CO6220937A2 - Compuestos triciclicos composiciones y procedimientos - Google Patents

Compuestos triciclicos composiciones y procedimientos

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Publication number
CO6220937A2
CO6220937A2 CO09079789A CO09079789A CO6220937A2 CO 6220937 A2 CO6220937 A2 CO 6220937A2 CO 09079789 A CO09079789 A CO 09079789A CO 09079789 A CO09079789 A CO 09079789A CO 6220937 A2 CO6220937 A2 CO 6220937A2
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CO
Colombia
Prior art keywords
compound
formula
salt
procedures
compounds compositions
Prior art date
Application number
CO09079789A
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English (en)
Inventor
Hengmiao Cheng
Xiao Hu
Kevin D Jerome
Mark Gerrd Obukowicz
Lisa Olson
Paul V Rucker
Ronald Keith Webber
Original Assignee
Pfizer Prod Inc
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Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of CO6220937A2 publication Critical patent/CO6220937A2/es

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
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Abstract

En una realización, la invención se refiere a un compuesto de Fórmula I:en la que R1 es -H o -P(O)(OH)2; o una sal del mismo. En otra realización, la invención se refiere a composiciones que comprenden un compuesto de Fórmula I y un vehículo. En otra realización, la invención se refiere a un procedimiento de poner en contacto un receptor de glucocorticosteroides con un compuesto de Fórmula I. Una realización adicional incluye procedimientos de tratamiento de una afección en un sujeto mediado por la actividad del receptor de glucocorticosteroides mediante la administración al sujeto de un compuesto de Fórmula I. 1.- Un compuesto de fórmula I:en la que R1 es -H; o sal del mismo. 2.- El compuesto de la reivindicación 1, en el que el compuesto es:o sal del mismo. 3.- El compuesto de la reivindicación 1, en el que el compuesto es:4.- Una sal clorhidrato del compuesto de la reivindicación 1.5.- Una composición que comprende el compuesto de la reivindicación 1 o sal del mismo y un vehículo. 6.- Un procedimiento que comprende poner en contacto un receptor de glucocorticosteroides con el compuesto de la reivindicación 1 o sal del mismo.
CO09079789A 2007-02-02 2009-07-31 Compuestos triciclicos composiciones y procedimientos CO6220937A2 (es)

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CO09079789A CO6220937A2 (es) 2007-02-02 2009-07-31 Compuestos triciclicos composiciones y procedimientos
CO09079796A CO6190603A2 (es) 2007-02-02 2009-07-31 Acido 7-(2-metilpiridin-3-il carbomoil)-4a-benzil-2-(trifluorometil)-1,2,3,4,4a, 9, 10, 10a-octahidro fenantren-2-il-2-fosfonico como moduladores del receptor glucocorticoide

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CO09079796A CO6190603A2 (es) 2007-02-02 2009-07-31 Acido 7-(2-metilpiridin-3-il carbomoil)-4a-benzil-2-(trifluorometil)-1,2,3,4,4a, 9, 10, 10a-octahidro fenantren-2-il-2-fosfonico como moduladores del receptor glucocorticoide

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BRPI0917212A2 (pt) * 2008-07-28 2015-11-10 Pfizer compostos de fenantrenona, seus usos na preparação de composições, e composições compreendendo os referidos compostos
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