BR0205829A - Novas aminas como ligantes dos receptores de histamina-3 e suas aplicações terapêuticas - Google Patents
Novas aminas como ligantes dos receptores de histamina-3 e suas aplicações terapêuticasInfo
- Publication number
- BR0205829A BR0205829A BR0205829-4A BR0205829A BR0205829A BR 0205829 A BR0205829 A BR 0205829A BR 0205829 A BR0205829 A BR 0205829A BR 0205829 A BR0205829 A BR 0205829A
- Authority
- BR
- Brazil
- Prior art keywords
- histamine
- therapeutic applications
- receptor ligands
- novel amines
- receptors
- Prior art date
Links
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- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
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- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Addiction (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"NOVAS AMINAS COMO LIGANTES DOS RECEPTORES DE HISTAMINA-3 E SUAS APLICAçõES TERAPêUTICAS". Compostos de fórmula (I), ou um sal, éster, amida, ou pró-medicamento farmaceuticamente aceitável dos mesmos, os quais são úteis para a modulação dos receptores de histamina-3 em mamíferos e os quais são úteis para o tratamento de distúrbios melhorados por ligantes dos receptores de histamina-3.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/810,648 US20020177589A1 (en) | 2001-03-16 | 2001-03-16 | Novel amines as histamine-3 receptor ligands and their therapeutic applications |
US10/044,495 US20020183309A1 (en) | 2001-03-16 | 2002-01-11 | Novel amines as histamine-3 receptor ligands and their therapeutic applications |
US10/081,207 US6969730B2 (en) | 2001-03-16 | 2002-02-25 | Amines as histamine-3 receptor ligands and their therapeutic applications |
PCT/US2002/007107 WO2002074758A2 (en) | 2001-03-16 | 2002-03-11 | Novel amines as histamine-3 receptor ligands and their therapeutic applications |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0205829A true BR0205829A (pt) | 2005-03-08 |
Family
ID=27366495
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0205829-4A BR0205829A (pt) | 2001-03-16 | 2002-03-11 | Novas aminas como ligantes dos receptores de histamina-3 e suas aplicações terapêuticas |
Country Status (7)
Country | Link |
---|---|
EP (2) | EP2258694A1 (pt) |
JP (1) | JP4612990B2 (pt) |
AR (1) | AR035783A1 (pt) |
BR (1) | BR0205829A (pt) |
CA (1) | CA2440238C (pt) |
MX (1) | MXPA03008319A (pt) |
WO (1) | WO2002074758A2 (pt) |
Families Citing this family (38)
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---|---|---|---|---|
US7314937B2 (en) | 2002-03-21 | 2008-01-01 | Eli Lilly And Company | Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses |
US6822101B2 (en) | 2002-09-16 | 2004-11-23 | Abbott Laboratories | Process for preparing amine-substituted benzofurans |
JP4820094B2 (ja) * | 2002-11-12 | 2011-11-24 | アボット・ラボラトリーズ | ヒスタミン−3受容体リガンドとしての2環式置換アミン |
US7153889B2 (en) | 2002-11-12 | 2006-12-26 | Abbott Laboratories | Bicyclic-substituted amines as histamine-3 receptor ligands |
US7244852B2 (en) | 2003-02-27 | 2007-07-17 | Abbott Laboratories | Process for preparing 2-methylpyrrolidine and specific enantiomers thereof |
EP1604981A4 (en) | 2003-03-14 | 2008-12-24 | Ono Pharmaceutical Co | NITROGENIC HETEROCYCLIC DERIVATIVES AND MEDICAMENTS CONTAINING THEM AS AN ACTIVE SUBSTANCE |
CA2521000A1 (en) * | 2003-04-03 | 2004-10-21 | Kyowa Hakko Kogyo Co., Ltd. | Preventive and/or therapeutic agent for neuropathic pain |
US20040224952A1 (en) * | 2003-05-07 | 2004-11-11 | Cowart Marlon D. | Fused bicyclic-substituted amines as histamine-3 receptor ligands |
US7094790B2 (en) | 2003-05-07 | 2006-08-22 | Abbott Laboratories | Fused bicyclic-substituted amines as histamine-3 receptor ligands |
EP1620434B1 (en) * | 2003-05-07 | 2011-03-09 | Abbott Laboratories | Fused bicyclic-substituted amines as histamine-3 receptor ligands |
CA2542220A1 (en) * | 2003-10-22 | 2005-05-06 | Eli Lilly And Company | Novel mch receptor antagonists |
SE0303480D0 (sv) * | 2003-12-19 | 2003-12-19 | Biovitrum Ab | Benzofuranes |
JPWO2005085214A1 (ja) * | 2004-03-05 | 2008-01-17 | 萬有製薬株式会社 | ジアリール置換複素5員環誘導体 |
US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
US7145005B2 (en) | 2004-05-12 | 2006-12-05 | Abbott Laboratories | 2-(6-{2-[(2R)-2-Methyl-1-pyrrolidin-1-yl]-ethyl}-2-naphthalen-2-yl)-2H-pyridazin-3-one salts and their preparation |
US7205316B2 (en) | 2004-05-12 | 2007-04-17 | Abbott Laboratories | Tri- and bi-cyclic heteroaryl histamine-3 receptor ligands |
US7098222B2 (en) | 2004-05-12 | 2006-08-29 | Abbott Laboratories | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
US20050256118A1 (en) * | 2004-05-12 | 2005-11-17 | Altenbach Robert J | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
US20050256309A1 (en) * | 2004-05-12 | 2005-11-17 | Altenbach Robert J | Tri-and bi-cyclic heteroaryl histamine-3 receptor ligands |
DE102004030099A1 (de) * | 2004-06-22 | 2006-01-12 | Grünenthal GmbH | Gesättigte und ungesättigte 3-Pyridyl-benzocycloalkylmethyl-amine als Serotonin- und/oder Noradrenalin-Reuptake-Hemmer und/oder µ-Opioidrezeptor-Modulatoren |
TWI400232B (zh) | 2004-09-13 | 2013-07-01 | Ono Pharmaceutical Co | 含氮雜環衍生物及以該含氮雜環衍生物為有效成分之藥劑 |
CA2610655A1 (en) * | 2005-06-03 | 2006-12-14 | Abbott Laboratories | Cyclobutyl amine derivatives |
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JP2012082186A (ja) * | 2010-09-15 | 2012-04-26 | Bayer Cropscience Ag | 殺虫性アリールピロリジン類 |
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US4237144A (en) * | 1979-06-21 | 1980-12-02 | Merck & Co., Inc. | 2,3-Dihydro-2,6,7-trisubstituted-5-acylbenzofurans |
IL101785A0 (en) * | 1991-05-10 | 1992-12-30 | Fujisawa Pharmaceutical Co | Urea derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
US5436246A (en) * | 1992-09-17 | 1995-07-25 | Merrell Dow Pharmaceuticals Inc. | Serotonin receptor agents |
JP2759257B2 (ja) * | 1993-09-28 | 1998-05-28 | 大塚製薬株式会社 | 糖尿病治療剤 |
JPH07173158A (ja) * | 1993-12-17 | 1995-07-11 | Taiho Yakuhin Kogyo Kk | チアゾリジンジオン誘導体又はその塩 |
US5585492A (en) * | 1994-10-11 | 1996-12-17 | G. D. Searle & Co. | LTA4 Hydrolase inhibitors |
AU1670297A (en) * | 1996-02-09 | 1997-08-28 | Ihara Chemical Industry Co. Ltd. | Benzofuran-7-yluracil derivatives and herbicides |
US6077812A (en) * | 1997-02-26 | 2000-06-20 | Fmc Corporation | Cycloimido-substituted benzofused heterocyclic herbicides |
WO1998052946A1 (en) * | 1997-12-02 | 1998-11-26 | Dr. Reddy's Research Foundation | Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension |
EP0982300A3 (en) * | 1998-07-29 | 2000-03-08 | Societe Civile Bioprojet | Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications |
EP0978512A1 (en) | 1998-07-29 | 2000-02-09 | Societe Civile Bioprojet | Non-imidazole aryloxy (or arylthio) alkylamines as histamine H3-receptor antagonists and their therapeutic applications |
WO2002010156A1 (en) * | 2000-07-29 | 2002-02-07 | Arpida Ag | Benzofuran derivatives and their use as antibacterial agents |
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- 2002-03-11 BR BR0205829-4A patent/BR0205829A/pt not_active IP Right Cessation
- 2002-03-11 EP EP10180385A patent/EP2258694A1/en not_active Withdrawn
- 2002-03-11 JP JP2002573767A patent/JP4612990B2/ja not_active Expired - Fee Related
- 2002-03-11 CA CA2440238A patent/CA2440238C/en not_active Expired - Fee Related
- 2002-03-11 WO PCT/US2002/007107 patent/WO2002074758A2/en active Application Filing
- 2002-03-11 EP EP02715079A patent/EP1370546A2/en not_active Withdrawn
- 2002-03-15 AR ARP020100947A patent/AR035783A1/es unknown
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JP2005500986A (ja) | 2005-01-13 |
AR035783A1 (es) | 2004-07-14 |
WO2002074758A3 (en) | 2003-03-20 |
WO2002074758A2 (en) | 2002-09-26 |
JP4612990B2 (ja) | 2011-01-12 |
CA2440238A1 (en) | 2002-09-26 |
MXPA03008319A (es) | 2003-12-11 |
EP1370546A2 (en) | 2003-12-17 |
EP2258694A1 (en) | 2010-12-08 |
CA2440238C (en) | 2011-09-13 |
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