ATE359788T1 - Verwendung von diphenylmethylpiperazin-derivaten zur herstellung eines medikaments zur unterdrückung der proliferation von fibroblasten - Google Patents
Verwendung von diphenylmethylpiperazin-derivaten zur herstellung eines medikaments zur unterdrückung der proliferation von fibroblastenInfo
- Publication number
- ATE359788T1 ATE359788T1 AT05077245T AT05077245T ATE359788T1 AT E359788 T1 ATE359788 T1 AT E359788T1 AT 05077245 T AT05077245 T AT 05077245T AT 05077245 T AT05077245 T AT 05077245T AT E359788 T1 ATE359788 T1 AT E359788T1
- Authority
- AT
- Austria
- Prior art keywords
- fibroblasts
- medication
- producing
- derivatives
- suppressing proliferation
- Prior art date
Links
- 150000008640 diphenylmethylpiperazines Chemical class 0.000 title abstract 2
- 210000002950 fibroblast Anatomy 0.000 title abstract 2
- 230000035755 proliferation Effects 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 2
- 208000002260 Keloid Diseases 0.000 abstract 1
- 206010023330 Keloid scar Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 210000001117 keloid Anatomy 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 208000005069 pulmonary fibrosis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP28087499 | 1999-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE359788T1 true ATE359788T1 (de) | 2007-05-15 |
Family
ID=17631164
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05077245T ATE359788T1 (de) | 1999-09-30 | 2000-09-29 | Verwendung von diphenylmethylpiperazin-derivaten zur herstellung eines medikaments zur unterdrückung der proliferation von fibroblasten |
| AT00962991T ATE349212T1 (de) | 1999-09-30 | 2000-09-29 | Mittel gegen krebs |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00962991T ATE349212T1 (de) | 1999-09-30 | 2000-09-29 | Mittel gegen krebs |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6683083B1 (de) |
| EP (2) | EP1637140B1 (de) |
| AT (2) | ATE359788T1 (de) |
| AU (1) | AU776745B2 (de) |
| CA (1) | CA2385996C (de) |
| DE (2) | DE60034494T2 (de) |
| TW (1) | TWI289450B (de) |
| WO (1) | WO2001022968A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040048780A1 (en) * | 2000-05-10 | 2004-03-11 | The Trustees Of Columbia University In The City Of New York | Method for treating and preventing cardiac arrhythmia |
| US7879840B2 (en) * | 2005-08-25 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US7393652B2 (en) * | 2000-05-10 | 2008-07-01 | The Trustees Of Columbia University In The City Of New York | Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2) |
| US7718644B2 (en) * | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
| US6489125B1 (en) * | 2000-05-10 | 2002-12-03 | The Trustees Of Columbia University In The City Of New York | Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor |
| US20040229781A1 (en) * | 2000-05-10 | 2004-11-18 | Marks Andrew Robert | Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias |
| US20060293266A1 (en) * | 2000-05-10 | 2006-12-28 | The Trustees Of Columbia | Phosphodiesterase 4D in the ryanodine receptor complex protects against heart failure |
| US8022058B2 (en) | 2000-05-10 | 2011-09-20 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US7544678B2 (en) * | 2002-11-05 | 2009-06-09 | The Trustees Of Columbia University In The City Of New York | Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) |
| JP2007525165A (ja) | 2003-03-07 | 2007-09-06 | トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | タイプ１ライアノジン受容体に基づく方法 |
| US8710045B2 (en) * | 2004-01-22 | 2014-04-29 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the ryanodine receptors |
| US7704990B2 (en) * | 2005-08-25 | 2010-04-27 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US20070052304A1 (en) * | 2005-09-07 | 2007-03-08 | Philippe Masson | Multi-pattern high temperature superconducting motor using flux trapping and concentration |
| JP5318938B2 (ja) * | 2011-06-09 | 2013-10-16 | 株式会社アエタスファルマ | ジフェニルメチルピペラジン誘導体、及びそれを用いた医薬組成物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1340821C (en) * | 1988-10-06 | 1999-11-16 | Nobuyuki Fukazawa | Heterocyclic compounds and anticancer-drug reinforcing agents containing them as effective components |
| JP2651043B2 (ja) | 1990-07-10 | 1997-09-10 | 麒麟麦酒株式会社 | ジフェニルメチルピペラジン誘導体 |
| JP2518965B2 (ja) * | 1990-09-21 | 1996-07-31 | 三井東圧化学株式会社 | 新規ピリジン誘導体及びそれを有効成分として含有する制癌剤効果増強剤 |
-
2000
- 2000-09-29 AT AT05077245T patent/ATE359788T1/de active
- 2000-09-29 EP EP05077245A patent/EP1637140B1/de not_active Expired - Lifetime
- 2000-09-29 EP EP00962991A patent/EP1222924B1/de not_active Expired - Lifetime
- 2000-09-29 WO PCT/JP2000/006786 patent/WO2001022968A1/ja not_active Ceased
- 2000-09-29 DE DE60034494T patent/DE60034494T2/de not_active Expired - Lifetime
- 2000-09-29 DE DE60032620T patent/DE60032620T2/de not_active Expired - Lifetime
- 2000-09-29 AT AT00962991T patent/ATE349212T1/de active
- 2000-09-29 AU AU74498/00A patent/AU776745B2/en not_active Ceased
- 2000-09-29 CA CA002385996A patent/CA2385996C/en not_active Expired - Fee Related
- 2000-09-29 US US10/089,718 patent/US6683083B1/en not_active Expired - Fee Related
- 2000-09-30 TW TW089120410A patent/TWI289450B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60034494T2 (de) | 2008-01-03 |
| DE60032620D1 (de) | 2007-02-08 |
| US6683083B1 (en) | 2004-01-27 |
| EP1637140A1 (de) | 2006-03-22 |
| CA2385996C (en) | 2008-02-12 |
| ATE349212T1 (de) | 2007-01-15 |
| AU7449800A (en) | 2001-04-30 |
| CA2385996A1 (en) | 2001-04-05 |
| EP1222924A1 (de) | 2002-07-17 |
| WO2001022968A1 (en) | 2001-04-05 |
| EP1637140B1 (de) | 2007-04-18 |
| EP1222924A4 (de) | 2004-08-04 |
| TWI289450B (en) | 2007-11-11 |
| EP1222924B1 (de) | 2006-12-27 |
| DE60032620T2 (de) | 2007-10-04 |
| AU776745B2 (en) | 2004-09-23 |
| DE60034494D1 (de) | 2007-05-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE359788T1 (de) | Verwendung von diphenylmethylpiperazin-derivaten zur herstellung eines medikaments zur unterdrückung der proliferation von fibroblasten | |
| DK1029853T3 (da) | Heteroaromatiske bicykliske derivativer, der er egnede som anticancermidler | |
| ATE160341T1 (de) | Benzolsulfonamid-derivate und verfahren zur herstellung | |
| ATE238280T1 (de) | Verwendung eines pharmazeutisch geeigneten salzes von (3r,2'r)-3-((cyclopentyl- hydroxyphenylacetyl)oxy)-1,1-dimethyl- pyrrolidinium zur herstellung eines arzneimittels | |
| DE122011100040I1 (de) | Zusammensetzung, verfahren und instrument zur potenzierung der antitumoraktivitat und zur behandlungvon tumoren. | |
| EE200000583A (et) | Aminotsükloheksüüleeterühendid ja nende kasutamine | |
| AU689304B2 (en) | Quinazoline derivative | |
| ATE255579T1 (de) | Pyrrolidin-derivate die eine phospholipase-a2- hemmende wirkung haben | |
| BR9805734A (pt) | Derivados de imidazolin-4-ona úteis como agentes anticancerìgenos. | |
| ZA200108124B (en) | Pharmaceutical compounds. | |
| DE69433348D1 (de) | Verwendung von Raloxifen und dessen Analogen zur Herstellung eines Medikaments zur Hemmung der LDL Oxidation und der Atherosclerose | |
| NZ248099A (en) | Use of spiro-oxathiolane quinuclidine derivatives for treating sjoegren syndrome | |
| EE200000472A (et) | Kasvajavastased toimeained | |
| PT992509E (pt) | Novos derivados macrolidos | |
| ATE170852T1 (de) | Benzolsulfonamid-derivate zur behandlung der blaseninstabilität | |
| NZ332136A (en) | Phenylalkylcarboxylic acid derivatives useful for treating hyperglycemia | |
| NO921159L (no) | Tiazolidinon- og oksazolidinonderivater, fremgangsmaate til fremstilling derav, samt anvendelse av derivatene som vasodilatorer | |
| DE69828197D1 (de) | Amidderivate zur behandlung neurodegenerativer erkrankungen der netzhaut | |
| DE69924741D1 (de) | Verwendung einer zusammensetzung zur herstellung eines arzneimittels zur vorbeugung und behandlung von parodontitis | |
| FR2640969B1 (de) | ||
| IL149306A0 (en) | Benzamidine derivatives and pharmaceutical compositions containing the same | |
| DE69607890D1 (de) | Aromatische Hydroxamsäure-Verbindungen, ihre Herstellung und Verwendung | |
| MXPA05009763A (es) | 2-(butil-1-sulfonilamino)-n-[1 (r)-(6-metoxipiridin-3-il) propil] benzamida, su uso en forma de un farmaco y preparaciones farmaceuticas que contienen a dicho compuesto. | |
| ATE79259T1 (de) | Prophylaktische und heilende zusammensetzung enthaltende eine 8-chlorbenzothiazepin-verbindung und dessen verwendung. | |
| HUT69166A (en) | Process to preparare pharmaceutical compns. to prevent and to cure ulcus |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1637140 Country of ref document: EP |