KR20020013516A - 분해되어 재조립된 바이러스-유사 입자를 함유하는 사람파필로마바이러스 백신 - Google Patents
분해되어 재조립된 바이러스-유사 입자를 함유하는 사람파필로마바이러스 백신 Download PDFInfo
- Publication number
- KR20020013516A KR20020013516A KR1020017012229A KR20017012229A KR20020013516A KR 20020013516 A KR20020013516 A KR 20020013516A KR 1020017012229 A KR1020017012229 A KR 1020017012229A KR 20017012229 A KR20017012229 A KR 20017012229A KR 20020013516 A KR20020013516 A KR 20020013516A
- Authority
- KR
- South Korea
- Prior art keywords
- hpv
- vlps
- buffer
- nacl
- vlp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000002245 particle Substances 0.000 title claims abstract description 19
- 229940124866 human papillomavirus vaccine Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 claims abstract description 68
- 239000000203 mixture Substances 0.000 claims abstract description 58
- 239000000872 buffer Substances 0.000 claims abstract description 49
- 238000003860 storage Methods 0.000 claims abstract description 19
- 241000701806 Human papillomavirus Species 0.000 claims description 186
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 119
- 150000003839 salts Chemical class 0.000 claims description 69
- 239000011780 sodium chloride Substances 0.000 claims description 60
- 229910052782 aluminium Inorganic materials 0.000 claims description 38
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 37
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 37
- 229920000053 polysorbate 80 Polymers 0.000 claims description 37
- 229940068968 polysorbate 80 Drugs 0.000 claims description 37
- 238000010494 dissociation reaction Methods 0.000 claims description 35
- 230000005593 dissociations Effects 0.000 claims description 35
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 33
- 238000000502 dialysis Methods 0.000 claims description 31
- 239000000243 solution Substances 0.000 claims description 28
- 239000003638 chemical reducing agent Substances 0.000 claims description 26
- 239000002671 adjuvant Substances 0.000 claims description 22
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 claims description 21
- 229960005486 vaccine Drugs 0.000 claims description 21
- 229910019142 PO4 Inorganic materials 0.000 claims description 17
- 239000002736 nonionic surfactant Substances 0.000 claims description 17
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 17
- 239000010452 phosphate Substances 0.000 claims description 17
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 16
- 239000007983 Tris buffer Substances 0.000 claims description 15
- 150000002500 ions Chemical class 0.000 claims description 15
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 14
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 14
- 241000701828 Human papillomavirus type 11 Species 0.000 claims description 13
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 11
- 238000011026 diafiltration Methods 0.000 claims description 11
- 238000000108 ultra-filtration Methods 0.000 claims description 11
- 239000002738 chelating agent Substances 0.000 claims description 9
- 239000004471 Glycine Substances 0.000 claims description 8
- 239000003599 detergent Substances 0.000 claims description 8
- 229910052751 metal Inorganic materials 0.000 claims description 8
- 239000002184 metal Substances 0.000 claims description 8
- 229910021645 metal ion Inorganic materials 0.000 claims description 7
- 239000008363 phosphate buffer Substances 0.000 claims description 6
- 239000001509 sodium citrate Substances 0.000 claims description 6
