PL144822B1 - Method of obtaining novel pyrolobenzimidazoles - Google Patents
Method of obtaining novel pyrolobenzimidazoles Download PDFInfo
- Publication number
- PL144822B1 PL144822B1 PL1985253246A PL25324685A PL144822B1 PL 144822 B1 PL144822 B1 PL 144822B1 PL 1985253246 A PL1985253246 A PL 1985253246A PL 25324685 A PL25324685 A PL 25324685A PL 144822 B1 PL144822 B1 PL 144822B1
- Authority
- PL
- Poland
- Prior art keywords
- group
- general formula
- melting point
- yield
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843417643 DE3417643A1 (de) | 1984-05-12 | 1984-05-12 | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte |
| DE19843446417 DE3446417A1 (de) | 1984-12-20 | 1984-12-20 | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL253246A1 PL253246A1 (en) | 1986-08-26 |
| PL144822B1 true PL144822B1 (en) | 1988-07-30 |
Family
ID=25821132
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1985253246A PL144822B1 (en) | 1984-05-12 | 1985-05-06 | Method of obtaining novel pyrolobenzimidazoles |
| PL1985259261A PL147842B1 (en) | 1984-05-12 | 1985-05-06 | Method of obtaining novel pyroisobenzimidazoles |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1985259261A PL147842B1 (en) | 1984-05-12 | 1985-05-06 | Method of obtaining novel pyroisobenzimidazoles |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US4666923A (enExample) |
| EP (1) | EP0161632B1 (enExample) |
| JP (2) | JPH0647593B2 (enExample) |
| KR (1) | KR870001201B1 (enExample) |
| AU (1) | AU560349B2 (enExample) |
| DE (1) | DE3582447D1 (enExample) |
| DK (1) | DK209585A (enExample) |
| ES (1) | ES542976A0 (enExample) |
| FI (1) | FI81351C (enExample) |
| GR (1) | GR851085B (enExample) |
| HU (1) | HU193754B (enExample) |
| IL (1) | IL75120A (enExample) |
| NO (1) | NO851862L (enExample) |
| NZ (1) | NZ212005A (enExample) |
| PH (1) | PH22863A (enExample) |
| PL (2) | PL144822B1 (enExample) |
| PT (1) | PT80425B (enExample) |
| SU (1) | SU1480770A3 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR851085B (enExample) * | 1984-05-12 | 1985-11-25 | Boehringer Mannheim Gmbh | |
| DE3445669A1 (de) * | 1984-12-14 | 1986-06-19 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3501497A1 (de) * | 1985-01-18 | 1986-07-24 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte |
| DE3524067A1 (de) * | 1985-07-05 | 1987-01-08 | Boehringer Mannheim Gmbh | Neue benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte |
| DE3530825A1 (de) * | 1985-08-29 | 1987-03-05 | Boehringer Mannheim Gmbh | Neue benzodipyrrole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3531678A1 (de) * | 1985-09-05 | 1987-03-12 | Boehringer Mannheim Gmbh | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3626664A1 (de) * | 1986-08-07 | 1988-02-11 | Boehringer Mannheim Gmbh | Tricyclische benzotriazole, verfahren zu ihrer herstellung sowie arzneimittel |
| DE3639466A1 (de) * | 1986-11-18 | 1988-05-19 | Thomae Gmbh Dr K | Neue pyrrolo-benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE3642315A1 (de) * | 1986-12-11 | 1988-06-23 | Boehringer Mannheim Gmbh | Neue pyrrolobenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel |
| DE3740985A1 (de) * | 1987-12-03 | 1989-06-15 | Boehringer Mannheim Gmbh | Verwendung linear anellierter tricyclen als hemmer der erythrozytenaggregation |
| US4963677A (en) * | 1987-12-30 | 1990-10-16 | Orion Corporation Ltd. | Heterocyclic lactam compounds |
| DE3855327D1 (de) * | 1987-12-30 | 1996-07-04 | Orion Yhtymae Oy | Heterocyclische Verbindungen |
| DE3803775A1 (de) * | 1988-02-09 | 1989-08-17 | Boehringer Mannheim Gmbh | Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten |
| US5324911A (en) * | 1990-01-08 | 1994-06-28 | Schroer Manufacturing Company | Heated animal surgery table |
| DE4027592A1 (de) * | 1990-08-31 | 1992-03-05 | Beiersdorf Ag | Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US20060142247A1 (en) * | 2004-12-17 | 2006-06-29 | Guy Georges | Tricyclic heterocycles |
| JP2008533181A (ja) * | 2005-04-14 | 2008-08-21 | エフ．ホフマン−ラ ロシュ アーゲー | 三環式アゾール誘導体、それらの製造及び医薬品としての使用 |
| CA2603204A1 (en) * | 2005-04-14 | 2006-10-19 | F. Hoffmann-La Roche Ag | Aminopyrazole derivatives, their manufacture and use as pharmaceutical agents |
| WO2007068465A1 (en) * | 2005-12-15 | 2007-06-21 | F. Hoffmann-La Roche Ag | Tricyclic lactam derivatives, their manufacture and use as pharmaceutical agents |
| KR20080106284A (ko) * | 2006-03-23 | 2008-12-04 | 에프. 호프만-라 로슈 아게 | 치환된 인다졸 유도체, 이의 제조 및 약학적 제제로서의 용도 |
| US8063225B2 (en) | 2006-08-14 | 2011-11-22 | Chembridge Corporation | Tricyclic compound derivatives useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders |
| WO2008151257A2 (en) | 2007-06-04 | 2008-12-11 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| ES2627848T3 (es) | 2008-06-04 | 2017-07-31 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| RU2443704C1 (ru) * | 2010-10-29 | 2012-02-27 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" | СУЛЬФАТЫ 2-АРИЛ-4-ДИАЛКИЛАМИНОЭТИЛ-3-ФЕНИЛПИРРОЛО[1,2-a]-БЕНЗИМИДАЗОЛОВ, ОБЛАДАЮЩИЕ АНТИОКСИДАНТНЫМИ И АНТИРАДИКАЛЬНЫМИ СВОЙСТВАМИ |
| MX357121B (es) | 2011-03-01 | 2018-06-27 | Synergy Pharmaceuticals Inc Star | Proceso de preparacion de agonistas c de guanilato ciclasa. |
| ES2590531T3 (es) | 2012-09-13 | 2016-11-22 | F. Hoffmann-La Roche Ag | 2-oxo-2,3-dihidro-indoles para el tratamiento de trastornos del SNC |
| EP2958577A2 (en) | 2013-02-25 | 2015-12-30 | Synergy Pharmaceuticals Inc. | Guanylate cyclase receptor agonists for use in colonic cleansing |
| US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| EP2968439A2 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| PL3004138T3 (pl) | 2013-06-05 | 2024-07-29 | Bausch Health Ireland Limited | Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie |
| CA2920856C (en) | 2013-08-09 | 2026-03-03 | Ardelyx, Inc. | Ph modulating compounds for inhibiting gastrointestinal phosphate uptake |
| GB201709456D0 (en) * | 2017-06-14 | 2017-07-26 | Ucb Biopharma Sprl | Therapeutic agents |
| JP2022533251A (ja) | 2019-05-21 | 2022-07-21 | アルデリックス， インコーポレイテッド | 患者において血清リン酸塩を低下させるための組み合わせ |
| JP6854953B1 (ja) | 2020-06-16 | 2021-04-07 | 株式会社ソディック | ワイヤ放電加工装置 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1158532A (en) * | 1967-01-05 | 1969-07-16 | Centre Nat Rech Scient | 2-Oxoindoline-3-Carboxylic Acids and Esters thereof |
| FR1529901A (fr) * | 1967-05-12 | 1968-06-21 | Centre Nat Rech Scient | Procédé de préparation de lactames se rattachant à l'indolinone et à l'oxo quinoléine |
| BE714717A (enExample) * | 1967-05-12 | 1968-09-30 | ||
| US4322533A (en) * | 1980-03-17 | 1982-03-30 | Lesher George Y | 1H-Indole-2,3-dione derivatives |
| CH644116A5 (de) * | 1980-08-21 | 1984-07-13 | Hoffmann La Roche | Imidazolderivate. |
| DE3224512A1 (de) * | 1982-07-01 | 1984-01-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| GR851085B (enExample) * | 1984-05-12 | 1985-11-25 | Boehringer Mannheim Gmbh |
-
1985
- 1985-05-06 GR GR851085A patent/GR851085B/el unknown
- 1985-05-06 PL PL1985253246A patent/PL144822B1/pl unknown
- 1985-05-06 PL PL1985259261A patent/PL147842B1/pl unknown
- 1985-05-07 US US06/731,500 patent/US4666923A/en not_active Expired - Lifetime
- 1985-05-07 IL IL75120A patent/IL75120A/xx unknown
- 1985-05-07 NZ NZ212005A patent/NZ212005A/xx unknown
- 1985-05-08 PH PH32240A patent/PH22863A/en unknown
- 1985-05-09 AU AU42222/85A patent/AU560349B2/en not_active Ceased
- 1985-05-09 ES ES542976A patent/ES542976A0/es active Granted
- 1985-05-09 DE DE8585105675T patent/DE3582447D1/de not_active Expired - Lifetime
- 1985-05-09 EP EP85105675A patent/EP0161632B1/de not_active Expired - Lifetime
- 1985-05-09 PT PT80425A patent/PT80425B/pt not_active IP Right Cessation
- 1985-05-09 KR KR1019850003144A patent/KR870001201B1/ko not_active Expired
- 1985-05-10 NO NO851862A patent/NO851862L/no unknown
- 1985-05-10 DK DK209585A patent/DK209585A/da not_active Application Discontinuation
- 1985-05-10 SU SU853894709A patent/SU1480770A3/ru active
- 1985-05-10 HU HU851775A patent/HU193754B/hu not_active IP Right Cessation
- 1985-05-10 FI FI851869A patent/FI81351C/fi not_active Application Discontinuation
- 1985-05-13 JP JP60099742A patent/JPH0647593B2/ja not_active Expired - Lifetime
-
1988
- 1988-07-05 US US07/217,143 patent/US4963686A/en not_active Expired - Fee Related
-
1993
- 1993-12-10 JP JP5310823A patent/JPH0772185B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| PT80425B (de) | 1987-04-16 |
| NZ212005A (en) | 1989-07-27 |
| PL147842B1 (en) | 1989-08-31 |
| KR850008170A (ko) | 1985-12-13 |
| US4963686A (en) | 1990-10-16 |
| GR851085B (enExample) | 1985-11-25 |
| NO851862L (no) | 1985-11-13 |
| IL75120A0 (en) | 1985-09-29 |
| ES8603178A1 (es) | 1986-01-01 |
| DE3582447D1 (de) | 1991-05-16 |
| JPS60246386A (ja) | 1985-12-06 |
| FI851869A0 (fi) | 1985-05-10 |
| SU1480770A3 (ru) | 1989-05-15 |
| FI81351C (fi) | 1990-10-10 |
| EP0161632A3 (en) | 1986-06-11 |
| HU193754B (en) | 1987-11-30 |
| PL253246A1 (en) | 1986-08-26 |
| DK209585D0 (da) | 1985-05-10 |
| HUT37938A (en) | 1986-03-28 |
| JPH0772185B2 (ja) | 1995-08-02 |
| AU560349B2 (en) | 1987-04-02 |
| JPH0741474A (ja) | 1995-02-10 |
| IL75120A (en) | 1989-02-28 |
| FI81351B (fi) | 1990-06-29 |
| PT80425A (de) | 1985-06-01 |
| ES542976A0 (es) | 1986-01-01 |
| DK209585A (da) | 1985-11-13 |
| AU4222285A (en) | 1985-11-14 |
| US4666923A (en) | 1987-05-19 |
| EP0161632B1 (de) | 1991-04-10 |
| EP0161632A2 (de) | 1985-11-21 |
| PH22863A (en) | 1989-01-19 |
| JPH0647593B2 (ja) | 1994-06-22 |
| KR870001201B1 (ko) | 1987-06-20 |
| FI851869L (fi) | 1985-11-13 |
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