MA24760A1 - Gene de streptomyces avermitilis commandant le rapport des avermectines b2; b1, et procede nouveau pour la production d'avermectines - Google Patents

Gene de streptomyces avermitilis commandant le rapport des avermectines b2; b1, et procede nouveau pour la production d'avermectines

Info

Publication number
MA24760A1
MA24760A1 MA25460A MA25460A MA24760A1 MA 24760 A1 MA24760 A1 MA 24760A1 MA 25460 A MA25460 A MA 25460A MA 25460 A MA25460 A MA 25460A MA 24760 A1 MA24760 A1 MA 24760A1
Authority
MA
Morocco
Prior art keywords
avermectins
avermitilized
streptomyces
gene
report
Prior art date
Application number
MA25460A
Other languages
English (en)
French (fr)
Inventor
Alastair Irvine Hamish
Jonelle Stutzman-Engwall Kim
Katoh Yoshihiro
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MA24760A1 publication Critical patent/MA24760A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/60Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
MA25460A 1998-02-13 1999-02-10 Gene de streptomyces avermitilis commandant le rapport des avermectines b2; b1, et procede nouveau pour la production d'avermectines MA24760A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7463698P 1998-02-13 1998-02-13

Publications (1)

Publication Number Publication Date
MA24760A1 true MA24760A1 (fr) 1999-10-01

Family

ID=22120706

Family Applications (1)

Application Number Title Priority Date Filing Date
MA25460A MA24760A1 (fr) 1998-02-13 1999-02-10 Gene de streptomyces avermitilis commandant le rapport des avermectines b2; b1, et procede nouveau pour la production d'avermectines

Country Status (32)

Country Link
EP (1) EP1053335A1 (enrdf_load_stackoverflow)
JP (2) JP2002503473A (enrdf_load_stackoverflow)
KR (3) KR20040053390A (enrdf_load_stackoverflow)
CN (2) CN1521180A (enrdf_load_stackoverflow)
AP (1) AP9901463A0 (enrdf_load_stackoverflow)
AR (1) AR018085A1 (enrdf_load_stackoverflow)
AU (1) AU752343C (enrdf_load_stackoverflow)
BG (1) BG64911B1 (enrdf_load_stackoverflow)
BR (1) BR9907893A (enrdf_load_stackoverflow)
CA (2) CA2521289A1 (enrdf_load_stackoverflow)
CO (1) CO5070698A1 (enrdf_load_stackoverflow)
DZ (1) DZ2720A1 (enrdf_load_stackoverflow)
EA (1) EA003905B1 (enrdf_load_stackoverflow)
GT (1) GT199900014A (enrdf_load_stackoverflow)
HN (1) HN1999000008A (enrdf_load_stackoverflow)
HR (1) HRP20000539A2 (enrdf_load_stackoverflow)
HU (1) HUP0100784A3 (enrdf_load_stackoverflow)
IL (2) IL137610A0 (enrdf_load_stackoverflow)
IS (1) IS5567A (enrdf_load_stackoverflow)
MA (1) MA24760A1 (enrdf_load_stackoverflow)
NO (1) NO20004044L (enrdf_load_stackoverflow)
NZ (2) NZ518657A (enrdf_load_stackoverflow)
OA (1) OA11449A (enrdf_load_stackoverflow)
PA (1) PA8467601A1 (enrdf_load_stackoverflow)
PE (1) PE20000352A1 (enrdf_load_stackoverflow)
PL (1) PL194270B1 (enrdf_load_stackoverflow)
SK (1) SK11722000A3 (enrdf_load_stackoverflow)
TN (1) TNSN99017A1 (enrdf_load_stackoverflow)
TW (1) TW585910B (enrdf_load_stackoverflow)
WO (1) WO1999041389A1 (enrdf_load_stackoverflow)
YU (1) YU50900A (enrdf_load_stackoverflow)
ZA (1) ZA991138B (enrdf_load_stackoverflow)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040053390A (ko) * 1998-02-13 2004-06-23 화이자 프로덕츠 인코포레이티드 아베르멕틴의 비2:비1의 비를 제어할 수 있는 스트렙토마이세스 아베르미틸리스 유전자
US6248579B1 (en) * 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
JP3884651B2 (ja) 1999-08-12 2007-02-21 ファイザー・プロダクツ・インク B2アベルメクチン:b1アベルメクチンの比を指示するストレプトミセス・アベルミティリス遺伝子
US7630836B2 (en) 2001-05-30 2009-12-08 The Kitasato Institute Polynucleotides
ES2321827T3 (es) * 2002-02-12 2009-06-12 Pfizer Products Inc. Gen de streptomyces avermitilis que rige la relacion de avermectinas b2-b1.
CN107338210B (zh) * 2017-09-05 2021-08-17 天津科技大学 一种阿维链霉菌合成培养基及其发酵液的制备方法
CN111269296B (zh) * 2020-03-06 2021-11-05 山东大学 一种nLsA蛋白及其结构基因和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4429042A (en) * 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
IN167980B (enrdf_load_stackoverflow) * 1987-01-23 1991-01-19 Pfizer
DE3881147T2 (de) * 1987-10-23 1993-09-02 Pfizer Verfahren zur herstellung von aglykonen von avermectin und sie enthaltende kulturen.
JPH0747171B2 (ja) * 1988-09-20 1995-05-24 株式会社東芝 圧延機の設定方法および装置
ES2079436T3 (es) * 1989-03-31 1996-01-16 Merck & Co Inc Clonacion de genes de streptomyces avermitilis para biosintesis de avermectinas y procedimientos para su uso.
US5252474A (en) * 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
JP2888586B2 (ja) * 1990-03-05 1999-05-10 社団法人北里研究所 エバーメクチンの特定成分を選択生産するための微生物およびその選択的製造法
FI942725L (fi) * 1993-12-16 1995-06-17 Pfizer Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta
KR20040053390A (ko) * 1998-02-13 2004-06-23 화이자 프로덕츠 인코포레이티드 아베르멕틴의 비2:비1의 비를 제어할 수 있는 스트렙토마이세스 아베르미틸리스 유전자

