ATE303369T1 - Glucocorticoid rezeptor modulatoren - Google Patents
Glucocorticoid rezeptor modulatorenInfo
- Publication number
- ATE303369T1 ATE303369T1 AT01308789T AT01308789T ATE303369T1 AT E303369 T1 ATE303369 T1 AT E303369T1 AT 01308789 T AT01308789 T AT 01308789T AT 01308789 T AT01308789 T AT 01308789T AT E303369 T1 ATE303369 T1 AT E303369T1
- Authority
- AT
- Austria
- Prior art keywords
- glucocorticoid receptor
- compounds
- present
- receptor modulators
- provides
- Prior art date
Links
- 229940117965 Glucocorticoid receptor modulator Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 2
- JFUAWXPBHXKZGA-IBGZPJMESA-N 4-fluoro-2-[(4r)-5,5,5-trifluoro-4-hydroxy-2-methyl-4-(1h-pyrrolo[2,3-c]pyridin-2-ylmethyl)pentan-2-yl]phenol Chemical compound C([C@@](O)(CC=1NC2=CN=CC=C2C=1)C(F)(F)F)C(C)(C)C1=CC(F)=CC=C1O JFUAWXPBHXKZGA-IBGZPJMESA-N 0.000 abstract 1
- 102000003676 Glucocorticoid Receptors Human genes 0.000 abstract 1
- 108090000079 Glucocorticoid Receptors Proteins 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 108010085012 Steroid Receptors Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940124750 glucocorticoid receptor agonist Drugs 0.000 abstract 1
- 229940126013 glucocorticoid receptor antagonist Drugs 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000004031 partial agonist Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 102000005969 steroid hormone receptors Human genes 0.000 abstract 1
- 230000003637 steroidlike Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24430200P | 2000-10-30 | 2000-10-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE303369T1 true ATE303369T1 (de) | 2005-09-15 |
Family
ID=22922191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01308789T ATE303369T1 (de) | 2000-10-30 | 2001-10-16 | Glucocorticoid rezeptor modulatoren |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6852719B2 (de) |
| EP (1) | EP1201660B1 (de) |
| JP (1) | JP2002193955A (de) |
| AT (1) | ATE303369T1 (de) |
| BR (1) | BR0104834A (de) |
| CA (1) | CA2360313C (de) |
| DE (1) | DE60113032T2 (de) |
| ES (1) | ES2246292T3 (de) |
| MX (1) | MXPA01011108A (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL180679A0 (en) * | 2000-10-27 | 2009-02-11 | Pfizer Prod Inc | Process for the preparation of non-steroidal glucocorticoid receptor modulators |
| AU2003251970A1 (en) * | 2002-07-18 | 2004-02-09 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor and method |
| WO2004054587A1 (en) * | 2002-12-18 | 2004-07-01 | University Of Zurich | Treatment of neuro-psychiatric disorders |
| US7625921B2 (en) * | 2004-01-16 | 2009-12-01 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
| PT1778236E (pt) * | 2004-07-02 | 2010-10-19 | Corcept Therapeutics Inc | Moduladores do receptor de glucocorticóide de pirimidina modificada |
| US20060154981A1 (en) * | 2005-01-12 | 2006-07-13 | Alcon, Inc. | Method of reducing intraocular pressure and treating glaucoma |
| DE602006021535D1 (de) * | 2005-01-19 | 2011-06-09 | Merck Sharp & Dohme | Als inhibitoren von beta-secretase aktive tertiäre carbinamine mit substituierten heterocyclen zur behandlung der alzheimer-krankheit |
| CN101106994A (zh) * | 2005-01-19 | 2008-01-16 | 默克公司 | 用于治疗阿尔茨海默氏病的氨基甲基β-分泌酶抑制剂 |
| EP1944290B1 (de) | 2005-09-14 | 2013-12-04 | Santen Pharmaceutical Co., Ltd. | Neues 1,2-dihydrochinolinderivat mit glucocorticoidrezeptorbindender aktivität |
| PL1995242T3 (pl) * | 2006-03-14 | 2013-03-29 | Santen Pharmaceutical Co Ltd | Nowa pochodna 1,2,3,4-tetrahydrochinoksaliny, mająca aktywność wiążącą receptor glukokortykoidowy |
| PL2085388T3 (pl) * | 2006-11-14 | 2013-01-31 | Santen Pharmaceutical Co Ltd | Nowa pochodna 1,2-dihydrochinoliny, zawierająca jako podstawniki podstawioną grupę fenyloamino-niższą alkilową oraz wprowadzoną przez ester grupę fenylową |
| TWI410422B (zh) | 2007-01-15 | 2013-10-01 | Mitsubishi Tanabe Pharma Corp | 縮合四氫喹啉衍生物及其醫藥用途 |
| ATE518872T1 (de) * | 2007-02-02 | 2011-08-15 | Pfizer Prod Inc | Trizyklische verbindungen und deren verwendung als glucocorticoidrezeptormodulatoren |
| WO2008146871A1 (ja) * | 2007-05-29 | 2008-12-04 | Santen Pharmaceutical Co., Ltd. | グルココルチコイド受容体結合活性を有する、スルホン酸エステル又はスルホン酸アミド構造を導入したフェニル基を置換基として有する新規１，２，３，４－テトラヒドロキノキサリン誘導体 |
| WO2009139361A1 (ja) | 2008-05-12 | 2009-11-19 | 参天製薬株式会社 | 置換オキシ基を有する２，２，４－トリメチル－６－フェニル－１，２－ジヒドロキノリン誘導体からなるグルココルチコイド受容体アゴニスト |
| AP2744A (en) | 2008-07-28 | 2013-09-30 | Pfizer | Phenanthrenone compounds, compositions and methods |
| KR20110053467A (ko) | 2008-09-12 | 2011-05-23 | 산텐 세이야꾸 가부시키가이샤 | 술폰산에스테르 구조를 도입한 페닐기를 치환기로서 갖는 신규 1,2,3,4-테트라히드로퀴녹살린 유도체를 포함하는 글루코코르티코이드 수용체 작용제 |
| ES3050068T3 (en) | 2008-11-07 | 2025-12-19 | Univ Sheffield | Medicament and method of diagnosis |
| CA2821524A1 (en) | 2011-01-07 | 2012-07-12 | Corcept Therapeutics, Inc. | Combination steroid and glucocorticoid receptor antagonist therapy |
| PH12013501906A1 (en) | 2011-03-18 | 2013-12-16 | Corcept Therapeutics Inc | Pyrimidine cyclohexyl glucocorticoid receptor modulators |
| TW201422590A (zh) * | 2012-09-07 | 2014-06-16 | Abbvie Inc | 雜環核激素受體調節劑 |
| EP2935284A4 (de) | 2012-12-21 | 2016-04-27 | Abbvie Inc | Heterocyclische nuklearhormonrezeptormodulatoren |
| JP2017043614A (ja) | 2015-08-25 | 2017-03-02 | 参天製薬株式会社 | ［４−（１，３，３−トリメチル−２−オキソ−３，４−ジヒドロ−１ｈ−キノキサリン−７−イル）フェノキシ］エチルオキシ化合物またはその塩 |
| EP3768324B1 (de) | 2018-03-22 | 2025-11-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Verfahren zur modulierung der aktivität innater lymphoider zellen, antikörper-arzneimittelkonjugate und verwendungen in der therapie |
| CA3102099C (en) | 2018-06-04 | 2023-09-26 | Corcept Therapeutics Incorporated | Pyrimidine cyclohexenyl glucocorticoid receptor modulators |
| WO2021119432A1 (en) | 2019-12-11 | 2021-06-17 | Corcept Therapeutics Incorporated | Methods of treating antipsychotic-induced weight gain with miricorilant |
| WO2021226260A1 (en) | 2020-05-06 | 2021-11-11 | Corcept Therapeutics Incorporated | Polymorphs of pyrimidine cyclohexyl glucocorticoid receptor modulators |
| IL297840A (en) | 2020-05-06 | 2023-01-01 | Corcept Therapeutics Inc | Formulations of pyrimidine cyclohexyl glucocorticoid receptor modulators |
| CN116848092A (zh) | 2020-12-21 | 2023-10-03 | 科赛普特治疗公司 | 制备嘧啶环己基糖皮质激素受体调节剂的方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3683091A (en) | 1967-11-13 | 1972-08-08 | Wataru Nagata | Certain phenanthrene compounds for treatment of acne |
| JPS50111098A (de) | 1974-02-18 | 1975-09-01 | ||
| FR2576025B1 (fr) | 1985-01-14 | 1987-01-23 | Roussel Uclaf | Nouveaux steroides substitues en position 10, leur procede et les intermediaires de preparation, leur application comme medicaments, les compositions pharmaceutiques les contenant |
| JPH06263688A (ja) | 1991-09-04 | 1994-09-20 | Otsuka Pharmaceut Factory Inc | フェナンスレン誘導体 |
| US5654343A (en) | 1993-10-13 | 1997-08-05 | Otsuka Pharmaceutical Co., Ltd. | Method of treating a nitric oxide-associated disease with phenanthrene derivatives |
| EP0683172B1 (de) | 1994-05-19 | 1997-08-13 | Akzo Nobel N.V. | 11,21-Bisphenyl-19-nor-pregnan Derivate |
| JPH0952899A (ja) | 1994-09-30 | 1997-02-25 | Tsumura & Co | ロイコトリエン拮抗剤 |
| US5693647A (en) | 1994-12-22 | 1997-12-02 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
| US5767113A (en) | 1995-05-10 | 1998-06-16 | The Salk Institute For Biological Studies | Compounds useful for concurrently activating glucocorticoid-induced response and reducing multidrug resistance |
| FR2757400B1 (fr) | 1996-12-19 | 1999-12-17 | Hoechst Marion Roussel Inc | Application des composes antiglucocorticoides dans le traitement des psychoses ou des comportements addictifs |
| AU5729098A (en) | 1996-12-24 | 1998-07-17 | Zymogenetics Inc. | Treatment agents and methods for treating type ii diabetes and symptoms of type ii diabetes |
| IL122740A (en) * | 1997-01-15 | 2003-09-17 | Akzo Nobel Nv | 16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them |
| EP0903146A1 (de) | 1997-09-23 | 1999-03-24 | Applied Research Systems ARS Holdings N.V. | 21-Hydroy-6,19-oxidoprogesterone (21-0H-60P) als ANitoglucocortikoid |
| AR014195A1 (es) | 1997-12-29 | 2001-02-07 | Ortho Mcneil Pharm Inc | Compuestos de trifenilpropanamida utiles para el tratamiento de procesos inflamatorios, composiciones anti-inflamatorias que los comprenden, ymetodos para prepararlos |
| US6380207B2 (en) | 1998-02-13 | 2002-04-30 | Abbott Laboratories | Glucocortiocoid-selective antiinflammatory agents |
| CN1119348C (zh) | 1998-02-13 | 2003-08-27 | 艾博特公司 | 糖皮质激素衍生物，其组合物和用途 |
| CA2334116A1 (en) | 1998-06-08 | 1999-12-16 | Theresa Apelqvist | Treatment of diabetes |
| DK1022636T3 (da) | 1998-07-30 | 2005-02-07 | Hansgrohe Ag | Blandingsarmatur med etgrebsbetjening |
| GB9816935D0 (en) | 1998-08-05 | 1998-09-30 | Karobio Ab | Novel glucocortoid and thyroid receptor ligands for the treatment of metabolic disorders |
| AP1542A (en) * | 1999-04-30 | 2006-01-31 | Pfizer Prod Inc | Glucocorticoid receptor modulators. |
-
2001
- 2001-10-16 DE DE60113032T patent/DE60113032T2/de not_active Expired - Fee Related
- 2001-10-16 ES ES01308789T patent/ES2246292T3/es not_active Expired - Lifetime
- 2001-10-16 AT AT01308789T patent/ATE303369T1/de not_active IP Right Cessation
- 2001-10-16 EP EP01308789A patent/EP1201660B1/de not_active Expired - Lifetime
- 2001-10-26 CA CA002360313A patent/CA2360313C/en not_active Expired - Fee Related
- 2001-10-26 US US10/012,274 patent/US6852719B2/en not_active Expired - Fee Related
- 2001-10-29 BR BR0104834-1A patent/BR0104834A/pt not_active IP Right Cessation
- 2001-10-29 JP JP2001330283A patent/JP2002193955A/ja active Pending
- 2001-10-30 MX MXPA01011108A patent/MXPA01011108A/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| DE60113032T2 (de) | 2006-07-06 |
| EP1201660B1 (de) | 2005-08-31 |
| CA2360313A1 (en) | 2002-04-30 |
| CA2360313C (en) | 2006-12-05 |
| MXPA01011108A (es) | 2002-06-04 |
| US20040014741A1 (en) | 2004-01-22 |
| BR0104834A (pt) | 2002-08-20 |
| US6852719B2 (en) | 2005-02-08 |
| EP1201660A1 (de) | 2002-05-02 |
| JP2002193955A (ja) | 2002-07-10 |
| DE60113032D1 (de) | 2005-10-06 |
| ES2246292T3 (es) | 2006-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |