KR20250121615A - 위 억제 펩티드 수용체(gipr)에 대한 결합 단백질을 glp-1 효능제와 조합하여 사용하여 대사 장애를 치료하거나 개선시키는 방법 - Google Patents
위 억제 펩티드 수용체(gipr)에 대한 결합 단백질을 glp-1 효능제와 조합하여 사용하여 대사 장애를 치료하거나 개선시키는 방법Info
- Publication number
- KR20250121615A KR20250121615A KR1020257026330A KR20257026330A KR20250121615A KR 20250121615 A KR20250121615 A KR 20250121615A KR 1020257026330 A KR1020257026330 A KR 1020257026330A KR 20257026330 A KR20257026330 A KR 20257026330A KR 20250121615 A KR20250121615 A KR 20250121615A
- Authority
- KR
- South Korea
- Prior art keywords
- seq
- variable region
- heavy chain
- light chain
- chain variable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Marine Sciences & Fisheries (AREA)
- Child & Adolescent Psychology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562387486P | 2015-12-23 | 2015-12-23 | |
| US62/387,486 | 2015-12-23 | ||
| US201662337799P | 2016-05-17 | 2016-05-17 | |
| US62/337,799 | 2016-05-17 | ||
| US201662420415P | 2016-11-10 | 2016-11-10 | |
| US62/420,415 | 2016-11-10 | ||
| PCT/US2016/068138 WO2017112824A2 (en) | 2015-12-23 | 2016-12-21 | Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (gipr) in combination with glp-1 agonists |
| KR1020187020957A KR102844773B1 (ko) | 2015-12-23 | 2016-12-21 | 위 억제 펩티드 수용체 (gipr)에 대한 결합 단백질을 glp-1 효능제와 조합하여 사용하여 대사 장애를 치료하거나 개선시키는 방법 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187020957A Division KR102844773B1 (ko) | 2015-12-23 | 2016-12-21 | 위 억제 펩티드 수용체 (gipr)에 대한 결합 단백질을 glp-1 효능제와 조합하여 사용하여 대사 장애를 치료하거나 개선시키는 방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20250121615A true KR20250121615A (ko) | 2025-08-12 |
Family
ID=57956369
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020257026330A Pending KR20250121615A (ko) | 2015-12-23 | 2016-12-21 | 위 억제 펩티드 수용체(gipr)에 대한 결합 단백질을 glp-1 효능제와 조합하여 사용하여 대사 장애를 치료하거나 개선시키는 방법 |
| KR1020187020957A Active KR102844773B1 (ko) | 2015-12-23 | 2016-12-21 | 위 억제 펩티드 수용체 (gipr)에 대한 결합 단백질을 glp-1 효능제와 조합하여 사용하여 대사 장애를 치료하거나 개선시키는 방법 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187020957A Active KR102844773B1 (ko) | 2015-12-23 | 2016-12-21 | 위 억제 펩티드 수용체 (gipr)에 대한 결합 단백질을 glp-1 효능제와 조합하여 사용하여 대사 장애를 치료하거나 개선시키는 방법 |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US10294303B2 (enExample) |
| EP (1) | EP3394104A2 (enExample) |
| JP (4) | JP6948330B2 (enExample) |
| KR (2) | KR20250121615A (enExample) |
| CN (2) | CN109715662B (enExample) |
| AU (2) | AU2016378739A1 (enExample) |
| CA (2) | CA3223591A1 (enExample) |
| CL (2) | CL2018001695A1 (enExample) |
| CO (1) | CO2018007582A2 (enExample) |
| CR (1) | CR20180378A (enExample) |
| EA (1) | EA201891323A1 (enExample) |
| IL (2) | IL296682B1 (enExample) |
| MA (1) | MA44154A (enExample) |
| MX (2) | MX395677B (enExample) |
| MY (1) | MY197023A (enExample) |
| NZ (2) | NZ783798A (enExample) |
| PE (1) | PE20181327A1 (enExample) |
| PH (1) | PH12018501322A1 (enExample) |
| SG (1) | SG11201805255TA (enExample) |
| TN (1) | TN2018000225A1 (enExample) |
| TW (3) | TWI818277B (enExample) |
| UA (1) | UA127495C2 (enExample) |
| UY (1) | UY37049A (enExample) |
| WO (1) | WO2017112824A2 (enExample) |
| ZA (2) | ZA201803979B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180069903A (ko) | 2015-11-02 | 2018-06-25 | 파이브 프라임 테라퓨틱스, 인크. | Cd80 세포외 도메인 폴리펩타이드 및 이들의 암 치료에서의 용도 |
| MY197023A (en) * | 2015-12-23 | 2023-05-22 | Amgen Inc | Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (gipr) in combination with glp-1 agonists |
| KR102551269B1 (ko) | 2016-09-29 | 2023-07-05 | 암젠 인크 | 저-점도 항원 결합 단백질 및 이의 제조 방법 |