Also Published As

Publication number Publication date
CO5070698A1 (es) 2001-08-28
AU1887899A (en) 1999-08-30
KR100499214B1 (ko) 2005-07-07
IL183596A0 (enrdf_load_stackoverflow) 2007-09-20
CA2320031A1 (en) 1999-08-19
SK11722000A3 (sk) 2001-04-09
ZA991138B (en) 2000-08-14
EA003905B1 (ru) 2003-10-30
NZ518657A (en) 2003-10-31
OA11449A (en) 2003-12-03
KR20040053390A (ko) 2004-06-23
PA8467601A1 (es) 2000-09-29
KR20040099389A (ko) 2004-11-26
AU752343B2 (en) 2002-09-19
NO20004044D0 (no) 2000-08-11
HUP0100784A2 (hu) 2001-06-28
PL194270B1 (pl) 2007-05-31
TW585910B (en) 2004-05-01
EP1053335A1 (en) 2000-11-22
JP4011036B2 (ja) 2007-11-21
PL342468A1 (en) 2001-06-04
KR20010052166A (ko) 2001-06-25
HRP20000539A2 (en) 2001-04-30
CN1297485A (zh) 2001-05-30
IL137610A0 (en) 2001-07-24
CN1521180A (zh) 2004-08-18
CA2521289A1 (en) 1999-08-19
EA200000758A1 (ru) 2001-04-23
DZ2720A1 (fr) 2003-09-01
NO20004044L (no) 2000-10-11
PE20000352A1 (es) 2000-05-16
JP2002503473A (ja) 2002-02-05
BR9907893A (pt) 2000-11-14
BG64911B1 (bg) 2006-08-31
WO1999041389A1 (en) 1999-08-19
HUP0100784A3 (en) 2004-10-28
HN1999000008A (es) 1999-10-29
BG104759A (en) 2001-04-30
JP2004283174A (ja) 2004-10-14
NZ505676A (en) 2003-02-28
IS5567A (is) 2000-07-20
GT199900014A (es) 2000-07-25
TNSN99017A1 (fr) 2005-11-10
AU752343C (en) 2005-11-03
AR018085A1 (es) 2001-10-31
AP9901463A0 (en) 1999-03-31
YU50900A (sh) 2004-03-12

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