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 6
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 6
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 4
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 4
- 229940068977 polysorbate 20 Drugs 0.000 claims description 4
- 239000012537 formulation buffer Substances 0.000 claims description 3
- 239000001103 potassium chloride Substances 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 239000001488 sodium phosphate Substances 0.000 claims description 3
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 3
- IDOQDZANRZQBTP-UHFFFAOYSA-N 2-[2-(2,4,4-trimethylpentan-2-yl)phenoxy]ethanol Chemical compound CC(C)(C)CC(C)(C)C1=CC=CC=C1OCCO IDOQDZANRZQBTP-UHFFFAOYSA-N 0.000 claims description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims description 2
- 239000013504 Triton X-100 Substances 0.000 claims description 2
- 229920004890 Triton X-100 Polymers 0.000 claims description 2
- 229920004929 Triton X-114 Polymers 0.000 claims description 2
- 150000005215 alkyl ethers Chemical class 0.000 claims description 2
- 239000001110 calcium chloride Substances 0.000 claims description 2
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 2
- 238000011534 incubation Methods 0.000 claims description 2
- 229920001983 poloxamer Polymers 0.000 claims description 2
- -1 polyoxyethylene Polymers 0.000 claims description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 2
- 235000011148 calcium chloride Nutrition 0.000 claims 1
- 238000009472 formulation Methods 0.000 abstract description 23
- 230000029087 digestion Effects 0.000 abstract description 5
- 230000007774 longterm Effects 0.000 abstract description 3
- 102000004169 proteins and genes Human genes 0.000 description 33
- 108090000623 proteins and genes Proteins 0.000 description 33
- 238000004458 analytical method Methods 0.000 description 30
- 238000006731 degradation reaction Methods 0.000 description 18
- 230000015556 catabolic process Effects 0.000 description 16
- 238000000338 in vitro Methods 0.000 description 16
- 238000000354 decomposition reaction Methods 0.000 description 12
- 238000009826 distribution Methods 0.000 description 12
- 238000013103 analytical ultracentrifugation Methods 0.000 description 11
- 238000003556 assay Methods 0.000 description 11
- 238000011282 treatment Methods 0.000 description 11
- 239000000427 antigen Substances 0.000 description 6
- 102000036639 antigens Human genes 0.000 description 6
- 108091007433 antigens Proteins 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 238000011084 recovery Methods 0.000 description 6
- 230000002776 aggregation Effects 0.000 description 5
- 239000012266 salt solution Substances 0.000 description 5
- 238000003998 size exclusion chromatography high performance liquid chromatography Methods 0.000 description 5
- 208000022361 Human papillomavirus infectious disease Diseases 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 238000004220 aggregation Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000001493 electron microscopy Methods 0.000 description 4
- 241000238631 Hexapoda Species 0.000 description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000005847 immunogenicity Effects 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 229920000447 polyanionic polymer Polymers 0.000 description 3
- 238000010186 staining Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 230000000890 antigenic effect Effects 0.000 description 2