| JOP20190177A1 (ar) * | 2017-01-17 | 2019-07-16 | Amgen Inc | طريقة لعلاج أو تحسين اضطرابات أيضية باستخدام مساعدات مستقبل glp-1 مقترنة بمناهضات لمستقبل ببتيد مثبط معوي (gipr) |
| EA201992502A1 (ru) | 2017-06-20 | 2020-04-22 | Эмджен Инк. | Способ лечения или уменьшения интенсивности метаболических нарушений с применением белков, связывающих рецептор гастроингибиторного пептида (gipr), в комбинации с агонистами glp-1 |
| WO2018237095A1 (en) * | 2017-06-21 | 2018-12-27 | Amgen Inc. | METHOD OF TREATING OR ENHANCING METABOLIC DISORDERS USING ANTAGONISTIC BINDING PROTEINS FOR AGONIST FUSION PROTEINS FROM THE GASTRIC INHIBITOR PEPTIDE RECEPTOR (GIPR) / GLP-1 RECEPTOR |
| EP4464719A3 (en) * | 2017-08-04 | 2025-03-05 | Amgen Inc. | Method of conjugation of cys-mabs |
| IL322969A (en) | 2017-10-12 | 2025-10-01 | Novo Nordisk As | Semaglutide in medical therapy |
| CN117126279A (zh) * | 2018-03-20 | 2023-11-28 | 鸿运华宁(杭州)生物医药有限公司 | Gipr抗体及其与glp-1的融合蛋白质,以及其药物组合物和应用 |
| WO2020185533A1 (en) | 2019-03-08 | 2020-09-17 | Amgen Inc. | Growth differentiation factor 15 combination therapy |
| CN112521501A (zh) * | 2019-09-18 | 2021-03-19 | 鸿运华宁(杭州)生物医药有限公司 | Gipr抗体及其与glp-1的融合蛋白质,以及其药物组合物和应用 |
| US20210093792A1 (en) * | 2019-09-30 | 2021-04-01 | Amgen Inc. | Drug delivery device and methods of delivering a drug |
| AU2020360255A1 (en) * | 2019-09-30 | 2022-03-17 | Amgen Inc. | Drug delivery device |
| CA3160302A1 (en) * | 2019-11-07 | 2021-05-14 | Amgen Inc. | Method of treating or ameliorating cushing's syndrome using binding proteins for gastric inhibitory peptide receptor (gipr) |
| AU2021246922A1 (en) * | 2020-03-30 | 2022-10-20 | Crystal Bioscience Inc. | Anti-GIPR antibody and methods of use thereof |
| CA3221655A1 (en) * | 2021-06-09 | 2022-12-15 | Swiftnovo Therapeutics Inc. | Therapeutics and methods for treating or ameliorating metabolic disorders |
| CN117659189A (zh) | 2022-09-08 | 2024-03-08 | 鸿运华宁(杭州)生物医药有限公司 | Gipr抗体及其与fgf21的融合蛋白,以及其药物组合物和应用 |
| KR102679905B1 (ko) * | 2022-10-12 | 2024-07-02 | 서울대학교병원 | Gipr 마커를 이용한 설폰요소제 의존성 예측용 조성물 및 그 예측 방법 |
| CN120019167A (zh) * | 2022-10-12 | 2025-05-16 | 首尔大学医院 | 利用gipr标记物的用于预测磺酰脲类依赖性的组合物及其预测方法 |
| JP2025537215A (ja) | 2022-11-02 | 2025-11-14 | ▲蘇▼州康▲寧▼杰瑞生物科技有限公司 | Gipr結合タンパク質及びその使用 |
| WO2024209050A1 (en) | 2023-04-05 | 2024-10-10 | Antag Therapeutics Aps | Gip activity modulators and orthostatic intolerance |
| EP4455159A1 (en) * | 2023-04-25 | 2024-10-30 | 3B Pharmaceuticals GmbH | Gastric inhibitory peptide receptor ligands with bio-distribution modifier |
| WO2025104668A1 (en) | 2023-11-17 | 2025-05-22 | Pfizer Inc. | Anti-gastric inhibitory polypeptide receptor (gipr) antibodies and antibody conjugates for the treatment of metabolic disorders |
| WO2025163561A1 (en) * | 2024-02-01 | 2025-08-07 | Pfizer Inc. | Glucose-dependent insulinotropic polypeptide receptor antagonists and uses thereof |
| WO2025199030A1 (en) | 2024-03-18 | 2025-09-25 | Amgen Inc. | Glp-1 receptor agonists and their medical use |
Family Cites Families (144)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| EP0088046B1 (de) | 1982-02-17 | 1987-12-09 | Ciba-Geigy Ag | Lipide in wässriger Phase |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| US4615885A (en) | 1983-11-01 | 1986-10-07 | Terumo Kabushiki Kaisha | Pharmaceutical composition containing urokinase |
| US4740461A (en) | 1983-12-27 | 1988-04-26 | Genetics Institute, Inc. | Vectors and methods for transformation of eucaryotic cells |
