FI851869A0 - Nya pyrrolo-bensimidazoler, foerfarande foer framstaellning av desamma och laekemedel innehaollande dessa foereningar samt mellanprodukter. - Google Patents

Nya pyrrolo-bensimidazoler, foerfarande foer framstaellning av desamma och laekemedel innehaollande dessa foereningar samt mellanprodukter.

Info

Publication number
FI851869A0
FI851869A0 FI851869A FI851869A FI851869A0 FI 851869 A0 FI851869 A0 FI 851869A0 FI 851869 A FI851869 A FI 851869A FI 851869 A FI851869 A FI 851869A FI 851869 A0 FI851869 A0 FI 851869A0
Authority
FI
Finland
Prior art keywords
bensimidazoler
desamma
mellanprodukter
nya
pyrrolo
Prior art date
Application number
FI851869A
Other languages
English (en)
Other versions
FI81351B (fi
FI81351C (fi
FI851869L (fi
Inventor
Jens-Peter Hoelck
Alfred Mertens
Wolfgang Kampe
Bernd Mueller-Beckmann
Gisbert Sponer
Klaus Strein
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19843417643 external-priority patent/DE3417643A1/de
Priority claimed from DE19843446417 external-priority patent/DE3446417A1/de
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of FI851869A0 publication Critical patent/FI851869A0/fi
Publication of FI851869L publication Critical patent/FI851869L/fi
Priority to FI883391A priority Critical patent/FI883391A0/fi
Publication of FI81351B publication Critical patent/FI81351B/fi
Application granted granted Critical
Publication of FI81351C publication Critical patent/FI81351C/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/34Oxygen atoms in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/96Spiro-condensed ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI851869A 1984-05-12 1985-05-10 Foerfarande foer framstaellning av farmakologiskt aktiva 2-pyridylsubstituerade 6,7-dihydro-3h,5h-pyrrolo/ 2,3-f/bentsimidazol-6-oner och -6-tioner. FI81351C (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI883391A FI883391A0 (fi) 1984-05-12 1988-07-15 Saosom mellanprodukter anvaendbara indolinderivat.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19843417643 DE3417643A1 (de) 1984-05-12 1984-05-12 Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3417643 1984-05-12
DE19843446417 DE3446417A1 (de) 1984-12-20 1984-12-20 Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3446417 1984-12-20

Publications (4)

Publication Number Publication Date
FI851869A0 true FI851869A0 (fi) 1985-05-10
FI851869L FI851869L (fi) 1985-11-13
FI81351B FI81351B (fi) 1990-06-29
FI81351C FI81351C (fi) 1990-10-10

Family

ID=25821132

Family Applications (1)

Application Number Title Priority Date Filing Date
FI851869A FI81351C (fi) 1984-05-12 1985-05-10 Foerfarande foer framstaellning av farmakologiskt aktiva 2-pyridylsubstituerade 6,7-dihydro-3h,5h-pyrrolo/ 2,3-f/bentsimidazol-6-oner och -6-tioner.

Country Status (18)

Country Link
US (2) US4666923A (fi)
EP (1) EP0161632B1 (fi)
JP (2) JPH0647593B2 (fi)
KR (1) KR870001201B1 (fi)
AU (1) AU560349B2 (fi)
DE (1) DE3582447D1 (fi)
DK (1) DK209585A (fi)
ES (1) ES8603178A1 (fi)
FI (1) FI81351C (fi)
GR (1) GR851085B (fi)
HU (1) HU193754B (fi)
IL (1) IL75120A (fi)
NO (1) NO851862L (fi)
NZ (1) NZ212005A (fi)
PH (1) PH22863A (fi)
PL (2) PL144822B1 (fi)
PT (1) PT80425B (fi)
SU (1) SU1480770A3 (fi)

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PL144822B1 (en) * 1984-05-12 1988-07-30 Boehringer Mannheim Gmbh Method of obtaining novel pyrolobenzimidazoles
DE3445669A1 (de) * 1984-12-14 1986-06-19 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3501497A1 (de) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3524067A1 (de) * 1985-07-05 1987-01-08 Boehringer Mannheim Gmbh Neue benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3530825A1 (de) * 1985-08-29 1987-03-05 Boehringer Mannheim Gmbh Neue benzodipyrrole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3531678A1 (de) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3626664A1 (de) * 1986-08-07 1988-02-11 Boehringer Mannheim Gmbh Tricyclische benzotriazole, verfahren zu ihrer herstellung sowie arzneimittel
DE3639466A1 (de) * 1986-11-18 1988-05-19 Thomae Gmbh Dr K Neue pyrrolo-benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3642315A1 (de) * 1986-12-11 1988-06-23 Boehringer Mannheim Gmbh Neue pyrrolobenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel
DE3740985A1 (de) * 1987-12-03 1989-06-15 Boehringer Mannheim Gmbh Verwendung linear anellierter tricyclen als hemmer der erythrozytenaggregation
US4963677A (en) * 1987-12-30 1990-10-16 Orion Corporation Ltd. Heterocyclic lactam compounds
ATE138658T1 (de) * 1987-12-30 1996-06-15 Orion Yhtymae Oy Heterocyclische verbindungen
DE3803775A1 (de) * 1988-02-09 1989-08-17 Boehringer Mannheim Gmbh Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
US5324911A (en) * 1990-01-08 1994-06-28 Schroer Manufacturing Company Heated animal surgery table
DE4027592A1 (de) * 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US20060142247A1 (en) * 2004-12-17 2006-06-29 Guy Georges Tricyclic heterocycles
CA2603204A1 (en) * 2005-04-14 2006-10-19 F. Hoffmann-La Roche Ag Aminopyrazole derivatives, their manufacture and use as pharmaceutical agents
DE602006002887D1 (de) * 2005-04-14 2008-11-06 Hoffmann La Roche Tricyclische azolderivate, ihre herstellung und ihre verwendung als pharmazeutische mittel
BRPI0619955A2 (pt) * 2005-12-15 2011-10-25 Hoffmann La Roche derivados tricìclicos da lactama, sua produção e seus usos como agentes farmacêuticos
US20090291968A1 (en) * 2006-03-23 2009-11-26 Guy Georges Substituted indazole derivatives, their manufacture and use as pharmaceutical agents
US8063225B2 (en) 2006-08-14 2011-11-22 Chembridge Corporation Tricyclic compound derivatives useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
AU2009256157B2 (en) 2008-06-04 2014-12-18 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
RU2443704C1 (ru) * 2010-10-29 2012-02-27 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" СУЛЬФАТЫ 2-АРИЛ-4-ДИАЛКИЛАМИНОЭТИЛ-3-ФЕНИЛПИРРОЛО[1,2-a]-БЕНЗИМИДАЗОЛОВ, ОБЛАДАЮЩИЕ АНТИОКСИДАНТНЫМИ И АНТИРАДИКАЛЬНЫМИ СВОЙСТВАМИ
EA201391254A1 (ru) 2011-03-01 2014-02-28 Синерджи Фармасьютикалз Инк. Способ получения агонистов гуанилатциклазы c
JP6116693B2 (ja) 2012-09-13 2017-04-19 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Cns障害の処置のための2−オキソ−2,3−ジヒドロ−インドール
CA2902348C (en) 2013-02-25 2021-11-30 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
WO2014197720A2 (en) 2013-06-05 2014-12-11 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same
US20160184387A1 (en) 2013-08-09 2016-06-30 Dominique Charmot Compounds and methods for inhibiting phosphate transport
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JP6854953B1 (ja) 2020-06-16 2021-04-07 株式会社ソディック ワイヤ放電加工装置

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GB1158532A (en) * 1967-01-05 1969-07-16 Centre Nat Rech Scient 2-Oxoindoline-3-Carboxylic Acids and Esters thereof
FR1529901A (fr) * 1967-05-12 1968-06-21 Centre Nat Rech Scient Procédé de préparation de lactames se rattachant à l'indolinone et à l'oxo quinoléine
BE714717A (fi) * 1967-05-12 1968-09-30
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CH644116A5 (de) * 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
DE3224512A1 (de) * 1982-07-01 1984-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
PL144822B1 (en) * 1984-05-12 1988-07-30 Boehringer Mannheim Gmbh Method of obtaining novel pyrolobenzimidazoles

Also Published As

Publication number Publication date
NZ212005A (en) 1989-07-27
PH22863A (en) 1989-01-19
ES542976A0 (es) 1986-01-01
DK209585A (da) 1985-11-13
EP0161632B1 (de) 1991-04-10
DK209585D0 (da) 1985-05-10
GR851085B (fi) 1985-11-25
EP0161632A2 (de) 1985-11-21
US4666923A (en) 1987-05-19
FI81351B (fi) 1990-06-29
PL147842B1 (en) 1989-08-31
US4963686A (en) 1990-10-16
JPH0772185B2 (ja) 1995-08-02
FI81351C (fi) 1990-10-10
JPS60246386A (ja) 1985-12-06
HUT37938A (en) 1986-03-28
KR850008170A (ko) 1985-12-13
IL75120A0 (en) 1985-09-29
HU193754B (en) 1987-11-30
DE3582447D1 (de) 1991-05-16
ES8603178A1 (es) 1986-01-01
AU560349B2 (en) 1987-04-02
KR870001201B1 (ko) 1987-06-20
IL75120A (en) 1989-02-28
PT80425B (de) 1987-04-16
JPH0741474A (ja) 1995-02-10
PL144822B1 (en) 1988-07-30
FI851869L (fi) 1985-11-13
AU4222285A (en) 1985-11-14
SU1480770A3 (ru) 1989-05-15
PT80425A (de) 1985-06-01
EP0161632A3 (en) 1986-06-11
PL253246A1 (en) 1986-08-26
NO851862L (no) 1985-11-13
JPH0647593B2 (ja) 1994-06-22

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