CO6430490A2 - Biomarcadores de proteina para el diagnostico de enfermedades de tejido blando y como objetivos terapeuticos para intervenciones de cuidado oral - Google Patents

Biomarcadores de proteina para el diagnostico de enfermedades de tejido blando y como objetivos terapeuticos para intervenciones de cuidado oral

Info

Publication number
CO6430490A2
CO6430490A2 CO11126599A CO11126599A CO6430490A2 CO 6430490 A2 CO6430490 A2 CO 6430490A2 CO 11126599 A CO11126599 A CO 11126599A CO 11126599 A CO11126599 A CO 11126599A CO 6430490 A2 CO6430490 A2 CO 6430490A2
Authority
CO
Colombia
Prior art keywords
biomarkers
expression
diagnosis
oral cavity
soft tissue
Prior art date
Application number
CO11126599A
Other languages
English (en)
Inventor
Harsh M Trivedi
Tao Xu
Ying Yang
Original Assignee
Colgate Palmolive Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Colgate Palmolive Co filed Critical Colgate Palmolive Co
Publication of CO6430490A2 publication Critical patent/CO6430490A2/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56955—Bacteria involved in periodontal diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1.- Un método para identificar un compuesto útil para el tratamiento de una enfermedad o afección de la cavidad oral, donde dicha enfermedad o afección de la cavidad oral es gingivitis o periodontitis, dicho método comprende:obtener una primera muestra gingival de un mamífero que padece dicha enfermedad o afección de la cavidad oral;obtener una segunda muestra gingival de la cavidad oral de dicho mamífero;poner en contacto dicha primera muestra con un compuesto de prueba;poner en contacto dicha segunda muestra con un control positivo, donde dicho control positivo es un compuesto que se sabe disminuye la expresión de uno o más biomarcadores;establecer en qué medida la expresión de uno o más de dichos biomarcadores es disminuida por dicho compuesto de prueba;establecer en qué medida la expresión de uno o más de dichos biomarcadores es disminuida por dicho control positivo ycomparar la medida en que la expresión de uno o más de dichos biomarcadores se ve disminuida por dicho compuesto de prueba con la medida en que la expresión de uno o más de dichos biomarcadores es disminuida por dicho control positivo;donde un compuesto de prueba que disminuye la expresión de uno o más de dichos biomarcadores en igual o mayor medida que dicho control positivo es un compuesto útil para el tratamiento de dicha enfermedad o afección de la cavidad oral.
CO11126599A 2009-04-01 2011-09-27 Biomarcadores de proteina para el diagnostico de enfermedades de tejido blando y como objetivos terapeuticos para intervenciones de cuidado oral CO6430490A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16567409P 2009-04-01 2009-04-01

Publications (1)

Publication Number Publication Date
CO6430490A2 true CO6430490A2 (es) 2012-04-30

Family

ID=42813186

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11126599A CO6430490A2 (es) 2009-04-01 2011-09-27 Biomarcadores de proteina para el diagnostico de enfermedades de tejido blando y como objetivos terapeuticos para intervenciones de cuidado oral

Country Status (15)

Country Link
US (1) US8753820B2 (es)
EP (1) EP2414837B1 (es)
JP (1) JP5643288B2 (es)
CN (1) CN102549432B (es)
AR (1) AR076041A1 (es)
BR (1) BRPI1013184A2 (es)
CA (1) CA2753718C (es)
CO (1) CO6430490A2 (es)
MX (1) MX2011008439A (es)
MY (1) MY179250A (es)
RU (1) RU2523383C2 (es)
SG (1) SG173461A1 (es)
TW (1) TWI481870B (es)
WO (1) WO2010115034A2 (es)
ZA (1) ZA201106056B (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR076177A1 (es) * 2009-04-01 2011-05-26 Colgate Palmolive Co MÉTODO PARA IDENTIFICAR UN COMPUESTO uTIL PARA TRATAR UNA ENFERMEDAD O CONDICIoN DE LA CAVIDAD ORAL
US9949671B2 (en) 2013-03-13 2018-04-24 Orthoaccel Technologies, Inc. Diagnostic mouthpieces
WO2018129043A1 (en) * 2017-01-03 2018-07-12 The Trustees Of The University Of Pennsylvania Compositions and methods for predicting risk of preterm birth
WO2018215596A1 (en) * 2017-05-24 2018-11-29 Koninklijke Philips N.V. Diagnostics of gingivitis based on salivary il-1beta and hgf
US11768207B2 (en) * 2017-05-24 2023-09-26 Koninklijke Philips N.V. Diagnostics of periodontitis based on salivary HGF and MMP-8
CN111226118A (zh) 2017-10-27 2020-06-02 加利福尼亚大学董事会 用于牙龈炎的唾液细胞外rna生物标记物
EP3477306A1 (en) * 2017-10-30 2019-05-01 Koninklijke Philips N.V. Classification of periodontitis patients

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Also Published As

Publication number Publication date
ZA201106056B (en) 2015-05-27
RU2523383C2 (ru) 2014-07-20
JP5643288B2 (ja) 2014-12-17
TWI481870B (zh) 2015-04-21
EP2414837A2 (en) 2012-02-08
MY179250A (en) 2020-11-02
RU2011144032A (ru) 2013-05-10
CN102549432B (zh) 2015-03-25
SG173461A1 (en) 2011-09-29
US20120028261A1 (en) 2012-02-02
CN102549432A (zh) 2012-07-04
MX2011008439A (es) 2011-09-06
AU2010232593A1 (en) 2011-08-25
AR076041A1 (es) 2011-05-11
JP2012522994A (ja) 2012-09-27
TW201102653A (en) 2011-01-16
US8753820B2 (en) 2014-06-17
WO2010115034A3 (en) 2010-12-29
CA2753718A1 (en) 2010-10-07
BRPI1013184A2 (pt) 2016-04-12
EP2414837B1 (en) 2015-06-03
WO2010115034A2 (en) 2010-10-07
CA2753718C (en) 2015-06-23

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