- 238000000149 argon plasma sintering Methods 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 239000010432 diamond Substances 0.000 description 2
- 238000011978 dissolution method Methods 0.000 description 2
- 238000002296 dynamic light scattering Methods 0.000 description 2
- 229960002897 heparin Drugs 0.000 description 2
- 229920000669 heparin Polymers 0.000 description 2
- 230000008696 hypoxemic pulmonary vasoconstriction Effects 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 229960002566 papillomavirus vaccine Drugs 0.000 description 2
- 108091033319 polynucleotide Proteins 0.000 description 2
- 102000040430 polynucleotide Human genes 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 2
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 206010058314 Dysplasia Diseases 0.000 description 1
- 238000012286 ELISA Assay Methods 0.000 description 1
- ZZIFPJZQHRJERU-WDSKDSINSA-N Glu-Cys-Gly Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](CS)C(=O)NCC(O)=O ZZIFPJZQHRJERU-WDSKDSINSA-N 0.000 description 1
- 108010053070 Glutathione Disulfide Proteins 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- 241001082241 Lythrum hyssopifolia Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 108091034057 RNA (poly(A)) Proteins 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008364 bulk solution Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000011210 chromatographic step Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000000385 dialysis solution Substances 0.000 description 1
- 238000000188 dichroism spectroscopy Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000001506 fluorescence spectroscopy Methods 0.000 description 1
- YPZRWBKMTBYPTK-BJDJZHNGSA-N glutathione disulfide Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@H](C(=O)NCC(O)=O)CSSC[C@@H](C(=O)NCC(O)=O)NC(=O)CC[C@H](N)C(O)=O YPZRWBKMTBYPTK-BJDJZHNGSA-N 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
- 229940031348 multivalent vaccine Drugs 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- YPZRWBKMTBYPTK-UHFFFAOYSA-N oxidized gamma-L-glutamyl-L-cysteinylglycine Natural products OC(=O)C(N)CCC(=O)NC(C(=O)NCC(O)=O)CSSCC(C(=O)NCC(O)=O)NC(=O)CCC(N)C(O)=O YPZRWBKMTBYPTK-UHFFFAOYSA-N 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- IYDGMDWEHDFVQI-UHFFFAOYSA-N phosphoric acid;trioxotungsten Chemical compound O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.OP(O)(O)=O IYDGMDWEHDFVQI-UHFFFAOYSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000004845 protein aggregation Effects 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000005000 reproductive tract Anatomy 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- PVGBHEUCHKGFQP-UHFFFAOYSA-N sodium;n-[5-amino-2-(4-aminophenyl)sulfonylphenyl]sulfonylacetamide Chemical compound [Na+].CC(=O)NS(=O)(=O)C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=C1 PVGBHEUCHKGFQP-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000006076 specific stabilizer Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000001370 static light scattering Methods 0.000 description 1
- 238000004627 transmission electron microscopy Methods 0.000 description 1
- 239000013638 trimer Substances 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12652899P | 1999-03-26 | 1999-03-26 | |
| US60/126,528 | 1999-03-26 | ||
| US09/524,624 | 2000-03-13 | ||
| US09/524,624 US6245568B1 (en) | 1999-03-26 | 2000-03-13 | Human papilloma virus vaccine with disassembled and reassembled virus-like particles |