| US4959455A (en) | 1986-07-14 | 1990-09-25 | Genetics Institute, Inc. | Primate hematopoietic growth factors IL-3 and pharmaceutical compositions |
| DE3785186T2 (de) | 1986-09-02 | 1993-07-15 | Enzon Lab Inc | Bindungsmolekuele mit einzelpolypeptidkette. |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US4912040A (en) | 1986-11-14 | 1990-03-27 | Genetics Institute, Inc. | Eucaryotic expression system |
| US5011912A (en) | 1986-12-19 | 1991-04-30 | Immunex Corporation | Hybridoma and monoclonal antibody for use in an immunoaffinity purification system |
| US4965195A (en) | 1987-10-26 | 1990-10-23 | Immunex Corp. | Interleukin-7 |
| US4968607A (en) | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| AU643427B2 (en) | 1988-10-31 | 1993-11-18 | Immunex Corporation | Interleukin-4 receptors |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5683888A (en) | 1989-07-22 | 1997-11-04 | University Of Wales College Of Medicine | Modified bioluminescent proteins and their use |
| US5292658A (en) | 1989-12-29 | 1994-03-08 | University Of Georgia Research Foundation, Inc. Boyd Graduate Studies Research Center | Cloning and expressions of Renilla luciferase |
| EP1690935A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US6713610B1 (en) | 1990-01-12 | 2004-03-30 | Raju Kucherlapati | Human antibodies derived from immunized xenomice |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US5545618A (en) | 1990-01-24 | 1996-08-13 | Buckley; Douglas I. | GLP-1 analogs useful for diabetes treatment |
| AU651596B2 (en) | 1990-06-05 | 1994-07-28 | Immunex Corporation | Type II interleukin-1 receptors |
| US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| JP2938569B2 (ja) | 1990-08-29 | 1999-08-23 | ジェンファーム インターナショナル,インコーポレイティド | 異種免疫グロブリンを作る方法及びトランスジェニックマウス |
| US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| EP0575319B1 (en) | 1991-03-11 | 1999-11-10 | The University Of Georgia Research Foundation, Inc. | Cloning and expression of renilla luciferase |
| US6565841B1 (en) | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| AU2249592A (en) | 1991-06-14 | 1993-01-12 | Dnx Corporation | Production of human hemoglobin in transgenic pigs |
| DE69224906T2 (de) | 1991-07-08 | 1998-10-29 | Univ Massachusetts | Thermotropes flüssig-kristallines segment-blockcopolymer |
| WO1993015722A1 (en) | 1992-02-07 | 1993-08-19 | Syntex (Usa) Inc. | Controlled delivery of pharmaceuticals from preformed porous microparticles |
| SG48760A1 (en) | 1992-07-24 | 2003-03-18 | Abgenix Inc | Generation of xenogenetic antibodies |
| ATE400651T1 (de) | 1993-09-10 | 2008-07-15 | Univ Columbia | Verwendung von grünem fluoreszenzprotein |
| WO1995021191A1 (en) | 1994-02-04 | 1995-08-10 | William Ward | Bioluminescent indicator based upon the expression of a gene for a modified green-fluorescent protein |
| US5777079A (en) | 1994-11-10 | 1998-07-07 | The Regents Of The University Of California | Modified green fluorescent proteins |
| DE69637481T2 (de) | 1995-04-27 | 2009-04-09 | Amgen Fremont Inc. | Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8 |
| US5874304A (en) | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
| US5804387A (en) | 1996-02-01 | 1998-09-08 | The Board Of Trustees Of The Leland Stanford Junior University | FACS-optimized mutants of the green fluorescent protein (GFP) |
| US5876995A (en) | 1996-02-06 | 1999-03-02 | Bryan; Bruce | Bioluminescent novelty items |
| US5925558A (en) | 1996-07-16 | 1999-07-20 | The Regents Of The University Of California | Assays for protein kinases using fluorescent protein substrates |
