KR20120127739A - 라이아노딘 수용체 (ｒｙｒ２)에서의 누출을 표적화하는 신규한 항-부정맥 및 심부전 약물과 그 용도 - Google Patents

라이아노딘 수용체 (ｒｙｒ２)에서의 누출을 표적화하는 신규한 항-부정맥 및 심부전 약물과 그 용도 Download PDF

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Publication number
KR20120127739A
KR20120127739A KR1020127025766A KR20127025766A KR20120127739A KR 20120127739 A KR20120127739 A KR 20120127739A KR 1020127025766 A KR1020127025766 A KR 1020127025766A KR 20127025766 A KR20127025766 A KR 20127025766A KR 20120127739 A KR20120127739 A KR 20120127739A
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Prior art keywords
ryr2
jtv
cardiac
alkyl
pka
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Abandoned
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KR1020127025766A
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English (en)
Korean (ko)
Inventor
앤드류 알. 마크스
도날드 더블유. 랜드리
시지안 뎅
젠 주앙 쳉
Original Assignee
더 트러스티이스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕
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Publication of KR20120127739A publication Critical patent/KR20120127739A/ko
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
KR1020127025766A 2004-03-25 2005-03-22 라이아노딘 수용체 (ｒｙｒ２)에서의 누출을 표적화하는 신규한 항-부정맥 및 심부전 약물과 그 용도 Abandoned KR20120127739A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/809,089 2004-03-25
US10/809,089 US7718644B2 (en) 2004-01-22 2004-03-25 Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
PCT/US2005/009495 WO2005094457A2 (en) 2004-03-25 2005-03-22 Novel anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (ryr2) and uses thereof

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020067022060A Division KR20070041432A (ko) 2004-03-25 2005-03-22 라이아노딘 수용체 (ｒｙｒ２)에서의 누출을 표적화하는신규한 항-부정맥 및 심부전 약물과 그 용도

Publications (1)

Publication Number Publication Date
KR20120127739A true KR20120127739A (ko) 2012-11-23

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020127025766A Abandoned KR20120127739A (ko) 2004-03-25 2005-03-22 라이아노딘 수용체 (ｒｙｒ２)에서의 누출을 표적화하는 신규한 항-부정맥 및 심부전 약물과 그 용도
KR1020067022060A Ceased KR20070041432A (ko) 2004-03-25 2005-03-22 라이아노딘 수용체 (ｒｙｒ２)에서의 누출을 표적화하는신규한 항-부정맥 및 심부전 약물과 그 용도

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020067022060A Ceased KR20070041432A (ko) 2004-03-25 2005-03-22 라이아노딘 수용체 (ｒｙｒ２)에서의 누출을 표적화하는신규한 항-부정맥 및 심부전 약물과 그 용도

Country Status (25)

Country Link
US (1) US7718644B2 (https=)
EP (3) EP2163248B1 (https=)
JP (2) JP5274831B2 (https=)
KR (2) KR20120127739A (https=)
CN (2) CN101704799B (https=)
AU (1) AU2005227907B2 (https=)
BR (1) BRPI0509199A (https=)
CA (1) CA2560866A1 (https=)
CY (1) CY1113426T1 (https=)
DK (1) DK2163248T3 (https=)
EA (1) EA015010B1 (https=)
ES (1) ES2394104T3 (https=)
GE (1) GEP20115301B (https=)
HR (1) HRP20120938T1 (https=)
IL (1) IL178157A (https=)
MA (1) MA28629B1 (https=)
NO (1) NO20064843L (https=)
NZ (1) NZ550750A (https=)
PL (1) PL2163248T3 (https=)
PT (1) PT2163248E (https=)
RS (1) RS52601B (https=)
SG (1) SG153862A1 (https=)
SI (1) SI2163248T1 (https=)
UA (1) UA96914C2 (https=)
WO (1) WO2005094457A2 (https=)

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US7879840B2 (en) 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7393652B2 (en) 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US7312044B2 (en) 2003-03-07 2007-12-25 The Trustees Of Columbia University In The City Of New York Type 1 ryanodine receptor-based methods
US7718644B2 (en) 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
US7704990B2 (en) * 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
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