| PCT/US2000/007595 WO2000057906A1 (en) | 1999-03-26 | 2000-03-22 | Human papillomavirus vaccine with disassembled and reassembled virus-like particles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20020013516A true KR20020013516A (ko) | 2002-02-20 |
Family
ID=26824774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020017012229A Withdrawn KR20020013516A (ko) | 1999-03-26 | 2000-03-22 | 분해되어 재조립된 바이러스-유사 입자를 함유하는 사람파필로마바이러스 백신 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US6245568B1 (enExample) |
| EP (1) | EP1165126B1 (enExample) |
| JP (1) | JP4594534B2 (enExample) |
| KR (1) | KR20020013516A (enExample) |
| AR (1) | AR023166A1 (enExample) |
| AT (1) | ATE339222T1 (enExample) |
| AU (1) | AU778937B2 (enExample) |
| CA (1) | CA2368391C (enExample) |
| CY (4) | CY1105779T1 (enExample) |
| DE (4) | DE122007000032I1 (enExample) |
| DK (1) | DK1165126T3 (enExample) |
| ES (1) | ES2270822T3 (enExample) |
| FR (1) | FR07C0026I2 (enExample) |
| LT (1) | LTC1165126I2 (enExample) |
| LU (3) | LU91327I2 (enExample) |
| NL (3) | NL300269I2 (enExample) |
| PT (1) | PT1165126E (enExample) |
| SI (1) | SI1165126T1 (enExample) |
| WO (1) | WO2000057906A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6962777B1 (en) * | 1997-09-05 | 2005-11-08 | Medimmune, Inc. | In vitro method for disassembly/reassembly of papillomavirus virus-like particles (vlps), homogeneous vlp and capsomere compositions produced by said methods; use thereof as vehicle for improved purification, and delivery of active agents |
| US7351533B2 (en) | 1997-09-05 | 2008-04-01 | Medimmune, Inc. | In vitro method for disassmbly/reassembly of papillomavirus virus-like particles (VLPs). Homogeneous VLP and cavsomere compositions produced by said methods: use thereof as vehicle for improved purification, and delivery of active agents |
| ATE426803T1 (de) * | 1999-12-09 | 2009-04-15 | Medimmune Inc | In-vitro-methode zur zerlegung und zum wiederzusammenfugen von papillomavirusartigen partikeln |
| AU2002330681C1 (en) * | 2001-07-26 | 2015-04-02 | Glaxosmithkline Biologicals S.A. | Vaccines comprising aluminium adjuvants and histidine |
| GB0118249D0 (en) * | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
| DE10137102A1 (de) * | 2001-07-30 | 2003-02-27 | Deutsches Krebsforsch | Polyvalente Vakzine gegen durch Papillomaviren verursachte Erkrankungen, Verfahren zu deren Herstellung und deren Verwendung |
| US20060073530A1 (en) * | 2001-08-15 | 2006-04-06 | Olaf Schneewind | Methods and compositions involving sortase B |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| US20040063188A1 (en) * | 2002-02-14 | 2004-04-01 | Novavax, Inc. | Kit for treating gastrointestinal tract |
| GB0206360D0 (en) * | 2002-03-18 | 2002-05-01 | Glaxosmithkline Biolog Sa | Viral antigens |
| GB0206359D0 (en) * | 2002-03-18 | 2002-05-01 | Glaxosmithkline Biolog Sa | Viral antigens |
| DE10237639A1 (de) * | 2002-08-13 | 2004-02-26 | Martin-Luther-Universität Halle-Wittenberg | Verfahren zur Herstellung von virusanalogen Partikeln durch in vitro-Assemblierung von Kapsomeren oder von Kapsomeren, an die biologisch aktive Makromoleküle gebunden sind, bei gleichzeitiger Verpackung der Makromoleküle |
| GB0220194D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
| WO2004039399A1 (en) | 2002-11-01 | 2004-05-13 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
| US7858098B2 (en) * | 2002-12-20 | 2010-12-28 | Glaxosmithkline Biologicals, S.A. | Vaccine |
| JP5475939B2 (ja) | 2002-12-20 | 2014-04-16 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | Ｈｐｖ−１６およびｈｐｖ−１８ｌ１ｖｌｐワクチン |
