KR830002772A - 메탄디올의 페니실린 및 페니실란산 1,1-디옥사이드 와의 비스-에스테르 - Google Patents

메탄디올의 페니실린 및 페니실란산 1,1-디옥사이드 와의 비스-에스테르 Download PDF

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KR830002772A
KR830002772A KR1019800001917A KR800001917A KR830002772A KR 830002772 A KR830002772 A KR 830002772A KR 1019800001917 A KR1019800001917 A KR 1019800001917A KR 800001917 A KR800001917 A KR 800001917A KR 830002772 A KR830002772 A KR 830002772A
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formula
group
compound
methanediol
penicillin
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KR1019800001917A
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KR840000105B1 (ko
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클리브랜드 빅햄 에릭
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폴 에스. 밀러
화이자 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C07D499/32—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음

Description

메탄디올의 페니실린 및 페니실란산 1, 1-디옥사이드 와의 비스-에스테르
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 구조식(a)의 화합물을 구조식(Ⅶ)의 화합물과 반응시킨 후, 필요하면 아미노 및 카복시 보호그룹을 제거시킴을 특징으로 하여 구조식(Ⅰ)의 화합물 또는 그의 약제학적으로 허용되는 염을 제조하는 방법.
    상기 구조식중
    R1은 유기 카복실산의 아실그룹이고
    R2는 유리의 아미노 또는 카복시 그룹이 보호되어 있는 그룹 R1이며
    M은 카복실레이트염 생성양이온이며
    X는 클로로, 브로모, 요도, 탄소수 1 내지 4의 알킬설포닐옥시, 벤젠설포닐옥시 및 톨루엔설포닐로 구성되는 그룹중에서 선택된다.
  2. 구조식(Ⅷ)의 화합물과 구조식(Ⅸ)의 화합물을 반응시킨 후, 필요하면 아미노 및 카복시 보호그룹을 제거시킴을 특징으로 하여 구조식(Ⅰ)의 화합물 또는 그의 약제학적으로 허용되는 염을 제조하는 방법.
    상기 구조식중
    R1은 유기 카복실산의 아실 그룹이고
    R2는 유리의 아미노 또는 카복시그룹이 보호되어 있는 그룹 R1이며
    M은 카복실레이트 염 생성 양이온이며
    X는 클로로, 브로모, 요도, 탄소수 1 내지 4의 알킬설포닐 옥시, 벤젠설포닐옥시 및 톨루엔설포닐옥시로 구성되는 그룹중에서 선택된다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800001917A 1979-05-16 1980-05-15 메탄디올의 페니실린 및 페니실란산 1, 1-디옥사이드와의 비스-에스테르 제조방법 KR840000105B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/039,539 US4244951A (en) 1979-05-16 1979-05-16 Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US39539 1979-05-16

Publications (2)

Publication Number Publication Date
KR830002772A true KR830002772A (ko) 1983-05-30
KR840000105B1 KR840000105B1 (ko) 1984-02-11

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KR1019800001917A KR840000105B1 (ko) 1979-05-16 1980-05-15 메탄디올의 페니실린 및 페니실란산 1, 1-디옥사이드와의 비스-에스테르 제조방법

Country Status (44)

Country Link
US (1) US4244951A (ko)
JP (1) JPS55157589A (ko)
KR (1) KR840000105B1 (ko)
AR (1) AR226062A1 (ko)
AT (2) AT369373B (ko)
AU (1) AU520066B2 (ko)
BE (1) BE883299A (ko)
BG (1) BG35467A3 (ko)
CA (1) CA1200545A (ko)
CH (1) CH646177A5 (ko)
CS (1) CS276964B6 (ko)
DD (1) DD150898A5 (ko)
DE (2) DE3018590A1 (ko)
DK (1) DK159786C (ko)
EC (1) ECSP941080A (ko)
EG (1) EG15129A (ko)
ES (1) ES491534A0 (ko)
FI (1) FI71742C (ko)
FR (2) FR2456745A1 (ko)
GB (2) GB2051057B (ko)
GR (1) GR68468B (ko)
GT (1) GT198063473A (ko)
HK (2) HK66787A (ko)
HU (1) HU184754B (ko)
IE (1) IE49892B1 (ko)
IL (1) IL60074A (ko)
IN (1) IN154371B (ko)
IT (1) IT1131187B (ko)
KE (2) KE3460A (ko)
LU (1) LU82452A1 (ko)
MX (1) MX6717E (ko)
MY (2) MY8500322A (ko)
NL (1) NL8002793A (ko)
NO (3) NO801415L (ko)
NZ (1) NZ193713A (ko)
PH (3) PH16554A (ko)
PL (2) PL127434B1 (ko)
PT (1) PT71248A (ko)
RO (2) RO84151B (ko)
SE (1) SE449749B (ko)
SG (1) SG56284G (ko)
SU (2) SU1122226A3 (ko)
YU (1) YU41925B (ko)
ZA (1) ZA801885B (ko)

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GB2081269A (en) 1982-02-17
BG35467A3 (en) 1984-04-15
JPS6318595B2 (ko) 1988-04-19
RO84151B (ro) 1984-07-30
GT198063473A (es) 1981-11-07
HU184754B (en) 1984-10-29
FR2477154A1 (fr) 1981-09-04
DD150898A5 (de) 1981-09-23
FR2456745A1 (fr) 1980-12-12
HK66787A (en) 1987-09-25
FR2477154B1 (ko) 1983-08-19
YU41925B (en) 1988-02-29
IT8022097A0 (it) 1980-05-15
FI801546A (fi) 1980-11-17
ZA801885B (en) 1981-04-29
KE3460A (en) 1984-10-12
FR2456745B1 (ko) 1983-08-19
DE3018590A1 (de) 1980-11-20
KE3457A (en) 1984-10-12
NO831025L (no) 1980-11-17
IE49892B1 (en) 1986-01-08
JPS55157589A (en) 1980-12-08
DK159786B (da) 1990-12-03
NO801415L (no) 1980-11-17
HK66987A (en) 1987-09-25
PL224225A1 (ko) 1981-02-13
MY8500322A (en) 1985-12-31
ES8104300A1 (es) 1981-04-01
ECSP941080A (es) 1995-02-27
BE883299A (fr) 1980-11-14
SU1122226A3 (ru) 1984-10-30
FI71742B (fi) 1986-10-31
CS276964B6 (en) 1992-11-18
GB2051057B (en) 1983-02-09
MX6717E (es) 1985-11-07
ATA258880A (de) 1982-05-15
CA1200545A (en) 1986-02-11
AT369373B (de) 1982-12-27
SU1122228A3 (ru) 1984-10-30
DK159786C (da) 1991-04-22
PH15706A (en) 1983-03-14
AU5839680A (en) 1980-11-20
SG56284G (en) 1985-03-08
IL60074A0 (en) 1980-07-31
CH646177A5 (de) 1984-11-15
IN154371B (ko) 1984-10-20
AU520066B2 (en) 1982-01-14
SE449749B (sv) 1987-05-18
PL127283B1 (en) 1983-10-31
SE8003603L (sv) 1980-11-17
IT1131187B (it) 1986-06-18
DE3050440A1 (ko) 1982-07-29
KR840000105B1 (ko) 1984-02-11
NZ193713A (en) 1984-05-31
IL60074A (en) 1983-09-30
GB2081269B (en) 1983-01-19
IE801007L (en) 1980-11-16
US4244951A (en) 1981-01-13
FI71742C (fi) 1987-02-09
GB2051057A (en) 1981-01-14
MY8500324A (en) 1985-12-31
NO831026L (no) 1980-11-17
GR68468B (ko) 1982-01-04
AR226062A1 (es) 1982-05-31
PT71248A (en) 1980-06-01
EG15129A (en) 1985-12-31
RO84151A (ro) 1984-05-23
PL127434B1 (en) 1983-10-31
CS325280A3 (en) 1992-05-13
DK211880A (da) 1980-11-17
PH15539A (en) 1983-02-09
YU130380A (en) 1983-02-28
RO80220A (ro) 1982-10-26
AT377522B (de) 1985-03-25
PH16554A (en) 1983-11-16
ES491534A0 (es) 1981-04-01
ATA16082A (de) 1984-08-15
LU82452A1 (fr) 1980-12-16
NL8002793A (nl) 1980-11-18

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