ATE411985T1 - Substituierte piperazine als modulatoren des melanocortinrezeptors - Google Patents

Substituierte piperazine als modulatoren des melanocortinrezeptors

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Publication number
ATE411985T1
ATE411985T1 AT02761189T AT02761189T ATE411985T1 AT E411985 T1 ATE411985 T1 AT E411985T1 AT 02761189 T AT02761189 T AT 02761189T AT 02761189 T AT02761189 T AT 02761189T AT E411985 T1 ATE411985 T1 AT E411985T1
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Austria
Prior art keywords
melanocortin receptor
modulators
compounds
substituted piperazines
prophylaxis
Prior art date
Application number
AT02761189T
Other languages
English (en)
Inventor
Christopher Fotsch
Premilla Arasasingham
Yunxin Bo
Ning Chen
Martin Goldberg
Nianhe Han
Feng-Yin Hsieh
Michael Kelly
Qingyian Liu
Mark Norman
Duncan Smith
Markian Stec
Nuria Tamayo
Ning Xi
Shimin Xu
Original Assignee
Amgen Inc
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Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of ATE411985T1 publication Critical patent/ATE411985T1/de

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/06—Dipeptides
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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US7115607B2 (en) 2006-10-03
EP1417190B1 (de) 2008-10-22
JP2005503369A (ja) 2005-02-03
US20030220324A1 (en) 2003-11-27
AU2002326469B2 (en) 2006-03-30
PL370381A1 (en) 2005-05-30
MXPA04000761A (es) 2004-07-08
WO2003009850A1 (en) 2003-02-06
CA2454903A1 (en) 2003-02-06
EP1417190A1 (de) 2004-05-12
US20070265248A1 (en) 2007-11-15
US7560460B2 (en) 2009-07-14
DE60229530D1 (de) 2008-12-04

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