| JP4734608B2 (ja) * | 2004-07-01 | 2011-07-27 | 国立大学法人東京工業大学 | 生理的条件下でのウイルス粒子様構造体及びその形成方法 |
| CN101107022B (zh) * | 2005-01-25 | 2013-07-17 | 辉瑞爱尔兰药品合伙公司 | 用于渗滤的方法 |
| JP2009501520A (ja) * | 2005-07-14 | 2009-01-22 | メイヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ | パラミクソウイルス科ウイルス調製物 |
| CA2618439A1 (en) * | 2005-08-12 | 2007-02-22 | Astellas Pharma Inc. | Technique for stabilization of yw753 reparation |
| BRPI0520505B1 (pt) * | 2005-09-01 | 2015-03-31 | José Luis Nuño Ayalá | Fórmula estabilizadora de vacinas com antígenos vivos para uso em sistemas de vacinação em massa |
| TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| CA2652118C (en) * | 2006-05-11 | 2015-07-07 | Becton, Dickinson And Company | Method of protein extraction from cells |
| US9207240B2 (en) * | 2007-11-14 | 2015-12-08 | Arbor Vita Corporation | Method of efficient extraction of protein from cells |
| JP5313231B2 (ja) * | 2008-03-31 | 2013-10-09 | 森永乳業株式会社 | 耐熱性を付与する薬剤及び組成物 |
| CN102575220B (zh) | 2009-09-03 | 2015-09-16 | 贝克顿·迪金森公司 | 用于直接化学裂解的方法和组合物 |
| SI3831406T1 (sl) | 2010-08-23 | 2024-08-30 | Wyeth Llc | Stabilne formulacije antigenov neisseria meningitidis RLP2086 |
| NZ607224A (en) | 2010-09-10 | 2014-11-28 | Wyeth Llc | Non-lipidated variants of neisseria meningitidis orf2086 antigens |
| RU2665841C2 (ru) | 2012-03-09 | 2018-09-04 | Пфайзер Инк. | Композиции neisseria meningitidis и способы их применения |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| CA2866582A1 (en) | 2012-03-18 | 2013-09-26 | Brigitte Desiree Alberte Colau | Method of vaccination against human papillomavirus |
| KR101559622B1 (ko) * | 2012-07-30 | 2015-10-13 | 중앙대학교 산학협력단 | 인유두종바이러스 바이러스 유사입자의 고효율 정제방법 |
| EP2964665B1 (en) | 2013-03-08 | 2018-08-01 | Pfizer Inc | Immunogenic fusion polypeptides |
| BR112016004463A2 (pt) | 2013-09-08 | 2017-10-17 | Pfizer | composições de neisseria meningitidis e métodos das mesmas |
| US10888611B2 (en) | 2015-02-19 | 2021-01-12 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| CN118021947A (zh) | 2017-01-31 | 2024-05-14 | 辉瑞大药厂 | 脑膜炎奈瑟菌组合物及其使用方法 |
| US20200010850A1 (en) | 2017-02-17 | 2020-01-09 | The USA, as represeented by the Secretary, Dept. of Health and Human Services | Efficient cell free production of papillomavirus gene transfer vectors |
| SG11202003793WA (en) | 2017-10-30 | 2020-05-28 | Baxalta GmbH | Environmentally compatible detergents for inactivation of lipid-enveloped viruses |
| MX2022003682A (es) | 2019-09-27 | 2022-04-25 | Pfizer | Composiciones de neisseria meningitidis y metodos de las mismas. |
| CN110987571A (zh) * | 2019-12-31 | 2020-04-10 | 广州金域医学检验中心有限公司 | 一种单克隆多聚体m蛋白解聚方法 |
| CN111812313B (zh) * | 2020-06-22 | 2021-10-08 | 北京生物制品研究所有限责任公司 | 铝佐剂吸附型新型冠状病毒灭活疫苗中抗原的解离方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0971696B1 (en) * | 1997-02-06 | 2010-06-09 | Merck Sharp & Dohme Corp. | Thimerosal-free preservatives for vaccines |
| SK138199A3 (en) | 1997-04-08 | 2000-06-12 | Merck & Co Inc | Human papillomavirus antigen formulation and method for stabilizing a population of virus-like purified particles, derived from protein l1 or protein l1 and l2 of human papillomavirus |
| CA2295316C (en) | 1997-07-03 | 2007-06-26 | University Of Colorado, University Technology Corporation | Homogeneous human papilloma virus capsomere containing compositions, methods for manufacture, and the use thereof as diagnostic, prophylactic or therapy |
-
2000
- 2000-03-13 US US09/524,624 patent/US6245568B1/en not_active Expired - Lifetime
- 2000-03-22 AT AT00918248T patent/ATE339222T1/de active