| ES2319936T5 (es) | 1996-08-08 | 2013-06-24 | Amylin Pharmaceuticals, Inc. | Regulación de la motilidad gastrointestinal |
| US5976796A (en) | 1996-10-04 | 1999-11-02 | Loma Linda University | Construction and expression of renilla luciferase and green fluorescent protein fusion genes |
| US7091183B1 (en) | 1996-12-03 | 2006-08-15 | Boston Medical Center Corporation | Specific antagonists for glucose-dependent insulinotropic polypeptide (GIP) |
| ES2301183T3 (es) | 1996-12-03 | 2008-06-16 | Amgen Fremont Inc. | Anticuerpo completamente humano que se une al receptor del egfr. |
| WO1998024464A1 (en) * | 1996-12-03 | 1998-06-11 | Trustees Of Boston University | Specific antagonists for glucose-dependent insulinotropic polypeptide (gip) |
| EP1015872B1 (en) | 1996-12-12 | 2005-03-02 | Prolume, Ltd. | Apparatus and method for detecting and identifying infectious agents |
| JP4798814B2 (ja) | 1997-01-07 | 2011-10-19 | アミリン・ファーマシューティカルズ,インコーポレイテッド | 食物摂取低減用のエキセンジンおよびそのアゴニストの使用 |
| CA2196496A1 (en) | 1997-01-31 | 1998-07-31 | Stephen William Watson Michnick | Protein fragment complementation assay for the detection of protein-protein interactions |
| US6753165B1 (en) | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| US7157555B1 (en) | 1997-08-08 | 2007-01-02 | Amylin Pharmaceuticals, Inc. | Exendin agonist compounds |
| AU749914B2 (en) | 1997-08-08 | 2002-07-04 | Amylin Pharmaceuticals, Inc. | Novel exendin agonist compounds |
| US6342220B1 (en) | 1997-08-25 | 2002-01-29 | Genentech, Inc. | Agonist antibodies |
| US7220721B1 (en) | 1997-11-14 | 2007-05-22 | Amylin Pharmaceuticals, Inc. | Exendin agonist peptides |
| EP1032587B2 (en) | 1997-11-14 | 2013-03-13 | Amylin Pharmaceuticals, Inc. | Novel exendin agonist compounds |
| US7223725B1 (en) | 1997-11-14 | 2007-05-29 | Amylin Pharmaceuticals, Inc. | Exendin agonist compounds |
| NZ504258A (en) | 1997-11-14 | 2002-12-20 | Amylin Pharmaceuticals Inc | Exendin 3 and 4 agonist compounds for the treatment of diabetes |
| US6703359B1 (en) | 1998-02-13 | 2004-03-09 | Amylin Pharmaceuticals, Inc. | Inotropic and diuretic effects of exendin and GLP-1 |
| DE69936446T2 (de) | 1998-02-13 | 2008-03-06 | Amylin Pharmaceuticals, Inc., San Diego | Inotropische und diuretische effekte von exendin und glp-1 |
| DE69938293T2 (de) | 1998-03-27 | 2009-03-12 | Bruce J. Beverly Hills Bryan | Luciferase, gfp fluoreszenzproteine, kodierende nukleinsaüre und ihre verwendung in der diagnose |
| AU6294899A (en) * | 1998-10-07 | 2000-04-26 | Medical College Of Georgia Research Institute, Inc. | Glucose-dependent insulinotropic peptide for use as an osteotropic hormone |
| DE69938669D1 (de) | 1998-12-07 | 2008-06-19 | Sod Conseils Rech Applic | Analoge des glucagon ähnlichen peptides-1 (glp-1) |
| DK1140148T3 (da) | 1998-12-22 | 2006-01-30 | Lilly Co Eli | Lagerholdbar formulering af glucagon-agtigt peptid-1 |
| DK1140145T4 (da) | 1999-01-14 | 2019-07-22 | Amylin Pharmaceuticals Llc | Hidtil ukendte exendinagonistformuleringer og fremgangsmåder til indgivelse deraf |
| US20030087820A1 (en) | 1999-01-14 | 2003-05-08 | Young Andrew A. | Novel exendin agonist formulations and methods of administration thereof |
| ES2343072T3 (es) | 1999-01-14 | 2010-07-22 | Amylin Pharmaceuticals, Inc. | Exendina para la supresion del glucagon. |
| US20050272652A1 (en) | 1999-03-29 | 2005-12-08 | Gault Victor A | Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity |
| MXPA01009805A (es) | 1999-03-29 | 2004-07-30 | Univ Ulster | Peptido. |
