MX345788B (es) |
WO (1) | WO2012018948A2 (es) |
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MX345788B (es) | 2010-08-04 | 2017-02-15 | Pellficure Pharmaceuticals Inc * | Nuevo tratamiento del carcinoma de prostata. |
CN102617664A (zh) * | 2012-04-14 | 2012-08-01 | 广西师范大学 | 白花丹素-5-o-葡萄糖及其合成方法和应用 |
WO2013164683A1 (en) * | 2012-04-30 | 2013-11-07 | King Abdullah University Of Science And Technology | Anti-cancer lead molecule |
KR101388776B1 (ko) | 2012-07-31 | 2014-04-23 | 성균관대학교산학협력단 | 2,3―비스[(2―하이드록시에틸)티오]―1,4―나프토퀴논을 포함하는 항염증용 조성물 |
SI3305285T1 (sl) * | 2012-09-26 | 2021-03-31 | Aragon Pharmaceuticals, Inc. | Anti-androgeni za zdravljenje proti kastraciji odpornega ne-metastatskega raka |
WO2014060358A1 (en) * | 2012-10-15 | 2014-04-24 | Chamaeleo Pharma Bvba | Fosfestrol for use in curative or palliative treatment of cancer in female mammals |
JOP20200097A1 (ar) * | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | معدل مستقبل أندروجين واستخداماته |
WO2014158875A1 (en) * | 2013-03-14 | 2014-10-02 | Pellficure Pharmaceuticals Inc. | Novel therapy for prostate carcinoma |
CA2905649A1 (en) * | 2013-03-15 | 2014-09-18 | The Penn State Research Foundation | Compositions and methods including celecoxib and plumbagin relating to treatment of cancer |
AU2015314772B2 (en) * | 2014-09-12 | 2020-02-27 | Pellficure Pharmaceuticals, Inc. | Compositions and methods for treatment of prostate carcinoma |
WO2016135633A1 (en) * | 2015-02-24 | 2016-09-01 | King Abdullah University Of Science & Technology | Cholesteryl ester transfer protein (cetp) inhibition in the treatment of cancer |
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WO2018195202A1 (en) * | 2017-04-21 | 2018-10-25 | Pellficure Pharmaceuticals Inc. | Compositions and methods for the treatment of cancer |
KR101990054B1 (ko) * | 2017-04-25 | 2019-06-17 | 대구대학교 산학협력단 | 로손을 유효성분으로 포함하는 항암 조성물 |
JOP20200076A1 (ar) | 2017-10-16 | 2020-04-30 | Aragon Pharmaceuticals Inc | مضادات أندروجين لعلاج سرطان البروستاتا غير النقيلي المقاوم للاستئصال |
CN107879958B (zh) * | 2017-10-30 | 2019-07-19 | 黑龙江八一农垦大学 | 2-(4-甲氧基苯巯基)-5,8-二甲氧基-1,4-萘醌及其制备方法和含其的药物 |
CN108645927A (zh) * | 2018-05-03 | 2018-10-12 | 四川农业大学 | 一种利用hplc测定蓝花丹中白花丹素含量的方法 |
ES2811674B2 (es) | 2018-06-06 | 2024-02-07 | Ic Medtech Corp | Compuestos de ácido ascórbico y quinona en combinación con un agente antiparasitario para el tratamiento de una enfermedad parasitaria |
CA3132623A1 (en) * | 2019-03-06 | 2020-09-10 | The Regents Of The University Of Michigan | Substituted bicyclic and tetracyclic quinones and related methods of use |
CN113134007B (zh) * | 2020-01-20 | 2024-01-30 | 鲁南制药集团股份有限公司 | 一种醋酸阿比特龙口服制剂及其制备方法 |
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MX345788B (es) * | 2010-08-04 | 2017-02-15 | Pellficure Pharmaceuticals Inc * | Nuevo tratamiento del carcinoma de prostata. |
CA2816088A1 (en) | 2010-10-28 | 2012-05-03 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
US8389543B2 (en) | 2010-11-13 | 2013-03-05 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
WO2012158884A1 (en) | 2011-05-17 | 2012-11-22 | Takeda Pharmaceutical Company Limited | Pharmaceutical compositions and methods for treating cancer |
WO2014158875A1 (en) | 2013-03-14 | 2014-10-02 | Pellficure Pharmaceuticals Inc. | Novel therapy for prostate carcinoma |
AU2015314772B2 (en) | 2014-09-12 | 2020-02-27 | Pellficure Pharmaceuticals, Inc. | Compositions and methods for treatment of prostate carcinoma |
-
2011
- 2011-08-03 MX MX2013001272A patent/MX345788B/es active IP Right Grant
- 2011-08-03 WO PCT/US2011/046474 patent/WO2012018948A2/en active Application Filing
- 2011-08-03 CA CA2807149A patent/CA2807149C/en active Active
- 2011-08-03 US US13/813,394 patent/US9132105B2/en active Active
- 2011-08-03 JP JP2013523318A patent/JP5998137B2/ja active Active
- 2011-08-03 KR KR1020187002020A patent/KR101926320B1/ko active IP Right Grant
- 2011-08-03 KR KR1020137005592A patent/KR101594660B1/ko active IP Right Grant
- 2011-08-03 KR KR1020167000661A patent/KR101823275B1/ko active IP Right Grant
- 2011-08-03 EP EP11746718.3A patent/EP2600855A2/en active Pending
- 2011-08-03 CN CN201180046484.8A patent/CN103124563B/zh active Active
- 2011-08-03 BR BR112013002655A patent/BR112013002655A2/pt not_active Application Discontinuation
- 2011-08-03 AU AU2011285724A patent/AU2011285724B2/en active Active
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2013
- 2013-01-23 IL IL224370A patent/IL224370B/en active IP Right Grant
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2015
- 2015-08-18 US US14/829,443 patent/US9655868B2/en active Active
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2017
- 2017-01-13 US US15/405,653 patent/US9877932B2/en active Active
- 2017-12-20 US US15/849,373 patent/US20180116977A1/en not_active Abandoned
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2018
- 2018-06-21 US US16/015,105 patent/US10245240B2/en active Active
Also Published As
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US20180116977A1 (en) | 2018-05-03 |
KR20180010346A (ko) | 2018-01-30 |
US20180296500A1 (en) | 2018-10-18 |
CA2807149A1 (en) | 2012-02-09 |
KR101594660B1 (ko) | 2016-02-16 |
US9655868B2 (en) | 2017-05-23 |
MX2013001272A (es) | 2013-05-22 |
KR20130099928A (ko) | 2013-09-06 |
JP2013532733A (ja) | 2013-08-19 |
JP5998137B2 (ja) | 2016-09-28 |
BR112013002655A2 (pt) | 2016-05-31 |
AU2011285724A1 (en) | 2013-03-21 |
US9132105B2 (en) | 2015-09-15 |
KR101823275B1 (ko) | 2018-03-08 |
US20170258744A1 (en) | 2017-09-14 |
WO2012018948A3 (en) | 2012-10-26 |
KR20160010889A (ko) | 2016-01-28 |
US9877932B2 (en) | 2018-01-30 |
AU2011285724B2 (en) | 2015-01-22 |
EP2600855A2 (en) | 2013-06-12 |
US10245240B2 (en) | 2019-04-02 |
KR101926320B1 (ko) | 2018-12-06 |
CN103124563B (zh) | 2016-08-10 |
US20130219528A1 (en) | 2013-08-22 |
CN103124563A (zh) | 2013-05-29 |
CA2807149C (en) | 2017-05-02 |
IL224370B (en) | 2018-04-30 |
WO2012018948A2 (en) | 2012-02-09 |
US20150352060A1 (en) | 2015-12-10 |
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