KR840002241A - 센나 약제로부터 완화제를 제조하는 공정 - Google Patents
센나 약제로부터 완화제를 제조하는 공정 Download PDFInfo
- Publication number
- KR840002241A KR840002241A KR1019820004908A KR820004908A KR840002241A KR 840002241 A KR840002241 A KR 840002241A KR 1019820004908 A KR1019820004908 A KR 1019820004908A KR 820004908 A KR820004908 A KR 820004908A KR 840002241 A KR840002241 A KR 840002241A
- Authority
- KR
- South Korea
- Prior art keywords
- process according
- senna
- laxative
- butan
- methanol
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 16
- 239000008141 laxative Substances 0.000 title claims 5
- 229940124513 senna glycoside Drugs 0.000 title claims 5
- 235000006693 Cassia laevigata Nutrition 0.000 title claims 4
- 230000002475 laxative effect Effects 0.000 title claims 4
- 241000735631 Senna pendula Species 0.000 title 1
- 238000000605 extraction Methods 0.000 claims description 3
- 238000000622 liquid--liquid extraction Methods 0.000 claims description 2
- 238000001953 recrystallisation Methods 0.000 claims description 2
- 238000000638 solvent extraction Methods 0.000 claims description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 9
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 claims 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 4
- 239000013078 crystal Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 3
- 241000522641 Senna Species 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000003960 organic solvent Substances 0.000 claims 3
- 238000003756 stirring Methods 0.000 claims 3
- SYBYTAAJFKOIEJ-UHFFFAOYSA-N 3-Methylbutan-2-one Chemical compound CC(C)C(C)=O SYBYTAAJFKOIEJ-UHFFFAOYSA-N 0.000 claims 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- 238000002425 crystallisation Methods 0.000 claims 1
- 230000008025 crystallization Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 229940125722 laxative agent Drugs 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000003204 osmotic effect Effects 0.000 claims 1
- 230000020477 pH reduction Effects 0.000 claims 1
- 239000008024 pharmaceutical diluent Substances 0.000 claims 1
- OVARTBFNCCXQKS-UHFFFAOYSA-N propan-2-one;hydrate Chemical compound O.CC(C)=O OVARTBFNCCXQKS-UHFFFAOYSA-N 0.000 claims 1
- 239000013014 purified material Substances 0.000 claims 1
- 238000001223 reverse osmosis Methods 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 229930186851 sennoside Natural products 0.000 claims 1
- IPQVTOJGNYVQEO-KGFNBKMBSA-N sennoside A Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC2=C1C(=O)C1=C(O)C=C(C(O)=O)C=C1[C@@H]2[C@H]1C2=CC(C(O)=O)=CC(O)=C2C(=O)C2=C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C=CC=C21 IPQVTOJGNYVQEO-KGFNBKMBSA-N 0.000 claims 1
- 229910052709 silver Inorganic materials 0.000 claims 1
- 239000004332 silver Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000011550 stock solution Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 230000008961 swelling Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명의 추출 과정의 플로우 차트이다.
제2도는 본 발명의 액상-액상 추출과정의 플로우차트이다.
제3도는 본 발명의 재결정화 과정의 플로우 차트이다.
Claims (13)
- a) 센타약제를 수성메탄올을 써서 역류삼투에 의해 추출하고 50℃ 이하에서 농축하여 메르탄올을 완전히 제거시킨 다음, b) 유기용매에 의한 연속 액상-액상 추출로서 정제하고, c) 정제된 물질(라피네이트)을 결정화장치에 옮겨 교반하면서 산성화하고(pH 11.5∼2.0)센노 사이드 결정을 결정핵으로 넣어주고, 교반을계속하며 결정이 생기게 둔 다음 생성된 조센노사이드 결정을 분리해 내고, d) 필요한 경우에는 재결정화 하고, e) c)의 원액을 무게로 10부분 취하여 교반중에 염화나트륨 2부분을 넣어 혼합시키고, 표면의 반고형 응고물을 경사로 분리하여 세척하고 95% 메탄올로 추출하고, 이 추출액은 농축시키고, 잔류물은 건조시키는 것으로 구성된, 센나 약제로부터 완하제를 제조하는 공정.
- 제1항에 있어서, a)단계의 추출용제로써 70% 메탄올을 사용하는 것을 특징으로 하는 공정.
- 제1항, 2항에 있어서 a)단계의 추출과정이 35℃정도까지의 온도에서 행해지는 것을 특징으로 하는 공정.
- 제1,2,3항에 있어서, 역류 삼투과정이 2∼4개의 시리즈로 연결된 삼투기로 된 장치에서 행해지는 것을 특징으로 하는 공정.
- 제 1항 내지 4항에 있어서, 센나 약제를 삼투하기 전에 후삼투물로 팽윤시키는 것을 특징으로 하는 공정.
- 제1항 내지 5항에 있어서, a)단계에서 얻어진 농축물이 약 5% 부탄-2-올과 한합되는 것을 특징으로 하는 공정.
- 제1항 내지 6항에 있어서, b)단계에서 사용한 유기용제가 부탄올, 메틸에틸케톤 혹은 메틸 이소프로필 케톤인 것을 특징으로 하는 공정.
- 제7항에 있어서, 사용된 유기용제가 물로 포화된 부탄-2-올인 것을 특징으로 하는 공정.
- 제8항에 있어서, 부탄-2-올대 라피네이트의 런 오프(run off)비가 0.7∼0.8:1인 것을 특징으로 하는 공정.
- 제1항 내지 9항에 있어서 c)단계의 산성화 과정이 염산 혹은 황산에 의해 행해지는 것을 특징으로 하는 공정.
- 제1항 내지 10항에 있어서, c)단계에서 얻어진 조센노사이드가 재결정화 과정을 위해 아세톤-물(50/50) 혼합물에 부유되어 약 10% 부유물이 되고 pH를 약 1.5∼2 되도록 염산으로 조정하여 센노사이드가 재침전되게 하여 분리해내어 수성 아세톤으로 세척하고 건조시키는 것을 특징으로 하는 공정.
- 제1항에 있어서 센나 약제로부터 완하제 화합물이 상기와 같이 기술되고 예증외는 것을 특징으로 하는 공정.
- 센나약제에서 얻어진 완하제 화하물을 적어도 하나 포함하고 고형 또는 액상의 약학적 희석액 또는 담체와의 혼합물로 된 완하제 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3200131A DE3200131A1 (de) | 1982-01-05 | 1982-01-05 | "verfahren zur gewinnung von laxativen verbindungen aus sennadroge" |
| DE3200131 | 1982-01-05 | ||
| DE32·00131 | 1984-01-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR840002241A true KR840002241A (ko) | 1984-06-25 |
| KR880000018B1 KR880000018B1 (ko) | 1988-02-15 |
Family
ID=6152636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR8204908A KR880000018B1 (ko) | 1982-01-05 | 1982-11-01 | 센나 약제로부터 완하제를 제조하는 공정 |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS58131997A (ko) |
| KR (1) | KR880000018B1 (ko) |
| AR (1) | AR228690A1 (ko) |
| AT (1) | AT376368B (ko) |
| AU (1) | AU557773B2 (ko) |
| BE (1) | BE895536A (ko) |
| CA (1) | CA1203800A (ko) |
| CH (1) | CH653339A5 (ko) |
| DE (1) | DE3200131A1 (ko) |
| DK (1) | DK169075B1 (ko) |
| FI (1) | FI75992C (ko) |
| FR (1) | FR2519253B1 (ko) |
| GB (1) | GB2112640B (ko) |
| GR (1) | GR77138B (ko) |
| HK (1) | HK90585A (ko) |
| HU (1) | HU188241B (ko) |
| IE (1) | IE54425B1 (ko) |
| IL (1) | IL67147A (ko) |
| IT (1) | IT1191156B (ko) |
| LU (1) | LU84534A1 (ko) |
| MX (1) | MX7121E (ko) |
| NL (1) | NL188680C (ko) |
| PT (1) | PT75934B (ko) |
| SE (1) | SE8207515L (ko) |
| SG (1) | SG45385G (ko) |
| YU (1) | YU42829B (ko) |
| ZA (1) | ZA829570B (ko) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4120991A1 (de) * | 1991-06-25 | 1993-01-07 | Madaus Ag | Verfahren zur gewinnung der sennoside a, b und a1 |
| DE4120989C2 (de) * | 1991-06-25 | 1995-07-27 | Madaus Ag | Verfahren zur Herstellung von Diacetylrhein |
| DE4120990C2 (de) * | 1991-06-25 | 1995-07-27 | Madaus Ag | Verfahren zur Herstellung von Diacetylrhein |
| US5710260A (en) * | 1991-06-25 | 1998-01-20 | Madaus Ag | Method of extracting sennosides A, B and A1 |
| JP5449710B2 (ja) * | 2008-07-11 | 2014-03-19 | 株式会社ブルックスホールディングス | 機能性食品素材 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB744876A (en) * | 1953-10-27 | 1956-02-15 | Westminster Lab Ltd | Process for extracting the active principles from senna |
| GB804232A (en) * | 1956-01-09 | 1958-11-12 | Byk Gulden Lomberg Chem Fab | Improvements in or relating to the production of sennosides from folia sennae or folliculi sennae |
| DE1032888B (de) * | 1956-01-09 | 1958-06-26 | Byk Gulden Lomberg Chem Fab | Verfahren zur Gewinnung von die natuerlichen Sennosidsalze enthaltenden Wirkstoffen aus Sennesdrogen |
| GB832017A (en) * | 1957-10-02 | 1960-04-06 | Westminster Lab Ltd | Senna preparations |
| DE1158211B (de) * | 1961-09-02 | 1963-11-28 | Ludwig Heumann & Co Chemisch P | Verfahren zur Herstellung von Trockenpulvern mit Wirkstoffen der Sennesblaetter oder-schoten |
| US3364113A (en) * | 1962-04-23 | 1968-01-16 | Westminster Lab Ltd | Senna preparations and methods of making and using them |
| FR1490738A (fr) * | 1966-06-24 | 1967-08-04 | Ile De Rech Pharmaceutiqje Et | Procédé d'extraction de dérivés anthracéniques contenus dans certaines plantes |
| DE1617667B1 (de) * | 1966-09-08 | 1970-09-03 | Nattermann A & Cie | Verfahren zur Gewinnung eines sennosideichen Wirkstoffkonzentrates aus Sennesschoten |
| FR1536622A (fr) * | 1966-09-08 | 1968-08-16 | Nattermann & Compagnie A | Procédé pour la production d'un concentré de substance active riche en sennacidesavec des follicules de séné |
| JPS5936604B2 (ja) * | 1975-07-18 | 1984-09-05 | 大日本製薬株式会社 | センノサイド類のカルシウム塩の製造法 |
| FR2422678A1 (fr) * | 1978-04-14 | 1979-11-09 | Synthelabo | Extraction de sennosides |
-
1982
- 1982-01-05 DE DE3200131A patent/DE3200131A1/de active Granted
- 1982-10-20 AR AR291034A patent/AR228690A1/es active
- 1982-10-29 CA CA000414539A patent/CA1203800A/en not_active Expired
- 1982-11-01 KR KR8204908A patent/KR880000018B1/ko active
- 1982-11-01 IL IL67147A patent/IL67147A/xx unknown
- 1982-11-11 AU AU90375/82A patent/AU557773B2/en not_active Ceased
- 1982-11-22 NL NLAANVRAGE8204533,A patent/NL188680C/xx not_active IP Right Cessation
- 1982-11-24 GB GB08233475A patent/GB2112640B/en not_active Expired
- 1982-11-30 AT AT0435582A patent/AT376368B/de not_active IP Right Cessation
- 1982-12-03 PT PT75934A patent/PT75934B/pt not_active IP Right Cessation
- 1982-12-06 IE IE2884/82A patent/IE54425B1/en not_active IP Right Cessation
- 1982-12-15 LU LU84534A patent/LU84534A1/de unknown
- 1982-12-17 DK DK559682A patent/DK169075B1/da active
- 1982-12-27 FI FI824454A patent/FI75992C/fi not_active IP Right Cessation
- 1982-12-28 IT IT25002/82A patent/IT1191156B/it active
- 1982-12-28 JP JP57227837A patent/JPS58131997A/ja active Granted
- 1982-12-30 ZA ZA829570A patent/ZA829570B/xx unknown
- 1982-12-30 SE SE8207515A patent/SE8207515L/xx not_active Application Discontinuation
- 1982-12-31 YU YU2925/82A patent/YU42829B/xx unknown
- 1982-12-31 CH CH7650/82A patent/CH653339A5/de not_active IP Right Cessation
-
1983
- 1983-01-04 MX MX8310437U patent/MX7121E/es unknown
- 1983-01-04 BE BE0/209848A patent/BE895536A/fr not_active IP Right Cessation
- 1983-01-04 HU HU8318A patent/HU188241B/hu not_active IP Right Cessation
- 1983-01-04 GR GR70202A patent/GR77138B/el unknown
- 1983-01-05 FR FR8300110A patent/FR2519253B1/fr not_active Expired
-
1985
- 1985-06-15 SG SG45385A patent/SG45385G/en unknown
- 1985-11-14 HK HK905/85A patent/HK90585A/xx unknown
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