DE60113032D1 - Glucocorticoid Rezeptor Modulatoren - Google Patents
Glucocorticoid Rezeptor ModulatorenInfo
- Publication number
- DE60113032D1 DE60113032D1 DE60113032T DE60113032T DE60113032D1 DE 60113032 D1 DE60113032 D1 DE 60113032D1 DE 60113032 T DE60113032 T DE 60113032T DE 60113032 T DE60113032 T DE 60113032T DE 60113032 D1 DE60113032 D1 DE 60113032D1
- Authority
- DE
- Germany
- Prior art keywords
- glucocorticoid receptor
- compounds
- present
- receptor modulators
- provides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24430200P | 2000-10-30 | 2000-10-30 | |
US244302P | 2000-10-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60113032D1 true DE60113032D1 (de) | 2005-10-06 |
DE60113032T2 DE60113032T2 (de) | 2006-07-06 |
Family
ID=22922191
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60113032T Expired - Fee Related DE60113032T2 (de) | 2000-10-30 | 2001-10-16 | Glukokortikoidrezeptor-Modulatoren |
Country Status (9)
Country | Link |
---|---|
US (1) | US6852719B2 (de) |
EP (1) | EP1201660B1 (de) |
JP (1) | JP2002193955A (de) |
AT (1) | ATE303369T1 (de) |
BR (1) | BR0104834A (de) |
CA (1) | CA2360313C (de) |
DE (1) | DE60113032T2 (de) |
ES (1) | ES2246292T3 (de) |
MX (1) | MXPA01011108A (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL146057A (en) * | 2000-10-27 | 2007-09-20 | Pfizer Prod Inc | A process for the preparation of modulators of a non-steroidal glucocorticoid receptor |
JP2006508042A (ja) * | 2002-07-18 | 2006-03-09 | ブリストル−マイヤーズ スクイブ カンパニー | グルココルチコイド受容体の修飾物質および方法 |
WO2004054587A1 (en) * | 2002-12-18 | 2004-07-01 | University Of Zurich | Treatment of neuro-psychiatric disorders |
US7625921B2 (en) * | 2004-01-16 | 2009-12-01 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
DK1778236T3 (da) * | 2004-07-02 | 2010-10-25 | Corcept Therapeutics Inc | Modificerede pyrimidin-glucocorticoid-receptor-modulatorer |
US20060154981A1 (en) * | 2005-01-12 | 2006-07-13 | Alcon, Inc. | Method of reducing intraocular pressure and treating glaucoma |
EP1841426B1 (de) * | 2005-01-19 | 2011-04-27 | Merck Sharp & Dohme Corp. | Als inhibitoren von beta-secretase aktive tertiäre carbinamine mit substituierten heterocyclen zur behandlung der alzheimer-krankheit |
EP1855679B1 (de) * | 2005-01-19 | 2016-06-29 | Merck Sharp & Dohme Corp. | Aminomethyl-beta-sekretase-hemmer zur behandlung von alzheimer |
WO2007032556A1 (ja) | 2005-09-14 | 2007-03-22 | Santen Pharmaceutical Co., Ltd. | グルココルチコイド受容体結合活性を有する新規1,2−ジヒドロキノリン誘導体 |
SI1995242T1 (sl) * | 2006-03-14 | 2013-01-31 | Santen Pharmaceutical Co., Ltd. | Nov derivat 1,2,3,4-tetrahidrokinoksalina z aktivnostjo vezanja glukokortikoidnega receptorja |
JP4898635B2 (ja) * | 2006-11-14 | 2012-03-21 | 参天製薬株式会社 | 置換フェニルアミノ低級アルキル基とエステル構造を導入したフェニル基を置換基として有する新規1,2−ジヒドロキノリン誘導体 |
TWI410422B (zh) | 2007-01-15 | 2013-10-01 | Mitsubishi Tanabe Pharma Corp | 縮合四氫喹啉衍生物及其醫藥用途 |
MX2009008284A (es) * | 2007-02-02 | 2009-08-12 | Pfizer Prod Inc | Compuestos triciclicos y su uso como moduladores de receptor de glucocorticoides. |
US8193187B2 (en) * | 2007-05-29 | 2012-06-05 | Santen Pharmaceutical Co., Ltd. | 1,2,3,4-tetrahydroquinoxaline compound with a phenyl group substituent having a sulfonic acid ester structure or a sulfonic acid amide structure introduced therein and having glucocorticoid receptor-binding activity |
CN102089283B (zh) | 2008-05-12 | 2015-11-25 | 步制药股份有限公司 | 含有具有取代氧基的2,2,4-三甲基-6-苯基-1,2-二氢喹啉衍生物的糖皮质激素受体激动剂 |
MX2011001053A (es) | 2008-07-28 | 2011-04-21 | Pfizer | Compuestos de fenantrenona, composiciones y metodos. |
MX2011002677A (es) * | 2008-09-12 | 2011-04-12 | Santen Pharma Co Ltd | Agonista del receptor de glucocorticoide que comprende nuevos derivados de 1,2,3,-4-tetrahidroquinoxalina que contienen un grupo fenilo que tiene una estructura de ester de acido sulfonico introducida en el mismo como sustituyente. |
CA2742964C (en) | 2008-11-07 | 2020-07-07 | University Of Sheffield | Medicament and method of diagnosis |
JP2014501785A (ja) * | 2011-01-07 | 2014-01-23 | コーセプト セラピューティクス, インコーポレイテッド | ステロイドおよびグルココルチコイド受容体アンタゴニスト組合せ治療 |
SG193509A1 (en) | 2011-03-18 | 2013-10-30 | Corcept Therapeutics Inc | Pyrimidine cyclohexyl glucocorticoid receptor modulators |
TW201422590A (zh) * | 2012-09-07 | 2014-06-16 | Abbvie Inc | 雜環核激素受體調節劑 |
EP2935284A4 (de) | 2012-12-21 | 2016-04-27 | Abbvie Inc | Heterocyclische nuklearhormonrezeptormodulatoren |
CA2996278A1 (en) | 2015-08-25 | 2017-03-02 | Santen Pharmaceutical Co., Ltd. | [4-(1,3,3-trimethyl-2-oxo-3,4-dihydro-1h-quinoxalin-7-yl)-phenoxy]ethyloxy compound or salt thereof |
EP3768324A1 (de) | 2018-03-22 | 2021-01-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Verfahren zur modulierung der angeborenen lymphoidzellaktivität, antikörper-arzneimittelkonjugate und verwendungen in der therapie |
MX2020012831A (es) | 2018-06-04 | 2021-04-28 | Corcept Therapeutics Inc | Moduladores del receptor de glucocorticoide de pirimidina ciclohexenilo. |
CA3158745A1 (en) | 2019-12-11 | 2021-06-17 | Corcept Therapeutics Incorporated | Methods of treating antipsychotic-induced weight gain with miricorilant |
AU2021268944B2 (en) | 2020-05-06 | 2024-04-18 | Corcept Therapeutics Incorporated | Polymorphs of pyrimidine cyclohexyl glucocorticoid receptor modulators |
JP2024503244A (ja) | 2020-12-21 | 2024-01-25 | コーセプト セラピューティクス, インコーポレイテッド | ピリミジンシクロヘキシルグルココルチコイド受容体調節因子を調製する方法 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3683091A (en) * | 1967-11-13 | 1972-08-08 | Wataru Nagata | Certain phenanthrene compounds for treatment of acne |
JPS50111098A (de) | 1974-02-18 | 1975-09-01 | ||
FR2576025B1 (fr) | 1985-01-14 | 1987-01-23 | Roussel Uclaf | Nouveaux steroides substitues en position 10, leur procede et les intermediaires de preparation, leur application comme medicaments, les compositions pharmaceutiques les contenant |
JPH06263688A (ja) | 1991-09-04 | 1994-09-20 | Otsuka Pharmaceut Factory Inc | フェナンスレン誘導体 |
EP0676196A1 (de) | 1993-10-13 | 1995-10-11 | Otsuka Pharmaceutical Co., Ltd. | Stickstoffmonoxid-synthese-inhibitoren |
CA2149496C (en) | 1994-05-19 | 2006-12-19 | Ronald Gebhard | 11,21-bisphenyl-19-norpregnane derivatives |
JPH0952899A (ja) | 1994-09-30 | 1997-02-25 | Tsumura & Co | ロイコトリエン拮抗剤 |
US5688808A (en) * | 1994-12-22 | 1997-11-18 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
US5767113A (en) * | 1995-05-10 | 1998-06-16 | The Salk Institute For Biological Studies | Compounds useful for concurrently activating glucocorticoid-induced response and reducing multidrug resistance |
FR2757400B1 (fr) | 1996-12-19 | 1999-12-17 | Hoechst Marion Roussel Inc | Application des composes antiglucocorticoides dans le traitement des psychoses ou des comportements addictifs |
AU5729098A (en) | 1996-12-24 | 1998-07-17 | Zymogenetics Inc. | Treatment agents and methods for treating type ii diabetes and symptoms of type ii diabetes |
IL122740A (en) * | 1997-01-15 | 2003-09-17 | Akzo Nobel Nv | 16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them |
EP0903146A1 (de) | 1997-09-23 | 1999-03-24 | Applied Research Systems ARS Holdings N.V. | 21-Hydroy-6,19-oxidoprogesterone (21-0H-60P) als ANitoglucocortikoid |
ZA9811898B (en) | 1997-12-29 | 2000-06-28 | Ortho Mcneil Pharm Inc | Anti-Inflammatory Compounds. |
AU766441B2 (en) | 1998-02-13 | 2003-10-16 | Abbott Laboratories | Glucocorticoid-selective anti-inflammatory agents |
US6380207B2 (en) | 1998-02-13 | 2002-04-30 | Abbott Laboratories | Glucocortiocoid-selective antiinflammatory agents |
JP2002527355A (ja) | 1998-06-08 | 2002-08-27 | カロ バイオ アクチェブラーグ | 糖尿病の治療 |
WO2000006137A2 (en) | 1998-07-30 | 2000-02-10 | Abbott Laboratories | Glucocorticoid-selective anti-inflammatory agents |
GB9816935D0 (en) | 1998-08-05 | 1998-09-30 | Karobio Ab | Novel glucocortoid and thyroid receptor ligands for the treatment of metabolic disorders |
NZ514465A (en) * | 1999-04-30 | 2003-11-28 | Pfizer Prod Inc | Glucocorticoid receptor modulators |
-
2001
- 2001-10-16 DE DE60113032T patent/DE60113032T2/de not_active Expired - Fee Related
- 2001-10-16 EP EP01308789A patent/EP1201660B1/de not_active Expired - Lifetime
- 2001-10-16 ES ES01308789T patent/ES2246292T3/es not_active Expired - Lifetime
- 2001-10-16 AT AT01308789T patent/ATE303369T1/de not_active IP Right Cessation
- 2001-10-26 CA CA002360313A patent/CA2360313C/en not_active Expired - Fee Related
- 2001-10-26 US US10/012,274 patent/US6852719B2/en not_active Expired - Fee Related
- 2001-10-29 BR BR0104834-1A patent/BR0104834A/pt not_active IP Right Cessation
- 2001-10-29 JP JP2001330283A patent/JP2002193955A/ja active Pending
- 2001-10-30 MX MXPA01011108A patent/MXPA01011108A/es active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
US6852719B2 (en) | 2005-02-08 |
CA2360313A1 (en) | 2002-04-30 |
BR0104834A (pt) | 2002-08-20 |
CA2360313C (en) | 2006-12-05 |
JP2002193955A (ja) | 2002-07-10 |
EP1201660B1 (de) | 2005-08-31 |
US20040014741A1 (en) | 2004-01-22 |
EP1201660A1 (de) | 2002-05-02 |
DE60113032T2 (de) | 2006-07-06 |
ES2246292T3 (es) | 2006-02-16 |
MXPA01011108A (es) | 2002-06-04 |
ATE303369T1 (de) | 2005-09-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |