KR870010030A - 치환된 벤즈아미드 유도체, 그 제조방법 및 이를 함유하는 약학적 조성물 - Google Patents
치환된 벤즈아미드 유도체, 그 제조방법 및 이를 함유하는 약학적 조성물 Download PDFInfo
- Publication number
- KR870010030A KR870010030A KR870004220A KR870004220A KR870010030A KR 870010030 A KR870010030 A KR 870010030A KR 870004220 A KR870004220 A KR 870004220A KR 870004220 A KR870004220 A KR 870004220A KR 870010030 A KR870010030 A KR 870010030A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- amino
- methyl
- hydrogen
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000003936 benzamides Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 24
- -1 C 1 -C 4 alkoxy Chemical group 0.000 claims 19
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 229910052736 halogen Inorganic materials 0.000 claims 11
- 150000002367 halogens Chemical class 0.000 claims 11
- 239000002253 acid Substances 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 150000002431 hydrogen Chemical group 0.000 claims 7
- 150000001204 N-oxides Chemical class 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 3
- 125000004803 chlorobenzyl group Chemical group 0.000 claims 3
- 125000004175 fluorobenzyl group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
- 125000005236 alkanoylamino group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 2
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 2
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 claims 1
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 claims 1
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000004343 1-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000006012 2-chloroethoxy group Chemical group 0.000 claims 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- IRFRTRMQNPJOAG-UHFFFAOYSA-N 4-amino-n-[(4-benzylmorpholin-2-yl)methyl]-2-butoxy-5-chlorobenzamide Chemical compound CCCCOC1=CC(N)=C(Cl)C=C1C(=O)NCC1OCCN(CC=2C=CC=CC=2)C1 IRFRTRMQNPJOAG-UHFFFAOYSA-N 0.000 claims 1
- 125000004176 4-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])* 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Chemical group 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003302 alkenyloxy group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000005530 alkylenedioxy group Chemical group 0.000 claims 1
- 125000005133 alkynyloxy group Chemical group 0.000 claims 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000002946 cyanobenzyl group Chemical group 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000005921 isopentoxy group Chemical group 0.000 claims 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 125000004998 naphthylethyl group Chemical group C1(=CC=CC2=CC=CC=C12)CC* 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical group [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- GJVFBWCTGUSGDD-UHFFFAOYSA-L pentamethonium bromide Chemical compound [Br-].[Br-].C[N+](C)(C)CCCCC[N+](C)(C)C GJVFBWCTGUSGDD-UHFFFAOYSA-L 0.000 claims 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 1
- 125000005544 phthalimido group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000006493 trifluoromethyl benzyl group Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10155286 | 1986-04-30 | ||
| JP101552 | 1986-04-30 | ||
| JP31509086 | 1986-12-31 | ||
| JP315090 | 1986-12-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR870010030A true KR870010030A (ko) | 1987-11-30 |
Family
ID=26442419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR870004220A Withdrawn KR870010030A (ko) | 1986-04-30 | 1987-04-30 | 치환된 벤즈아미드 유도체, 그 제조방법 및 이를 함유하는 약학적 조성물 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4870074A (enExample) |
| EP (1) | EP0243959B1 (enExample) |
| KR (1) | KR870010030A (enExample) |
| AR (1) | AR242953A1 (enExample) |
| AU (1) | AU592177B2 (enExample) |
| CA (1) | CA1291135C (enExample) |
| CZ (1) | CZ284687B6 (enExample) |
| DE (1) | DE3781195T2 (enExample) |
| DK (1) | DK175281B1 (enExample) |
| ES (1) | ES2043617T3 (enExample) |
| FI (1) | FI87776C (enExample) |
| GR (1) | GR3005934T3 (enExample) |
| HK (1) | HK18194A (enExample) |
| HU (1) | HU198193B (enExample) |
| NZ (1) | NZ220120A (enExample) |
| PH (1) | PH24049A (enExample) |
| SK (1) | SK289787A3 (enExample) |
| SU (1) | SU1597101A3 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2640139A1 (fr) * | 1988-12-14 | 1990-06-15 | Delagrange Laboratoires | Application de benzamides substitues comme gastromoteurs |
| US5395832A (en) * | 1991-02-15 | 1995-03-07 | Hokuriku Seiyaku Co., Ltd. | Benzamide derivatives |
| TW243449B (enExample) * | 1991-02-15 | 1995-03-21 | Hokuriku Pharmaceutical | |
| KR970702247A (ko) * | 1994-03-30 | 1997-05-13 | 고야 마사시 | 벤조산 화합물 및 이들의 약제로서의 용도(benzoic acid compound and use thereof as medicine) |
| US5864039A (en) * | 1994-03-30 | 1999-01-26 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzoic acid compounds and use thereof as medicaments |
| JPH11505815A (ja) * | 1995-05-23 | 1999-05-25 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | （２−モルホリニルメチル）ベンズアミン誘導体 |
| JP2001064177A (ja) * | 1999-08-16 | 2001-03-13 | Schering Ag | ベンズアミド誘導体を有効成分とする製剤 |
| AR035205A1 (es) * | 2000-09-29 | 2004-05-05 | Glaxo Group Ltd | Compuestos utiles en el tratamiento de enfermedades inflamatorias, proceso para su preparacion, intermediarios y composiciones farmaceuticas |
| EP1353918B1 (en) * | 2000-11-28 | 2005-01-12 | Smithkline Beecham Plc | Morpholine derivatives as antagonists of orexin receptors |
| JP4829417B2 (ja) * | 2001-03-26 | 2011-12-07 | 明夫 乾 | インスリン抵抗性改善薬 |
| HUP0402611A2 (hu) * | 2001-10-08 | 2005-07-28 | Sun Pharmaceutical Industries Limited | Görcsoldó hatóanyag szakaszos leadására szolgáló rendszer |
| GB0207447D0 (en) * | 2002-03-28 | 2002-05-08 | Glaxo Group Ltd | Novel compounds |
| GB0207449D0 (en) * | 2002-03-28 | 2002-05-08 | Glaxo Group Ltd | Novel compounds |
| GB0208158D0 (en) * | 2002-03-28 | 2002-05-22 | Glaxo Group Ltd | Novel compounds |
| HUP0201980A3 (en) * | 2002-06-13 | 2008-06-30 | Richter Gedeon Nyrt | Process for preparing a benzamide derivative and intermediates thereof |
| KR20060126688A (ko) * | 2003-12-09 | 2006-12-08 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 약물-함유 입자 및 그 입자를 함유하는 고형 제제 |
| US8524736B2 (en) | 2004-01-07 | 2013-09-03 | Armetheon, Inc. | Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders |
| US8138204B2 (en) * | 2004-01-07 | 2012-03-20 | Aryx Therapeutics, Inc. | Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders |
| CA2551686C (en) | 2004-01-07 | 2014-09-23 | Ian Irwin | Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders |
| CA2579207C (en) | 2004-09-08 | 2011-10-18 | Mitsubishi Pharma Corporation | Morpholine compound |
| EP1904481B1 (en) | 2005-06-23 | 2016-02-17 | Array Biopharma, Inc. | Process for preparing benzimidazole compounds |
| EP1919909B1 (en) * | 2005-08-31 | 2013-08-21 | Armetheon, Inc. | Synthetic methods and intermediates for stereoisomeric compounds useful for the treatment of gastrointestinal and central nervous system disorders |
| CA2633042A1 (en) * | 2005-12-20 | 2007-07-05 | Merck & Co., Inc. | Niacin receptor agonists, compositions containing such compounds and methods of treatment |
| KR100750593B1 (ko) * | 2006-03-16 | 2007-08-20 | 동우신테크 주식회사 | 치환된 벤즈아미드 유도체의 제조방법 |
| WO2007149929A1 (en) * | 2006-06-23 | 2007-12-27 | Aryx Therapeutics, Inc. | Piperidine derivatives for the treatment of gastrointestinal and cns disorders |
| US7528131B2 (en) | 2007-04-19 | 2009-05-05 | Concert Pharmaceuticals Inc. | Substituted morpholinyl compounds |
| CN101402633A (zh) * | 2007-09-11 | 2009-04-08 | 上海恒瑞医药有限公司 | 苯甲酰胺类衍生物、其制备方法及其在医药上的用途 |
| US20110053942A1 (en) | 2008-02-13 | 2011-03-03 | Dainippon Sumitomo Pharma Co., Ltd. | Orally disintegrating tablets |
| TWI423967B (zh) * | 2008-02-21 | 2014-01-21 | Dainippon Sumitomo Pharma Co | 醯胺衍生物及含有其之醫藥組合物 |
| CN102548542B (zh) | 2009-08-11 | 2013-11-20 | 大日本住友制药株式会社 | 含有两种以上粒子的口腔速崩片 |
| WO2011107903A1 (en) | 2010-03-04 | 2011-09-09 | Ranbaxy Laboratories Limited | Highly pure mosapride citrate dihydrate and processes for its preparation |
| ES2587304T3 (es) | 2011-02-25 | 2016-10-21 | Yuhan Corporation | Derivados de diaminopirimidina y procedimientos para la preparación de los mismos |
| KR101657616B1 (ko) | 2013-05-24 | 2016-09-19 | 주식회사유한양행 | 피리미딘 고리를 포함하는 바이사이클릭 유도체 및 그의 제조방법 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| CN111349052B (zh) * | 2020-04-07 | 2021-02-12 | 福建海西新药创制有限公司 | 一种枸橼酸莫沙必利的合成方法 |
| CN114560822B (zh) * | 2020-11-27 | 2024-05-28 | 鲁南制药集团股份有限公司 | 一种莫沙必利的二羧酸晶体 |
| CN114591260B (zh) * | 2020-12-05 | 2025-07-11 | 鲁南制药集团股份有限公司 | 一种莫沙必利有机酸盐 |
| CN119241464A (zh) * | 2024-10-22 | 2025-01-03 | 吉林修正药业新药开发有限公司 | 一种枸橼酸莫沙必利杂质化合物及其制备方法 |
| CN119241463A (zh) * | 2024-10-22 | 2025-01-03 | 吉林修正药业新药开发有限公司 | 一种枸橼酸莫沙必利杂质化合物及其制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH451142A (de) * | 1965-01-19 | 1968-05-15 | Sandoz Ag | Verfahren zur Herstellung neuer basisch substituierter Benzoesäureamide |
| US4029786A (en) * | 1972-08-11 | 1977-06-14 | Imperial Chemical Industries Limited | Morpholine derivatives for treating depression |
| US4323503A (en) * | 1976-08-04 | 1982-04-06 | Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France | Substituted 2,3-alkylene di (oxy) benzamides and derivatives |
| US4210754A (en) * | 1977-02-01 | 1980-07-01 | Hoffmann-La Roche Inc. | Morpholino containing benzamides |
| US4692445A (en) * | 1983-04-29 | 1987-09-08 | Rorer Pharmaceutical Corporation | Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use |
| FR2575158B1 (fr) * | 1984-12-20 | 1987-10-02 | Pf Medicament | Arylalcoyloxymethyl-2 morpholines, leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central |
| JPH0390274A (ja) * | 1989-08-28 | 1991-04-16 | Furukawa Alum Co Ltd | Ａｌ又はＡｌ合金の気相ろう付法 |
-
1987
- 1987-04-24 CZ CS872897A patent/CZ284687B6/cs not_active IP Right Cessation
- 1987-04-24 SK SK2897-87A patent/SK289787A3/sk unknown
- 1987-04-24 US US07/042,474 patent/US4870074A/en not_active Expired - Lifetime
- 1987-04-27 FI FI871828A patent/FI87776C/fi not_active IP Right Cessation
- 1987-04-28 NZ NZ220120A patent/NZ220120A/xx unknown
- 1987-04-28 CA CA000535794A patent/CA1291135C/en not_active Expired - Lifetime
- 1987-04-29 DK DK198702187A patent/DK175281B1/da not_active IP Right Cessation
- 1987-04-29 HU HU871946A patent/HU198193B/hu unknown
- 1987-04-29 EP EP87106266A patent/EP0243959B1/en not_active Expired - Lifetime
- 1987-04-29 SU SU874202484A patent/SU1597101A3/ru active
- 1987-04-29 ES ES87106266T patent/ES2043617T3/es not_active Expired - Lifetime
- 1987-04-29 PH PH35203A patent/PH24049A/en unknown
- 1987-04-29 DE DE8787106266T patent/DE3781195T2/de not_active Expired - Lifetime
- 1987-04-30 AR AR87307449A patent/AR242953A1/es active
- 1987-04-30 AU AU72275/87A patent/AU592177B2/en not_active Expired
- 1987-04-30 KR KR870004220A patent/KR870010030A/ko not_active Withdrawn
-
1992
- 1992-10-12 GR GR920402254T patent/GR3005934T3/el unknown
-
1994
- 1994-03-03 HK HK181/94A patent/HK18194A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SK279058B6 (sk) | 1998-06-03 |
| HK18194A (en) | 1994-03-11 |
| EP0243959B1 (en) | 1992-08-19 |
| CZ289787A3 (cs) | 1998-11-11 |
| EP0243959A1 (en) | 1987-11-04 |
| DK218787D0 (da) | 1987-04-29 |
| FI871828A7 (fi) | 1987-10-31 |
| AU592177B2 (en) | 1990-01-04 |
| FI87776B (fi) | 1992-11-13 |
| GR3005934T3 (enExample) | 1993-06-07 |
| HU198193B (en) | 1989-08-28 |
| US4870074A (en) | 1989-09-26 |
| PH24049A (en) | 1990-03-05 |
| DK218787A (da) | 1987-10-31 |
| NZ220120A (en) | 1989-06-28 |
| HUT45514A (en) | 1988-07-28 |
| SU1597101A3 (ru) | 1990-09-30 |
| ES2043617T3 (es) | 1994-01-01 |
| SK289787A3 (en) | 1998-06-03 |
| DE3781195T2 (de) | 1993-02-18 |
| FI87776C (fi) | 1993-02-25 |
| DE3781195D1 (de) | 1992-09-24 |
| FI871828A0 (fi) | 1987-04-27 |
| AU7227587A (en) | 1987-11-05 |
| CA1291135C (en) | 1991-10-22 |
| DK175281B1 (da) | 2004-08-09 |
| CZ284687B6 (cs) | 1999-02-17 |
| AR242953A1 (es) | 1993-06-30 |
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