KR20040099389A - 스트렙토마이세스 하이그로스코피쿠스 유전자 - Google Patents

스트렙토마이세스 하이그로스코피쿠스 유전자 Download PDF

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Publication number
KR20040099389A
KR20040099389A KR10-2004-7015691A KR20047015691A KR20040099389A KR 20040099389 A KR20040099389 A KR 20040099389A KR 20047015691 A KR20047015691 A KR 20047015691A KR 20040099389 A KR20040099389 A KR 20040099389A
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KR
South Korea
Prior art keywords
avec
streptomyces
avermectin
streptomyces avermitilis
strain
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Ceased
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KR10-2004-7015691A
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English (en)
Korean (ko)
Inventor
스투츠만-엔그월킴조넬
가토요시히로
맥아써하미쉬알라스테어어빈
Original Assignee
화이자 프로덕츠 인코포레이티드
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Application filed by 화이자 프로덕츠 인코포레이티드 filed Critical 화이자 프로덕츠 인코포레이티드
Publication of KR20040099389A publication Critical patent/KR20040099389A/ko
Ceased legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/60Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR10-2004-7015691A 1998-02-13 1999-01-25 스트렙토마이세스 하이그로스코피쿠스 유전자 Ceased KR20040099389A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7463698P 1998-02-13 1998-02-13
US60/074,636 1998-02-13
PCT/IB1999/000130 WO1999041389A1 (en) 1998-02-13 1999-01-25 Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR10-2004-7008310A Division KR20040053390A (ko) 1998-02-13 1999-01-25 아베르멕틴의 비2:비1의 비를 제어할 수 있는 스트렙토마이세스 아베르미틸리스 유전자

Publications (1)

Publication Number Publication Date
KR20040099389A true KR20040099389A (ko) 2004-11-26

Family

ID=22120706

Family Applications (3)

Application Number Title Priority Date Filing Date
KR10-2004-7015691A Ceased KR20040099389A (ko) 1998-02-13 1999-01-25 스트렙토마이세스 하이그로스코피쿠스 유전자
KR10-2004-7008310A Ceased KR20040053390A (ko) 1998-02-13 1999-01-25 아베르멕틴의 비2:비1의 비를 제어할 수 있는 스트렙토마이세스 아베르미틸리스 유전자
KR10-2000-7008870A Expired - Fee Related KR100499214B1 (ko) 1998-02-13 1999-01-25 아베르멕틴의 b2:b1의 비를 제어할 수 있는 스트렙토마이세스 아베르미틸리스 유전자

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR10-2004-7008310A Ceased KR20040053390A (ko) 1998-02-13 1999-01-25 아베르멕틴의 비2:비1의 비를 제어할 수 있는 스트렙토마이세스 아베르미틸리스 유전자
KR10-2000-7008870A Expired - Fee Related KR100499214B1 (ko) 1998-02-13 1999-01-25 아베르멕틴의 b2:b1의 비를 제어할 수 있는 스트렙토마이세스 아베르미틸리스 유전자

Country Status (32)

Country Link
EP (1) EP1053335A1 (enrdf_load_stackoverflow)
JP (2) JP2002503473A (enrdf_load_stackoverflow)
KR (3) KR20040099389A (enrdf_load_stackoverflow)
CN (2) CN1297485A (enrdf_load_stackoverflow)
AP (1) AP9901463A0 (enrdf_load_stackoverflow)
AR (1) AR018085A1 (enrdf_load_stackoverflow)
AU (1) AU752343C (enrdf_load_stackoverflow)
BG (1) BG64911B1 (enrdf_load_stackoverflow)
BR (1) BR9907893A (enrdf_load_stackoverflow)
CA (2) CA2320031A1 (enrdf_load_stackoverflow)
CO (1) CO5070698A1 (enrdf_load_stackoverflow)
DZ (1) DZ2720A1 (enrdf_load_stackoverflow)
EA (1) EA003905B1 (enrdf_load_stackoverflow)
GT (1) GT199900014A (enrdf_load_stackoverflow)
HN (1) HN1999000008A (enrdf_load_stackoverflow)
HR (1) HRP20000539A2 (enrdf_load_stackoverflow)
HU (1) HUP0100784A3 (enrdf_load_stackoverflow)
IL (2) IL137610A0 (enrdf_load_stackoverflow)
IS (1) IS5567A (enrdf_load_stackoverflow)
MA (1) MA24760A1 (enrdf_load_stackoverflow)
NO (1) NO20004044L (enrdf_load_stackoverflow)
NZ (2) NZ505676A (enrdf_load_stackoverflow)
OA (1) OA11449A (enrdf_load_stackoverflow)
PA (1) PA8467601A1 (enrdf_load_stackoverflow)
PE (1) PE20000352A1 (enrdf_load_stackoverflow)
PL (1) PL194270B1 (enrdf_load_stackoverflow)
SK (1) SK11722000A3 (enrdf_load_stackoverflow)
TN (1) TNSN99017A1 (enrdf_load_stackoverflow)
TW (1) TW585910B (enrdf_load_stackoverflow)
WO (1) WO1999041389A1 (enrdf_load_stackoverflow)
YU (1) YU50900A (enrdf_load_stackoverflow)
ZA (1) ZA991138B (enrdf_load_stackoverflow)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6248579B1 (en) * 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
HRP20000539A2 (en) * 1998-02-13 2001-04-30 Pfizer Prod Inc Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
MXPA02001513A (es) 1999-08-12 2002-07-02 Pfizer Prod Inc Gen de streptomyces avermitilis que dirige la relacion de avermectinas b2:b1.
US7630836B2 (en) 2001-05-30 2009-12-08 The Kitasato Institute Polynucleotides
RS50813B (sr) * 2002-02-12 2010-08-31 Pfizer Products Inc. Streptomyces avermitilis gen koji određuje odnos b2:b1 avermektina
CN107338210B (zh) * 2017-09-05 2021-08-17 天津科技大学 一种阿维链霉菌合成培养基及其发酵液的制备方法
CN111269296B (zh) * 2020-03-06 2021-11-05 山东大学 一种nLsA蛋白及其结构基因和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4429042A (en) * 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
IN167980B (enrdf_load_stackoverflow) * 1987-01-23 1991-01-19 Pfizer
DE3881147T2 (de) * 1987-10-23 1993-09-02 Pfizer Verfahren zur herstellung von aglykonen von avermectin und sie enthaltende kulturen.
JPH0747171B2 (ja) * 1988-09-20 1995-05-24 株式会社東芝 圧延機の設定方法および装置
US5252474A (en) * 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
ES2079436T3 (es) * 1989-03-31 1996-01-16 Merck & Co Inc Clonacion de genes de streptomyces avermitilis para biosintesis de avermectinas y procedimientos para su uso.
JP2888586B2 (ja) * 1990-03-05 1999-05-10 社団法人北里研究所 エバーメクチンの特定成分を選択生産するための微生物およびその選択的製造法
FI942725L (fi) * 1993-12-16 1995-06-17 Pfizer Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta
HRP20000539A2 (en) * 1998-02-13 2001-04-30 Pfizer Prod Inc Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins

Also Published As

Publication number Publication date
CA2521289A1 (en) 1999-08-19
IL137610A0 (en) 2001-07-24
NZ518657A (en) 2003-10-31
CN1521180A (zh) 2004-08-18
YU50900A (sh) 2004-03-12
GT199900014A (es) 2000-07-25
KR20040053390A (ko) 2004-06-23
CA2320031A1 (en) 1999-08-19
WO1999041389A1 (en) 1999-08-19
AP9901463A0 (en) 1999-03-31
JP4011036B2 (ja) 2007-11-21
JP2004283174A (ja) 2004-10-14
KR20010052166A (ko) 2001-06-25
CN1297485A (zh) 2001-05-30
SK11722000A3 (sk) 2001-04-09
HN1999000008A (es) 1999-10-29
NO20004044D0 (no) 2000-08-11
AU752343C (en) 2005-11-03
BG64911B1 (bg) 2006-08-31
TW585910B (en) 2004-05-01
MA24760A1 (fr) 1999-10-01
NZ505676A (en) 2003-02-28
PA8467601A1 (es) 2000-09-29
ZA991138B (en) 2000-08-14
PE20000352A1 (es) 2000-05-16
AR018085A1 (es) 2001-10-31
HUP0100784A2 (hu) 2001-06-28
PL194270B1 (pl) 2007-05-31
OA11449A (en) 2003-12-03
HUP0100784A3 (en) 2004-10-28
TNSN99017A1 (fr) 2005-11-10
NO20004044L (no) 2000-10-11
EA200000758A1 (ru) 2001-04-23
EA003905B1 (ru) 2003-10-30
JP2002503473A (ja) 2002-02-05
CO5070698A1 (es) 2001-08-28
HRP20000539A2 (en) 2001-04-30
BR9907893A (pt) 2000-11-14
PL342468A1 (en) 2001-06-04
DZ2720A1 (fr) 2003-09-01
IL183596A0 (enrdf_load_stackoverflow) 2007-09-20
AU1887899A (en) 1999-08-30
BG104759A (en) 2001-04-30
AU752343B2 (en) 2002-09-19
IS5567A (is) 2000-07-20
EP1053335A1 (en) 2000-11-22
KR100499214B1 (ko) 2005-07-07

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