ES455404A1 - Un procedimiento para la preparacion de nuevos derivados de beta-lactama. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de beta-lactama.

Info

Publication number
ES455404A1
ES455404A1 ES455404A ES455404A ES455404A1 ES 455404 A1 ES455404 A1 ES 455404A1 ES 455404 A ES455404 A ES 455404A ES 455404 A ES455404 A ES 455404A ES 455404 A1 ES455404 A1 ES 455404A1
Authority
ES
Spain
Prior art keywords
lactams
compounds containing
therapeutic compounds
containing beta
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES455404A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB3892/76A external-priority patent/GB1574906A/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES455404A1 publication Critical patent/ES455404A1/es
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/429Thiazoles condensed with heterocyclic ring systems
    • A61K31/43Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D503/00Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Un procedimiento para la preparación de nuevos derivados de beta-lactama de formula (**formula**) donde x es s, SO o SO2, R es un grupo orgánico de hasta 20 átomos de carbono y A es un grupo tal que CO2A representa un grupo ácido carboxílico o una sal o ester del mismo, cuyo procedimiento consiste en hacer reaccionar un éster del ácido clavulanicos con un compuesto de formula H-S-R donde R es el definido en relación con la formula en presencia de un catalizador ácido, en un disolvente inerte, a una temperatura comprendida entre -80 y +30ºC, y después, opcionalmente, realizar una o mas de las siguientes etapas: a) desesterificar el ester asi producido para formar el ácido libre o salificado de formula; b) reesterificar el ácido libre o salificado así producido para dar otro ester de formula; c) oxidar el sulfuro obtenido con un perácido, en un disolvente inerte, para obtener el correspondiente sulfoxidi o sulfona de formula .
ES455404A 1976-01-31 1977-01-27 Un procedimiento para la preparacion de nuevos derivados de beta-lactama. Expired ES455404A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB3892/76A GB1574906A (en) 1976-01-31 1976-01-31 Therapeutic compounds containing - lactams
GB1900276 1976-05-08

Publications (1)

Publication Number Publication Date
ES455404A1 true ES455404A1 (es) 1978-05-01

Family

ID=26238678

Family Applications (1)

Application Number Title Priority Date Filing Date
ES455404A Expired ES455404A1 (es) 1976-01-31 1977-01-27 Un procedimiento para la preparacion de nuevos derivados de beta-lactama.

Country Status (31)

Country Link
US (2) US4428958A (es)
JP (1) JPS5295689A (es)
AR (3) AR214306A1 (es)
AT (1) AT351675B (es)
AU (1) AU515736B2 (es)
BG (1) BG27751A3 (es)
CA (1) CA1089471A (es)
CH (2) CH637655A5 (es)
CS (1) CS196341B2 (es)
DD (1) DD128196A5 (es)
DE (1) DE2702954A1 (es)
DK (1) DK146940C (es)
ES (1) ES455404A1 (es)
FI (1) FI63581C (es)
FR (1) FR2339616A1 (es)
GR (1) GR62544B (es)
HK (1) HK69883A (es)
IE (1) IE44759B1 (es)
IL (1) IL51267A (es)
KE (1) KE3303A (es)
LU (1) LU76668A1 (es)
MX (1) MX4950E (es)
NL (1) NL7700892A (es)
NO (1) NO770279L (es)
NZ (1) NZ183117A (es)
PH (1) PH13924A (es)
PT (1) PT66071B (es)
RO (1) RO69712A (es)
SE (1) SE441359B (es)
SU (1) SU645583A3 (es)
YU (1) YU10777A (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1582884A (en) * 1977-05-19 1981-01-14 Beecham Group Ltd Clavulanic acid derivatives their preparation and use
GB2004541B (en) * 1977-09-16 1982-05-12 Beecham Group Ltd Ethers of clavulanic acid a process for their preparation and pharmaceutical compositions containing them
EP0008899B1 (en) * 1978-09-05 1982-09-15 Beecham Group Plc Clavulanic acid derivatives, their preparation and pharmaceutical compositions containing them
EP0018203B1 (en) * 1979-04-21 1983-03-02 Beecham Group Plc Clavulanic acid derivatives, their preparation and use in pharmaceutical compositions
IL60056A0 (en) * 1979-05-17 1980-07-31 Beecham Group Ltd Clavulanic acid derivatives,their preparation and pharmaceutical compositions containing them
ZA804670B (en) * 1979-08-03 1981-07-29 Beecham Group Ltd Derivatives of clavulanic acid, a process for their preparation and their use
NZ199061A (en) * 1980-12-09 1984-10-19 Beecham Group Ltd 9-(n-tetrazolyl)-deoxyclavulanic acids,salts,esters,and pharmaceutical compositions
US4562182A (en) * 1980-12-23 1985-12-31 Beecham Group P.L.C. Compounds containing beta-lactams
GB9518917D0 (en) * 1995-09-15 1995-11-15 Smithkline Beecham Plc Compounds
US5958462A (en) * 1997-05-23 1999-09-28 Mclean; Linsey Therapeutic bath salts and method of use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4039673A (en) 1973-10-30 1977-08-02 Bayer Aktiengesellschaft Penicillins and cephalosporins and their production
US3983113A (en) 1975-08-15 1976-09-28 Syntex (U.S.A.) Inc. Cephalosporin type antibacterials

Also Published As

Publication number Publication date
IE44759B1 (en) 1982-03-24
DK38577A (da) 1977-08-01
CH638529A5 (de) 1983-09-30
HK69883A (en) 1983-12-23
FI63581B (fi) 1983-03-31
FI770295A (es) 1977-08-01
DD128196A5 (de) 1977-11-02
AR214306A1 (es) 1979-05-31
DK146940C (da) 1984-07-30
AU515736B2 (en) 1981-04-30
IE44759L (en) 1977-07-31
YU10777A (en) 1982-06-30
JPS613349B2 (es) 1986-01-31
NL7700892A (nl) 1977-08-02
RO69712A (fr) 1980-07-15
AR216555A1 (es) 1979-12-28
CA1089471A (en) 1980-11-11
CS196341B2 (en) 1980-03-31
SE7700946L (sv) 1977-08-01
DE2702954A1 (de) 1977-08-04
AT351675B (de) 1979-08-10
AR216925A1 (es) 1980-02-15
BG27751A3 (en) 1979-12-12
IL51267A (en) 1979-12-30
PT66071A (en) 1977-02-01
KE3303A (en) 1983-08-05
CH637655A5 (de) 1983-08-15
PT66071B (en) 1978-06-23
MX4950E (es) 1983-01-12
PH13924A (en) 1980-11-04
FR2339616A1 (fr) 1977-08-26
DK146940B (da) 1984-02-20
AU2177077A (en) 1978-08-03
NZ183117A (en) 1979-10-25
US4428958A (en) 1984-01-31
IL51267A0 (en) 1977-03-31
SE441359B (sv) 1985-09-30
FR2339616B1 (es) 1980-04-11
LU76668A1 (es) 1977-06-28
FI63581C (fi) 1983-07-11
ATA53477A (de) 1979-01-15
SU645583A3 (ru) 1979-01-30
US4505894A (en) 1985-03-19
JPS5295689A (en) 1977-08-11
GR62544B (en) 1979-05-07
NO770279L (no) 1977-08-02

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991108