- 2000-03-22 DE DE200712000032 patent/DE122007000032I1/de active Pending
- 2000-03-22 ES ES00918248T patent/ES2270822T3/es not_active Expired - Lifetime
- 2000-03-22 EP EP00918248A patent/EP1165126B1/en not_active Expired - Lifetime
- 2000-03-22 CA CA2368391A patent/CA2368391C/en not_active Expired - Lifetime
- 2000-03-22 JP JP2000607656A patent/JP4594534B2/ja not_active Expired - Lifetime
- 2000-03-22 AU AU39093/00A patent/AU778937B2/en not_active Expired
- 2000-03-22 DE DE200712000034 patent/DE122007000034I1/de active Pending
- 2000-03-22 WO PCT/US2000/007595 patent/WO2000057906A1/en not_active Ceased
- 2000-03-22 KR KR1020017012229A patent/KR20020013516A/ko not_active Withdrawn
- 2000-03-22 SI SI200030893T patent/SI1165126T1/sl unknown
- 2000-03-22 DK DK00918248T patent/DK1165126T3/da active
- 2000-03-22 PT PT00918248T patent/PT1165126E/pt unknown
- 2000-03-22 DE DE60030698T patent/DE60030698T2/de not_active Expired - Lifetime
- 2000-03-22 DE DE200712000033 patent/DE122007000033I1/de active Pending
- 2000-03-24 AR ARP000101345A patent/AR023166A1/es unknown
-
2001
- 2001-01-30 US US09/772,365 patent/US20010021385A1/en not_active Abandoned
-
2006
- 2006-11-14 CY CY20061101649T patent/CY1105779T1/el unknown
-
2007
- 2007-03-13 LU LU91327C patent/LU91327I2/fr unknown
- 2007-03-13 LU LU91326C patent/LU91326I2/fr unknown
- 2007-03-13 NL NL300269C patent/NL300269I2/nl unknown
- 2007-03-13 NL NL300270C patent/NL300270I1/nl unknown
- 2007-03-13 LU LU91328C patent/LU91328I2/fr unknown
- 2007-03-13 NL NL300268C patent/NL300268I1/nl unknown
- 2007-03-16 CY CY200700008C patent/CY2007008I2/el unknown
- 2007-03-16 CY CY2007009C patent/CY2007009I2/el unknown
- 2007-03-16 CY CY200700010C patent/CY2007010I2/el unknown
- 2007-03-19 LT LTPA2007002C patent/LTC1165126I2/lt unknown
- 2007-03-20 FR FR07C0026C patent/FR07C0026I2/fr active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR20020013516A (ko) | 분해되어 재조립된 바이러스-유사 입자를 함유하는 사람파필로마바이러스 백신 | |
| AU764138B2 (en) | Human papilloma virus vaccine formulations | |
| Shi et al. | Stabilization of human papillomavirus virus-like particles by non-ionic surfactants | |
| JP2019052169A (ja) | （ポリ）ペプチドのアンフォールディングを防止し、および／または（ポリ）ペプチドの（リ）フォールディングを誘導するための方法 | |
| US20220202717A1 (en) | Novel Method for Obtaining Efficient Viral Vector-Based Compositions for Vaccination or Gene Therapy | |
| MX2008014398A (es) | Formulacion de vacuna de nicotina-portador. | |
| JP2024517229A (ja) | インフルエンザに対する免疫原性組成物 | |
| JP2023552681A (ja) | 製剤安定化の向上および凍結乾燥プロセスの改善 | |
| US20240075124A1 (en) | Stable formulation of human papillomavirus virus-like particle vaccine | |
| JP2002504085A (ja) | Ｄｎａワクチン製剤 | |
| JP2004536129A (ja) | セツキシマブおよびポリオキシエチレンソルビタン脂肪酸エステルを含む液体製剤 | |
| JP2003512031A (ja) | 改善された特性を有するヒトパピローマウイルスウイルス様粒子の新規製造方法 | |
| JP4036494B2 (ja) | ウイルスを不活化した静脈内注射可能な免疫血清グロブリンの調製 | |
| CN109982716B (zh) | 在加工过程中稳定生物制药药物产品的新方法 | |
| AU2022207569B2 (en) | Stable preparation of human papillomavirus virus-like particle vaccine | |
| RU2745307C1 (ru) | Способ очистки рекомбинантного аденовируса 26 серотипа (Ad26) | |
| WO2025176145A1 (zh) | 九价人乳头瘤病毒疫苗及其应用 | |
| JP2001526292A (ja) | クエン酸またはトリエタノールアミンおよびそれらの組合せを含むｄｎａ医薬製剤 | |
| TW529953B (en) | Preparation of human recombinant erythropoietin and it's stabilized solution | |
| AU2003203737B2 (en) | DNA Pharmaceutical Formulations Comprising Citrate or Triethanolamine and Combinations Thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20010925 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |