KR20140035995A - 고순도 및 결정질 다이메틸 푸마레이트의 제조 방법 - Google Patents

고순도 및 결정질 다이메틸 푸마레이트의 제조 방법 Download PDF

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KR20140035995A
KR20140035995A KR1020147000390A KR20147000390A KR20140035995A KR 20140035995 A KR20140035995 A KR 20140035995A KR 1020147000390 A KR1020147000390 A KR 1020147000390A KR 20147000390 A KR20147000390 A KR 20147000390A KR 20140035995 A KR20140035995 A KR 20140035995A
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dimethyl
dimethyl fumarate
fumarate
ppm
methanol
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Korean (ko)
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존 구조우스키
윌리엄 키스먼
어윈 얼댐
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바이오겐 아이덱 엠에이 인코포레이티드
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Application filed by 바이오겐 아이덱 엠에이 인코포레이티드 filed Critical 바이오겐 아이덱 엠에이 인코포레이티드
Publication of KR20140035995A publication Critical patent/KR20140035995A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/62—Use of additives, e.g. for stabilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/297—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/593—Dicarboxylic acid esters having only one carbon-to-carbon double bond
    • C07C69/60—Maleic acid esters; Fumaric acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/604—Polycarboxylic acid esters, the acid moiety containing more than two carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
KR1020147000390A 2011-06-08 2012-06-08 고순도 및 결정질 다이메틸 푸마레이트의 제조 방법 Ceased KR20140035995A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161494775P 2011-06-08 2011-06-08
US61/494,775 2011-06-08
PCT/US2012/041715 WO2012170923A1 (en) 2011-06-08 2012-06-08 Process for preparing high purity and crystalline dimethyl fumarate

Related Child Applications (1)

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KR1020157017537A Division KR20150080037A (ko) 2011-06-08 2012-06-08 고순도 및 결정질 다이메틸 푸마레이트의 제조 방법

Publications (1)

Publication Number Publication Date
KR20140035995A true KR20140035995A (ko) 2014-03-24

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ID=47296498

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KR1020147000390A Ceased KR20140035995A (ko) 2011-06-08 2012-06-08 고순도 및 결정질 다이메틸 푸마레이트의 제조 방법
KR1020157017537A Withdrawn KR20150080037A (ko) 2011-06-08 2012-06-08 고순도 및 결정질 다이메틸 푸마레이트의 제조 방법

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US (1) US9422226B2 (enExample)
EP (1) EP2718257B1 (enExample)
JP (3) JP6385273B6 (enExample)
KR (2) KR20140035995A (enExample)
CN (1) CN103649041A (enExample)
AU (1) AU2012267524A1 (enExample)
BR (1) BR112013031616A2 (enExample)
CA (1) CA2838271A1 (enExample)
CL (1) CL2013003483A1 (enExample)
CO (1) CO6821956A2 (enExample)
CY (1) CY1119920T1 (enExample)
DK (1) DK2718257T3 (enExample)
EA (1) EA201391638A1 (enExample)
EC (1) ECSP14013123A (enExample)
ES (1) ES2659771T3 (enExample)
HR (1) HRP20180203T1 (enExample)
HU (1) HUE036085T2 (enExample)
IL (1) IL229656A0 (enExample)
LT (1) LT2718257T (enExample)
ME (1) ME02960B (enExample)
MX (1) MX355421B (enExample)
NO (1) NO2820009T3 (enExample)
NZ (1) NZ618178A (enExample)
PE (1) PE20141639A1 (enExample)
PH (1) PH12013502498A1 (enExample)
PL (1) PL2718257T3 (enExample)
PT (1) PT2718257T (enExample)
RS (1) RS56972B1 (enExample)
SG (1) SG195227A1 (enExample)
SI (1) SI2718257T1 (enExample)
SM (1) SMT201800098T1 (enExample)
WO (1) WO2012170923A1 (enExample)

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CN104761453A (zh) * 2015-04-22 2015-07-08 河南中帅医药科技股份有限公司 一种富马酸二甲酯晶型及其制备方法
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CN106316841A (zh) * 2015-06-30 2017-01-11 深圳翰宇药业股份有限公司 一种富马酸二甲酯的制备方法
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CN107285320A (zh) * 2017-08-02 2017-10-24 内蒙古新福地科技有限公司 一种氟硅酸钠的结晶方法及装置
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