ES452362A1 - Un procedimiento para la preparacion de esteres de acido clavulanico. - Google Patents

Un procedimiento para la preparacion de esteres de acido clavulanico.

Info

Publication number
ES452362A1
ES452362A1 ES452362A ES452362A ES452362A1 ES 452362 A1 ES452362 A1 ES 452362A1 ES 452362 A ES452362 A ES 452362A ES 452362 A ES452362 A ES 452362A ES 452362 A1 ES452362 A1 ES 452362A1
Authority
ES
Spain
Prior art keywords
clavulanic acid
synergysts
cephalosporin
penicillin
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES452362A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB4189775A external-priority patent/GB1565209A/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES452362A1 publication Critical patent/ES452362A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

Un procedimiento para la preparación de ésteres de ácido clavulánico de fórmula (II): **(Fórmula)** donde R es un grupo orgánico inerte de hasta 18 átomos de carbono y A es un grupo éter de ácido carboxílico, cuyo procedimiento consiste en eterificar el correspondiente éster.
ES452362A 1975-10-13 1976-10-13 Un procedimiento para la preparacion de esteres de acido clavulanico. Expired ES452362A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB4189775A GB1565209A (en) 1975-10-13 1975-10-13 Clavulanic acid derivatives
GB262976 1976-01-23
GB1900076 1976-05-08

Publications (1)

Publication Number Publication Date
ES452362A1 true ES452362A1 (es) 1978-01-16

Family

ID=27254098

Family Applications (3)

Application Number Title Priority Date Filing Date
ES452362A Expired ES452362A1 (es) 1975-10-13 1976-10-13 Un procedimiento para la preparacion de esteres de acido clavulanico.
ES464123A Expired ES464123A1 (es) 1975-10-13 1977-11-14 Un procedimiento para la preparacion de esteres de acido clavulanico.
ES464122A Expired ES464122A1 (es) 1975-10-13 1977-11-14 Un procedimiento para la preparacion de eteres de acido cla-vulanico.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES464123A Expired ES464123A1 (es) 1975-10-13 1977-11-14 Un procedimiento para la preparacion de esteres de acido clavulanico.
ES464122A Expired ES464122A1 (es) 1975-10-13 1977-11-14 Un procedimiento para la preparacion de eteres de acido cla-vulanico.

Country Status (28)

Country Link
US (1) US4228174A (es)
JP (1) JPS5268195A (es)
AR (1) AR213828A1 (es)
AU (1) AU512859B2 (es)
BG (1) BG35466A3 (es)
CA (1) CA1081699A (es)
CH (1) CH629207A5 (es)
DD (1) DD127630A5 (es)
DE (1) DE2646004A1 (es)
DK (1) DK457476A (es)
ES (3) ES452362A1 (es)
FI (1) FI64162C (es)
FR (1) FR2327776A1 (es)
GR (1) GR61645B (es)
HK (1) HK48983A (es)
IE (1) IE44295B1 (es)
IL (1) IL50514A (es)
KE (1) KE3292A (es)
LU (1) LU75980A1 (es)
NL (1) NL7611286A (es)
NO (3) NO763473L (es)
NZ (1) NZ182046A (es)
PH (1) PH16904A (es)
PT (1) PT65622B (es)
RO (1) RO69458A (es)
SE (3) SE440080B (es)
YU (1) YU251676A (es)
ZA (1) ZA765560B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1587612A (en) * 1976-10-30 1981-04-08 Beecham Group Ltd Isoclavulanic acid derivatives
GB1595176A (en) * 1976-12-03 1981-08-12 Beecham Group Ltd Clavulanic acid ethers
US4215128A (en) 1977-09-20 1980-07-29 Beecham Group Limited Clavulanic acid derivatives their preparation and use
DE2862254D1 (en) * 1977-12-02 1983-06-16 Beecham Group Plc A process for the preparation of ether derivatives of clavulanic acid
EP0003254B1 (en) * 1978-01-26 1984-03-28 Beecham Group Plc Derivatives of clavulanic acid, process for their preparation and compositions containing them
US4244965A (en) 1978-06-15 1981-01-13 Beecham Group Limited Azetidinoyl ethers
EP0013790B1 (en) * 1978-07-05 1982-09-22 Beecham Group Plc Clavulanic acid derivatives, their preparation and pharmaceutical compositions containing them
ZA805850B (en) 1979-09-27 1981-09-30 Beecham Group Ltd Derivatives of clavulanic acid, a process for their preparation and their use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus

Also Published As

Publication number Publication date
SE7611045L (sv) 1977-04-14
SE8005662L (sv) 1980-08-11
FR2327776B1 (es) 1978-12-15
JPS618064B2 (es) 1986-03-11
CH629207A5 (de) 1982-04-15
JPS5268195A (en) 1977-06-06
DK457476A (da) 1977-04-14
IE44295B1 (en) 1981-10-07
HK48983A (en) 1983-11-04
DD127630A5 (es) 1977-10-05
IL50514A0 (en) 1976-11-30
CA1081699A (en) 1980-07-15
LU75980A1 (es) 1977-05-09
NO833842L (no) 1977-07-14
BG35466A3 (en) 1984-04-15
NO763473L (es) 1977-04-14
PH16904A (en) 1984-04-10
ZA765560B (en) 1977-08-31
FI762908A (es) 1977-04-14
AR213828A1 (es) 1979-03-30
RO69458A (ro) 1981-08-30
NL7611286A (nl) 1977-04-15
NZ182046A (en) 1979-03-16
ES464122A1 (es) 1978-12-16
PT65622B (en) 1978-04-05
AU1803376A (en) 1978-04-06
FI64162C (fi) 1983-10-10
ES464123A1 (es) 1978-12-16
KE3292A (en) 1983-07-01
IL50514A (en) 1979-07-25
SE8005663L (sv) 1980-08-11
AU512859B2 (en) 1980-10-30
YU251676A (en) 1982-06-30
DE2646004A1 (de) 1977-04-21
GR61645B (en) 1978-12-05
US4228174A (en) 1980-10-14
NO833841L (no) 1977-07-14
SE440080B (sv) 1985-07-15
PT65622A (en) 1976-10-01
FI64162B (fi) 1983-06-30
IE44295L (en) 1977-04-13
FR2327776A1 (fr) 1977-05-13

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