AR076177A1 - MÉTODO PARA IDENTIFICAR UN COMPUESTO uTIL PARA TRATAR UNA ENFERMEDAD O CONDICIoN DE LA CAVIDAD ORAL - Google Patents

MÉTODO PARA IDENTIFICAR UN COMPUESTO uTIL PARA TRATAR UNA ENFERMEDAD O CONDICIoN DE LA CAVIDAD ORAL

Info

Publication number
AR076177A1
AR076177A1 ARP100101094A ARP100101094A AR076177A1 AR 076177 A1 AR076177 A1 AR 076177A1 AR P100101094 A ARP100101094 A AR P100101094A AR P100101094 A ARP100101094 A AR P100101094A AR 076177 A1 AR076177 A1 AR 076177A1
Authority
AR
Argentina
Prior art keywords
oral cavity
condition
matrix metalloproteinases
expression
positive control
Prior art date
Application number
ARP100101094A
Other languages
English (en)
Inventor
Virginia Barnes
Harsh M Trivedi
Wei Wang
Tao Xu
Emi Shimizu
Original Assignee
Colgate Palmolive Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42328354&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR076177(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Colgate Palmolive Co filed Critical Colgate Palmolive Co
Publication of AR076177A1 publication Critical patent/AR076177A1/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56955—Bacteria involved in periodontal diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)

Abstract

Reivindicacion 1: Un método para identificar un compuesto que es util para tratar una enfermedad o condicion de la cavidad oral, caracterizado por que comprende: Obtener una primera muestra gingival, a partir de un mamífero que sufre de una enfermedad o condicion de la cavidad oral; Obtener una segunda muestra gingival de la cavidad oral de dicho mamífero; contactar dicha primera muestra con un compuesto de prueba; contactar dicha segunda muestra con un control positivo, en donde dicho control positivo es un compuesto conocido por regular decrecientemente la expresion de uno o más metaloproteinasas de matriz; Medir la extension a la cual la expresion de uno o más de dicha metaloproteinasas de matriz que es regulada decrecientemente por dicho compuesto de prueba; Medir la extension a la cual la expresion de uno o más de dicha metaloproteinasas de matriz es regulada decrecientemente, por dicho control positivo; y comparar la extension a la cual la expresion de una o más de dicha metaloproteinasas de matriz es regulada decrecientemente, por dicho compuesto de prueba, con la medida con la que la expresion de uno o más de dichas metaloproteinasas de matriz es regulada decrecientemente por dicho control positivo; en donde un compuesto de prueba que regula decrecientemente la expresion de uno o más de dichas metaloproteinasas de matriz a una medida igual o mayor que la de dicho control positivo, es un compuesto util en tratar una enfermedad o condicion de una cavidad oral. Reivindicacion 2: El método de la reivindicacion 1, caracterizado por que dicha una o más metaloproteinasas de matriz son seleccionadas del grupo que consiste de: MMP-8, MMP-9, y MMP-13. Reivindicacion 4: El método de cualquiera de las reivindicaciones precedentes, caracterizado por que dicha enfermedad o condicion de la cavidad oral, es una gingivitis o periodontitis. Reivindicacion 6: El método de cualquiera de las reivindicaciones precedentes, caracterizado por que el control positivo es triclosán.
ARP100101094A 2009-04-01 2010-03-31 MÉTODO PARA IDENTIFICAR UN COMPUESTO uTIL PARA TRATAR UNA ENFERMEDAD O CONDICIoN DE LA CAVIDAD ORAL AR076177A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16568509P 2009-04-01 2009-04-01

Publications (1)

Publication Number Publication Date
AR076177A1 true AR076177A1 (es) 2011-05-26

Family

ID=42328354

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100101094A AR076177A1 (es) 2009-04-01 2010-03-31 MÉTODO PARA IDENTIFICAR UN COMPUESTO uTIL PARA TRATAR UNA ENFERMEDAD O CONDICIoN DE LA CAVIDAD ORAL

Country Status (20)

Country Link
US (1) US8637266B2 (es)
EP (1) EP2414838B1 (es)
JP (1) JP5330596B2 (es)
CN (1) CN102365550B (es)
AR (1) AR076177A1 (es)
AU (1) AU2010232590B2 (es)
BR (1) BRPI1013185A2 (es)
CA (1) CA2757317C (es)
CO (1) CO6420374A2 (es)
DK (1) DK2414838T3 (es)
ES (1) ES2432864T3 (es)
HK (1) HK1167272A1 (es)
MX (1) MX2011008438A (es)
MY (1) MY158406A (es)
PL (1) PL2414838T3 (es)
RU (1) RU2524629C2 (es)
SG (1) SG173487A1 (es)
TW (1) TWI405565B (es)
WO (1) WO2010115031A1 (es)
ZA (1) ZA201106054B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101745067B1 (ko) * 2014-12-31 2017-06-12 서울대학교산학협력단 치주질환 예측 시스템 및 이를 이용한 치주질환 예측 방법
KR102098624B1 (ko) * 2019-09-20 2020-04-08 서울대학교산학협력단 타액 mmp-9 및 il-8를 이용한 치주염 예측 시스템 및 이를 이용한 치주염 예측 방법

Family Cites Families (40)

* Cited by examiner, † Cited by third party
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FR2794457B1 (fr) 1999-06-01 2001-08-10 Oreal Derives carbonates de retinol, procede de preparation et utilisations
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Also Published As

Publication number Publication date
ES2432864T3 (es) 2013-12-05
JP2012524884A (ja) 2012-10-18
US20120107843A1 (en) 2012-05-03
MY158406A (en) 2016-10-14
SG173487A1 (en) 2011-09-29
CO6420374A2 (es) 2012-04-16
RU2524629C2 (ru) 2014-07-27
PL2414838T3 (pl) 2014-01-31
MX2011008438A (es) 2011-09-06
JP5330596B2 (ja) 2013-10-30
ZA201106054B (en) 2014-01-29
CN102365550B (zh) 2014-08-13
HK1167272A1 (en) 2012-11-23
CA2757317A1 (en) 2010-10-07
TW201039812A (en) 2010-11-16
TWI405565B (zh) 2013-08-21
EP2414838A1 (en) 2012-02-08
CA2757317C (en) 2014-03-11
EP2414838B1 (en) 2013-08-28
CN102365550A (zh) 2012-02-29
AU2010232590A1 (en) 2011-08-18
BRPI1013185A2 (pt) 2016-04-12
RU2011144028A (ru) 2013-05-10
WO2010115031A1 (en) 2010-10-07
AU2010232590B2 (en) 2013-03-07
US8637266B2 (en) 2014-01-28
DK2414838T3 (da) 2013-11-04

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