KR970042536A - 아스코르브산의 제조방법 - Google Patents

아스코르브산의 제조방법 Download PDF

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Publication number
KR970042536A
KR970042536A KR1019960064372A KR19960064372A KR970042536A KR 970042536 A KR970042536 A KR 970042536A KR 1019960064372 A KR1019960064372 A KR 1019960064372A KR 19960064372 A KR19960064372 A KR 19960064372A KR 970042536 A KR970042536 A KR 970042536A
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KR
South Korea
Prior art keywords
acid
chloride
acid chloride
process according
ascorbic acid
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KR1019960064372A
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English (en)
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KR100483775B1 (ko
Inventor
울리히 페흐텔
칼하인츠 벰바처
Original Assignee
슈틀러, 하르트만
메르크 파텐트 게젤샤프트 미트 베쉬랭크터 하프퉁
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Application filed by 슈틀러, 하르트만, 메르크 파텐트 게젤샤프트 미트 베쉬랭크터 하프퉁 filed Critical 슈틀러, 하르트만
Publication of KR970042536A publication Critical patent/KR970042536A/ko
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Publication of KR100483775B1 publication Critical patent/KR100483775B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/62—Three oxygen atoms, e.g. ascorbic acid

Abstract

불활성 용매, 지방족 케논 및 산 염화물을 함유하는 용매 혼합물 중에서 2-케토-L-글루콘산을 수성 무기산과 반응시킴으로써 L-아스코르브산을 제조하는 방법

Description

아스코르브산의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 산 염화물이 첨가됨을 특징으로 하는, 불활성 유기 용매 및 지방족 케톤을 함유한 용매 혼합물 중에서 2-케토-L-글루콘산을 수성 무기산과 반응시킴으로써 L-아스코르브산을 제조하는 방법
  2. 제1항에 있어서, 1부의 불활성 용매에 대해 0.01 내지 1부의 산 염화물을 사용하는 것을 특징으로 하는 방법
  3. 제1항 또는 제2항에 있어서, 반응이 40 내지 100℃의 온도에서 수행되는 것을 특징으로 하는 방법
  4. 제1항 내지 제3항 중 어느 한 항에 있어서, 2-케토-L-글루콘산, 불황성 용매, 케톤 및 수성 무기산으로 구성된 혼합물을 가열하고, 후속적으로 산 염화물을 첨가하는 것을 특징으로 하는 방법
  5. 제1항 내지 제4항 중 어느 한 항에 있어서, 산 염화물이 탄소수 1 내지 4의 지방족 카복실산 클로라이드인 것을 특징으로 하는 방법
  6. 제1항 내지 제5항 중 어느 한 항에 있어서, 산 염화물이 티오닐 클로라이드인 것을 특징으로 하는 방법
  7. 제5항에 있어서, 산 염화물이 아세틸 클로라이드, 옥살릴 클로라이드, 포스겐 및 디포스겐을 포함하는 그룹으로부터 선택되는 지방족 카복실산 클로라이드인 것을 특징으로 하는 방법
KR1019960064372A 1995-12-16 1996-12-11 아스코르브산의제조방법 KR100483775B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19547073A DE19547073C1 (de) 1995-12-16 1995-12-16 Verfahren zur Herstellung von Ascorbinsäure
DE19547073.7 1995-12-16

Publications (2)

Publication Number Publication Date
KR970042536A true KR970042536A (ko) 1997-07-24
KR100483775B1 KR100483775B1 (ko) 2005-11-25

Family

ID=7780344

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960064372A KR100483775B1 (ko) 1995-12-16 1996-12-11 아스코르브산의제조방법

Country Status (6)

Country Link
US (1) US5744618A (ko)
EP (1) EP0779285B1 (ko)
JP (1) JPH09176145A (ko)
KR (1) KR100483775B1 (ko)
AT (1) ATE181325T1 (ko)
DE (2) DE19547073C1 (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19547073C1 (de) * 1995-12-16 1996-11-14 Merck Patent Gmbh Verfahren zur Herstellung von Ascorbinsäure
US5998634A (en) * 1999-03-15 1999-12-07 The United States Of America As Represented By The Secretary Of The Interior One-step synthesis of vitamin-C (L-ascorbic acid)
DE19919203A1 (de) 1999-04-28 2000-11-02 Basf Ag Verfahren zur Herstellung von L-Ascorbinsäure
DE19938980A1 (de) * 1999-08-19 2001-02-22 Basf Ag Verfahren zur Herstellung von 2-Keto-L-gulonsäureestern
DE19954511A1 (de) 1999-11-12 2001-05-17 Basf Ag Verfahren zur Herstellung von Alkalisalzen der L-Ascorbinsäure
DE10022518A1 (de) 2000-05-10 2001-11-15 Basf Ag Verfahren zur Herstellung von L-Ascorbinsäure durch Lactonisierung von 2-Keto-L-gulonsäure oder 2-Keto-L-gulonsäureestern
WO2002051826A1 (en) 2000-12-22 2002-07-04 Eastman Chemical Company Continuous process for producing l-ascorbic acid
US6864376B2 (en) 2000-12-22 2005-03-08 Eastman Chemical Company Process for producing ascorbic acid
US6740762B2 (en) 2001-08-24 2004-05-25 Eastman Chemical Company Process for ascorbic acids using alkaline earth silicate catalysts
US6716997B1 (en) 2001-10-09 2004-04-06 Eastman Chemical Company Systems and methods for generation of ascorbic acid with reduced color
US6476239B1 (en) 2002-02-12 2002-11-05 Eastman Chemical Company Process for the preparation of ascorbic acid
US6872314B2 (en) * 2003-08-29 2005-03-29 Eastman Chemical Company Dewatering process
CN102424695A (zh) * 2011-10-28 2012-04-25 安徽泰格生物技术股份有限公司 一种古龙酸甲酯钠及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2185383A (en) 1937-04-28 1940-01-02 Charles Pflzer & Company Preparation of levo-ascorbic acid
US2205567A (en) * 1938-07-15 1940-06-25 Warren Buckley Nonrefillable bottle closure
JPS4815931B1 (ko) 1970-10-05 1973-05-18
JPS58177986A (ja) 1982-04-09 1983-10-18 Shionogi & Co Ltd Ｌ−アスコルビン酸の製造方法
CN86105960A (zh) 1985-08-09 1987-05-13 鲁布里佐尔公司 在基本无水条件下从2-酮-l-古洛糖酸制备l-抗坏血酸
DE3819045C2 (de) 1987-06-08 1997-06-19 Takeda Chemical Industries Ltd Herstellung von L-Ascorbinsäure
EP0324261A1 (en) * 1988-01-06 1989-07-19 Pfizer Inc. Production of L-ascorbic acid from 2-keto-L-gulonic acid with an acid catalyst and a lipophilic surfactant having a low hydrophilic: lipophilic balance under substantially anhydrous conditions
FR2648136B1 (fr) * 1989-06-12 1994-06-17 Rhone Poulenc Sante Procede de preparation de l'acide ascorbique
JPH08188578A (ja) * 1994-11-11 1996-07-23 Takeda Chem Ind Ltd Ｌ−アスコルビン酸の製造方法
DE19547073C1 (de) * 1995-12-16 1996-11-14 Merck Patent Gmbh Verfahren zur Herstellung von Ascorbinsäure

Also Published As

Publication number Publication date
KR100483775B1 (ko) 2005-11-25
EP0779285A1 (de) 1997-06-18
EP0779285B1 (de) 1999-06-16
ATE181325T1 (de) 1999-07-15
JPH09176145A (ja) 1997-07-08
DE59602236D1 (de) 1999-07-22
DE19547073C1 (de) 1996-11-14
US5744618A (en) 1998-04-28

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