KR900009048A - 항플라크 항균성 구강 조성물 - Google Patents

항플라크 항균성 구강 조성물 Download PDF

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KR900009048A
KR900009048A KR1019890020633A KR890020633A KR900009048A KR 900009048 A KR900009048 A KR 900009048A KR 1019890020633 A KR1019890020633 A KR 1019890020633A KR 890020633 A KR890020633 A KR 890020633A KR 900009048 A KR900009048 A KR 900009048A
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나비 누란
개퍼 압둘
아플리토우 존
스트링어 오럼
프렌시프 마이클
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콜게이트-파아므올리브 캄파니
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Abstract

내용 없음.

Description

항플라크 항균성 구강 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (40)

  1. 효과적인 항플라크양의 본질적으로 수(水)불용성 비양이온 항균제, 구강표면으로으리 항균제의 전달 및 구강 표면상의 보유도를 증진시키는 약 0.005-4중량%의 항균성 증진제 및 상기 항균제를 타액안에 효과적인 항플라크양으로 용해시킬 수 있는데 효과적인 구강적으로 허용가능한 부형제로 구성되는, 본질적으로 폴리포스페이트 항치석제가 없는 구강 조성물.
  2. 제1항에 있어서, 상기 구강 조성물이 약 5-30중량%의 규산질 연마제로 구성되는 치약이고 상기 항균제가 약 0.25-0.35중량%의 양으로 존재하고 적어도 하나의 표면-활성제 및 향미유가 존재하는 구강 조성물.
  3. 제1항에 있어서, 상기 구강 조성물이 약 5-30중량%의 규산질 연마제로 구성되는 치약이고, 상기 항균제가 약 0.01-5중량%의 양으로 존재하고 상기 구강 조성물이 타액안에 상기 항균제를 용해시키기에 충분한 양의 가용화 물질로 구성되는 구강 조성물.
  4. 제3항에 있어서, 상기 항균제가 약 0.05중량%-약 0.25중량%의 양으로 존재하는 구강 조성물.
  5. 제3항에 있어서, 상기 항균제가 약 0.35중량%-약 5중량%의 양으로 존재하는 구강 조성물.
  6. 제5항에 있어서, 상기 항균제가 약 0.35중량%-약 0.5중량%의 양으로 존재하는 구강 조성물.
  7. 제1항에 있어서, 상기 구강 조성물이 약 30-75중량%의 치과용으로 허용가능한 수-불용성 연마제로 구성되는 치약인 구강 조성물.
  8. 제1항에 있어서, 상기 구강 조성물이 구세액 또는 액체 치약이고 상기 구강적으로 허용가능한 부형제가 적어도 하나의 표면-활성제, 향미유 또는 비-독성 알콜이 존재하는 수성부형제인 구강 조성물.
  9. 제1항 내지 제8항중 어느 한항에 있어서, 약 0.5-5중량%의 양으로 표면-활성제가 존재하는 구강 조성물.
  10. 제1항 내지 제9항중 어느 한항에 있어서 약 0.1-5중량%의 양으로 향미유가 존재하는 구강 조성물.
  11. 제8항에 있어서, 상기 조성물이 구세액이고 상기 수성 부형제가 에탄올을 함유하고 물대 에탄올의 중량비율이 약 1:1-약 20:1인 구강 조성물.
  12. 제8항에 있어서, 상기 구강 조성물이 현탁 및 증점제로서, 2:1:1:1의 적절한 비율로 만노오스, 글루코스, 칼륨 글루쿠로네이트 및 아세틸 부분을 함유하는 1,000,000을 넘는 고분자량의 폴리사카라이드 약 0.3-2.0중량% 및 약 10-20중량%의 연마 물질을 함유하는 액체 치약인 구강 조성물.
  13. 제1항 내지 제8항중 어느 한항에 있어서, 상기 항균제가 할로겐화된 디페닐 에테르, 할로겐화된 살리실아닐리드, 벤조산에스테르, 할로겐화된 카르바닐리드 및 페놀화합물로 이루어진 군으로부터 선택되는 구강 조성물.
  14. 제13항에 있어서, 상기 항균제가 할로겐화된 디페닐에테르인 구강 조성물.
  15. 제14항에 있어서, 상기 할로겐화된 디페닐 에테르가 2,4,4′-트리클로로-2′-히드록시페닐에테르인 구강 조성물.
  16. 제1항 및 제3항 내지 제6항중 어느 한항에 있어서, 가용화제가 약 0.5-50중량%의 양으로 존재하고 프로필렌 글리콜, 디프로필렌글리콜, 헥실렌글리콜, 메틸 세로솔브, 에틸 셀로솔브, 적어도 약 12개의 탄소원자를 함유하는 식물성유, 및 왁스, 아밀 아세테이트, 에틸 아세테이트, 글리세릴 트리스테아레이트 및 벤질 벤조에이트로 이루어진 군으로부터 선택되는 구강 조성물 치약.
  17. 제16항에 있어서, 가용화제가 프로필렌 글리콜이고 약 0.5중량%의 양으로 존재하는 구강 조성물 치약.
  18. 제1항 또는 제16중 어느 한항에 있어서, 연마제가 나트륨 메라포스 페이트, 트리칼슘 포스페이트, 이수화된 디칼슘 포스페이트, 무수 디칼슘 포스페이트, 무수 디칼슘 포스페이트, 칼슘 피로포스페이트, 마그네슘 오르토포스페이트, 트리마그네슘 포스페이트, 탄산칼슘, 규산 알루미늄, 수화된 알루미나, 실리카, 벤토나이트 및 이들의 혼합물들로 이루어진 군으로 부터 선택되어 존재하고 상기 구강 조성물이 치약인 구강 조성물.
  19. 제18항에 있어서, 상기 연마제가 디칼슘 포스페이트 디히드레이트 또는 수화된 알루미나인 구강 조성물.
  20. 제1항 내지 제8항중 어느 한항에 있어서, 상기 항균성-증진제가 약 100-약 1,000,000의 평균 부자량을 갖는 구강 조성물.
  21. 제20항에 있어서, 상기 항균성-증진제가 적어도 하나의 전달-증진관능기 및 적어도 하나의 유기 보유-증진기를 함유하는 구강 조성물.
  22. 제21항에 있어서, 상기 전달-증진기가 산성인 구강 조성물.
  23. 제22항에 있어서, 상기 전달-증진기가 카르복실산, 포스폰산, 포스핀산 및 설폰산, 및 이들의 염, 및 이들의 혼합물들로 이루어진 군으로 부터 선택되는 구강 조성물.
  24. 제23항에 있어서, 상기 유기 보유-증진기가, X가 O, N, S, SO, SO2, P, PO 또는 Si이고, R이 소수성알킬, 알킬렌, 아실, 아릴, 알카릴, 아르알킬, 헤테로시클릭, 또는 이들의 불활성-치환 유도체이고, n인 1 또는 0인 일반식 O(X)n-R로 구성되는 구강 조성물.
  25. 제20항 내지 제24항중 어느 한항에 있어서, 상기 항균성-증진제가 다수의 상기 전달-증진 및 보유-증진기를 함유하는 음이온 중합체인 구강 조성물.
  26. 제25항에 있어서, 상기 음이온 중합체가 각각 적어도 하나의 탄소 원자를 함유하는 반복 단위를 함유하는 사슬로 구성되는 구강 조성물.
  27. 제26항에 있어서, 각 단위가 사슬내 같은, 인접한, 또는 다른 원자에 결합된 적어도 하나의 전달-증진기를 함유하는 구강 조성물.
  28. 제23항에 있어서, 전달-증진기가 카르복실기 또는 그염인 구강 조성물.
  29. 제28항에 있어서, 항균성-증진제가 말레산 또는 무수물과 또 다른 불활성 에틸렌형으로 불포화된 중합성 단량체와의 공중합체인 구강 조성물.
  30. 제29항에 있어서, 상기 공중합체의 상기 다른 단량체가 말레산 또는 무수물과 4:1-1:4를 비율로 있는 메틸 비닐 에테르인 구강 조성물.
  31. 제30항에 있어서, 상기 공중합체가 약 30,000-1,000,000의 분자량을 갖고 약 0.1-2중량%의 양으로 존재하는 구강 조성물.
  32. 제31항에 있어서, 공중합체가 약 70,000이 평균분자량을 갖는 조성물.
  33. 제23항에 있어서, 전달-증진기가 포스폰기 또는 그 염인 조성물.
  34. 제33항에 있어서, 항균성-증진제가 폴리(배타-스티렌포스폰 산) 또는 폴리(알파-스티렌포스폰 산 중합체 또는 두 스티렌포스폰 산 중 하나와 또 다른 에틸렌형 불포화 단량체와의 공중합체인 조성물.
  35. 제1항 내지 제34항중 어느 한항에 정의된 조성물의 효과적인 플라크-억제량을 구강 표면에 적용시키는 것으로 구성되는 구강 플라크를 억제하는 방법.
  36. 구강적으로 허용가능한 부형제, 수용성 알카리 금속 또는 약 1,000-약 1,000,000의 분자량을 갖는 암모늄 합성 음이온 선형 중합체 폴리카르복실테이트 염이 없거나 본질적으로 없는 기들을 함유하는, 효과적인 항플라크양의 본질적으로 수-불용성 비양이온 항균제 및 평균 분자량 또는 약 1,000-약 1,000,000을 갖고, 적어도 하나의 전달 증진 관능기 및 적어도 하나의 유기 보유 증진기를 함유하는 항균성-증진제로 구성되는 구강 조성물.
  37. 제36항에 있어서, 상기 항균제가 약 0.25중량%-0.5중량%의 양으로 존재하는 구강 제제.
  38. 제36항에 있어서, 상기 항균제가 약 0.25-약 0.35중량%의 양으로 존재하는 구강 제제.
  39. 제37항에 있어서, 상기 구강 조성물이 규산질 연마제를 함유하는 구강 제제.
  40. 제38항에 있어서, 상기 구강 조성물이 규산질 연마제를 함유하는 구강 제제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
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US07/291,712 US4894220A (en) 1987-01-30 1988-12-29 Antibacterial antiplaque oral composition
US291,712 1988-12-29
US399,669 1989-08-25
US398,566 1989-08-25
US398,592 1989-08-25
US398,605 1989-08-25
US398,606 1989-08-25
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KR900009047A (ko) 1990-07-02
ZA899972B (en) 1991-11-27
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CA2006719C (en) 2000-10-17
AU2451992A (en) 1992-11-19
AU654874B2 (en) 1994-11-24
US4894220A (en) 1990-01-16
DD291246A5 (de) 1991-06-27
DD291245A5 (de) 1991-06-27
ZA899971B (en) 1991-08-28
PH26686A (en) 1992-09-15
CA2006719A1 (en) 1990-06-29
IT8948695A1 (it) 1991-06-22
KR0155985B1 (en) 1998-11-16
KR0138911B1 (en) 1998-05-15

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