| US6506724B1 (en) | 1999-06-01 | 2003-01-14 | Amylin Pharmaceuticals, Inc. | Use of exendins and agonists thereof for the treatment of gestational diabetes mellitus |
| US6833268B1 (en) | 1999-06-10 | 2004-12-21 | Abgenix, Inc. | Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions |
| US6528486B1 (en) | 1999-07-12 | 2003-03-04 | Zealand Pharma A/S | Peptide agonists of GLP-1 activity |
| EP1246638B2 (en) | 2000-01-10 | 2014-07-30 | Amylin Pharmaceuticals, Inc. | Use of exendins and agonists thereof for the treatment of hypertriglyceridemia |
| MXPA02007231A (es) | 2000-01-27 | 2002-12-09 | Lilly Co Eli | Proceso para solubilizar los compuestos de peptido 1 similares a glucagon. |
| WO2001087341A1 (en) | 2000-05-16 | 2001-11-22 | Sanwa Kagaku Kenkyusho Co.,Ltd. | Agents for preventing or ameliorating insulin resistance and/or obesity |
| JP2005502322A (ja) | 2001-04-19 | 2005-01-27 | ザ スクリップス リサーチ インスティテュート | 非天然アミノ酸のインビボ組込み |
| US20050159379A1 (en) | 2001-05-18 | 2005-07-21 | Sirna Therapeutics, Inc | RNA interference mediated inhibition of gastric inhibitory polypeptide (GIP) and gastric inhibitory polypeptide receptor (GIPR) gene expression using short interfering nucleic acid (siNA) |
| JP4566459B2 (ja) | 2001-06-07 | 2010-10-20 | 株式会社日立製作所 | 表示装置 |
| AU2002358469A1 (en) * | 2001-12-21 | 2003-07-15 | 7Tm Pharma A/S | Modified receptors for the discovery of therapeutic ligands |
| MXPA04008068A (es) | 2002-02-20 | 2004-11-26 | Lilly Co Eli | Metodo para administrar moleculas de glp-1. |
| EP1506777A4 (en) | 2002-05-22 | 2007-07-18 | Sanwa Kagaku Kenkyusho Co | MEANS FOR PREVENTING OR REDUCING FAT SUPPORT WITH A METHYLIDENHYDRAZIDE COMPOUND AS AN ACTIVE SUBSTANCE |
| JP2006502100A (ja) * | 2002-06-11 | 2006-01-19 | エーザイ株式会社 | 細胞の異常消失に関わる障害の治療のための、および/または、肥満の治療のためのgip活性を有する化合物の使用 |
| AU2003248676A1 (en) | 2002-06-15 | 2003-12-31 | Enteromed, Inc. | Treatment of non-alcoholic fatty liver disease |
| JP2006213598A (ja) | 2003-03-19 | 2006-08-17 | Sanwa Kagaku Kenkyusho Co Ltd | ピラゾロピリミジン化合物及びその用途 |
| ATE525395T1 (de) | 2003-06-12 | 2011-10-15 | Lilly Co Eli | Fusions proteine von glp-1-analoga |
| EP1663295A2 (en) | 2003-09-01 | 2006-06-07 | Novo Nordisk A/S | Stable formulations of peptides |
| IN2012DN03921A (enExample) | 2004-02-11 | 2015-09-04 | Amylin Pharmaceuticals Inc | |
| US7456254B2 (en) | 2004-04-15 | 2008-11-25 | Alkermes, Inc. | Polymer-based sustained release device |
| US7991890B2 (en) | 2004-09-30 | 2011-08-02 | Microsoft Corporation | Game console communication with a device |
| EP1809335A2 (en) | 2004-10-25 | 2007-07-25 | Cytos Biotechnology AG | Gastric inhibitory polypeptide (gip) antigen arrays and uses thereof |
| SI1831252T1 (sl) | 2004-12-22 | 2009-12-31 | Lilly Co Eli | Formulacije analogov glp-1 fuzijskih proteinov |
| US20060275288A1 (en) | 2005-01-20 | 2006-12-07 | Grihalde Nelson D | GLP-1 receptor agonist and allosteric modulator monoclonal antibodies and uses thereof |
| US8263545B2 (en) | 2005-02-11 | 2012-09-11 | Amylin Pharmaceuticals, Inc. | GIP analog and hybrid polypeptides with selectable properties |
| WO2006086769A2 (en) | 2005-02-11 | 2006-08-17 | Amylin Pharmaceuticals, Inc. | Gip analog and hybrid polypeptides with selectable properties |
| JP2008539742A (ja) | 2005-05-11 | 2008-11-20 | サノフィ−アベンティス | Gipプロモーター多型の使用 |
| US8097584B2 (en) | 2005-05-25 | 2012-01-17 | Novo Nordisk A/S | Stabilized formulations of insulin that comprise ethylenediamine |
| US20090170762A1 (en) | 2005-09-08 | 2009-07-02 | Uutech Limited | Treatment of Diabetes Related Obesity |
