KR870001201B1 - 피롤로벤즈이미다졸 유도체의 제조방법 - Google Patents

피롤로벤즈이미다졸 유도체의 제조방법 Download PDF

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Publication number
KR870001201B1
KR870001201B1 KR1019850003144A KR850003144A KR870001201B1 KR 870001201 B1 KR870001201 B1 KR 870001201B1 KR 1019850003144 A KR1019850003144 A KR 1019850003144A KR 850003144 A KR850003144 A KR 850003144A KR 870001201 B1 KR870001201 B1 KR 870001201B1
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KR
South Korea
Prior art keywords
group
pyrrolo
dihydro
pyridyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019850003144A
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English (en)
Korean (ko)
Other versions
KR850008170A (ko
Inventor
옌스-페터휠크
머텐스 알프레드
캄페 볼프강
뮐러-베크만
스포너 지스베르트
슈트라인 클라우스
Original Assignee
뵈링거 만하임 게엠베하
다움, 그루스도르프
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19843417643 external-priority patent/DE3417643A1/de
Priority claimed from DE19843446417 external-priority patent/DE3446417A1/de
Application filed by 뵈링거 만하임 게엠베하, 다움, 그루스도르프 filed Critical 뵈링거 만하임 게엠베하
Publication of KR850008170A publication Critical patent/KR850008170A/ko
Priority to KR1019870004128A priority Critical patent/KR870001202B1/ko
Application granted granted Critical
Publication of KR870001201B1 publication Critical patent/KR870001201B1/ko
Expired legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1019850003144A 1984-05-12 1985-05-09 피롤로벤즈이미다졸 유도체의 제조방법 Expired KR870001201B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019870004128A KR870001202B1 (ko) 1984-05-12 1987-04-27 피롤로벤즈이미다졸의 제조방법

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DEP3417643.8 1984-05-12
DE19843417643 DE3417643A1 (de) 1984-05-12 1984-05-12 Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3417643.8 1984-05-12
DE19843446417 DE3446417A1 (de) 1984-12-20 1984-12-20 Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3446417.4 1984-12-20

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019870004128A Division KR870001202B1 (ko) 1984-05-12 1987-04-27 피롤로벤즈이미다졸의 제조방법

Publications (2)

Publication Number Publication Date
KR850008170A KR850008170A (ko) 1985-12-13
KR870001201B1 true KR870001201B1 (ko) 1987-06-20

Family

ID=25821132

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850003144A Expired KR870001201B1 (ko) 1984-05-12 1985-05-09 피롤로벤즈이미다졸 유도체의 제조방법

Country Status (18)

Country Link
US (2) US4666923A (enExample)
EP (1) EP0161632B1 (enExample)
JP (2) JPH0647593B2 (enExample)
KR (1) KR870001201B1 (enExample)
AU (1) AU560349B2 (enExample)
DE (1) DE3582447D1 (enExample)
DK (1) DK209585A (enExample)
ES (1) ES542976A0 (enExample)
FI (1) FI81351C (enExample)
GR (1) GR851085B (enExample)
HU (1) HU193754B (enExample)
IL (1) IL75120A (enExample)
NO (1) NO851862L (enExample)
NZ (1) NZ212005A (enExample)
PH (1) PH22863A (enExample)
PL (2) PL144822B1 (enExample)
PT (1) PT80425B (enExample)
SU (1) SU1480770A3 (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
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GR851085B (enExample) * 1984-05-12 1985-11-25 Boehringer Mannheim Gmbh
DE3445669A1 (de) * 1984-12-14 1986-06-19 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3501497A1 (de) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3524067A1 (de) * 1985-07-05 1987-01-08 Boehringer Mannheim Gmbh Neue benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3530825A1 (de) * 1985-08-29 1987-03-05 Boehringer Mannheim Gmbh Neue benzodipyrrole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3531678A1 (de) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3626664A1 (de) * 1986-08-07 1988-02-11 Boehringer Mannheim Gmbh Tricyclische benzotriazole, verfahren zu ihrer herstellung sowie arzneimittel
DE3639466A1 (de) * 1986-11-18 1988-05-19 Thomae Gmbh Dr K Neue pyrrolo-benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3642315A1 (de) * 1986-12-11 1988-06-23 Boehringer Mannheim Gmbh Neue pyrrolobenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel
DE3740985A1 (de) * 1987-12-03 1989-06-15 Boehringer Mannheim Gmbh Verwendung linear anellierter tricyclen als hemmer der erythrozytenaggregation
US4963677A (en) * 1987-12-30 1990-10-16 Orion Corporation Ltd. Heterocyclic lactam compounds
DE3855327D1 (de) * 1987-12-30 1996-07-04 Orion Yhtymae Oy Heterocyclische Verbindungen
DE3803775A1 (de) * 1988-02-09 1989-08-17 Boehringer Mannheim Gmbh Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
US5324911A (en) * 1990-01-08 1994-06-28 Schroer Manufacturing Company Heated animal surgery table
DE4027592A1 (de) * 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US20060142247A1 (en) * 2004-12-17 2006-06-29 Guy Georges Tricyclic heterocycles
JP2008533181A (ja) * 2005-04-14 2008-08-21 エフ．ホフマン−ラ ロシュ アーゲー 三環式アゾール誘導体、それらの製造及び医薬品としての使用
CA2603204A1 (en) * 2005-04-14 2006-10-19 F. Hoffmann-La Roche Ag Aminopyrazole derivatives, their manufacture and use as pharmaceutical agents
WO2007068465A1 (en) * 2005-12-15 2007-06-21 F. Hoffmann-La Roche Ag Tricyclic lactam derivatives, their manufacture and use as pharmaceutical agents
KR20080106284A (ko) * 2006-03-23 2008-12-04 에프. 호프만-라 로슈 아게 치환된 인다졸 유도체, 이의 제조 및 약학적 제제로서의 용도
US8063225B2 (en) 2006-08-14 2011-11-22 Chembridge Corporation Tricyclic compound derivatives useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2627848T3 (es) 2008-06-04 2017-07-31 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
RU2443704C1 (ru) * 2010-10-29 2012-02-27 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" СУЛЬФАТЫ 2-АРИЛ-4-ДИАЛКИЛАМИНОЭТИЛ-3-ФЕНИЛПИРРОЛО[1,2-a]-БЕНЗИМИДАЗОЛОВ, ОБЛАДАЮЩИЕ АНТИОКСИДАНТНЫМИ И АНТИРАДИКАЛЬНЫМИ СВОЙСТВАМИ
MX357121B (es) 2011-03-01 2018-06-27 Synergy Pharmaceuticals Inc Star Proceso de preparacion de agonistas c de guanilato ciclasa.
ES2590531T3 (es) 2012-09-13 2016-11-22 F. Hoffmann-La Roche Ag 2-oxo-2,3-dihidro-indoles para el tratamiento de trastornos del SNC
EP2958577A2 (en) 2013-02-25 2015-12-30 Synergy Pharmaceuticals Inc. Guanylate cyclase receptor agonists for use in colonic cleansing
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
PL3004138T3 (pl) 2013-06-05 2024-07-29 Bausch Health Ireland Limited Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie
CA2920856C (en) 2013-08-09 2026-03-03 Ardelyx, Inc. Ph modulating compounds for inhibiting gastrointestinal phosphate uptake
GB201709456D0 (en) * 2017-06-14 2017-07-26 Ucb Biopharma Sprl Therapeutic agents
JP2022533251A (ja) 2019-05-21 2022-07-21 アルデリックス， インコーポレイテッド 患者において血清リン酸塩を低下させるための組み合わせ
JP6854953B1 (ja) 2020-06-16 2021-04-07 株式会社ソディック ワイヤ放電加工装置

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Publication number Priority date Publication date Assignee Title
GB1158532A (en) * 1967-01-05 1969-07-16 Centre Nat Rech Scient 2-Oxoindoline-3-Carboxylic Acids and Esters thereof
FR1529901A (fr) * 1967-05-12 1968-06-21 Centre Nat Rech Scient Procédé de préparation de lactames se rattachant à l'indolinone et à l'oxo quinoléine
BE714717A (enExample) * 1967-05-12 1968-09-30
US4322533A (en) * 1980-03-17 1982-03-30 Lesher George Y 1H-Indole-2,3-dione derivatives
CH644116A5 (de) * 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
DE3224512A1 (de) * 1982-07-01 1984-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
GR851085B (enExample) * 1984-05-12 1985-11-25 Boehringer Mannheim Gmbh

Also Published As

Publication number Publication date
PL144822B1 (en) 1988-07-30
PT80425B (de) 1987-04-16
NZ212005A (en) 1989-07-27
PL147842B1 (en) 1989-08-31
KR850008170A (ko) 1985-12-13
US4963686A (en) 1990-10-16
GR851085B (enExample) 1985-11-25
NO851862L (no) 1985-11-13
IL75120A0 (en) 1985-09-29
ES8603178A1 (es) 1986-01-01
DE3582447D1 (de) 1991-05-16
JPS60246386A (ja) 1985-12-06
FI851869A0 (fi) 1985-05-10
SU1480770A3 (ru) 1989-05-15
FI81351C (fi) 1990-10-10
EP0161632A3 (en) 1986-06-11
HU193754B (en) 1987-11-30
PL253246A1 (en) 1986-08-26
DK209585D0 (da) 1985-05-10
HUT37938A (en) 1986-03-28
JPH0772185B2 (ja) 1995-08-02
AU560349B2 (en) 1987-04-02
JPH0741474A (ja) 1995-02-10
IL75120A (en) 1989-02-28
FI81351B (fi) 1990-06-29
PT80425A (de) 1985-06-01
ES542976A0 (es) 1986-01-01
DK209585A (da) 1985-11-13
AU4222285A (en) 1985-11-14
US4666923A (en) 1987-05-19
EP0161632B1 (de) 1991-04-10
EP0161632A2 (de) 1985-11-21
PH22863A (en) 1989-01-19
JPH0647593B2 (ja) 1994-06-22
FI851869L (fi) 1985-11-13

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