ES464123A1 - Un procedimiento para la preparacion de esteres de acido clavulanico. - Google Patents
Un procedimiento para la preparacion de esteres de acido clavulanico.Info
- Publication number
- ES464123A1 ES464123A1 ES464123A ES464123A ES464123A1 ES 464123 A1 ES464123 A1 ES 464123A1 ES 464123 A ES464123 A ES 464123A ES 464123 A ES464123 A ES 464123A ES 464123 A1 ES464123 A1 ES 464123A1
- Authority
- ES
- Spain
- Prior art keywords
- clavulanic acid
- synergysts
- cephalosporin
- penicillin
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un procedimiento para la preparación de éteres de ácido clavulánico de fórmula (II): **(Fórmula)** donde R es un grupo orgánico inerte de hasta 18 átomos de carbono y CO2A es un grupo carboxilo o un grupo carboxilo salificado o esterificado, cuyo procedimiento comprende la desesterificación de un compuesto de fórmula (II) donde CO2A es un grupo carboxilo esterificado, y posteriormente, si se desea, reesterificar el carboxilo o el grupo carboxilo salificado.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4189775A GB1565209A (en) | 1975-10-13 | 1975-10-13 | Clavulanic acid derivatives |
| GB262976 | 1976-01-23 | ||
| GB1900076 | 1976-05-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES464123A1 true ES464123A1 (es) | 1978-12-16 |
Family
ID=27254098
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES452362A Expired ES452362A1 (es) | 1975-10-13 | 1976-10-13 | Un procedimiento para la preparacion de esteres de acido clavulanico. |
| ES464123A Expired ES464123A1 (es) | 1975-10-13 | 1977-11-14 | Un procedimiento para la preparacion de esteres de acido clavulanico. |
| ES464122A Expired ES464122A1 (es) | 1975-10-13 | 1977-11-14 | Un procedimiento para la preparacion de eteres de acido cla-vulanico. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES452362A Expired ES452362A1 (es) | 1975-10-13 | 1976-10-13 | Un procedimiento para la preparacion de esteres de acido clavulanico. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES464122A Expired ES464122A1 (es) | 1975-10-13 | 1977-11-14 | Un procedimiento para la preparacion de eteres de acido cla-vulanico. |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US4228174A (es) |
| JP (1) | JPS5268195A (es) |
| AR (1) | AR213828A1 (es) |
| AU (1) | AU512859B2 (es) |
| BG (1) | BG35466A3 (es) |
| CA (1) | CA1081699A (es) |
| CH (1) | CH629207A5 (es) |
| DD (1) | DD127630A5 (es) |
| DE (1) | DE2646004A1 (es) |
| DK (1) | DK457476A (es) |
| ES (3) | ES452362A1 (es) |
| FI (1) | FI64162C (es) |
| FR (1) | FR2327776A1 (es) |
| GR (1) | GR61645B (es) |
| HK (1) | HK48983A (es) |
| IE (1) | IE44295B1 (es) |
| IL (1) | IL50514A (es) |
| KE (1) | KE3292A (es) |
| LU (1) | LU75980A1 (es) |
| NL (1) | NL7611286A (es) |
| NO (3) | NO763473L (es) |
| NZ (1) | NZ182046A (es) |
| PH (1) | PH16904A (es) |
| PT (1) | PT65622B (es) |
| RO (1) | RO69458A (es) |
| SE (3) | SE440080B (es) |
| YU (1) | YU251676A (es) |
| ZA (1) | ZA765560B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1587612A (en) * | 1976-10-30 | 1981-04-08 | Beecham Group Ltd | Isoclavulanic acid derivatives |
| GB1595176A (en) * | 1976-12-03 | 1981-08-12 | Beecham Group Ltd | Clavulanic acid ethers |
| US4215128A (en) | 1977-09-20 | 1980-07-29 | Beecham Group Limited | Clavulanic acid derivatives their preparation and use |
| EP0002370B1 (en) * | 1977-12-02 | 1983-05-11 | Beecham Group Plc | A process for the preparation of ether derivatives of clavulanic acid |
| DE2862394D1 (en) * | 1978-01-26 | 1984-05-03 | Beecham Group Plc | Derivatives of clavulanic acid, process for their preparation and compositions containing them |
| US4244965A (en) | 1978-06-15 | 1981-01-13 | Beecham Group Limited | Azetidinoyl ethers |
| EP0013790B1 (en) * | 1978-07-05 | 1982-09-22 | Beecham Group Plc | Clavulanic acid derivatives, their preparation and pharmaceutical compositions containing them |
| ZA805850B (en) | 1979-09-27 | 1981-09-30 | Beecham Group Ltd | Derivatives of clavulanic acid, a process for their preparation and their use |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1508977A (en) * | 1974-04-20 | 1978-04-26 | Beecham Group Ltd | Beta-lactam antibiotic from streptomyces clavuligerus |
-
1976
- 1976-09-14 IE IE2047/76A patent/IE44295B1/en unknown
- 1976-09-16 ZA ZA765560A patent/ZA765560B/xx unknown
- 1976-09-20 IL IL50514A patent/IL50514A/xx unknown
- 1976-09-22 PT PT65622A patent/PT65622B/pt unknown
- 1976-09-22 AU AU18033/76A patent/AU512859B2/en not_active Expired
- 1976-09-27 PH PH18946A patent/PH16904A/en unknown
- 1976-10-05 NZ NZ182046A patent/NZ182046A/xx unknown
- 1976-10-05 SE SE7611045A patent/SE440080B/xx unknown
- 1976-10-11 GR GR51905A patent/GR61645B/el unknown
- 1976-10-11 FR FR7630455A patent/FR2327776A1/fr active Granted
- 1976-10-12 JP JP51122725A patent/JPS5268195A/ja active Granted
- 1976-10-12 CH CH1290176A patent/CH629207A5/de not_active IP Right Cessation
- 1976-10-12 FI FI762908A patent/FI64162C/fi not_active IP Right Cessation
- 1976-10-12 DE DE19762646004 patent/DE2646004A1/de not_active Withdrawn
- 1976-10-12 RO RO7687984A patent/RO69458A/ro unknown
- 1976-10-12 NO NO763473A patent/NO763473L/no unknown
- 1976-10-12 DK DK457476A patent/DK457476A/da not_active Application Discontinuation
- 1976-10-12 CA CA263,105A patent/CA1081699A/en not_active Expired
- 1976-10-12 DD DD195243A patent/DD127630A5/xx unknown
- 1976-10-12 LU LU75980A patent/LU75980A1/xx unknown
- 1976-10-13 ES ES452362A patent/ES452362A1/es not_active Expired
- 1976-10-13 BG BG034436A patent/BG35466A3/xx unknown
- 1976-10-13 NL NL7611286A patent/NL7611286A/xx not_active Application Discontinuation
- 1976-10-13 YU YU02516/76A patent/YU251676A/xx unknown
- 1976-10-13 AR AR265081A patent/AR213828A1/es active
-
1977
- 1977-11-14 ES ES464123A patent/ES464123A1/es not_active Expired
- 1977-11-14 ES ES464122A patent/ES464122A1/es not_active Expired
-
1979
- 1979-02-01 US US06/008,421 patent/US4228174A/en not_active Expired - Lifetime
-
1980
- 1980-08-11 SE SE8005663A patent/SE8005663L/sv not_active Application Discontinuation
- 1980-08-11 SE SE8005662A patent/SE8005662L/sv not_active Application Discontinuation
-
1983
- 1983-05-31 KE KE3292A patent/KE3292A/xx unknown
- 1983-10-21 NO NO833842A patent/NO833842L/no unknown
- 1983-10-21 NO NO833841A patent/NO833841L/no unknown
- 1983-10-27 HK HK489/83A patent/HK48983A/xx unknown
Also Published As
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