| WO2007109354A2 (en) | 2006-03-21 | 2007-09-27 | Amylin Pharmaceuticals, Inc. | Peptide-peptidase inhibitor conjugates and methods of using same |
| WO2008006113A2 (en) | 2006-07-07 | 2008-01-10 | The Texas A & M University System | Novel belactosin derivatives as therapeutic agents/biological probes and their synthesis |
| WO2008019143A2 (en) | 2006-08-04 | 2008-02-14 | Amylin Pharmaceuticals, Inc | Use of exendins and glp-i receptor agonists for altering lipoprotein particle size and subclass composition |
| US8497240B2 (en) | 2006-08-17 | 2013-07-30 | Amylin Pharmaceuticals, Llc | DPP-IV resistant GIP hybrid polypeptides with selectable properties |
| AU2007284365A1 (en) | 2006-08-17 | 2008-02-21 | Amylin Pharmaceuticals, Inc. | DPP-IV resistant GIP hybrid polypeptides with selectable properties |
| US20090098130A1 (en) | 2007-01-05 | 2009-04-16 | Bradshaw Curt W | Glucagon-like protein-1 receptor (glp-1r) agonist compounds |
| BRPI0807728A2 (pt) | 2007-02-15 | 2012-04-17 | Univ Indiana Res & Tech Corp | co-agonistas de receptor glucagon/glp-1 |
| EP2195034A2 (en) | 2007-09-27 | 2010-06-16 | Amylin Pharmaceuticals, Inc. | Peptide-peptidase inhibitor conjugates and methods of making and using same |
| US20090144162A1 (en) | 2007-11-29 | 2009-06-04 | Neil Milne | Transaction Security Method and Apparatus |
| GB0814068D0 (en) | 2008-08-01 | 2008-09-10 | Univ Ulster | Active immunisation against GIP |
| WO2010016940A2 (en) | 2008-08-07 | 2010-02-11 | Ipsen Pharma S.A.S. | Analogues of glucose-dependent insulinotropic polypeptide |
| CA2732973A1 (en) * | 2008-08-07 | 2010-02-11 | Ipsen Pharma S.A.S. | Glucose-dependent insulinotropic polypeptide analogues |
| CN104231070B (zh) | 2008-08-07 | 2017-09-01 | 益普生制药股份有限公司 | N‑端修饰的葡萄糖依赖性促胰岛素多肽(gip)类似物 |
| WO2010016936A1 (en) | 2008-08-07 | 2010-02-11 | Ipsen Pharma S.A.S. | Pharmaceutical compositions of analogues of glucose-dependent insulinotropic polypeptide |
| CN104031140B (zh) | 2008-08-07 | 2017-04-12 | 益普生制药股份有限公司 | 糖依赖性胰岛素释放肽的截短类似物 |
| US20120157379A1 (en) | 2009-07-31 | 2012-06-21 | Sheau Yu Hsu | Gastric Inhibitory Peptide Variants and Their Uses |
| MX2012008603A (es) | 2010-01-27 | 2013-01-25 | Univ Indiana Res & Tech Corp | Conjugados de antagonista de glucagon-agonista de gip y composiciones para el tratamiento de desordenes metabolicos y obesidad. |
| MX2012012441A (es) * | 2010-05-04 | 2013-02-26 | Merrimack Pharmaceuticals Inc | Anticuerpos contra el receptor del factor de crecimiento epidermico (egfr) y usos de los mismos. |
| US9023986B2 (en) | 2010-10-25 | 2015-05-05 | Hoffmann-La Roche Inc. | Glucose-dependent insulinotropic peptide analogs |
| NZ612297A (en) | 2010-12-22 | 2015-10-30 | Univ Indiana Res & Tech Corp | Glucagon analogs exhibiting gip receptor activity |
| WO2012121302A1 (ja) | 2011-03-08 | 2012-09-13 | 株式会社 三和化学研究所 | 分析方法 |
| CN103764673A (zh) | 2011-06-10 | 2014-04-30 | 北京韩美药品有限公司 | 葡萄糖依赖性促胰岛素多肽类似物、其药物组合物及应用 |
| HK1207097A1 (en) | 2012-09-07 | 2016-01-22 | Sanofi | Fusion proteins for treating a metabolic syndrome |
| HK1226084A1 (zh) | 2013-08-16 | 2017-09-22 | Medimmune Limited | 用於治疗糖尿病的gip和glp-1受体双重激动剂 |
| WO2015081440A1 (en) | 2013-12-04 | 2015-06-11 | Innovative Targeting Solutions Inc. | G-protein coupled receptor agonists and methods |
| ES2869309T3 (es) | 2013-12-13 | 2021-10-25 | Novo Nordisk Healthcare Ag | Método para la conjugación de proteínas con tioéter |
| EP4410833A3 (en) | 2013-12-17 | 2024-10-23 | MHS Care - Innovation LLC | Compositions and methods for treating fatty tissue buildup |
| EP3151852A1 (en) | 2014-06-04 | 2017-04-12 | Novo Nordisk A/S | Glp-1/glucagon receptor co-agonists for medical use |
| AR104932A1 (es) | 2015-06-22 | 2017-08-23 | Lilly Co Eli | Compuestos co-agonistas del glucagón y péptido-1 similar al glugacón (glp-1) |
| TWI622596B (zh) | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
| MY197023A (en) * | 2015-12-23 | 2023-05-22 | Amgen Inc | Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (gipr) in combination with glp-1 agonists |
| JOP20190177A1 (ar) | 2017-01-17 | 2019-07-16 | Amgen Inc | طريقة لعلاج أو تحسين اضطرابات أيضية باستخدام مساعدات مستقبل glp-1 مقترنة بمناهضات لمستقبل ببتيد مثبط معوي (gipr) |
| EA201992502A1 (ru) | 2017-06-20 | 2020-04-22 | Эмджен Инк. | Способ лечения или уменьшения интенсивности метаболических нарушений с применением белков, связывающих рецептор гастроингибиторного пептида (gipr), в комбинации с агонистами glp-1 |
| WO2018237095A1 (en) | 2017-06-21 | 2018-12-27 | Amgen Inc. | METHOD OF TREATING OR ENHANCING METABOLIC DISORDERS USING ANTAGONISTIC BINDING PROTEINS FOR AGONIST FUSION PROTEINS FROM THE GASTRIC INHIBITOR PEPTIDE RECEPTOR (GIPR) / GLP-1 RECEPTOR |
| EP4464719A3 (en) * | 2017-08-04 | 2025-03-05 | Amgen Inc. | Method of conjugation of cys-mabs |
| WO2020185533A1 (en) * | 2019-03-08 | 2020-09-17 | Amgen Inc. | Growth differentiation factor 15 combination therapy |
-
2016
- 2016-12-21 MY MYPI2018000984A patent/MY197023A/en unknown
- 2016-12-21 TN TNP/2018/000225A patent/TN2018000225A1/en unknown
- 2016-12-21 UA UAA201806970A patent/UA127495C2/uk unknown
- 2016-12-21 IL IL296682A patent/IL296682B1/en unknown
- 2016-12-21 PE PE2018001184A patent/PE20181327A1/es unknown
- 2016-12-21 WO PCT/US2016/068138 patent/WO2017112824A2/en not_active Ceased
- 2016-12-21 CN CN201680082808.6A patent/CN109715662B/zh active Active
- 2016-12-21 CN CN202310816200.3A patent/CN117106085A/zh active Pending
- 2016-12-21 SG SG11201805255TA patent/SG11201805255TA/en unknown
- 2016-12-21 JP JP2018533055A patent/JP6948330B2/ja active Active
- 2016-12-21 MA MA044154A patent/MA44154A/fr unknown
- 2016-12-21 EA EA201891323A patent/EA201891323A1/ru unknown
- 2016-12-21 NZ NZ783798A patent/NZ783798A/en unknown
- 2016-12-21 EP EP16831950.7A patent/EP3394104A2/en active Pending
- 2016-12-21 MX MX2018007859A patent/MX395677B/es unknown
- 2016-12-21 NZ NZ743474A patent/NZ743474A/en unknown
- 2016-12-21 CA CA3223591A patent/CA3223591A1/en active Pending
- 2016-12-21 AU AU2016378739A patent/AU2016378739A1/en not_active Abandoned
- 2016-12-21 KR KR1020257026330A patent/KR20250121615A/ko active Pending
- 2016-12-21 CA CA3009650A patent/CA3009650A1/en active Pending
- 2016-12-21 US US15/387,542 patent/US10294303B2/en active Active
- 2016-12-21 KR KR1020187020957A patent/KR102844773B1/ko active Active
- 2016-12-21 CR CR20180378A patent/CR20180378A/es unknown
- 2016-12-23 TW TW110124017A patent/TWI818277B/zh active
- 2016-12-23 UY UY0001037049A patent/UY37049A/es active IP Right Grant
- 2016-12-23 TW TW105143109A patent/TWI734722B/zh active
- 2016-12-23 TW TW112134736A patent/TWI891060B/zh active
-
2018
- 2018-06-11 IL IL259940A patent/IL259940B2/en unknown
- 2018-06-14 ZA ZA2018/03979A patent/ZA201803979B/en unknown
- 2018-06-20 PH PH12018501322A patent/PH12018501322A1/en unknown
- 2018-06-21 CL CL2018001695A patent/CL2018001695A1/es unknown
- 2018-06-25 MX MX2022011277A patent/MX2022011277A/es unknown
- 2018-07-19 CO CONC2018/0007582A patent/CO2018007582A2/es unknown
-
2019
- 2019-02-25 US US16/285,118 patent/US11046774B2/en active Active
- 2019-09-13 ZA ZA2019/06059A patent/ZA201906059B/en unknown
-
2020
- 2020-12-14 CL CL2020003237A patent/CL2020003237A1/es unknown
-
2021
- 2021-05-27 US US17/332,578 patent/US12252540B2/en active Active
- 2021-09-16 JP JP2021150818A patent/JP2021193135A/ja active Pending
-
2023
- 2023-10-06 JP JP2023174100A patent/JP7686719B2/ja active Active
-
2024
- 2024-02-07 AU AU2024200758A patent/AU2024200758A1/en active Pending
-
2025
- 2025-01-17 US US19/027,327 patent/US20250376529A1/en active Pending
- 2025-05-20 JP JP2025083866A patent/JP2025124705A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102844773B1 (ko) | 위 억제 펩티드 수용체 (gipr)에 대한 결합 단백질을 glp-1 효능제와 조합하여 사용하여 대사 장애를 치료하거나 개선시키는 방법 | |
| KR102781241B1 (ko) | 위 저해 펩타이드 수용체(gipr)에 대한 길항제에 접합된 glp-1 수용체 작용제를 사용하여 대사 장애를 치료 또는 개선하는 방법 | |
| KR102831970B1 (ko) | 항-sars-cov-2 스파이크 당단백질 항체 및 항원-결합 단편 | |
| CN110869389B (zh) | 抗ror1抗体及其制备和使用方法 | |
| KR102121678B1 (ko) | β-KLOTHO, FGF 수용체 및 이들의 복합체에 결합하는 인간 항원 결합 단백질 | |
| KR20220167273A (ko) | 항-코로나바이러스 항체 및 사용 방법 | |
| KR101963923B1 (ko) | 이중특이적 t 세포 활성화 항원 결합 분자 | |
| CN111954680B (zh) | IL2Rβ/共同γ链抗体 | |
| KR102361237B1 (ko) | 코일드 코일 면역글로불린 융합 단백질 및 이것의 조성물 | |
| KR20210013156A (ko) | 항-cd33 항체, 항-cd33/항-cd3 이중특이성 항체, 및 이의 용도 | |
| CN112654363A (zh) | 组织特异性wnt信号增强分子和其用途 | |
| KR20230017841A (ko) | Cd3 항원 결합 도메인을 포함하는 단백질 및 이의 용도 | |
| KR20200109339A (ko) | Tim3에 대한 항체를 사용하여 암을 치료하는 방법 | |
| KR20230017815A (ko) | 항-sars-cov-2 스파이크 당단백질 항체 및 항원-결합 단편 | |
| CN113493506A (zh) | 新型冠状病毒抗体及其应用 | |
| KR20150140685A (ko) | Hgf에 대한 항체 및 이를 포함하는 조성물 | |
| KR20220140802A (ko) | 항-acvr1 항체 및 이의 용도 | |
| TW202216743A (zh) | Il-10突變蛋白及其融合蛋白 | |
| KR20240005894A (ko) | 항-tmprss6 항체 및 이의 용도 | |
| CN113316587B (zh) | 一种双特异性分子及其制备与用途 | |
| CN114502151A (zh) | 抗cd19抗体及其使用和制备方法 | |
| RU2800649C2 (ru) | Моноклональные антитела против рецептор-связывающего домена spike-белка вируса sars-cov-2 и их антигенсвязывающие фрагменты, кодирующие их нуклеиновые кислоты, а также способы применения | |
| TW202539736A (zh) | 對胃抑肽受體(gipr)具特異性之抗原結合蛋白之用途 | |
| RU2834996C1 (ru) | Антитела против cd19 и способы их применения и получения | |
| EA044746B1 (ru) | АНТИТЕЛА И АНТИГЕНСВЯЗЫВАЮЩИЕ ФРАГМЕНТЫ ПРОТИВ ГЛИКОПРОТЕИНА ШИПОВ SARS-CoV-2 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A16 | Divisional, continuation or continuation in part application filed |
Free format text: ST27 STATUS EVENT CODE: A-0-1-A10-A16-DIV-PA0104 (AS PROVIDED BY THE NATIONAL OFFICE) |
|
| A18 | Application divided or continuation or continuation in part accepted |
Free format text: ST27 STATUS EVENT CODE: A-0-1-A10-A18-DIV-PA0104 (AS PROVIDED BY THE NATIONAL OFFICE) |
|
| PA0104 | Divisional application for international application |
St.27 status event code: A-0-1-A10-A18-div-PA0104 St.27 status event code: A-0-1-A10-A16-div-PA0104 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| Q12 | Application published |
Free format text: ST27 STATUS EVENT CODE: A-1-1-Q10-Q12-NAP-PG1501 (AS PROVIDED BY THE NATIONAL OFFICE) |
|
| E13 | Pre-grant limitation requested |
Free format text: ST27 STATUS EVENT CODE: A-2-3-E10-E13-LIM-X000 (AS PROVIDED BY THE NATIONAL OFFICE) |
|
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11 | Amendment of application requested |
Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-NAP-X000 (AS PROVIDED BY THE NATIONAL OFFICE) |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13 | Application amended |
Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P13-NAP-X000 (AS PROVIDED BY THE NATIONAL OFFICE) |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |