CY1111602T1 - ΜΕΘΟΔΟΣ ΓΙΑ ΤΗΝ ΑΝΙΧΝΕΥΣΗ ΤΗΣ ΔΡΑΣΤΙΚΟΤΗΤΑΣ IN VIVO ΤΗΣ ΝΕΥΡΟΤΡΥΨΙΝΗΣ, ΧΡΗΣΗ ΤΗΣ ΜΕΘΟΔΟΥ ΚΑΙ ΧΡΗΣΗ TOY C-ΤΕΡΜΑΤΙΚΟΥ 22-kDa ΘΡΑΥΣΜΑΤΟΣ ΤΗΣ ΑΓΡΙΝΗΣ ΩΣ ΒΙΟΔΕΙΚΤΗ ΕΙΣ ΤΗΝ ΔΙΑΓΝΩΣΗ ΚΑΙ ΠΑΡΑΚΟΛΟΥΘΗΣΗ ΔΙΑΤΑΡΑΧΩΝ ΠΟΥ ΕΧΟΥΝ ΣΧΕΣΗ ΜΕ ΝΕΥΡΟΤΡΥΨΙΝΗ - Google Patents
ΜΕΘΟΔΟΣ ΓΙΑ ΤΗΝ ΑΝΙΧΝΕΥΣΗ ΤΗΣ ΔΡΑΣΤΙΚΟΤΗΤΑΣ IN VIVO ΤΗΣ ΝΕΥΡΟΤΡΥΨΙΝΗΣ, ΧΡΗΣΗ ΤΗΣ ΜΕΘΟΔΟΥ ΚΑΙ ΧΡΗΣΗ TOY C-ΤΕΡΜΑΤΙΚΟΥ 22-kDa ΘΡΑΥΣΜΑΤΟΣ ΤΗΣ ΑΓΡΙΝΗΣ ΩΣ ΒΙΟΔΕΙΚΤΗ ΕΙΣ ΤΗΝ ΔΙΑΓΝΩΣΗ ΚΑΙ ΠΑΡΑΚΟΛΟΥΘΗΣΗ ΔΙΑΤΑΡΑΧΩΝ ΠΟΥ ΕΧΟΥΝ ΣΧΕΣΗ ΜΕ ΝΕΥΡΟΤΡΥΨΙΝΗInfo
- Publication number
- CY1111602T1 CY1111602T1 CY20101101006T CY101101006T CY1111602T1 CY 1111602 T1 CY1111602 T1 CY 1111602T1 CY 20101101006 T CY20101101006 T CY 20101101006T CY 101101006 T CY101101006 T CY 101101006T CY 1111602 T1 CY1111602 T1 CY 1111602T1
- Authority
- CY
- Cyprus
- Prior art keywords
- neurotrypsin
- activity
- diagnosis
- detection
- vivo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/12—Pulmonary diseases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/34—Genitourinary disorders
- G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Μέθοδος για την ανίχνευση της δραστικότητας in vivo της νευροτρυψίνης, όπου η ποσότητα του C-τερματικού 22-kDa θραύσματος της αγρίνης μετριέται σε ένα δείγμα, το οποίο λαμβάνεται από έναν ασθενή και η μετρηθείσα ποσότητα 22-kDa θραύσματος της αγρίνης εις το δείγμα χρησιμοποιείται για να υπολογισθεί η δραστικότητα της νευροτρυψίνης, χρήση της μεθόδου για την διάγνωση και παρακολούθηση διαταραχών, οι οποίες σχετίζονται με την νευροτρυψίνη και χρήση του 22-kDa θραύσματος της αγρίνης ως βιοδείκτη για διαταραχές, οι οποίες σχετίζονται με την νευροτρυψίνη.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07009398A EP1990420B1 (en) | 2007-05-10 | 2007-05-10 | Method for the detection of the in-vivo activity of neurotrypsin, use of the method and use of the C-terminal 22-kDa fragment of agrin as biomarker in diagnosis and monitoring of neurotrypsin-related disturbances |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1111602T1 true CY1111602T1 (el) | 2015-10-07 |
Family
ID=38180345
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101101006T CY1111602T1 (el) | 2007-05-10 | 2010-11-08 | ΜΕΘΟΔΟΣ ΓΙΑ ΤΗΝ ΑΝΙΧΝΕΥΣΗ ΤΗΣ ΔΡΑΣΤΙΚΟΤΗΤΑΣ IN VIVO ΤΗΣ ΝΕΥΡΟΤΡΥΨΙΝΗΣ, ΧΡΗΣΗ ΤΗΣ ΜΕΘΟΔΟΥ ΚΑΙ ΧΡΗΣΗ TOY C-ΤΕΡΜΑΤΙΚΟΥ 22-kDa ΘΡΑΥΣΜΑΤΟΣ ΤΗΣ ΑΓΡΙΝΗΣ ΩΣ ΒΙΟΔΕΙΚΤΗ ΕΙΣ ΤΗΝ ΔΙΑΓΝΩΣΗ ΚΑΙ ΠΑΡΑΚΟΛΟΥΘΗΣΗ ΔΙΑΤΑΡΑΧΩΝ ΠΟΥ ΕΧΟΥΝ ΣΧΕΣΗ ΜΕ ΝΕΥΡΟΤΡΥΨΙΝΗ |
Country Status (16)
Country | Link |
---|---|
US (1) | US20100240083A1 (el) |
EP (1) | EP1990420B1 (el) |
JP (1) | JP2010526994A (el) |
CN (1) | CN101680022A (el) |
AT (1) | ATE477329T1 (el) |
AU (1) | AU2008250733A1 (el) |
BR (1) | BRPI0811429A2 (el) |
CA (1) | CA2692132A1 (el) |
CY (1) | CY1111602T1 (el) |
DE (1) | DE602007008370D1 (el) |
DK (1) | DK1990420T3 (el) |
ES (1) | ES2350254T3 (el) |
PL (1) | PL1990420T3 (el) |
PT (1) | PT1990420E (el) |
SI (1) | SI1990420T1 (el) |
WO (1) | WO2008138474A1 (el) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2484695A1 (en) | 2011-02-04 | 2012-08-08 | Neurotune AG | A method for the production of hybridoma cell lines producing monoclonal antibodies capable to specifically binding to a human C44-fragment of agrin |
EP2631657A1 (en) * | 2012-02-25 | 2013-08-28 | Neurotune AG | Immunoassay for the detection of the 22kDa C-terminal fragment (CAF) of agrin |
US20160274126A1 (en) * | 2012-11-13 | 2016-09-22 | William Beaumont Hospital | Biomarkers for the diagnosis of interstitial cystitis |
US11815515B2 (en) * | 2018-01-17 | 2023-11-14 | University Of Southampton | Methods to predict risk of and to stratify sarcopenia and NAD deficiency |
US11564983B1 (en) * | 2021-08-20 | 2023-01-31 | Betagen Scientific Limited | Efficient expression system of SARS-CoV-2 receptor binding domain (RBD), methods for purification and use thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101193858B (zh) * | 2005-03-30 | 2012-01-04 | 苏黎世大学 | 神经蛋白酶抑制剂及其确定 |
US20100095387A1 (en) * | 2005-07-15 | 2010-04-15 | Martin Smith | Methods and reagents for screening new drugs and for treating ion pump associated disorders and diseases |
-
2007
- 2007-05-10 DE DE602007008370T patent/DE602007008370D1/de active Active
- 2007-05-10 PT PT07009398T patent/PT1990420E/pt unknown
- 2007-05-10 PL PL07009398T patent/PL1990420T3/pl unknown
- 2007-05-10 EP EP07009398A patent/EP1990420B1/en not_active Not-in-force
- 2007-05-10 ES ES07009398T patent/ES2350254T3/es active Active
- 2007-05-10 SI SI200730401T patent/SI1990420T1/sl unknown
- 2007-05-10 DK DK07009398.4T patent/DK1990420T3/da active
- 2007-05-10 AT AT07009398T patent/ATE477329T1/de active
-
2008
- 2008-04-26 AU AU2008250733A patent/AU2008250733A1/en not_active Abandoned
- 2008-04-26 US US12/599,456 patent/US20100240083A1/en not_active Abandoned
- 2008-04-26 WO PCT/EP2008/003406 patent/WO2008138474A1/en active Application Filing
- 2008-04-26 CN CN200880015511A patent/CN101680022A/zh active Pending
- 2008-04-26 BR BRPI0811429A patent/BRPI0811429A2/pt not_active IP Right Cessation
- 2008-04-26 CA CA002692132A patent/CA2692132A1/en not_active Abandoned
- 2008-04-26 JP JP2010506829A patent/JP2010526994A/ja not_active Withdrawn
-
2010
- 2010-11-08 CY CY20101101006T patent/CY1111602T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
WO2008138474A1 (en) | 2008-11-20 |
SI1990420T1 (sl) | 2010-12-31 |
ES2350254T3 (es) | 2011-01-20 |
CA2692132A1 (en) | 2008-11-20 |
BRPI0811429A2 (pt) | 2016-05-17 |
DE602007008370D1 (de) | 2010-09-23 |
PL1990420T3 (pl) | 2011-01-31 |
PT1990420E (pt) | 2010-11-04 |
EP1990420A1 (en) | 2008-11-12 |
US20100240083A1 (en) | 2010-09-23 |
EP1990420B1 (en) | 2010-08-11 |
DK1990420T3 (da) | 2010-11-15 |
CN101680022A (zh) | 2010-03-24 |
AU2008250733A1 (en) | 2008-11-20 |
JP2010526994A (ja) | 2010-08-05 |
ATE477329T1 (de) | 2010-08-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB201116860D0 (en) | Patent monitoring method and monitoring device | |
ATE554389T1 (de) | Apex als marker für lungenkrebs | |
ATE473030T1 (de) | Aktivitätsmessung für die stimulator-kontrolle | |
WO2012018535A3 (en) | Wellness panel | |
CY1111602T1 (el) | ΜΕΘΟΔΟΣ ΓΙΑ ΤΗΝ ΑΝΙΧΝΕΥΣΗ ΤΗΣ ΔΡΑΣΤΙΚΟΤΗΤΑΣ IN VIVO ΤΗΣ ΝΕΥΡΟΤΡΥΨΙΝΗΣ, ΧΡΗΣΗ ΤΗΣ ΜΕΘΟΔΟΥ ΚΑΙ ΧΡΗΣΗ TOY C-ΤΕΡΜΑΤΙΚΟΥ 22-kDa ΘΡΑΥΣΜΑΤΟΣ ΤΗΣ ΑΓΡΙΝΗΣ ΩΣ ΒΙΟΔΕΙΚΤΗ ΕΙΣ ΤΗΝ ΔΙΑΓΝΩΣΗ ΚΑΙ ΠΑΡΑΚΟΛΟΥΘΗΣΗ ΔΙΑΤΑΡΑΧΩΝ ΠΟΥ ΕΧΟΥΝ ΣΧΕΣΗ ΜΕ ΝΕΥΡΟΤΡΥΨΙΝΗ | |
SG10201408392PA (en) | Methods of determining patient response by measurement of her-3 | |
GB201209668D0 (en) | Methods of monitoring conditions by sequence analysis | |
GB201021399D0 (en) | Oligonucleotide probe set and methods of microbiota profiling | |
WO2014066913A8 (en) | Health diagnostic systems and methods | |
DK1706019T3 (da) | Dermalt fastgjort sensorindretning | |
ATE507771T1 (de) | Blutdruckberechnungsverfahren für nichtinvasive blutdruckmessgeräte | |
DE112010001220A5 (de) | Messsystem zur beurteilung des schluckvorgangs und/oder bestimmung der aspiration | |
IN2014MN02060A (el) | ||
HK1115636A1 (en) | Use of cyfra 21-1 as a marker for colorectal cancer cyfra 21-1 | |
MX2010014228A (es) | Metodos y productos de diagnostico del p/gf-1 acompañante. | |
WO2008058014A3 (en) | Method and apparatus for noninvasive probe/skin tissue contact sensing | |
EP2509488A4 (en) | METHODS AND ARRANGEMENTS FOR THE ANALYSIS, DIAGNOSIS AND MONITORING OF VOCAL STRENGTH PROCESSING BY OPTICAL COHERENCE TOMOGRAPHY | |
BR112014005947A2 (pt) | sistema de monitoramento de uma cadeia de medida de um turborreator | |
BRPI1007668A2 (pt) | aparelho de medição do batimento cardíaco, uso do aparelho de medição do batimento cardíaco, método, adaptado para medir o batimento cardíaco e/ou a variação do batimento cardíaco de um indivíduo | |
BR112015014232A2 (pt) | lesão renal aguda | |
HK1136873A1 (en) | Use of nnmt as a marker for lung cancer | |
WO2010000467A8 (en) | Asc as a marker for lung cancer | |
WO2011159741A3 (en) | Tetranor-pgem/pgam specific immunogens, antibodies, tracers, assay kits and methods for making same | |
CY1114910T1 (el) | Βιοδεικτης για παρακολουθηση ασθενων | |
AR085164A1 (es) | Metodos para el analisis de la placa |