IE822884L - Process for obtaining laxative compounds from senna drug - Google Patents

Process for obtaining laxative compounds from senna drug

Info

Publication number
IE822884L
IE822884L IE822884A IE288482A IE822884L IE 822884 L IE822884 L IE 822884L IE 822884 A IE822884 A IE 822884A IE 288482 A IE288482 A IE 288482A IE 822884 L IE822884 L IE 822884L
Authority
IE
Ireland
Prior art keywords
methanol
stirring
extract
senna drug
sennoside
Prior art date
Application number
IE822884A
Other versions
IE54425B1 (en
Original Assignee
Madaus & Co Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Madaus & Co Dr filed Critical Madaus & Co Dr
Publication of IE822884L publication Critical patent/IE822884L/en
Publication of IE54425B1 publication Critical patent/IE54425B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482—Cassia, e.g. golden shower tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention provides a process for obtaining laxative compounds from senna drug, wherein a) the senna drug is extracted with aqueous methanol by countercurrent percolation and the extract concentrated at a temperature of >/=50 DEG C. until the methanol has been completely removed from the extract; b) the extract obtained is purified by continuous liquid-liquid extraction with an organic solvent; c) the refined material (raffinate) obtained is transferred to a crystallisation apparatus, acidified, while stirring, to a pH of 1.5 to 2.0, seeded with sennoside crystals, left to crystallise while stirring and the crystalline crude sennoside obtained separated off; d) whereafter, the crude senno- dies are, if desired, recrystallised and optionally e) 10 parts by weight of the mother liquor from c) mixed, while stirring, with 2 parts by weight of sodium chloride and the semi-solid mass coagulated on the surface is decanted off, washed and optionally extracted with 95% methanol and the methanol fraction concentrated and the residue dried. n [GB2112640A]
IE2884/82A 1982-01-05 1982-12-06 A process for obtaining laxative compounds from senna drug IE54425B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3200131A DE3200131A1 (en) 1982-01-05 1982-01-05 "METHOD FOR OBTAINING LAXATIVE COMPOUNDS FROM SENNADROGE"

Publications (2)

Publication Number Publication Date
IE822884L true IE822884L (en) 1983-07-05
IE54425B1 IE54425B1 (en) 1989-10-11

Family

ID=6152636

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2884/82A IE54425B1 (en) 1982-01-05 1982-12-06 A process for obtaining laxative compounds from senna drug

Country Status (27)

Country Link
JP (1) JPS58131997A (en)
KR (1) KR880000018B1 (en)
AR (1) AR228690A1 (en)
AT (1) AT376368B (en)
AU (1) AU557773B2 (en)
BE (1) BE895536A (en)
CA (1) CA1203800A (en)
CH (1) CH653339A5 (en)
DE (1) DE3200131A1 (en)
DK (1) DK169075B1 (en)
FI (1) FI75992C (en)
FR (1) FR2519253B1 (en)
GB (1) GB2112640B (en)
GR (1) GR77138B (en)
HK (1) HK90585A (en)
HU (1) HU188241B (en)
IE (1) IE54425B1 (en)
IL (1) IL67147A (en)
IT (1) IT1191156B (en)
LU (1) LU84534A1 (en)
MX (1) MX7121E (en)
NL (1) NL188680C (en)
PT (1) PT75934B (en)
SE (1) SE8207515L (en)
SG (1) SG45385G (en)
YU (1) YU42829B (en)
ZA (1) ZA829570B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4120989C2 (en) * 1991-06-25 1995-07-27 Madaus Ag Process for the preparation of diacetylrhein
DE4120990C2 (en) * 1991-06-25 1995-07-27 Madaus Ag Process for the preparation of diacetylrhein
US5710260A (en) * 1991-06-25 1998-01-20 Madaus Ag Method of extracting sennosides A, B and A1
DE4120991A1 (en) * 1991-06-25 1993-01-07 Madaus Ag PROCESS FOR OBTAINING SENNOSIDES A, B AND A1
JP5449710B2 (en) * 2008-07-11 2014-03-19 株式会社ブルックスホールディングス Functional food material

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB744876A (en) * 1953-10-27 1956-02-15 Westminster Lab Ltd Process for extracting the active principles from senna
GB804232A (en) * 1956-01-09 1958-11-12 Byk Gulden Lomberg Chem Fab Improvements in or relating to the production of sennosides from folia sennae or folliculi sennae
DE1032888B (en) * 1956-01-09 1958-06-26 Byk Gulden Lomberg Chem Fab Process for the production of active ingredients containing the natural sennoside salts from sennes drugs
GB832017A (en) * 1957-10-02 1960-04-06 Westminster Lab Ltd Senna preparations
DE1158211B (en) * 1961-09-02 1963-11-28 Ludwig Heumann & Co Chemisch P Process for the production of dry powders with active ingredients from senna leaves or pods
US3364113A (en) * 1962-04-23 1968-01-16 Westminster Lab Ltd Senna preparations and methods of making and using them
FR1490738A (en) * 1966-06-24 1967-08-04 Ile De Rech Pharmaceutiqje Et Process for the extraction of anthracene derivatives contained in certain plants
DE1617667B1 (en) * 1966-09-08 1970-09-03 Nattermann A & Cie Process for the production of a sennosid-rich active ingredient concentrate from sennessee pods
FR1536622A (en) * 1966-09-08 1968-08-16 Nattermann & Compagnie A Process for the production of an active substance concentrate rich in sennacids with senna follicles
JPS5936604B2 (en) * 1975-07-18 1984-09-05 大日本製薬株式会社 Method for producing calcium salts of sennosides
FR2422678A1 (en) * 1978-04-14 1979-11-09 Synthelabo SENNOSIDE EXTRACTION

Also Published As

Publication number Publication date
NL188680C (en) 1992-09-01
HUT28334A (en) 1983-12-28
IE54425B1 (en) 1989-10-11
SG45385G (en) 1986-01-17
YU292582A (en) 1985-03-20
KR880000018B1 (en) 1988-02-15
PT75934B (en) 1985-10-04
ATA435582A (en) 1984-04-15
GB2112640A (en) 1983-07-27
AU557773B2 (en) 1987-01-08
ZA829570B (en) 1983-11-30
FI824454L (en) 1983-07-06
BE895536A (en) 1983-07-04
IL67147A0 (en) 1983-03-31
GB2112640B (en) 1985-02-27
NL188680B (en) 1992-04-01
FI824454A0 (en) 1982-12-27
DK559682A (en) 1983-07-06
PT75934A (en) 1983-01-01
FR2519253B1 (en) 1986-04-18
AU9037582A (en) 1983-07-14
AT376368B (en) 1984-11-12
CA1203800A (en) 1986-04-29
FR2519253A1 (en) 1983-07-08
IT8225002A0 (en) 1982-12-28
SE8207515L (en) 1983-07-06
IL67147A (en) 1986-01-31
DE3200131C2 (en) 1988-06-16
YU42829B (en) 1988-12-31
MX7121E (en) 1987-06-29
HK90585A (en) 1985-11-22
IT8225002A1 (en) 1984-06-28
SE8207515D0 (en) 1982-12-30
HU188241B (en) 1986-03-28
JPS6227074B2 (en) 1987-06-12
NL8204533A (en) 1983-08-01
DE3200131A1 (en) 1983-07-14
JPS58131997A (en) 1983-08-06
DK169075B1 (en) 1994-08-08
FI75992B (en) 1988-05-31
FI75992C (en) 1988-09-09
GR77138B (en) 1984-09-07
KR840002241A (en) 1984-06-25
LU84534A1 (en) 1983-06-13
AR228690A1 (en) 1983-03-30
IT1191156B (en) 1988-02-24
CH653339A5 (en) 1985-12-31

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Legal Events

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MM4A Patent lapsed